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东海OBN和三维DAS-VSP数据的联合采集与处理方法研究 被引量:1
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作者 张少华 苟量 +8 位作者 余刚 刘海波 张昊 曹中林 陈沅忠 何光明 吴俊军 王熙明 王艳华 《石油物探》 CSCD 北大核心 2024年第1期30-44,共15页
近年来,光纤传感技术已经应用于地面地震数据、海洋地震数据、井中地震数据和井地联合地震数据的采集,推动了光纤传感技术在地球物理特别是地震数据采集中的应用。井地或井海联合地震勘探是陆地或海洋三维地震与三维DAS-VSP勘探相结合... 近年来,光纤传感技术已经应用于地面地震数据、海洋地震数据、井中地震数据和井地联合地震数据的采集,推动了光纤传感技术在地球物理特别是地震数据采集中的应用。井地或井海联合地震勘探是陆地或海洋三维地震与三维DAS-VSP勘探相结合形成的三维立体地震勘探方法,利用井海联采的三维DAS-VSP数据,可以获得地下井周围准确的时深关系、地层速度、反褶积算子、球面扩散补偿因子、吸收衰减因子、各向异性参数和井筒周围的高分辨率构造成像,这些参数可以基于井驱处理提高陆地或海洋三维地震数据的处理质量。在中国东海某OBN数据勘探中首次开展了井下套管内铠装光缆同步采集的三维DAS-VSP数据的处理方法研究以及成像处理。首先,采用常规的三维VSP数据成像处理技术对三维DAS-VSP数据进行常规处理,具体处理流程包括:观测系统定义、预处理、初至拾取、静校正、振幅补偿、反褶积、波场分离、速度分析与建模和利用上行反射波进行井周围地层的构造成像;然后,再根据海上三维DAS-VSP数据下行多次波的特点,研发了海上三维DAS-VSP数据的下行多次波成像技术,扩展了三维DAS-VSP数据成像范围,提高了三维DAS-VSP数据成像的整体质量。与本工区早期的三维OBC数据成像结果相比,本次三维DAS-VSP数据的下行多次波成像结果表明,井周围三维构造成像质量得到了显著改进,大幅度扩展了成像范围;新采集的OBN数据和三维DAS-VSP数据的成像结果展示了更为详细和较高分辨率的构造成像,基于新的成像资料,对储层顶部和储层内流体的识别与追踪变得更加容易和清晰。井海联采技术生产效率高且成本低,既能快速获得三维DAS-VSP数据及成像,还能对三维海洋地震数据进行井驱提高分辨率处理。此外,三维OBN或OBC数据和三维DAS-VSP数据还能够进行融合处理,实现井地或井海同步采集数据的联合偏移成像,可以大幅度提高三维海洋地震数据的成像品质,值得在有条件的地方推广应用。 展开更多
关键词 光纤 分布式 daS-VSP OBN OBC 联采 多次波偏移
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采用非稳相偏振滤波的DAS-VSP数据P/S波分离方法及其应用
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作者 王腾飞 程玖兵 +3 位作者 孟涛 曹中林 胡善政 段鹏飞 《地球物理学报》 SCIE EI CAS CSCD 北大核心 2024年第7期2761-2772,共12页
分布式光纤声学传感(DAS)因成本低、易布设以及高密度采样等优势正成为重要的地震观测技术,尤其是越来越多地与垂直地震剖面(VSP)结合,用于主动地震勘探或被动地震监测.DAS传感器通过感知弹性波场产生的轴向应变或应变速率来观测地震波... 分布式光纤声学传感(DAS)因成本低、易布设以及高密度采样等优势正成为重要的地震观测技术,尤其是越来越多地与垂直地震剖面(VSP)结合,用于主动地震勘探或被动地震监测.DAS传感器通过感知弹性波场产生的轴向应变或应变速率来观测地震波场振动.然而,目前单分量DAS-VSP数据未完整地记录地下弹性波场的三维矢量振动信号,因此如何从中分离出P波或S波用于后续地震成像与参数反演是重要且很有挑战的课题.以弹性波传播理论为基础,本文根据P波和S波的频散关系估算接收点处各自的偏振方向,通过随频率和空间位置变化的偏振滤波实现DAS-VSP数据的P/S波分离.理论模型合成数据与东海实际DAS-VSP数据实验结果表明,该方法能有效地将P波和S波信号从单分量DAS-VSP数据中分离出来,可为后续纵横波速度反演、PP与PS波成像提供关键的数据预条件处理. 展开更多
关键词 分布式光纤声学传感(daS) VSP P/S波分离 偏振投影 非稳相滤波
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基于“脑肠轴理论”探讨龟羚帕安丸对PD大鼠纹状体DA及血清CCK、VIP水平影响的研究
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作者 常学辉 张良芝 +2 位作者 陈帅杰 王冬莲 张创业 《四川中医》 2024年第1期80-83,共4页
目的:基于“脑肠轴理论”探讨龟羚帕安丸对PD大鼠纹状体裂解液多巴胺(Dopamine,DA)、血清胆囊收缩素(cholecystokinin,CCK)及血管活性肠肽(vasoactive intestinal peptide,VIP)水平的影响。方法:采用6-羟基多巴胺注射法制作PD大鼠模型,... 目的:基于“脑肠轴理论”探讨龟羚帕安丸对PD大鼠纹状体裂解液多巴胺(Dopamine,DA)、血清胆囊收缩素(cholecystokinin,CCK)及血管活性肠肽(vasoactive intestinal peptide,VIP)水平的影响。方法:采用6-羟基多巴胺注射法制作PD大鼠模型,随机分为模型组、西药组、中药高、中、低剂量组,每组15只,另设15只假手术组。模型组及假手术组给予等容积生理盐水灌胃,其余组给予相应药物灌胃,连续给药4周。酶联免疫吸附测定法(ELISA)检测纹状体裂解液DA及血清CCK、VIP水平。结果:模型组大鼠纹状体DA、血清CCK及VIP水平显著降低;中药各剂量组、西药组大鼠纹状体DA、血清CCK及VIP水平明显均增加(P<0.01)。结论:龟羚帕安丸具有明显神经保护作用,作用机制与激活脑肠轴、增加血清CCK及VIP水平、增加中脑黑质纹状体DA的水平、发挥改善肠道功能作用有关。 展开更多
关键词 帕金森病 龟羚帕安丸 多巴胺 胆囊收缩素 血管活性肠肽
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基于SDRS数据的钻石DA20飞机故障分析及处理
