Effect of sitagliptin combined with Yiqi yangyin huoxue decoction on clinical efficacy and hemorheology in early diabetic nephropathy

BACKGROUND Early diabetic nephropathy(DN)is a complication of diabetes mellitus.It mainly affects kidney microvessels and glomerular function,and its timely and effective treatment is critical for early DN.However,the effects of treatments comprising simple Western medicine are not optimal.With the promotion and implementation of integrated Chinese and western medicine treatments,remarkable results have been achieved for many diseases.To this end,we explored the clinical efficacy of integrated traditional Chinese and western medicines for the treatment of early DN.AIM To investigate the effect of sitagliptin tablets combined with Yiqi yangyin huoxue decoction on clinical efficacy and hemorheology in patients with early DN.METHODS Through a retrospective analysis,123 patients with early DN were admitted to the endocrinology clinic of the Changzhou NO.7 People’s Hospital from January 2021 to October 2022 and were selected as study subjects.After rigorous screening,100 patients with early DN were enrolled.The control group(CG,n=50)and the observation group(OG,n=50)were divided according to the treatment method.The CG were treated with sitagliptin,and the OG were treated with sitagliptin plus the Yiqi yangyin huoxue decoction.Both groups were treated for 3 mo.For both groups,the baseline data and clinical efficacy were compared,and changes in blood glucose levels,lipid levels,renal function,and hematological indicators before(T0)and after(T1)treatment were assessed.RESULTS The total effective rate for the OG was 94.00%and that of the CG was 80.00%(P<0.05).After treatment(T1),the levels of fasting blood glucose,2 h postprandial glucose,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol in OG patients were obviously lower than those in the CG(P<0.05),and cystatin C,homocysteine,urinary microalbumin,and blood creatinine values in OG patients were also obviously lower than those in the CG(P<0.05);erythrocyte deposition,plasma viscosity,whole blood high shear viscosity,and whole blood low shear viscosity were markedly lower in OG patients than in the CG(P<0.05).CONCLUSION Sitagliptin combined with Yiqi yangyin huoxue decoction has a remarkable effect when used to treat patients with early DN.Further,it is helpful in improving hemorheological indices and controlling disease progression.

Effect of Liangxuehuayu Recipe on hemorheology in rats with blood stasis syndrome

Objective:To investigate the effects of Uangxuehuayu Recipe on hemorheology in rats with blood stasis syndrome induced by mutifactor stimuli.Methods:SD rats were divided into control, model,Uangxuehuayu Recipe(high,middle and low dose,18,9,4.S g/kg accordingly).Except the control group,blood stasis model was established in the rest groups.The hemorheological parameters were measured and compared.Results:Blood viscosity at high,moderate and low level in rats with blood stasis significantly increased(P【0.05),but blood viscosity at high level and plasma viscosity was significantly decreased in rats induced by some stimuli after Uangxuehuayu Recipe were intra-gastrically administered for I weeks(P【0.01,P【0.05). Conclusions:Uangxuehuayu Recipe is effective in improving hemorheology,and has important application value in the prevention of occurrence and development of ischemic stroke.

The changes of nitric oxide and hemorheology in steroid-induced avas-cular necrosis of femoral head

Objective: To explore the pathogenesis of avascular necrosis of femoral head (ANFH), the early diagnosis index and the treatment effective index of ANFH in clinical practice. Methods: Twenty-four Japanese rabbits were divided into 2 groups: model group and control group. ANFH models were produced by intramuscular injection of large dosage of steroid to rabbits for 8 weeks. On the 4 th, 8 th week after the injection, two rabbits each time from each group were taken to observe the structure of femoral head by light microscope and scanning electron microscope. Four other stomach-empty rabbits from each group were also used to test the contents of Nitric Oxide (NO), contents of the hemorheology indexes. Results: Compared with the control group, the rabbits in the model group exhibited osteoporosis of femoral head and more bone lacuna and more fat cells through light microscope. Through scanning electron microscope observation bone trabecula were broken and sunk, and collagen fibers on the surface of bone matrix became loosen and broken, more osteocyte had pyknosis, adipocyte in the medullary cavity were enlarged and subchondral arterioles and capillaries of the femoral head were pressed by adipocyte. Compared with the control group, the model rabbits contained less NO and obvious increase of the plasma viscosity (PV), low blood viscosity (LBV), erythrocyte hematocrit (HCT), indices of erythrocyte rigidity (TK) and indices of erythrocyte aggregation (AI), plasma fibrin level (PFL) (P<0. 01) and an increase of erythrocyte electrophoresis rate (ERT) (P< 0.05). High blood viscosity (HBV), and erythrocyte sedimentation rate (ESR) were unchanged. Conclusion: The steroid-induced ANFH might be related to less NO and the abnormal hemorheology; and NO and hemorheology should be considered as an early diagnosis index for ANFH in clinical practice.

