Delineating homogeneous domains of fractured rocks using topological manifolds and deep learning

Determining homogeneous domains statistically is helpful for engineering geological modeling and rock mass stability evaluation.In this text,a technique that can integrate lithology,geotechnical and structural information is proposed to delineate homogeneous domains.This technique is then applied to a high and steep slope along a road.First,geological and geotechnical domains were described based on lithology,faults,and shear zones.Next,topological manifolds were used to eliminate the incompatibility between orientations and other parameters(i.e.trace length and roughness)so that the data concerning various properties of each discontinuity can be matched and characterized in the same Euclidean space.Thus,the influence of implicit combined effect in between parameter sequences on the homogeneous domains could be considered.Deep learning technique was employed to quantify abstract features of the characterization images of discontinuity properties,and to assess the similarity of rock mass structures.The results show that the technique can effectively distinguish structural variations and outperform conventional methods.It can handle multisource engineering geological information and multiple discontinuity parameters.This technique can also minimize the interference of human factors and delineate homogeneous domains based on orientations or multi-parameter with arbitrary distributions to satisfy different engineering requirements.

BIG HANKEL OPERATORS ON HARDY SPACES OF STRONGLY PSEUDOCONVEX DOMAINS

In this article,we investigate the(big) Hankel operator H_(f) on the Hardy spaces of bounded strongly pseudoconvex domains Ω in C^(n).We observe that H_(f ) is bounded on H~p(Ω)(1 <p <∞) if f belongs to BMO and we obtain some characterizations for Hf on H^(2)(Ω) of other pseudoconvex domains.In these arguments,Amar's L^(p)-estimations and Berndtsson's L^(2)-estimations for solutions of the ■_(b)-equation play a crucial role.In addition,we solve Gleason's problem for Hardy spaces H^(p)(Ω)(1 ≤p≤∞) of bounded strongly pseudoconvex domains.

MINIMIZERS OF L^(2)-SUBCRITICAL VARIATIONAL PROBLEMS WITH SPATIALLY DECAYING NONLINEARITIES IN BOUNDED DOMAINS

This paper is concerned with the minimizers of L^(2)-subcritical constraint variar tional problems with spatially decaying nonlinearities in a bounded domain Ω of R~N(N≥1).We prove that the problem admits minimizers for any M> 0.Moreover,the limiting behavior of minimizers as M→∞ is also analyzed rigorously.

Spatial correlations in time and frequency domains between chlorophyll-a concentration and environmental factors in the Bohai Sea

Based on the reconstructed MODIS data and ECMWF reanalysis data from 2003 to 2021,spatial correlations between chlorophyll a(Chl a)and sea surface temperature(SST),photosynthetically available radiation(PAR),aerosol optical thickness(AOT),and wind speed(WS)in the Bohai Sea were analyzed from the perspective of time domain and frequency domain.Results indicate that the frequency domain analysis was more conducive to revealing the correlations between Chl a and environmental factors.The spatial pattern of time-domain correlations was similar to the isobaths of the Bohai Sea,which was positive in shallow waters and negative in deep waters for SST,PAR,and AOT,and was reversed for WS.Frequency-domain correlations were obtained by performing Fourier Transform and were higher than correlations in time domain.The spatial distributions indicated that the effects of SST and PAR on Chl a were greater than AOT and WS in the Bohai Sea.Additionally,cross-spectrum analysis was applied to explore the response relationships.A depth-dependent pattern was shown in correlations and time lags,indicating that the influential mechanism of environmental factors on Chl-a concentration is related to seawater depth.

Targeting neuronal PAS domain protein 2 and KN motif/ankyrin repeat domains 1:Advances in type 2 diabetes therapy

This editorial summarizes the latest literature on the roles of neuronal PAS domain protein 2 and KN motif/ankyrin repeat domain 1 in type 2 diabetes(T2D).We highlight their involvement inβ-cell dysfunction,explore their potential as therapeutic targets,and discuss the implications for new treatment strategies.We offer valuable insights into relevant gene regulation and cellular mechanisms relevant for the targeted management of T2D.

Enhancing Relational Triple Extraction in Specific Domains:Semantic Enhancement and Synergy of Large Language Models and Small Pre-Trained Language Models

In the process of constructing domain-specific knowledge graphs,the task of relational triple extraction plays a critical role in transforming unstructured text into structured information.Existing relational triple extraction models facemultiple challenges when processing domain-specific data,including insufficient utilization of semantic interaction information between entities and relations,difficulties in handling challenging samples,and the scarcity of domain-specific datasets.To address these issues,our study introduces three innovative components:Relation semantic enhancement,data augmentation,and a voting strategy,all designed to significantly improve the model’s performance in tackling domain-specific relational triple extraction tasks.We first propose an innovative attention interaction module.This method significantly enhances the semantic interaction capabilities between entities and relations by integrating semantic information fromrelation labels.Second,we propose a voting strategy that effectively combines the strengths of large languagemodels(LLMs)and fine-tuned small pre-trained language models(SLMs)to reevaluate challenging samples,thereby improving the model’s adaptability in specific domains.Additionally,we explore the use of LLMs for data augmentation,aiming to generate domain-specific datasets to alleviate the scarcity of domain data.Experiments conducted on three domain-specific datasets demonstrate that our model outperforms existing comparative models in several aspects,with F1 scores exceeding the State of the Art models by 2%,1.6%,and 0.6%,respectively,validating the effectiveness and generalizability of our approach.