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作者 孙一 《机电信息》 2024年第16期47-49,53,共4页
基于使用困难报告系统(SDRS)对钻石DA20飞机的故障数据进行分析。基于SDRS系统收集到的数据,结合故障分类方法,对钻石DA20飞机的不同故障进行研究,并提出相应的解决措施,有利于提高钻石DA20飞机机队的可靠性和安全性。
关键词 SDRS da20飞机 故障 数据
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Effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization in high myopia mice 被引量:3
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作者 Yan-Yan Ji Shi-Xi Zhang +1 位作者 Ye Kang Song Chen 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第7期1034-1040,共7页
AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia mice.METHODS:The C57BL/6J mice were deprived of the right eye for 4wk,a... AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia mice.METHODS:The C57BL/6J mice were deprived of the right eye for 4wk,and the high myopia was diagnosed by optometry,the diopter was less than-6.00 D,and CNV was induced by 532 nm laser.The changes of dopamine D1 receptor(DRD1),dopamine D2 receptor(DRD2),and vascular endothelial growth factor A(VEGFA)were detected by Western blot technology at 0.5,1,2h,and 7d after 0.01%,0.05%,and 0.1%atropine eye drops,respectively,the area of CNV was measured.RESULTS:Significant increases were observed on the expression of DRD2 in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).Significant decreases were observed on the expression of DRD1 and VEGFA in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).The area of CNV induced by laser in the drug-treated group was significantly smaller than that in the control group,and the higher the concentration,the more significant the inhibitory effect(P<0.05).CONCLUSION:The 0.01%,0.05%,0.1%atropine eye drops can decrease the level of VEGFA and inhibit high myopia CNV indirectly by up-regulating the level of DRD2 and down-regulating the level of DRD1,and the effect of 0.05%and 0.1%atropine eye drops is more significant. 展开更多
关键词 high myopia choroidal neovascularization low concentration atropine eye drops dopamine D1 receptor dopamine D2 receptor
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Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease 被引量:2
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作者 Zihang Zhou Yalong Yan +4 位作者 Heng Gu Ruiao Sun Zihan Liao Ke Xue Chuanxi Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1759-1767,共9页
Parkinson’s disease can affect not only motor functions but also cognitive abilities,leading to cognitive impairment.One common issue in Parkinson’s disease with cognitive dysfunction is the difficulty in executive ... Parkinson’s disease can affect not only motor functions but also cognitive abilities,leading to cognitive impairment.One common issue in Parkinson’s disease with cognitive dysfunction is the difficulty in executive functioning.Executive functions help us plan,organize,and control our actions based on our goals.The brain area responsible for executive