Effect of Guhong injection combined with atorvastatin on angina pectoris of coronary heart disease and its influence on Hemorheology and oxidative stress

Objective:To explore the effect of Guhong injection combined with atorvastatin on CHD patients with angina pectoris and its influence on hemorheology and oxidative stress.Methods:80 CHD patients with angina pectoris admitted to our hospital from December 2018 to December 2019 were randomly divided into the observation group(40 cases)and the control group(40 cases)by use of the random number table.The patients in the control group were treated with atorvastatin,while those in the observation group were treated with Guhong injection on the basis of the control group.The course of treatment was 2 weeks for each group.The treatment effect,the frequency of angina pectoris seizure and its duration before and after treatment,the changes of hemorheology indexes and oxidative stress and the occurrence of adverse reactions were compared between the two groups.Results:the total effective rate of the observation group(92.50%)was higher than that of the control group(70.00%)(p<.05).The frequency of angina pectoris seizure and its duration in these two groups after treatment were lower than those before treatment(Observation group:t=25.588,23.009;Control group:t=16.587,16.263;p<.05);After treatment,the frequency of angina pectoris seizure and its duration in the observation group were lower than those in the control group(t=15.191,9.425;p<.05).In the observation group,the hemorheology indexes after treatment were lower than those before treatment(t=6.742,15.224,6.983,23.537,p<.05);the hemorheology indexes after treatment in the observation group were lower than those in the control group(t=5.201,13.913,5.539,13.745;p<.05).In the observation group,the level of serum SOD after treatment was higher than that before treatment,while the levels of LPO and MDA after treatment were lower than those before treatment(t=10.839,6.924,8.466;p<.05);the level of serum SOD after treatment in the observation group was higher than that in the control group,while the levels of LPO and MDA after treatment in the observation group were lower than those in the control group(t=6.171,6.432,5.394;p<.05).The incidence of adverse reactions in the observation group was lower than that in the control group(p<.05).Conclusions:Guhong injection combined with atorvastatin has an obvious clinical effect on CHD patients with angina pectoris,and it can improve hemorheology indexes and oxidative stress reaction with fewer adverse reactions.

Effect of nifedipine in combined with magnesium sulfate on the hemorheology and coagulation indicators in patients with gestational hypertension

Objective:To explore the effect of nifedipine in combined with magnesium sulfate on the hemorheology and coagulation indicators in patients with gestational hypertension.Methods:A total of 90 patients with gestational hypertension were included in the study and randomized into the observation group and the control group with 45 cases in each group. The patients in the observation group were given magnesium sulfate in combined with nifedipine, while the patients in the control group were only given magnesium sulfate. The patients in the two groups were continuously treated for 2 weeks. The blood pressure, hemorheology indicators, and coagulation indicators before and after treatment in the two groups were detected and compared.Results: SBP, DBP, whole blood high, moderate, and low shear viscosity, plasma viscosity, and HCT after treatment in the two groups were significantly reduced when compared with before treatment (P<0.05). The levels of the above indicators after treatment in the observation group were significantly lower than those in the control group (P<0.05). PT, APTT, and TT after treatment in the two groups were significantly elevated when compared with before treatment (P<0.05), while Fib was significantly reduced (P<0.05). PT, APTT, and TT after treatment in the observation group were significantly higher than those in the control group (P<0.05), while Fib was significantly lower than that in the control group (P<0.05). Conclusions:Nifedipine in combined with magnesium sulfate can significantly stabilize the blood pressure level in patients with gestational hypertension, and improve the hemodynamic and coagulation indicators, with a significant efficacy.

Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals?

