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Application of Theoretical Growth Functions for Mongolian Oak(Qurcus Mongolica)
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作者 李长胜 孙剑峰 +1 位作者 吴振海 FrancoisHoullier 《Journal of Forestry Research》 SCIE CAS CSCD 1997年第4期195-200,共6页
Four alternative functions are used for lilting tree height and diameter growth models for mongolian oak(Quercus mongolica Fisch et Turcz)The data set includes 1250 random trees and 755 dominant trees coming from 510l... Four alternative functions are used for lilting tree height and diameter growth models for mongolian oak(Quercus mongolica Fisch et Turcz)The data set includes 1250 random trees and 755 dominant trees coming from 510lemporary plots The resultsshow that the Richads function is the best model for predicting height diameter at breast height(DBH) and dominant height from age The average growth curveof domnant height is used as a guide curve for the construction of a site index table which is partially validated using an independent data set The Mischerlic function is the bestmodel for estimating height and dominam height from DBH 展开更多
关键词 growth functions Richards function Site index Mongolian oak Quercus mognlica)
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Effect of Glycyrrhiza uralensis Fisch polysaccharide on growth performance and immunologic function in mice in Ural City,Xinjiang 被引量:26
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作者 Jie Chen Xiao-Qing Zhu +5 位作者 Li Yang Yan Luo Meng-Yuan Wang Xiao-Ting Liu Ke-Xun Liang Xin-Li Gu 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2016年第11期1056-1061,共6页
Objective:To discuss the effect of Glycyrrhiza uralensis(G.uralensis) Fisch polysaccharide on growth performance and immunologic function in mice in Ural City,Xinjiang and to provide important data supporting the appl... Objective:To discuss the effect of Glycyrrhiza uralensis(G.uralensis) Fisch polysaccharide on growth performance and immunologic function in mice in Ural City,Xinjiang and to provide important data supporting the application of Glycyrrhiza polysaccharide.Methods:A total of100 Kunming mice aged 3 weeks old were randomly divided into 5 groups with 20 mice in each group(10 were females and 10 were males).About 0.5 mL normal saline was given to the mice of control group every day and 0.5 mL G.uralensis Fisch polysaccharide was given to the mice of other groups at the concentration of 1,20,50 and 100 mg/mL respectively.The growth performance(average body weight,average daily feed intake and feed efficiency),immune organ indexes(spleen index and thymus index) and immunologic function(serum IL-2,CD4^+/CD8^+ and the activity of NK cells) of mice in each group were detected continuously.Results:The average body weight,feed efficiency,serum IL-2,CD4^+/CD8^+ and the activity of NK cells of mice were increased with the increase of administrated time after administrating G.uralensis Fisch polysaccharide and were reached up the largest level on Day 28.At the same time,each index was proportional to the given dose and was significantly higher than those of control group and reached up the largest level at the administrated dose of 100 mg/mL.After administrating G.uralensis Fisch polysaccharide,the spleen index and thymus index of mice were increased with the increase of administrated dose and the spleen index and thymus index of mice administrated with the dose of 100 mg/mL were maximum which was more than 1.51 times and 1.43 times of that in control group respectively and the comparative differences showed statistical significance(P<0.05).The average daily feed intake of mice in each group was increased with the passage of lime and at the same time,the comparison of average daily feed intake of mice in each group was not significantly different(P>0.05).Conclusions:G.uralensis Fisch polysaccharide can significantly improve the growth performance and immunologic function of mice and laid a research basis for the clinical application of G.uralensis Fisch polysaccharide. 展开更多
关键词 Glycyrrhiza uralensis Fisch POLYSACCHARIDE Immune organ index growth performance Immunologic function