functions is called the prefrontal co rtex.It acts as the command center for the brain,especially when it comes to regulating executive functions.The role of the prefrontal cortex in cognitive processes is influenced by a chemical messenger called dopamine.However,little is known about how dopamine affects the cognitive functions of patients with Parkinson’s disease.In this article,the authors review the latest research on this topic.They start by looking at how the dopaminergic syste m,is alte red in Parkinson’s disease with executive dysfunction.Then,they explore how these changes in dopamine impact the synaptic structure,electrical activity,and connection components of the prefrontal cortex.The authors also summarize the relationship between Parkinson’s disease and dopamine-related cognitive issues.This information may offer valuable insights and directions for further research and improvement in the clinical treatment of cognitive impairment in Parkinson’s disease. 展开更多
关键词 dopamine dopamine receptor dopamine transporter executive dysfunction neural network neural oscillation prefrontal cortex synaptic plasticity
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黄芪续命汤对阿尔茨海默病患者认知功能及NE、DA、ChAT表达的影响 被引量:4
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作者 陶录岭 鹿滨麒 +1 位作者 袁艳 袁磊 《吉林中医药》 2024年第1期62-67,共6页
目的探究黄芪续命汤对阿尔茨海默病(Alzheimer’s disease,AD)患者认知功能及去甲肾上腺素(noradrenaline,NE)、多巴胺(dopamine,DA)、乙酰胆碱转移酶(acetylcholintransferase,ChAT)表达的影响。方法前瞻性选取2019年1月-2022年12月期... 目的探究黄芪续命汤对阿尔茨海默病(Alzheimer’s disease,AD)患者认知功能及去甲肾上腺素(noradrenaline,NE)、多巴胺(dopamine,DA)、乙酰胆碱转移酶(acetylcholintransferase,ChAT)表达的影响。方法前瞻性选取2019年1月-2022年12月期间于南阳市第二人民医院接受治疗的110例AD患者,采用随机数字表法将患者分为研究组与对照组,各55例。对照组采用多奈哌齐配合小续命汤治疗,研究组使用多奈哌齐配合黄芪续命汤治疗,2组均连续治疗15 d。比较患者治疗前后蒙特利尔认知评价量表(Mo CA)评分变化、神经精神量表(NPI)、日常生活能力(ADL)、精神状态检查量表(MMSE)、NE、DA、ChAT、血清同型半胱胺酸(Hcy)、血清淀粉蛋白前b位分解酶1(BACE1)与脑源性神经营养因子(BDNF)等指标变化。结果与本组治疗前相比,研究组患者治疗后的Mo CA评分中的回忆力、命名力、抽象、语言、注意力、视空间和执行、定向力评分均有明显升高(均P<0.01),与对照组治疗后的Mo CA评分相比,研究组的回忆力、命名力、抽象、语言、注意力、视空间和执行、定向力评分更高(均P<0.01);与本组治疗前相比,研究组的NPI、ADL评分明显降低而MMSE评分明显提高(均P<0.01),与对照组治疗后相比,研究组的NPI、ADL评分更低而MMSE评分明显更高(均P<0.01);与本组治疗前相比,研究组的NE、DA、ChAT指标水平明显提升(均P<0.01),与对照组治疗后相比,NE、DA、ChAT指标水平均更高(均P<0.01);与本组治疗前相比,研究组的Hcy、BACE1水平降低而BDNF水平提高(均P<0.01),与对照组治疗后相比,研究组的Hcy、BACE1水平明显更低而BDNF水平明显更高(均P<0.01);治疗后将实验组与对照组的总有效率进行对比,实验组总有效率明显更高(P<0.05)。结论黄芪续命汤结合多奈哌齐治疗AD患者具有较为良好的临床疗效,其能进一步改善患者的认知功能、精神状况、智能水平,可提高患者NE、DA、ChAT、BDNF水平,降低患者Hcy、BACE1水平,值得进一步研究。 展开更多
关键词 黄芪续命汤 阿尔茨海默病 去甲肾上腺素 多巴胺 乙酰胆碱转移酶
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Hippocampal dopamine as a key regulator for learning deficits in Parkinson's disease 被引量:1
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作者 Kun Wu Shuai Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第6期1193-1194,共2页