Objective:To examine the impact of a 6-week endurance training on red blood cell(RBC)aging and deformability of healthy participants to detect possible improved hemorheological and performance-related adaptations.Methods:A total of 31 participants(17 females and 14 males)performed a 6-week moderate training protocol(three 1-h running sessions per week at 70%of maximal heart rate).Blood was sampled before and after the training.RBCs from each participant were fractioned according to density and age into 4 RBC subfractions.Subfractions were examined for changes of RBC properties,including aging distribution,RBC deformability,RBC microparticles,and phosphatidylserine concentrations.RBC and plasma nitrite levels were measured as indicators of nitric oxide metabolism.Results:Aerobic performance,peak oxygen consumption,ventilatory thresholds,velocity at the aerobic-anaerobic threshold,and lactate at exhaustion improved after training.The relative amount of both young RBCs and old RBCs increased,and the amount of the main RBC fraction decreased.Phosphatidylserine externalization and RBC-derived microparticles decreased.Overall deformability expressed as shear stress required to achieve half-maximum deformation to theoretical maximal elongation index at infinite shear stress improved in unfractioned RBCs(p<0.001).Nitrite decreased in total(p=0.001),young(p<0.001),main(p<0.001),and old(p=0.020)aged RBCs and in plasma(p=0.002),but not in very old RBCs.Conclusion:These results indicate that non-endurance-trained healthy participants benefit from a regular moderate running training program because performance-related parameters improve and a younger RBC population with improved RBC properties is induced,which might support oxygen supply in the microcirculation.

Effects of Xintongding and labellol on hemorheology, oxidative stress and inflammatory endothelial factor in patients with gestational hypertension

Objective:To explore the effects of Xintongding and labellol on hemorheology, oxidative stress and inflammatory endothelial factor in patients with gestational hypertension.Methods:104 patients with gestational hypertension admitted to our hospital from March 2016 to January 2018 were selected as the research object. 52 patients in the control group and 52 patients in the observation group were randomly divided into two groups. The control group was treated with Xintongding, while the observation group was treated with Labellol on the basis of the control group. The changes of blood pressure, hemorheology, oxidative stress index and inflammatory endothelial factors were compared and analyzed between the two groups.Results:Before treatment, there were no significant differences in the levels of SBP, DBP, LBV, HBV, PV, FIB, LPO, MDA, SOD, TNF-α, CRP, VEGF and PLGF. After treatment, the levels of SBP, DBP, LBV, HBV, PV, FIB, LPO, MDA, TNF-α and CRP were significantly decreased, while the levels of SOD, VEGF and PLGF were significantly higher than before treatment, and the levels of SBP, DBP, LBV, HBV, PV, FIB, LPO, MDA, TNF-α and CRP in the observation group were significantly lower than those in the control group, and the levels of SOD, VEGF and PLGF were significantly higher than the control group. Conclusions: Xintongding combined with labetalol in the treatment of hypertensive disorder in pregnancy can effectively improve blood pressure, blood rheology and oxidative stress, reduce inflammation and promote angiogenesis, and has clinical significance.

Effect of Shuxuetong injection on platelet function, hemorheology and cerebral blood flow in patients with ischemic stroke

Objective:To investigate the effect of Shuxuetong injection on platelet function, hemorheology and cerebral blood flow in patients with ischemic stroke.Methods: One hundred cases of ischemic stroke admitted in our hospital from February 2015 to January 2017 were randomly divided into control group and observation group. The control group was given routine treatment. The observation group was given Shuxuetong injection on the basis of the control group. The changes of platelet function, hemorheology and cerebral blood flow before and after treatment were detected in both groups.Results: After treatment, the whole blood viscosity, plasma viscosity and fibrinogen level in both groups were significantly lower than those before treatment. The whole blood viscosity, plasma viscosity and fibrinogen level in the observation group were (4.18±0.05) mPa?s, (1.66±0.12) mPa?s and (3.45±0.08) g/L, respectively, which were significantly lower than the control group;After treatment, the levels of MCA, ACA and PCA in both groups were significantly increased. MCA, ACA and PCA levels in the observation group were (70.82±4.13) cm/s, (60.62±3.55) cm/s and (54.11±2.36) cm/s, which were significantly higher than those in the control group;After treatment, the maximum platelet aggregation rate, PLT, MPV and PDW levels in the two groups significantly decreased. The maximum platelet aggregation rate, PLT, MPV and PDW levels in the observation group were (27.93±1.44)% and (155.32±13.46)×109/L, (9.42±0.32) fL and (9.12±0.24) fL, respectively, which were significantly lower than those in the control group. Conclusions: Shuxuetong injection can effectively improve the patient's hemorheology and platelet function, improve the level of cerebral blood flow in patients with significant effect, it is worth further clinical application.