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Model Selection in Estimation of Covariance Functions for Growth of Angora Goats 被引量:2
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作者 LIU Wen-zhong ZHANG Yuan ZHOU Zhong-xiao 《Agricultural Sciences in China》 CAS CSCD 2010年第7期1041-1049,共9页
Covariance functions have been proposed as an alternative to model longitudinal data in animal breeding because of their various merits in comparison to the classical analytical methods.In practical estimation,differe... Covariance functions have been proposed as an alternative to model longitudinal data in animal breeding because of their various merits in comparison to the classical analytical methods.In practical estimation,different models and polynomial orders fitted can influence the estimates of covariance functions and thus genetic parameters.The objective of this study was to select model for estimation of covariance functions for body weights of Angora goats at 7 time points.Covariance functions were estimated by fitting 6 random regression models with birth year,birth month,sex,age of dam,birth type,and relative birth date as fixed effects.Random effects involved were direct and maternal additive genetic,and animal and maternal permanent environmental effects with different orders of fit.Selection of model and orders of fit were carried out by likelihood ratio test and 4 types of information criteria.The results showed that model with 6 orders of polynomial fit for direct additive genetic and animal permanent environmental effects and 4 and 5 orders for maternal genetic and permanent environmental effects,respectively,were preferable for estimation of covariance functions.Models with and without maternal effects influenced the estimates of covariance functions greatly.Maternal permanent environmental effect does not explain the variation of all permanent environments,well suggesting different sources of permanent environmental effects also has large influence on covariance function estimates. 展开更多
关键词 Angora goats growth covariance function model selection random regression model
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α-times Integrated Cosine Operator Functions with Growth ω 被引量:1
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作者 WANG Mei-ying XU Fei 《Chinese Quarterly Journal of Mathematics》 CSCD 2011年第2期229-233,共5页
For a continuous,increasing functionω:[0,∞)→C of finite exponential type,we establish a Hille-Yosida type theorem for strongly continuous α-times(α>0)integrated cosine operator functions with O(ω).It includes... For a continuous,increasing functionω:[0,∞)→C of finite exponential type,we establish a Hille-Yosida type theorem for strongly continuous α-times(α>0)integrated cosine operator functions with O(ω).It includes the corresponding results for n-times integrated cosine operator functions that are polynomially bounded and exponentially bounded. 展开更多
关键词 integrated cosine operator functions with growthω GENERATOR generation theorem
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Functions of Phytochrome in Rice Growth and Development 被引量:1
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作者 GU Jian-wei LIU Jing +2 位作者 XUE Yan-jiu ZANG Xin XIE Xian-zhi 《Rice science》 SCIE 2011年第3期231-237,共7页
Phytochrome family mainly senses red and far-red light to regulate a range of developmental processes throughout the life cycle of plants. Rice phytochrome gene family is composed of three members known as PHYA, PHYB ... Phytochrome family mainly senses red and far-red light to regulate a range of developmental processes throughout the life cycle of plants. Rice phytochrome gene family is composed of three members known as PHYA, PHYB and PHYC. It has been elucidated that individual phytochromes display both unique and overlapping roles in rice photomorphogenesis by characterization of all rice phytochrome mutants including single mutants, all combinations of double mutants as well as triple mutants. Based on the published data and authors’ ongoing studies, current knowledge of rice phytochrome functions in regulating seedling de-etiolation, root gravitropic response and elongation, plant architecture, flowering time and fertility is summarized. Additionally, the important issues in the field of rice phytochromes are proposed. 展开更多