Research fronts and researchers of World Journal of Psychiatry in 2023: A visualization and analysis of mapping knowledge domains

BACKGROUND In the rapidly evolving landscape of psychiatric research,2023 marked another year of significant progress globally,with the World Journal of Psychiatry(WJP)experiencing notable expansion and influence.AIM To conduct a comprehensive visualization and analysis of the articles published in the WJP throughout 2023.By delving into these publications,the aim is to deter-mine the valuable insights that can illuminate pathways for future research endeavors in the field of psychiatry.METHODS A selection process led to the inclusion of 107 papers from the WJP published in 2023,forming the dataset for the analysis.Employing advanced visualization techniques,this study mapped the knowledge domains represented in these papers.RESULTS The findings revealed a prevalent focus on key topics such as depression,mental health,anxiety,schizophrenia,and the impact of coronavirus disease 2019.Additionally,through keyword clustering,it became evident that these papers were predominantly focused on exploring mental health disorders,depression,anxiety,schizophrenia,and related factors.Noteworthy contributions hailed authors in regions such as China,the United Kingdom,United States,and Turkey.Particularly,the paper garnered the highest number of citations,while the American Psychiatric Association was the most cited reference.CONCLUSION It is recommended that the WJP continue in its efforts to enhance the quality of papers published in the field of psychiatry.Additionally,there is a pressing need to delve into the potential applications of digital interventions and artificial intelligence within the discipline.

Design,Development and Testing of the JTech Bolt for Use in Static,Quasi-Static and Dynamic Domains

Designing a rock reinforcement element requires knowledge of:geomechanical behaviour,interaction of the reinforcement element with rock mass and the element’s mechanistic response in static and dynamic environments.Using this knowledge the JTech bolt was developed and subjected to a thorough program to test,gather data and validate the bolt performance in varying domains.By conducting FE(finite element)modeling,the simulation reviews the JTech bolt design evaluating the effects of threadbar geometric variation,threadbar and nut engagement results under high stress,coating friction response and effects of thread tolerance extremes on the failure mode.These results determine safety factors,tolerances and quality management criteria.Once manufactured,in-situ system testing,laboratory and underground short encapsulation testing,resin mixing testing,double shear testing and dynamic testing at varying velocity and mass,determine the system’s capacity and effectiveness in static,quasi-static and dynamic mining environments.In this paper,the process and results are described.

Identification of Stability Domains for Flow Parameters in Fused Filament Fabrication Using Acoustic Emission

In Fused Filament Fabrication(FFF),the state of material flow significantly influences printing outcomes.However,online monitoring of these micro-physical processes within the extruder remains challenging.The flow state is affected by multiple parameters,with temperature and volumetric flow rate(VFR)being the most critical.The study explores the stable extrusion of flow with a highly sensitive acoustic emission(AE)sensor so that AE signals generated by the friction in the annular region can reflect the flow state more effectively.Nevertheless,the large volume and broad frequency range of the data present processing challenges.This study proposes a method that initially selects short impact signals and then uses the Fast Kurtogram(FK)to identify the frequency with the highest kurtosis for signal filtration.The results indicate that this approach significantly enhances processing speed and improves feature extraction capabilities.By correlating AE characteristics under various parameters with the quality of extruded raster beads,AE can monitor the real-time state of material flow.This study offers a concise and efficient method for monitoring the state of raster beads and demonstrates the potential of online monitoring of the flow states.

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults.Whether targeting this pathway is beneficial to brain injury remains unclear.In this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral deficits.Pharmacological inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology domain.Mechanistically,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin pathway.These findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly understood.The major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier function.It plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain barrier.Furthermore,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain barrier.This paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier permeability.This comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to date.This will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic monitoring.In addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier leakage in various diseases and the research progress on cross-blood-brain barrier drug delivery are summarized.This review may contribute to the development of new approaches for the treatment of neurological diseases.

The Growth Theorem for Almost Starlike Mappings of Order α on Bounded Starlike Circular Domains

In this paper,we extend the definition of almost starlike mappings of order 1/2 on B n to the almost starlike mappings of order α on the bounded starlike circular domains in C n,and give the growth theorem of it. This type of domain on which we discuss is rather general,in the sense that the domain must be starlike if there exists a normalized biholomorphic starlike mapping on it.