Effect of low-dose aspirin and Danshen injection on hemorheology, vascular endothelial function and oxidative stress in pregnancy-induced hypertension

Objective:To investigate the effect of low dose aspirin and salvia miltiorrhiza injection on hemorrheology, endothelial function and oxidative stress in patients with pregnancy induced hypertension.Methods: One hundred and eighty pregnancy-induced hypertension patients treated in our hospital from April 2015 to November 2016 were selected as study subjects and randomly divided into control group and observation group with 90 cases in each group. The control group was given routine treatment. The observation group was treated with low-dose aspirin plus Salvia miltiorrhiza in the control group. After treatment, blood rheology, vascular endothelial function and oxidative stress were measured in two groups.Results: The levels of MAP and 24 h Upro in both groups were significantly lower than those before treatment. After treatment, the MAP and 24 h Upro levels in the observation group were significantly lower than those in the control group. After treatment, the level of PT was significantly higher than that before treatment, while the level of DD and Fg was significantly lower than that before treatment. Comparing the two groups after treatment showed that the PT level, and the levels of DD and Fg were significantly lower than those in the control group;After treatment, NO levels in both groups were significantly higher than those before treatment, ET-1 and ET-1/NO levels were significantly lower than before treatment, after treatment, ET-1, NO and ET The NO level in the observation group was significantly higher than that in the control group, while ET-1 and ET-1/NO levels were significantly lower than those in the control group;Compared with those before treatment, the levels of SOD in the two groups were significantly increased and MDA significantly decreased after treatment. The SOD and MDA levels in the two groups after treatment showed that the SOD level in the observation group was significantly higher than that in the control group, while MDA level was significantly lower than that of the control group.Conclusion: The combination of low-dose aspirin and Salvia miltiorrhiza injection has significant therapeutic effect on gestational hypertension, and can effectively improve the hemorheological parameters and endothelial function of patients and reduce the oxidative stress injury in patients. It is worth further clinical promotion.

Effect of butylphthalide injection on inflammatory factors, neurological factors and hemorheology in patients with acute cerebral infarction

Objective: To investigate the effects of butylphthalide injection on inflammatory factors, neurological factors and hemorheology in patients with acute cerebral infarction. Methods:The patients in the observation group were treated with intravenous infusion of butyphthalide on the basis of the control group, 120 cases of acute cerebral infarction patients are randomly divided into control group (n=60) and observation group (n=60), patients in the control group were given conventional thraphy, on the basis of the thraphy of the control group, the observation group were treated with intravenous infusion of butyphthalide. Both groups were given sustainable treatment for 14 d, the levels of inflammatory factors, neurological factors and hemorheologywere compared before and after the treatment. Results: The levels of serum hs-CRP, TNF-α, NSE, MBP, S100B, whole blood viscosity, plasma specific viscosity, hematocrit and platelet aggregation rate in the two groups before treatment were no significant difference. After treatment, the levels of hs-CRP, TNF-α in the observation group and observation group were (4.98±1.14) mg/L, (5.54±1.29) ng/L and (7.54±0.93) mg/L, (8.32±1.31) ng/L, which were significantly lower than those in the same group before treatment, and the level of hs-CRP, TNF-α in the observation group were significantly lower than those in the control group;the levels of NSE, MBP, S100B in the observation group and observation group were (6.38±2.39) μg/L, (10.19±3.28) μg/L, (0.96±0.09) ng/L and (11.73±2.43) μg/L, (17.43±4.51) μg/L, (1.65±0.12) ng/L, which were significantly lower than those in the same group before treatment, and the observation group levels were significantly lower than those in the control group;the levels of whole blood viscosity, plasma specific viscosity, hematocrit and platelet aggregation rate in the observation group and observation group were(5.17±0.89) mPa?s,(1.32±0.22) mPa?s, (0.35±0.13)%, (0.32±0.08)% and (5.68±0.91) mPa?s, (1.63±0.24) mPa?s, (0.41±0.14)%, (0.40±0.11)%, which were significantly lower than those in the same group before treatment, and the observation group levels were significantly lower than those in the control group. Conclusion: On the basis of conventional treatment, the addition of butyphthalide can effectively reduce the level of serum inflammatory factors, promote the repair of nerve function, improve the level of hemorheology, which has important clinical value.