关键词 RICE phytochrome gene PHOTOMORPHOGENESIS growth and development function
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Renin and angiotensinogen expression and functions in growth and apoptosis of human glioblastoma 被引量:8
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作者 Juillerat-Jeanneret L Celerier J +6 位作者 Chapuis Bernasconi C Nguyen G Wostl W Maerki HP Janzer RC Corvol P Gasc JM 《中国神经肿瘤杂志》 2004年第1期66-66,共1页
The expression and function in growth and apoptosis of the renin-angiotensin system(RAS)was evaluated inhuman glioblastoma.Renin and angiotensinogen(AGT)mRNAs and proteins were found by in situ hybridisationand immuno... The expression and function in growth and apoptosis of the renin-angiotensin system(RAS)was evaluated inhuman glioblastoma.Renin and angiotensinogen(AGT)mRNAs and proteins were found by in situ hybridisationand immunohistochemistry in glioblastoma cells.Angiotensinogen was present in glioblastoma cystic fluids.Thus,human glioblastoma cells produce renin and AGT and secrete AGT.Human glioblastoma and glioblastoma cellsexpressed renin,AGT,renin receptor,AT(2)and/or AT(1)mRNAs and proteins determined by RT-PCR and/ 展开更多
关键词 Renin and angiotensinogen expression and functions in growth and apoptosis of human glioblastoma AGT
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Scalp electroacupuncture at the Baihui acupoint (DU 20) improves functional recovery in rats with cerebral ischemia Association with increased expression of vascular endothelial growth factors 被引量:4
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作者 Min-Wook Kim You Chul Chung +11 位作者 Hee Chan Jung Moon-Seo Park Young-Min Han Yong-An Chung Lee-So Maeng Sang-In Park Jiyeon Lim Seung Chan Kim Woo-Seok Im Jin Young Chung Minky Kim Manho Kim 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第36期2822-2828,共7页
In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint (DU 20). Motor and sensory function was tested... In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint (DU 20). Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor. 展开更多
关键词 ELECTROACUPUNCTURE cerebrovascular disorder vascular endothelial growth factor Baihui acupoint functional improvement
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Evaluation of unconstrained and constrained mathematical functions to model girth growth of rubber trees (Hevea brasiliensis) using young agemeasurements 被引量:6
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作者 T.R.Chandrasekhar 《Journal of Forestry Research》 CAS CSCD 2012年第3期365-375,共11页
No attempt has been made to date to model growth in girth of rubber tree (Hevea brasiliansis). We evaluated the few widely used growth functions to identify the most parsimonious and biologically reasonable model fo... No attempt has been made to date to model growth in girth of rubber tree (Hevea brasiliansis). We evaluated the few widely used growth functions to identify the most parsimonious and biologically reasonable model for describing the girth growth of young rubber trees based on an incomplete set of young age measurements. Monthly data for girth of immature trees (age 2 to 12 yearsi from two locations were sub- jected to modelling. Re-parameterized, unconstrained and constrained growth functions,of Richards (RM), Gompertz (GM) and the monomo- lecular 'model ^(MM) were fitted to data. Duration of growth was the firsf constraint introduced. In the stagel We attempted a population aver- age (PA) model to capture the trend in growth. The best PA model was fitted as a subject specific (SS) model. We used appropriate error vari- ance-covariance structure to account for correlation due to repeated measurements over time. Unconstrainecl functions underestimated the asymptotic maximum that did not reflective carrying capacity of the locations. Underestimafions were attributed to the partial set' of meas- urements made during the early growth phase of the trees. MM proved superior to RM and GM. In the randomcoefficient models, both Gf and Go appeared to be influenced by tree level effects. Inclusion of diagonal definite positive matrix removed the correlation between random effects. The results were similar at both locations. In the overall assessment MM appeared as the candidate model for studying the girth-age relationships in Hevea trees. Based on the fitted model we conclude that, in Hevea trees, growth rate is maintained at maximum value at to, then decreases until the final state at dG/dt 〉 0, resulting in yield curve with no period of accelerating growth. One physiological explanation is that photosynthetic activity in Hevea trees decreases as girth increases and constructive metabolism is larger than destructive metabolism. 展开更多