Parkinson's disease(PD)is a progressive neurodegenerative disorder with clinical symptoms of involuntary or uncontrollable movements such as tremors,rigidity,and incoordination.The learning deficit is largely over... Parkinson's disease(PD)is a progressive neurodegenerative disorder with clinical symptoms of involuntary or uncontrollable movements such as tremors,rigidity,and incoordination.The learning deficit is largely overlooked in the past because it is generally less impaired in the early stages of PD than in Alzheimer's disease. 展开更多
关键词 IMPAIRED dopamine CLINICAL
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TA对基于DA/PEI的PVDF复合疏松纳滤膜的结构与性能影响的研究
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作者 张琪 陈淑怡 +3 位作者 张晨 蒋淑红 陈红 王军 《现代化工》 CAS CSCD 北大核心 2024年第7期116-123,共8页
为了对染料废水中染料和盐进行有效地分离与回收,以聚偏氟乙烯(PVDF)超滤膜为基膜,以多巴胺(DA)、单宁酸(TA)及聚乙烯亚胺(PEI)为共沉积物,以均苯三甲酰氯(TMC)为有机相,采用界面聚合法制备了PVDF复合疏松纳滤膜,探讨了DA与TA及PEI与TA... 为了对染料废水中染料和盐进行有效地分离与回收,以聚偏氟乙烯(PVDF)超滤膜为基膜,以多巴胺(DA)、单宁酸(TA)及聚乙烯亚胺(PEI)为共沉积物,以均苯三甲酰氯(TMC)为有机相,采用界面聚合法制备了PVDF复合疏松纳滤膜,探讨了DA与TA及PEI与TA的质量浓度比对PVDF复合疏松纳滤膜结构与性能及处理模拟RB5染料废水效果的影响。结果表明,当ρ(DA)/ρ(TA)与ρ(PEI)/ρ(TA)分别为2/8和4/6时,膜性能最佳,此时纯水通量较不添加TA时分别提高36%和114%;模拟RB5染料废水通量较不添加TA时分别提高37%和87%;染料截留率分别为95.5%、95.4%,盐(NaCl)的截留率分别为3.95%、3.15%。PVDF复合疏松纳滤膜在处理模拟RB5染料废水中运行稳定性良好。 展开更多
关键词 多巴胺 单宁酸 聚乙烯亚胺 PVDF复合疏松纳滤膜 染料/盐
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舒肌汤对L-DOPA诱发的帕金森病肌僵直大鼠的作用及其脑组织TH、DA含量和FosB、p-ERK蛋白的影响
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作者 刘超平 孙婷 鲍玺 《中国中医药科技》 CAS 2024年第5期785-790,共6页
目的:观察舒肌汤对左旋多巴(Levodopa,L-DOPA)诱发的帕金森病(Parkinson’s disease,PD)肌僵直模型大鼠的影响,并探讨其作用机制。方法:L-DOPA诱导建立PD肌僵直大鼠模型,随机分为模型组(等体积生理盐水),舒肌汤低、中、高剂量组(10、20... 目的:观察舒肌汤对左旋多巴(Levodopa,L-DOPA)诱发的帕金森病(Parkinson’s disease,PD)肌僵直模型大鼠的影响,并探讨其作用机制。方法:L-DOPA诱导建立PD肌僵直大鼠模型,随机分为模型组(等体积生理盐水),舒肌汤低、中、高剂量组(10、20、40 g/kg),同时设假手术组(等体积生理盐水)作为对照,每组6只大鼠,每天灌胃给药1次,连续给药28 d。给药完成后通过旋转次数实验、翻正反射实验、肌电图检测行为学表现。免疫组化检测脑组织酪氨酸羟化酶(tyrosine hydroxylase,TH)表达水平。ELISA检测脑纹状体组织多巴胺(dopamine,DA)和TH的含量。Western blot检测脑纹状体组织FBJ鼠科骨肉瘤病毒癌基因同源物B(FBJ Murine Osteosarcoma Viral Oncogene Homolog B,FosB)、磷酸化细胞外信号调节激酶(phosphorylation-extracellular signal-regulated kinase,p-ERK)蛋白表达水平。结果:与假手术组相比,模型组大鼠旋转次数、翻正反射时间与评分、肌肉动作电位波幅和潜伏期显著升高或延长(P<0.01),MCV显著降低(P<0.01);与模型组相比,舒肌汤组大鼠旋转次数、翻正反射时间与评分、肌肉动作电位波幅和潜伏期显著降低或缩短(P<0.05),MCV显著升高(P<0.01)。免疫组化结果显示舒肌汤可上调脑组织TH表达水平;ELISA结果显示舒肌汤可上调DA和TH含量。Western blot结果显示舒肌汤可下调FosB、p-ERK蛋白表达水平。结论:舒肌汤对帕金森病模型大鼠肌僵直有显著疗效,其作用机制可能与上调DA和TH含量、下调FosB、p-ERK蛋白表达有关。 展开更多
关键词 帕金森病 肌僵直 左旋多巴 舒肌汤 多巴胺 酪氨酸氢化酶 FOSB P-ERK 大鼠
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长庆安塞油田剩余油开发区DAS井地联采技术探索与实践
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作者 陈策 王学刚 +3 位作者 陈浩林 代波 周丽萍 黄建华 《石油科技论坛》 2024年第3期95-103,117,共10页
中国石油集团东方地球物理勘探有限责任公司结合长庆安塞油田开发区“三低”和“双复杂”的典型特点,面对老油田剩余油预测突出问题,从井地、井震协同一体化研究思路出发,开展国内首次面向开发区剩余油预测的多井DAS三维井地联采技术探... 中国石油集团东方地球物理勘探有限责任公司结合长庆安塞油田开发区“三低”和“双复杂”的典型特点,面对老油田剩余油预测突出问题,从井地、井震协同一体化研究思路出发,开展国内首次面向开发区剩余油预测的多井DAS三维井地联采技术探索与实践,通过井地联合勘探实现地面地震测量和井中地震测量的优势互补,取得了良好成果。(1)通过井震同步井驱处理,三维地震资料保真度和分辨率明显提升,有效频带拓宽8%以上。(2)通过井地、井震一体化油藏静态描述剩余油预测研究,减少了单一地面地震解释成果多解性,可分辨更小地质单元,为油田精细开发提供了可靠的资料依据。(3)DAS三维井地联采配套技术支撑了安塞油田新增地质储量,并通过低产低效井组挖潜措施调整,提产效果明显。通过本次研究得出,井地联合立体探测是提升油田开发过程中微幅构造刻画和储层、流体预测精度的有效技术手段,形成的技术可推动物探技术向油田开发延伸、向井地立体探测发展,可为老油田稳产增效、推进高效开发提供支撑。 展开更多