Seasonal Changes of Hemorheology in Patients with Intracerebral Hemorrhage in Acute Phase

Objective.To explore the seasonal changes of hemorheology in patients with intracerebral hemorrhage in acute phase.Methods.The hemorheology indexes were detected in 100 acute cerebral hemorrhage patients and 30 normal persons.The observed group were divided into summer group,transition season group and winter group according to traditional solar terms,then the hemorheology indexes of different groups were compared.Results.Compared with control group,the whole blood viscosity increased with statistical significance(P<0.05).The whole blood viscosity of four cut blood rates and plasma viscosity were further compared in summer group,transition season group and winter group,and the indexes were the highest in winter group.Compared with transition season group,the erythrocyte aggregation index and erythrocyte transformation index acute intracerebral hemorrhage patients were decreased in winter group and summer group.The whole blood viscosity,plasma viscosity and erythrocyte sedimentation rate(ESR)compared in each group were increased with statistical significance.There were no significant statistical differences in hematocrit(HCT)among each groups(P>0.05).Conclusion.The hemorheology indexes in acute intracerebral hemorrhage patients are influenced by changes of different seasons and The blood of acute cerebral hemorrhage patients shows a concentrated tendency.The whole blood viscosity and plasma viscosity of acute cerebral hemorrhage patients were increased more obviously in winter group,which may be a pathophysiological basis of high incidence of acute cerebral hemorrhage in cold season and increase of severe cases.

EFFECT OF ACUPUNCTURE TREATMENT ON CELLULAR HEMORHEOLOGY, CHOLESTEROL AND TRIGLYCERIDE OF SIMPLE OBESITY PATIENTS

Objective: To observe the effect of acupuncture on simple obesity and cellular hemorheology. Methods: Thirty-two cases of simple obesity patients were enrolled into this study. Acupoints of the Stomach Meridian and Spleen Meridian as Zhongwan (中脘 CV 12), Liangmen (梁门 ST 21), Tianshu (天枢 ST 25), Guayuan (关元 CV 4), etc. were punctured, once daily in the first 5 days, and once every other day afterwards, with 10 sessions being a therapeutic course. Before treatment and after 3 courses of treatment, the body weight, waistline, weight index, seam cholesterol (CH), triglyceride and aggregation index of red blood cell (RBC) were detected. Results: After acupuncture treatment, all the indexes of body weight, waistline, weight index, serum CH, triglyceride and aggregation index of RBC decreased significantly in comparison with those of pre-treatment(P< 0.05). Conclusion: Acupuncture can apparently improve cellular hemorheology, reduce body weight, serum cholesterol and TG levels in simple obesity patients.

Effect of atorvastatin combined with trimetazidine on oxidative stress, hemorheology, and NT-proBNP, hs-CRP in patients with coronary heart disease

Objective:To explore the effect of Atorvastatin Combined with trimetazidine on oxidative stress, hemorheology and NT-proBNP and hs-CRP in patients with coronary heart disease. Method:A total of 84 patients with coronary heart disease were admitted in our hospital from February 2015 to February 2017 were randomly divided into the observation group and the control group, each group with 42 cases. The two groups received routine treatment of coronary heart disease, while the control group was treated with atorvastatin and the observation group was treated with Atorvastatin Combined with trimetazidine. Both groups were treated continuously for one month. The levels of oxidative stress indexes (SOD), malondialdehyde, (MDA), blood rheology indexes (ESR, whole blood hyposhear viscosity, whole blood hypershear viscosity, plasma viscosity, Fibrinogen (Fib) and serum N-terminal pro-brain natriuretic peptide (NT-proBNP), hypersensitive C reaction protein (hs-CRP) index in two groups were compared analytically.Results: Before treatment, there was no significant difference between the observation group and the control group in terms of oxidative stress, blood rheology and NT-proBNP and hs-CRP index. Compared with before treatment, the level of SOD in observation group and the control group was significantly increased and MDA significantly decreased. While the level of SOD in observation group was significantly higher than the control group, and MDA level was significantly lower than the control group after treatment. Compared with before treatment, the levels of hemorheology indexes included ESR, whole blood viscosity, plasma viscosity and Fib in observation group and control group were significantly decreased. After treatment, the levels of ESR, whole blood viscosity, plasma viscosity and Fib in the observation group were significantly lower than the control group. Compared with before treatment, the levels of NT-proBNP and hs-CRP in the observation group and control group were significantly decreased. After treatment, the levels of NT-proBNP and hs-CRP in the observation group were significantly lower than the control group,there was significantly statistical difference.Conclusion:Atorvastatin combined with trimetazidine can significantly reduce oxidative stress, restore normal blood rheology, and improve levels of NT-proBNP and hs-CRP in patients with coronary heart disease. This treatment is worthy of clinical promotion.