关键词 natural rubber Hevea Brasiliensis growth modelling un-constrained functions constrained functions mixed model
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STRONGLY CONTINUOUS INTEGRATED COSINE OPERATOR FUNCTIONS WITH GROWTHω
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作者 Meiying Wang Guoxiang Chen 《Analysis in Theory and Applications》 2007年第1期1-8,共8页
For a continuous increasing function ω : [0, ∞) → (0, ∞) of finite exponetial type, we establish a Hille-Yosida type theorem for strongly continuous integrated cosine operator functions with O(ω). It includ... For a continuous increasing function ω : [0, ∞) → (0, ∞) of finite exponetial type, we establish a Hille-Yosida type theorem for strongly continuous integrated cosine operator functions with O(ω). It includes the well-known polynomially bounded and exponentially bounded cases. 展开更多
关键词 cosine operator functions with growth ω GENERATOR generation theorem
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Comparison of the Chapman-Richards Function with the Schnute Model in Stand growth 被引量:2
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作者 李凤日 王永和 侯丽君 《Journal of Forestry Research》 SCIE CAS CSCD 1997年第3期137-143,共7页
The Chapman-Richards Function and its two exception cases in applications were discussed and compared with the Schnute model in stand growth studies. Compared from all perspective, it was found that the Schnute model ... The Chapman-Richards Function and its two exception cases in applications were discussed and compared with the Schnute model in stand growth studies. Compared from all perspective, it was found that the Schnute model commonly used in foreitry was identical to the Chapman-Richards function. If some parameter in the Chapman-Richdrds Function was unconstraint, the function could also be very versatile to fit some exceptional growth curves, the fitted function should be identical to that the Schnute model. 展开更多
关键词 Chapman-Richards function Schnute model Stand growth Model fitting
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The43,000Growth - associated Protein Functions as a Negative Growth Regulator in Glioma. 被引量:1
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作者 Huang ZY Wu Y +1 位作者 Burke SP Gutmann DH 《中国神经肿瘤杂志》 2003年第2期97-97,共1页
Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocy-toma formation and progression.In an effort to identify novel gene expression changes associated with astr... Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocy-toma formation and progression.In an effort to identify novel gene expression changes associated with astrocytomaformation,which might reveal new potential targets for glioma therapeutic drug design,we used the B8-RAS-transgenic mouse astrocytoma model.Using multiplex gene expression profiling,we found that 展开更多
关键词 in associated Protein functions as a Negative growth Regulator in Glioma The43 000growth
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The Control of Population Growth Is the Function of the Central Government 
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《China Population Today》 1994年第2期2-3,1,共3页
Mr.Jiang Zcmin,Gencral-Seerctary of the Cen-tral Committee of the Chincse Communist Party and.Chairman of the People's Republic of China,in a rC-ccnt spcech cm phasized that the family planning pro-gramme should b... Mr.Jiang Zcmin,Gencral-Seerctary of the Cen-tral Committee of the Chincse Communist Party and.Chairman of the People's Republic of China,in a rC-ccnt spcech cm phasized that the family planning pro-gramme should be strictly and effectively im plemented in 1994,a year of crucial importance for promoting re-form and opening and thc drive lowards.modernization.To makc continucd contributions to the sociocconomic development in the country,we must fulfil the plan for controlling population growth..The spcech was delivcred at the anua!National Fo-rum on Family Planning Work convened jointly by the Party's Central Committcc and the Statc Council. 展开更多