The Growth Theorem for Strongly Starlike Mappings of Order α on Bounded Starlike Circular Domains

The authors obtain the growth and covering theorems for strongly starlike mappings of order α on bounded starlike circular domains.This kind of domain discussed is rather general,since the domain must be starlike if exists a normalized biholomorphic starlike mapping on it.

Multilinear Calder′on Zygmund operators on variableexponent Morrey spaces over domains

The boundedness of multilinear singular integrals of Calder′on-Zygmund type onproduct of variable exponent Lebesgue spaces over both bounded and unbounded domains areobtained. Further more, the boundedness for this type multilinear operators on product ofvariable exponent Morrey spaces over domains is shown in the paper.

Protein-protein Interaction Between Domains of PDZ and BAR from PICK1

Two DNA fragments encoding PDZ domain （21-110 residues） and BAR domain （ 150-360 residues） from PICK1 （1-416 residues） were amplified by PCR and then introduced into vectors, pET-32M and pMAL-e2X respectively to generate recombinant plasmids, pE-pdz and pM-bar. Having been separately transferred into the hosts E. coli BL21 and E. coli JM109, these two strains can express fusion proteins： His-tagged PDZ（PDZ domain） and maltose binding protein-BAR（ MBP-BAR domain） respectively, as confirmed by both SDS-PAGE and Wostem blotting. The interaction between these two domains is dose-dependence, as identified by a pull-down test. Moreover, it has been shown from the ELISA analysis that the actual amount of PDZ bound to MBP-BAR-amylose beads reaches （ 16 ± 0. 5）%, as calculated by the molar ratio of PDZ to MBP-BAR. In addition, the interaction between BAR（bait） and PDZ（prey） in vivo was also examined with a yeast two-hybrid system.

Orientational Domains at Room Temperature in La_(0.33) Ca_(0.67) MnO_3 Perovskite

Orientational domains at room temperature in orthorhombic perovskite La 0.33 Ca 0.67 MnO 3 were studied by group theory and observed systematically using transmission electron microscopy. There are six orientational variants ( A, A', B,B', C and C' ) in orthorhombic perovskite La 0.33 Ca 0.67 MnO 3. Their orthorhombic b O directions are parallel to the a P, b P and c P directions of the cubic prototypic perovskite, respectively. In each case there are two orientational variants (e.g., A and A' ) with their a O and c O axes interchanged. Among the possible 15 boundaries between these 6 variants there are only two types of domain boundaries: (1) m<100> boundaries C'/C, A'/A, and B'/B. (2) m<110> boundaryies C'/A, C'/A', C'/B, C'/B', C/A, C/A', C/B, C/B', B'/A, B'/A', B/A, and B/A' .

ROUGH MARCINKIEWICZ INTEGRALS ASSOCIATED TO SURFACES OF REVOLUTION ON PRODUCT DOMAINS

In this article, certain Marcinkiewicz integral operators associated to surfaces of revolution on product domains were studied. The Lp boundedness for these operators are established under some rather weak conditions on kernels. The main results essentially improve and extend some known results.

Zeroes of the Bergman Kernels on Some New Hartogs Domains

We obtain the Bergman kernel for a new type of Hartogs domain.The corresponding LU Qi-Keng's problem is considered.

SCHWARZ-PICK ESTIMATES FOR BOUNDED HOLOMORPHIC FUNCTIONS ON CLASSICAL DOMAINS

In this paper, Schwarz-Pick estimates for high order Fr′echet derivatives of bounded holomorphic functions on three kinds of classical domains are presented. We generalize the early work on Schwarz-Pick estimates of higher order partial derivatives for bounded holomorphic functions on the disk and unit ball.

Community capacity domains of dengue prevention and control

Objective:To explore the meanings and domains for giving communities the capacity to be successful in dengue prevention and control.Methods:One hundred and twenty participants were purposely selected from 4 sub-districts of 4 provinces in Southern Thailand with a high dengue incidence.Sixty community leaders and sixty non-community leaders participated in this study.In-depth interviews(IDIs),as well as focus group discussions (FGDs) with tape-recorders and note-taking,were used to collect data.All records were transcribed verbatim and analyzed by using the Colaizzi method for content analysis.Results:The findings showed that people view the creation of a sustainable dengue community program as possible only with the support of each community in its entirety:"everyone,every sector,all participating,and with continuing activities." Community capacity for dengue prevention and control was dependent on ten domains:1) stakeholder participation, 2) community leadership,3) a core-activities group,4) a problem-solving needs assessment,5) dengue information transfer,6) resource mobilization,7 ) a sense of community for the dengue problem,8) a dengue network partnership,9) critical dengue situation-management,and 10) continuing dengue prevention and control activities.Conclusion:These community capacity domains can be developed into an assessment tool for the community capacity-building process.Community capacity domains require community leaders and non-community leaders to clarify dengue prevention and control assistance required.