Hepatocellular carcinoma(HCC) is one of the most common cancers and the third highest cause of cancerassociated mortality worldwide. The treatment of HCC is complicated by its variable biological behavior and the freq...Hepatocellular carcinoma(HCC) is one of the most common cancers and the third highest cause of cancerassociated mortality worldwide. The treatment of HCC is complicated by its variable biological behavior and the frequent coexistence of chronic liver disease, particularly cirrhosis. To date, multiple treatment modalities have been developed according to the stage of the tumor and the hepatic functional reserve, including transarterial treatments such as transarterial chemoembolization, transarterial oily chemoembolization(TOCE), and hepatic arterial infusion chemotherapy(HAIC). We conducted a phase I and II study of the combination therapy with double platinum agents, miriplatin and cisplatin, and confirmed its safety and efficacy. Here, we describe two cases of unresectable HCC who were successfully treated by miriplatin-TOCE/cisplatin-HAIC combination therapy, resulting in complete responses with no significant adverse events. This report will provide that the combination therapy can be the therapeutic option for HCC patients in the advanced stage.展开更多
Depending on double compound synchronization and compound combination synchronization, a new kind of syn- chronization is introduced which is the double compound combination synchronization （DCCS） of eight n-dimensi...Depending on double compound synchronization and compound combination synchronization, a new kind of syn- chronization is introduced which is the double compound combination synchronization （DCCS） of eight n-dimensional chaotic systems. This kind may be considered as a generalization of many types of synchronization. In the communica- tion, based on many of drive and response systems, the transmitted and received signals will be more secure. Using the Lyapunov stability theory and nonlinear feedback control, analytical formulas of control functions are obtained to insure our results. The corresponding analytical expression and numerical treatment are used to show the validity and feasibility of our proposed synchronization scheme. The eight memristor-based Chua oscillators are considered as an example. Other examples can be similarly investigated. The proposed synchronization technique is supported using the MATLAB simula- tion outcomes. We obtain the same results of numerical treatment of our synchronization using simulation observations of our example.展开更多
This paper investigates Q420 dual-angle cross combined section columns under axial and eccentric compression by conducting experiments.The specimen parameters,experimental setup,and test results are presented.It showe...This paper investigates Q420 dual-angle cross combined section columns under axial and eccentric compression by conducting experiments.The specimen parameters,experimental setup,and test results are presented.It showed that local buckling occurred apparently for single internode specimens(λ<35)under axial compression,while overall bending buckling appeared for others,and no torsional buckling occurred.The theoretical formulas on stability factor were derived by the energy approach.Non-linear finite element models considering residual stress were established using ANSYS which were verified by the corresponding experimental results.The parametric study was to evaluate the effects of slenderness ratio(λ),width to thickness ratio of angles(b/t),the number of filled plate(n),load relative eccentricity(e)and the lateral support stiffness on the ultimate strengths of dual-angle cross combined section columns.Based on above analysis,the design equations are proposed by using curve fitting technique.It is shown from comparison between test results,finite element analysis and related specifications that the ultimate strength from theoretical formulas,proposed equations and finite element models are consistent with experiments results.展开更多
In this paper interfacial edge crack problems are considered by the application of the finite element method. The stress intensity factors are accurately determined from the ratio of crack-tip-stress value between the...In this paper interfacial edge crack problems are considered by the application of the finite element method. The stress intensity factors are accurately determined from the ratio of crack-tip-stress value between the target given unknown and reference problems. The reference problem is chosen to produce the singular stress fields proportional to those of the given unknown problem. Here the original proportional method is improved through utilizing very refined meshes and post-processing technique of linear extrapolation. The results for a double-edge interface crack in a bonded strip are newly obtained and compared with those of a single-edge interface crack for different forms of combination of material. It is found that the stress intensity factors should be compared in the three different zones of relative crack lengths. Different from the case of a cracked homogeneous strip, the results for the double edge interface cracks are found to possibly be bigger than those for a single edge interface crack under the same relative crack length.展开更多