关键词 井地联采 daS 剩余油预测 三维地震 安塞油田
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砂土含水率对DAS振幅响应影响的试验研究
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作者 李俊鹏 张诚成 +3 位作者 施斌 陈卓 谢涛 郭君仪 《防灾减灾工程学报》 CSCD 北大核心 2024年第2期434-441,458,共9页
利用分布式声波传感(DAS)技术和地下通讯光纤网进行周界安防(入侵)监控、管道泄漏监测、交通状况评估等是城市安全动态监测的新方向。为探究DAS监测过程中暗光纤周围岩土介质含水率变化对DAS振幅响应特性的影响,设计了小球撞击圆盘与小... 利用分布式声波传感(DAS)技术和地下通讯光纤网进行周界安防(入侵)监控、管道泄漏监测、交通状况评估等是城市安全动态监测的新方向。为探究DAS监测过程中暗光纤周围岩土介质含水率变化对DAS振幅响应特性的影响,设计了小球撞击圆盘与小球直接撞击砂土面二种激振方式下五种质量含水率0%、5%、10%、15%和20%砂土的DAS振幅响应试验。试验结果表明:(1)小球自由下落撞击砂土面激发的振动信号和传感光纤圆环布设可提高DAS信噪比,试验装置可靠性高、试验结果重复性好;(2)受砂土似黏聚力和声波传播衰减两个因素共同影响,DAS信号振幅随砂土含水率变化存在一个临界含水率。当砂土含水率小于临界含水率时,DAS信号振幅随含水率增大而减小,而当砂土含水率大于临界含水率时,DAS信号振幅随含水率增大而增大;(3)因砂土似黏聚力作用和小球撞击时能量转化的差异,小球与砂土的接触形式对DAS振幅响应有显著影响。研究结果为城市地下工程安全动态DAS精细监测提供理论依据。 展开更多
关键词 daS 砂土 含水率 振幅响应特性 似黏聚力 声波衰减
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How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease
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作者 Livia La Barbera Paraskevi Krashia Annalisa Nobili 《Neural Regeneration Research》 SCIE CAS 2025年第5期1405-1406,共2页
Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc ear.AD is cha racterized by featured histo... Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc ear.AD is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes. 展开更多
关键词 ALZHEIMER alterations dopamine
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基于PLS-DA的盘龙七及其易混品大盘龙七差异性成分分析
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作者 何姬 刘妍如 +8 位作者 段金廒 唐志书 宋忠兴 赵艳婷 游雪莲 张德柱 杨国伟 张丽 权伟 《中国现代中药》 CAS 2024年第9期1520-1527,共8页
目的:确定盘龙七及其同名异物药材大盘龙七的差异性成分并建立其含量测定方法。方法:采用偏最小二乘法-判别分析(PLS-DA)结合超高效液相色谱-四极杆-飞行时间质谱法(UPLC-Q-TOF-MS)分析盘龙七和大盘龙七差异性成分,并建立差异性成分定... 目的:确定盘龙七及其同名异物药材大盘龙七的差异性成分并建立其含量测定方法。方法:采用偏最小二乘法-判别分析(PLS-DA)结合超高效液相色谱-四极杆-飞行时间质谱法(UPLC-Q-TOF-MS)分析盘龙七和大盘龙七差异性成分,并建立差异性成分定性、定量分析方法。结果:PLS-DA结果显示以t检验(P<0.05)和变量重要性投影(VIP)值(VIP>1.0)为标准,筛选出盘龙七和大盘龙七差异性成分共296个。对排名靠前的差异性成分进行表征分析,进一步筛选出符合碎片裂解规律及文献记载的差异性成分共8个,其中绿原酸、没食子酸、岩白菜素3个成分含量差异最显著。结论:该方法能有效分析盘龙七和大盘龙七的差异性,为盘龙七及大盘龙七的质量评价及定性、定量分析提供参考。 展开更多
关键词 盘龙七 大盘龙七 偏最小二乘法-判别分析 超高效液相色谱-四极杆-飞行时间质谱法 绿原酸 没食子酸 岩白菜素
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Melatonin and dopamine alleviate waterlogging stress in apples by recruiting beneficial endophytes to enhance physiological resilience
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作者 Yang Cao Peihua Du +5 位作者 Yuwei Shang Jiahao Ji Leiqing Tan Xue Zhang Jizhong Xu Bowen Liang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第7期2270-2291,共22页