关键词 The Control of Population growth Is the function of the Central Government
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ON THE DIMENSIONS OF SPACES OF HARMONIC FUNCTIONS WITH POLYNOMIAL GROWTH
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作者 Xiantao HUANG 《Acta Mathematica Scientia》 SCIE CSCD 2019年第5期1219-1234,共16页
In this paper, we obtain an estimate for the lower bound for the dimensions of harmonic functions with polynomial growth and a Liouville type theorem on manifolds with nonnegative Ricci curvature whose tangent cone at... In this paper, we obtain an estimate for the lower bound for the dimensions of harmonic functions with polynomial growth and a Liouville type theorem on manifolds with nonnegative Ricci curvature whose tangent cone at infinity is a unique metric cone with a conic measure. 展开更多
关键词 RICCI CURVATURE HARMONIC function with POLYNOMIAL growth EIGENVALUE
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Effects of Diet with Picria fel-tarrae Lour Particle on the Growth Performance, Blood Biochemical Indexes, Immune and Antioxidant Function of Hongguang Yellow Chickens
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作者 Cui YANG Zhuyue WU +12 位作者 Tingjun HU Qiang WU Yingfei HUANG Huofu WAN Jixian DENG Fengying WEI Li HUANG Liang WU Junhua ZHOU Hongye HUANG Fulin WANG Yuying LIAO Jiahuang YANG 《Medicinal Plant》 CAS 2019年第5期30-35,共6页
[Objectives]To investigate the effect of diet with Picria fel-tarrae Lour particle(PFLp)on growth performance,blood biochemical indexes,immune and antioxidant function of Hongguang yellow chickens(HYC).[Methods]80 HYC... [Objectives]To investigate the effect of diet with Picria fel-tarrae Lour particle(PFLp)on growth performance,blood biochemical indexes,immune and antioxidant function of Hongguang yellow chickens(HYC).[Methods]80 HYC in age of 1 d were divided into 4 groups randomly and each group was assigned to 5 replicates with 24 chicks in each replicate.Group A was control group fed only basal diet.Group B,C and D were treatment groups and fed diets with 0.125%,0.25%and 0.50%of PFLp respectively during the trial of 49 d.Serum samples were taken from 10 chicks in each group in the age of 21,35 and 49 d respectively and analyzed for biochemical,immune and antioxidant parameters in blood.[Results]ADG from group C in 21 d was increased significantly than that from group A,B and D(P<0.01),and ADG in 35 d from group C was also significantly greater than that from group A,B and D(P<0.05),but not much difference was found on ADG among the 4 groups in 49 d(P>0.05);ADFI from group C in 35 d was significantly higher than that from group A,B and D(P<0.05).ADFI from group C in 21 and 49 d were also higher than that from group A(P>0.05).FCR from group C in 21 d was much better than that from the other three groups(P<0.01).Death rate of group C was 50 percent lower than group A;There was no difference occurred in serum biochemical and immune parameters among the 4 groups during the trial(P>0.05).However,the T-AOC from group C and D in 21 d was enhanced significantly than that from group A and B(P<0.01),and the one from group C in 35 d was also increased greatly than that from group A,B and D(P<0.05).GSH from group C and D in 21 d was much higher than that from group A and B(P<0.05),and the ones from group C and D in 35 d were also significantly higher than those from group A and B(P<0.01).T-SOD in three stages trended up also in group C and D(P>0.05).[Conclusions]The diet with 0.25%PFLp in 21 and 35 d could dramatically improve the growth performance,significantly increase the antioxidant capacity and effectively reduce death rate.Diet with 0.25%PFLp is the most appropriate among the three different additions. 展开更多
关键词 Picria fel-tarrae Lour particle(PFLp) HONGGUANG yellow chickens(HYC) growth performance IMMUNE function T-AOC