Effect of Tongmai Huoxue decoction combined with warm needling on hemorheology and antioxidant capacity in patients with high altitude polycythemia

Objective: To investigate the curative effect of Tongmai Huoxue Decoction combined with warm needling on the treatment of High altitude polycythemia (HAPC), and to analyze the changes of hemorheology and antioxidant ability before and after treatment. Methods: A total of 90 HAPC patients were randomly divided into control group and observation group. The control group was treated with low molecular weight dextran and captopril. On the basis of this, the observation group was supplemented with Tongmai Huoxue Decoction combined with warm needling. Hemorheology and antioxidant markers were measured before and after treatment in all subjects. Results: Before treatment, there were no significant differences in the hemorheology indexes between the control group and the observation group. After treatment, the two groups of hemorheology related indicators were significantly lower than those before treatment, including whole blood low shear reduction viscosity, whole blood high shear reduction viscosity, plasma viscosity, Hb, Hct and RBC. The levels of the observation group were significantly lower than that of the control group. Before treatment, there was no significant difference in antioxidant indexes between the control group and the observation group. After treatment, the levels of serum superoxide dismutase (SOD) and glutathione (GSH) in the two groups were higher than those in the pre-treatment, while the content of malondialdehyde (MDA) was lower than that before treatment. The levels of serum SOD and GSH in the observation group were higher than those in the control group, and the MDA content was lower than that in the control group. Conclusion: Routine treatment of Western medicine combined with Tongmai Huoxue Decoction joint warm needling method may reduce hemoglobin, improve hemorheology and improve antioxidant ability in HAPC patients, and it may be one of the potential effective drugs for adjuvant therapy of HAPC.

Effect of hydromorphone hydrochloride postoperative analgesia on the stress reaction and hemorheology in elderly patients after total hip replacement

Objective:To explore the effect of hydromorphone hydrochloride postoperative analgesia on the stress reaction and hemorheology in elderly patients after total hip replacement (THR). Methods:A total of 70 patients who were admitted in our hospital from June, 2015 to June, 2016 for THR were included in the study and randomized into the observation group and the control group with 35 cases in each group. After operation, the patients in the two groups were immediately given patient-controlled analgesia. The patients in the observation group were given hydromorphone hydrochloride, while the patients in the control group were given sufentanil. The peripheral venous blood before operation, 12 and 24 h after operation in the two groups was collected. RIA was used to detect BG and Cor. ELISA was used to detect NE. The peripheral venous blood before operation, 24 and 72 h after operation was collected. The full automatic hematology analyzer was used to detect the plasma PV, BV, and RWBV. Results:Cor and NE levels in the observation group, and BG, Cor, and NE levels in the control group 12 and 24 h after operation were significantly elevated when compared with before operation (P<0.05), but the above indicators at each timing point in the control group were significantly higher than those in the observation group (P<0.05). PV, BV (low-shear, middle-shear, and high-shear), and RWBV (low-shear, middle-shear, and high-shear) levels 24 and 72 h after operation in the two groups were significantly elevated when compared with before operation (P<0.05), but the above indicators at each timing point in the control group were significantly higher than those in the observation group (P<0.05). Conclusions:Application of hydromorphone hydrochloride in the postoperative analgesia in elderly patients with THR has a preferable analgesia effect, can effectively alleviate the postoperative stress reaction, stabilize the hemorheology, and contribute to the rehabilitation.