A modified spectral beam combining(SBC) approach based on double asymmetrical filters was proposed. By using this scheme, the high-order lateral modes at the edge of the far-field pattern can be suppressed in the exte...A modified spectral beam combining(SBC) approach based on double asymmetrical filters was proposed. By using this scheme, the high-order lateral modes at the edge of the far-field pattern can be suppressed in the external cavity, and the beam quality in the slow-axis direction was improved from 16.1 to 13.4 compared to the conventional SBC. In the meanwhile, the electrical-to-optical efficiency from the modified SBC was more than 40% with an output power of 34.1 W, which is similar to that of the conventional SBC.展开更多
文摘Hepatocellular carcinoma(HCC) is one of the most common cancers and the third highest cause of cancerassociated mortality worldwide. The treatment of HCC is complicated by its variable biological behavior and the frequent coexistence of chronic liver disease, particularly cirrhosis. To date, multiple treatment modalities have been developed according to the stage of the tumor and the hepatic functional reserve, including transarterial treatments such as transarterial chemoembolization, transarterial oily chemoembolization(TOCE), and hepatic arterial infusion chemotherapy(HAIC). We conducted a phase I and II study of the combination therapy with double platinum agents, miriplatin and cisplatin, and confirmed its safety and efficacy. Here, we describe two cases of unresectable HCC who were successfully treated by miriplatin-TOCE/cisplatin-HAIC combination therapy, resulting in complete responses with no significant adverse events. This report will provide that the combination therapy can be the therapeutic option for HCC patients in the advanced stage.
文摘Depending on double compound synchronization and compound combination synchronization, a new kind of syn- chronization is introduced which is the double compound combination synchronization （DCCS） of eight n-dimensional chaotic systems. This kind may be considered as a generalization of many types of synchronization. In the communica- tion, based on many of drive and response systems, the transmitted and received signals will be more secure. Using the Lyapunov stability theory and nonlinear feedback control, analytical formulas of control functions are obtained to insure our results. The corresponding analytical expression and numerical treatment are used to show the validity and feasibility of our proposed synchronization scheme. The eight memristor-based Chua oscillators are considered as an example. Other examples can be similarly investigated. The proposed synchronization technique is supported using the MATLAB simula- tion outcomes. We obtain the same results of numerical treatment of our synchronization using simulation observations of our example.
文摘This paper investigates Q420 dual-angle cross combined section columns under axial and eccentric compression by conducting experiments.The specimen parameters,experimental setup,and test results are presented.It showed that local buckling occurred apparently for single internode specimens(λ<35)under axial compression,while overall bending buckling appeared for others,and no torsional buckling occurred.The theoretical formulas on stability factor were derived by the energy approach.Non-linear finite element models considering residual stress were established using ANSYS which were verified by the corresponding experimental results.The parametric study was to evaluate the effects of slenderness ratio(λ),width to thickness ratio of angles(b/t),the number of filled plate(n),load relative eccentricity(e)and the lateral support stiffness on the ultimate strengths of dual-angle cross combined section columns.Based on above analysis,the design equations are proposed by using curve fitting technique.It is shown from comparison between test results,finite element analysis and related specifications that the ultimate strength from theoretical formulas,proposed equations and finite element models are consistent with experiments results.
文摘In this paper interfacial edge crack problems are considered by the application of the finite element method. The stress intensity factors are accurately determined from the ratio of crack-tip-stress value between the target given unknown and reference problems. The reference problem is chosen to produce the singular stress fields proportional to those of the given unknown problem. Here the original proportional method is improved through utilizing very refined meshes and post-processing technique of linear extrapolation. The results for a double-edge interface crack in a bonded strip are newly obtained and compared with those of a single-edge interface crack for different forms of combination of material. It is found that the stress intensity factors should be compared in the three different zones of relative crack lengths. Different from the case of a cracked homogeneous strip, the results for the double edge interface cracks are found to possibly be bigger than those for a single edge interface crack under the same relative crack length.
基金supported by the National Natural Science Foundation of China(Nos.61790584 and 617741s53)
文摘A modified spectral beam combining(SBC) approach based on double asymmetrical filters was proposed. By using this scheme, the high-order lateral modes at the edge of the far-field pattern can be suppressed in the external cavity, and the beam quality in the slow-axis direction was improved from 16.1 to 13.4 compared to the conventional SBC. In the meanwhile, the electrical-to-optical efficiency from the modified SBC was more than 40% with an output power of 34.1 W, which is similar to that of the conventional SBC.