Melatonin and dopamine can potentially prevent waterlogging stress in apples.The current study investigated the mechanism by which melatonin and dopamine alleviate apple waterlogging stress.This study demonstrated tha... Melatonin and dopamine can potentially prevent waterlogging stress in apples.The current study investigated the mechanism by which melatonin and dopamine alleviate apple waterlogging stress.This study demonstrated that melatonin and dopamine alleviated waterlogging by removing reactive oxygen species(ROS),and that the nitric oxide(NO)content and nitrate reductase(NR)activity were significantly correlated.Melatonin and dopamine were also found to recruit different candidate beneficial endophytes(melatonin:Novosphingobium,Propionivibrio,and Cellvibrio;dopamine:Hydrogenophaga,Simplicispira,Methyloversatilis,Candidatus_Kaiserbacteria,and Humicola),and these endophytes were significantly and positively correlated with plant growth.Network analyses showed that melatonin and dopamine significantly affected the endophytic bacterial and fungal communities under waterlogging stress.The metabolomic results showed that melatonin and dopamine led to waterlogging resistance by upregulating the abundance of beneficial substances such as amino acids,flavonoids,coumarins,and organic acids.In addition,melatonin and dopamine regulated the physicochemical properties of the soil,which altered the endophyte community and affected plant growth.The co-occurrence network demonstrated close and complex relationships among endophytes,metabolites,soil,and the plants.Our results demonstrate that melatonin and dopamine alleviate waterlogging stress in apples by recruiting beneficial endophytes to enhance physiological resilience.This study provides new insights into how melatonin and dopamine alleviate stress and a theoretical basis for synergistic beneficial microbial resistance to waterlogging stress. 展开更多
关键词 dopamine ENDOPHYTES Malus hupehensis MELATONIN metabolomics WATERLOGGING
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高压氧联合舍曲林对创伤性颅脑损伤后抑郁患者疗效及血清DA、5-HT的影响 被引量:1
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作者 向勇 朱建萍 +1 位作者 徐俊芳 汪林涛 《中国药物应用与监测》 CAS 2024年第3期264-267,共4页
目的探讨高压氧联合舍曲林对创伤性颅脑损伤后抑郁患者疗效及血清多巴胺(DA)、5-羟色胺(5-HT)水平的影响。方法选取2021年1月至2023年1月在十堰市人民医院接受治疗的创伤性颅脑损伤后抑郁患者102例,按照随机数字表法分为对照组(n=51)与... 目的探讨高压氧联合舍曲林对创伤性颅脑损伤后抑郁患者疗效及血清多巴胺(DA)、5-羟色胺(5-HT)水平的影响。方法选取2021年1月至2023年1月在十堰市人民医院接受治疗的创伤性颅脑损伤后抑郁患者102例,按照随机数字表法分为对照组(n=51)与研究组(n=51)。对照组给予舍曲林治疗,研究组给予舍曲林联合高压氧治疗。比较两组患者治疗前后Barthel指数(BI)、血清DA、5-HT水平、汉密尔顿抑郁量表(HAMD)评分、洛文斯顿作业疗法认知评定量表(LOTCA)评分。结果治疗4周后,研究组BI评分高于对照组[(89.56±5.90)分,(76.89±3.27)分;P<0.05],研究组DA[(79.66±30.89)nmol·L^(-1),(62.58±20.52)nmol·L^(-1)]、5-HT水平[(479.85±219.52)ng·mL^(-1),(364.14±200.41)ng·mL^(-1)]均高于对照组(均P<0.05)。治疗4周后,研究组HAMD评分低于对照组(P<0.05),LOTCA各维度评分均高于对照组(均P<0.05)。结论高压氧联合舍曲林能缓解患者抑郁行为,并改善其认知功能,这可能与血清DA、5-HT水平上调有关。 展开更多
关键词 高压氧 舍曲林 创伤性颅脑损伤 抑郁 多巴胺 5-羟色胺
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Comparison of da Vinci 5 with previous versions of da Vinci and Sina:A review