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Transforming growth factor beta 1, a cytokine with regenerative functions 被引量:9
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作者 Wale Sulaiman Doan H. Nguyen 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第10期1549-1552,共4页
We review the biology and role of transforming growth factor beta 1 (TGF-β1) in peripheral nerve injury and regeneration, as it relates to injuries to large nerve trunks (i.e., sciatic nerve, brachial plexus), wh... We review the biology and role of transforming growth factor beta 1 (TGF-β1) in peripheral nerve injury and regeneration, as it relates to injuries to large nerve trunks (i.e., sciatic nerve, brachial plexus), which often leads to suboptimal functional recovery. Experimental studies have suggested that the reason for the lack of functional recovery resides in the lack of sufficient mature axons reaching their targets, which is a result of the loss of the growth-supportive environment provided by the Schwann cells in the distal stump of injured nerves. Using an established chronic nerve injury and delayed repair animal model that accu- rately mimics chronic nerve injuries in humans, we summarize our key findings as well as others to better understand the pathophysiology of poor functional recovery. We demonstrated that 6 month TGF-β1 treat- ment for chronic nerve injury significantly improved Schwann cell capacity to support axonal regeneration. When combined with forskolin, the effect was additive, as evidenced by a near doubling of regenerated axons proximal to the repair site. We showed that in vivo application of TGF-β1 and forskolin directly onto chronically injured nerves reactivated chronically denervated Schwann cells, induced their proliferation, and upregulated the expression of regeneration-associated proteins. The effect of TGF-β1 and forskolin on old nerve injuries is quite impressive and the treatment regiment appears to mediate a growth-supportive milieu in the injured peripheral nerves. In summary, TGF-β1 and forskolin treatment reactivates chronical- ly denervated Schwann cells and could potentially be used to extend and prolong the regenerative responses to promote axonal regeneration. 展开更多
关键词 chronic nerve injuries transforming growth factor Schwann cells axonal regeneration regeneration-associatedproteins functional recovery
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Can amino-functionalized carbon nanotubes carry functional nerve growth factor? 被引量:2
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作者 Wen Chen Qing Xiong +2 位作者 Quanxia Ren Yake Guo Gao Li 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第3期285-292,共8页
Carbon nanotubes can carry protein into cells to induce biological effects. Amino-functionalized carbon nanotubes are soluble and biocompatible, have high reactivity and low toxicity, and can help promote nerve cell g... Carbon nanotubes can carry protein into cells to induce biological effects. Amino-functionalized carbon nanotubes are soluble and biocompatible, have high reactivity and low toxicity, and can help promote nerve cell growth. In this study, amino-functionalized ethylenediamine-treated multi-walled carbon nanotubes were used to prepare carbon nanotubes-nerve growth factor complexes by non-covalent grafting. The physicochemical properties, cytotoxicity to PC12 and chick embryo dorsal root ganglion, and biological activity of the carbon nanotubes-nerve growth factor complexes were investigated. The results showed that amino functionalization improved carbon nanotubes-nerve growth factor complex dispersibility, reduced their toxicity to PC12 cells, and promoted PC 12 cell differentiation and chick embryo dorsal root ganglion. 展开更多
关键词 nerve regeneration spinal cord injury carbon nanotubes amino functionalization ner-ve growth factor cytotoxicity biological activity DISPERSIBILITY PC12 cells chick embryo dorsal rootganglion NSFC grant neural regeneration
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Age and Growth Characteristics of Crimson Sea Bream Paragyrops edita Tanaka in Beibu Gulf 被引量:4