Effect of salvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injection on serum BNP, Hcy, MMP-2, S100B protein and hemorheology in patients with acute cerebral watershed infarction

Objective:To study the effect of salvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injection on serum BNP, Hcy, MMP-2, S100B protein and hemorheology in patients with acute cerebral watershed infarction.Methods:A total of 90 patientswith acute cerebral watershed infarction in our hospital from August 2014 to December 2016 were enrolled in this study. The subjects were divided into the control group (n=45) and the treatment group (n=45) randomly. The control group was treated with hydroxyethyl starch injection, the treatment group was treated withsalvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injection, and both the two groups were treated for 2 weeks. The serum BNP, Hcy, MMP-2, S100B protein and hemorheology of the two groups before and after treatments were compared.Results:There were no significantly differences of the serum BNP, Hcy, MMP-2, S100B protein and hemorheology of the two groups before treatment. The serum BNP, Hcy, MMP-2, S100B proteinlevels of the two groups after treatment were significantly lower than before treatment, and that of the treatment group after treatment were significantly lower than the control group. The PV, Lr, Mr, Hr and RE of the two groups after treatment were significantly lower than before treatment, and that of the treatment group after treatment were significantly lower than the control group.Conclusion:Salvia miltiorrhiza and ligustrazine hydrochloride injection combined with hydroxyethyl starch injectioncan significantlyimprovetheneurological function and hemorheology, reduce inflammation of the patients with acute cerebral watershed infarction, and it was worthy clinical application.

THE HEMORHEOLOGY CHANGE IN ISCHEMIC REGION BY CORONARY STENOSIS AFTER LASER IRRADIATION ON BLOOD

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Effects of different directions of moxibustion therapy on hemorheology in rats with blood stasis due to cold retention

Objective： To investigate the effects of different directions of moxibustion therapy on hemorheology in rat models with blood stasis due to cold retention. Methods： A total of 32 Wistar rats were randomly divided into 4 groups, based on the random digits table, including a normal group, a model group, a moxibustion along the meridian group, and a moxibustion against the meridian group, with 8 rats in each group. Except the normal group, the other 3 groups were used to make the rat models with blood stasis due to cold retention. Rats in the moxibustion along and against the meridian groups accepted moxibustion therapy in different directions on the trunk segment of the Bladder Meridian after successful modeling. Moxibustion for 10 min every day, and 7 d as a course of treatment. Two courses of treatment（a total of 14 d） were carried out. Quantitative score of signs and symptoms change was observed once a week, with a total of 7 times. Hemorheological indexes of rats were detected when the treatment finished. Results： The quantitative scores of signs and symptoms in the model, moxibustion along the meridian and against the meridian groups were significantly higher than those in the normal group after modeling（P〈0.05）. When the treatment finished, the quantitative score of signs and symptoms in the model group was significantly higher than that in the normal group（P〈0.05）; the quantitative scores of signs and symptoms of rats in the moxibustion along and against the meridian groups were significantly lower than that in the model group（P〈0.05）; the quantitative score of signs and symptoms in the moxibustion along the meridian group was significantly lower than that in the moxibustion against the meridian group（P〈0.05）; the whole blood viscosity and erythrocyte aggregation index in the model group were significantly higher than those in the normal group（P〈0.05）, however the increases of erythrocyte hematocrit and erythrocyte sedimentation rate were not obvious（P〈0.05）; whole blood viscosity and erythrocyte aggregation index in the moxibustion along and against the meridian groups were significantly lower than those in the model group（P〈0.05）, while there were no statistically significant differences between the moxibustion along the meridian group and moxibustion against the meridian group（P〈0.05）. Conclusion： Moxibustion along and against the meridian both showed different degrees of improvement for hemorrheology and symptoms of blood stasis due to cold retention. Improvement for symptoms of blood stasis due to cold retention was better in the moxibustion along the meridian group than that in the moxibustion against the meridian group. The influence on rat hemorrheology showed no significant difference between moxibustion along the meridian and moxibustion against the meridian.

晚期恶性肿瘤患者的血液流变指标观察

Hemorheological changes of 45 cases with malignant tumors are investigated and compared with 709 healthy persons. Results show that blood viscosity, plasma viscosity, fibrinogen, erythrocyte deformability index, erythrocyte sedimentation rate(ESR), ESR -K and erythrocyte electrophoresis time are obviously increased, while hematocrit is significantly lower than that of control groups. This indicates that patients with malignant tumors have hyperviscosity syndromes.