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作者 Arya Asadizeidabadi Seyedmohammadamin Hosseini +2 位作者 Fedor Vetshev Sergey Osminin Seyedali Hosseini 《Laparoscopic, Endoscopic and Robotic Surgery》 2024年第2期60-65,共6页
Robotic systems have become popular in modern surgical procedures.The option of telesurgery has effectively addressed geographic limitations.These systems are offered by numerous companies worldwide.In this review art... Robotic systems have become popular in modern surgical procedures.The option of telesurgery has effectively addressed geographic limitations.These systems are offered by numerous companies worldwide.In this review article,we discuss four models of robotic systems to determine their advantages:the Sina flex system from Iran and the da Vinci Xi,SP,and 5 systems from the USA.We compared aspects such as architecture,instruments,visualizations,clinical use,and costs.Our findings suggest that the da Vinci robot,which was introduced earlier than the Sina system,utilizes proprietary and limited-use EndoWrist instruments with diameters ranging from 8 to 12 mm and features advanced imaging capabilities,including three-dimensional optical,tomographic,and fluorescence imaging.It is well established and widely utilized in various surgical procedures.Conversely,the Sina flex system employs single-use 5 mm instruments and is equipped with two-dimensional optical imaging as a standard,with optional three-dimensional and fluorescence imaging upgrades available.Despite its affordability,the Sina flex system is relatively new and has not yet been clinically tested.Additionally,the Sina flex system is more user-friendly. 展开更多
关键词 Robot-assisted surgery Robotic surgery da Vinci 5 da Vinci SINA TELESURGERY
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The dopaminergic system and Alzheimer's disease
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作者 Yuhan Zhang Yuan Liang Yixue Gu 《Neural Regeneration Research》 SCIE CAS 2025年第9期2495-2512,共18页
Alzheimer's disease is a common neurodegenerative disorder in older adults.Despite its prevalence,its pathogenesis remains unclea r.In addition to the most widely accepted causes,which in clude excessive amyloid-b... Alzheimer's disease is a common neurodegenerative disorder in older adults.Despite its prevalence,its pathogenesis remains unclea r.In addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this condition.Dopamine is a crucial catecholaminergic neurotransmitter in the human body.Dopamine-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical manifestations.Howeve r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive impairment.This review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related drugs.The aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options. 展开更多