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作者 HOU Gang FENG Bo LU Huosheng ZHU Junfeng 《Journal of Ocean University of China》 SCIE CAS 2008年第4期457-465,共9页
Age and growth characteristics of crimson sea bream Paragyrops edita Tanaka in Beibu Gulf were studied through bottom trawling and gillnet fleets fishing from July 2006 to December 2007. A total number of 1155 individ... Age and growth characteristics of crimson sea bream Paragyrops edita Tanaka in Beibu Gulf were studied through bottom trawling and gillnet fleets fishing from July 2006 to December 2007. A total number of 1155 individuals, ranging from 49 to 249mm in standard length was examined. The age of the fish was determined from sagittal otoliths. One year growth was made up of one translucent and one opaque zone. A maximum likelihood estimation procedure was used to fit the Von Bertalanffy, Logistic and Gompertz growth functions to the length-at-age data. ARSS indicated that there were no significant differences in growth between sexes in the three growth models (P〉0.05), and the Von Bertalanffy growth function Lr=292.8{1 cxp[-0.167(t+1.l16)]} was selected as the most appropriate growth model according to Akaike's information criterion (AIC). 展开更多
关键词 Paragyrops edita Tanaka growth function sagittal otolith maximum likelihood estimation Beibu Gulf
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The Spatial Distribution Characteristics of Resident Population Growth Rate in Henan Province, China
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作者 Kaiguang Zhang Hongling Meng +1 位作者 Mingting Ba Danhuan Wen 《Journal of Geoscience and Environment Protection》 2024年第11期191-206,共16页
Population is an important strategic resource for national development, a fundamental element of socio-economic development. The coordinated development of population and economy is an effective way to achieve rapid e... Population is an important strategic resource for national development, a fundamental element of socio-economic development. The coordinated development of population and economy is an effective way to achieve rapid economic growth. Based on the population statistics data of counties (districts) in Henan Province, China, from 2006 to 2021. The paper firstly uses the logistic population growth mathematical model to calculate the resident population growth rate of counties (districts), then utilizes the hotspot analysis and spatial semi-variogram analysis, to research the spatial distribution characteristics of the resident population growth rate in Henan Province. The research results show that the evolution of the regional resident population in the province basically conforms to the logistic natural growth model. The resident population growth rate shows the characteristics of high in the north and low in the south, high in the center and low in the surrounding regions. The resident population growth rate is positively correlated with the level of economic development;the urban built-up areas, especially the new regions in urban planning, have a fast growth rate of resident population, which has a significant siphon effect on the population of surrounding regions. The hotspots of resident population growth rate in the province are mainly distributed in the urban built-up areas and surrounding regions of Zhengzhou, Luoyang, and Xinxiang, accounting for about 3.51% of the total area of the province. The cold spots are mainly distributed in the eastern part of the province, forming zonal distribution, which spans across Shangqiu City, Zhoukou City, and Zhumadian City, accounting for about 8.61% of the total area of the province. The area with negative growth of resident population accounts for approximately 53.47% of the total province. The spatial distribution of the growth rate of the resident population in the whole province basically conforms to the spherical model, with a small dispersion degree and a short range. In the range, there is a high degree of variability in resident population growth rate. 展开更多
关键词 Resident Population growth Rate Logistic Natural growth Model Cold and Hot Spot Analysis Semi-Variogram function Spatial Interpolation Henan Province
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环黄芪醇促进脊髓损伤小鼠运动功能恢复及皮质神经元再生的相关机制
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作者 陶紫晗 赛吉拉夫 《中国组织工程研究》 CAS 北大核心 2025年第20期4258-4265,共8页
背景:前期研究证实,环黄芪醇能够促进坐骨神经损伤修复,且环黄芪醇能够激活端粒酶反转录酶进一步参与外周感觉神经元轴突再生的调节。但环黄芪醇是否可以激活皮质神经元轴突再生仍然未知,尤其是环黄芪醇是否参与脊髓损伤修复过程中运动... 背景:前期研究证实,环黄芪醇能够促进坐骨神经损伤修复,且环黄芪醇能够激活端粒酶反转录酶进一步参与外周感觉神经元轴突再生的调节。但环黄芪醇是否可以激活皮质神经元轴突再生仍然未知,尤其是环黄芪醇是否参与脊髓损伤修复过程中运动功能的恢复。目的:探究环黄芪醇对小鼠脊髓损伤后运动功能恢复的影响,以及环黄芪醇促进皮质神经元再生的相关机制。方法:①将12只ICR小鼠随机分为溶剂组、环黄芪醇组,每组6只,构建脊髓损伤模型后分别腹腔注射含2%吐温20和5%二甲基亚砜的PBS、环黄芪醇(20 mg/kg),连续给药12周,使用BMS运动功能评分评估小鼠肢体运动功能;②体外培养E14胎鼠大脑皮质神经元,分为二甲基亚砜组与环黄芪醇组,分别用二甲基亚砜、0.5μmol/L环黄芪醇体外培养3 d;③E7孕鼠分为溶剂组与环黄芪醇组,分别腹腔注射含2%吐温20和5%二甲基亚砜的PBS、20 mg/kg环黄芪醇,连续给药7 d,分离出胎鼠大脑皮质,体外培养皮质神经元3 d;④对胎鼠大脑皮质神经元进行Tuj1免疫荧光染色,分析Tuj1阳性细胞的轴突长度,验证环黄芪醇对皮质神经元轴突再生的作用;对胎鼠大脑皮质神经元进行Tuj1、端粒酶反转录酶双标免疫荧光染色,分析环黄芪醇对端粒酶反转录酶表达的影响;蛋白免疫印迹分析胎鼠大脑皮质神经元中端粒酶反转录酶蛋白的相对表达;⑤将6只ICR小鼠随机分为溶剂组、环黄芪醇组,每组3只,构建脊髓损伤模型后分别腹腔注射含2%吐温20和5%二甲基亚砜的PBS和环黄芪醇(20 mg/kg),连续给药7 d,蛋白免疫印迹检测脊髓组织中端粒酶反转录酶蛋白的相对表达。结果与结论:①脊髓损伤后环黄芪醇治疗4,6,8,12周,环黄芪醇组小鼠运动功能评分显著高于溶剂组(P<0.0001);脊髓损伤后环黄芪醇治疗7 d,环黄芪醇组小鼠脊髓组织中端粒酶反转录酶蛋白相对表达量显著高于溶剂组(P<0.05);②Tuj1免疫荧光染色结果显示,0.5μmol/L环黄芪醇组体外干预的皮质神经元轴突长度显著大于二甲基亚砜组(P<0.001),腹腔注射20 mg/kg环黄芪醇组的皮质神经元轴突长度显著大于溶剂组(P<0.01);③端粒酶反转录酶免疫荧光染色结果显示,0.5μmol/L环黄芪醇组体外干预的皮质神经元的端粒酶反转录酶荧光强度显著大于二甲基亚砜组(P<0.01);④蛋白免疫印迹检测显示,0.5μmol/L环黄芪醇组体外干预的皮质神经元中端粒酶反转录酶蛋白相对表达量显著高于二甲基亚砜组(P<0.05),腹腔注射20 mg/kg环黄芪醇组的皮质神经元中端粒酶反转录酶蛋白相对表达量显著高于溶剂组(P<0.05)。结果表明,环黄芪醇能够促进皮质神经元轴突生长并改善小鼠脊髓损伤后运动功能,这一现象可能与端粒酶反转录酶的表达升高有关。 展开更多
关键词 环黄芪醇 皮质神经元 轴突生长 端粒酶反转录酶 运动功能 脊髓损伤 工程化动物模型
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Corticoreticular tract lesion in children with developmental delay presenting with gait dysfunction and trunk instability 被引量:1
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作者 Yong Min Kwon Jessica Rose +1 位作者 Ae Ryoung Kim Su Min Son 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第9期1465-1471,共7页
The corticoreticular tract (CRT) is known to be involved in walking and postural control. Using diffusion tensor tractography (DTT), we investigated the relationship between the CRT and gait dysfunction, includ- i... The corticoreticular tract (CRT) is known to be involved in walking and postural control. Using diffusion tensor tractography (DTT), we investigated the relationship between the CRT and gait dysfunction, includ- ing trunk instability, in pediatric patients. Thirty patients with delayed development and 15 age-matched, typically-developed (TD) children were recruited. Fifteen patients with gait dysfunction (bilateral trunk instability) were included in the group A, and the other 15 patients with gait dysfunction (unilateral trunk instability) were included in the group B. The Growth Motor Function Classification System, Functional Ambulation Category scale, and Functional Ambulation Category scale were used for measurement of functional state. Fractional anisotropy, apparent diffusion coefficient, fiber number, and tract integrity of the CRT and corticospinal tract were measured. Diffusion parameters or integrity of corticospinal tract were not significantly different in the three study groups. However, CRT results revealed that both CRTs were disrupted in the group A, whereas CRT disruption in the hemispheres contralateral to clinical mani- festations was observed in the group B. Fractional anisotropy values and fiber numbers in both CRTs were decreased in the group A than in the group TD. The extents of decreases of fractional anisotropy values and fiber numbers on the ipsilateral side relative to those on the contralateral side were greater in the group B than in the group TD. Functional evaluation data and clinical manifestations were found to show strong correlations with CRT status, rather than with corticospinal tract status. These findings suggest that CRT status appears to be clinically important for gait function and trunk stability in pediatric patients and DTT can help assess CRT status in pediatric patients with gait dysfunction. 展开更多
关键词 nerve regeneration corticoreticular tract corticospinal tract GAIT TRUNK diffusion tensor Trunk Control Measurement Scale functional Ambulation Category growth Motor function Classification System cerebral palsy motor neural regeneration
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