关键词 adverse drug reaction Alzheimer's disease CATECHOLAMINE dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease NEUROTRANSMITTER signaling pathways traditional Chinese medicine TREATMENT
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Mussel-inspired Methacrylic Gelatin-dopamine/Ag Nanoparticles/Graphene Oxide Hydrogels with Improved Adhesive and Antibacterial Properties for Applications as Wound Dressings
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作者 宿正楠 HU Yanru +5 位作者 MENG Lihui OUYANG Zhiyuan LI Wenchao ZHU Fang XIE Bin 吴庆知 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第2期512-521,共10页
A novel strategy was developed to prepare the methacrylic gelatin-dopamine(GelMA-DA)/Ag nanoparticles(NPs)/graphene oxide(GO) composite hydrogels with good biocompatibility,mechanical properties,and antibacterial acti... A novel strategy was developed to prepare the methacrylic gelatin-dopamine(GelMA-DA)/Ag nanoparticles(NPs)/graphene oxide(GO) composite hydrogels with good biocompatibility,mechanical properties,and antibacterial activity.Mussel-inspired DA was utilized to modify the GelMA molecules,which imparts good adhesive performance to the hydrogels.GO,interfacial enhancer,not only improves mechanical properties of the hydrogels,but also provides anchor sites for loading Ag NPs through numerous oxygencontaining functional groups on the surface.The experimental results show that the GelMA/Ag NPs/GO hydrogels have good biocompatibility,and exhibit a swelling rate of 202±16%,the lap shear strength of 147±17 kPa,and compressive modulus of 136±53 kPa,in the case of the Ag NPs/GO content of 2 mg/mL.Antibacterial activity of the hydrogels against both gram-negative and gram-positive bacteria is dependent on the Ag NPs/GO content derived from the release of Ag^(+).Furthermore,the GelMA/Ag NPs/GO hydrogels possess good adhesive ability,which is resistant to highly twisted state when stuck on the surface of pigskin.These results demonstrate promising potential of the GelMA-DA/Ag NPs/GO hydrogels as wound dressings for biomedical applications in clinical and emergent treatment. 展开更多
关键词 GelMA dopamine graphene oxide adhesion antibacterial ability
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基于Fe^(3+)-DA-APS自催化体系的Fe_(3)O_(4)/PAA水凝胶的制备及性能研究
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作者 温暖 何新宇 +2 位作者 黄欣薏 何帅 左芳 《广东化工》 CAS 2024年第4期5-8,共4页
以Fe_(3)O_(4)纳米粒子为磁性组分,基于AA(丙烯酸)与部分Fe3O4反应产生的Fe3+、多巴胺(DA)构建双重自催化过硫酸铵(APS)的自由基聚合体系,在低温下制备了Fe_(3)O_(4)/聚丙烯酸(PAA)水凝胶,并对其进行表征。研究结果表明:Fe_(3)O_(4)/PA... 以Fe_(3)O_(4)纳米粒子为磁性组分,基于AA(丙烯酸)与部分Fe3O4反应产生的Fe3+、多巴胺(DA)构建双重自催化过硫酸铵(APS)的自由基聚合体系,在低温下制备了Fe_(3)O_(4)/聚丙烯酸(PAA)水凝胶,并对其进行表征。研究结果表明:Fe_(3)O_(4)/PAA水凝胶具有良好的力学性能,断裂伸长率、拉伸强度分别为900%、251.1 kPa;同时,其可较好粘附不同基材,在钢材上粘附-剥离循环20次后粘附强度仍稳定在30.7 kPa左右;此外,其还可感应极小形变,并在166 ms内快速响应。该Fe_(3)O_(4)/PAA水凝胶综合性能良好,具备应用于柔性传感器等领域的潜力。 展开更多
关键词 Fe^(3+)-da-APS 自催化 自由基聚合 水凝胶 柔性传感器
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