The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal c...The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal cord injury, established using a modified Allen＇s method, was injected with basic fibroblast growth factor solution via subarachnoid catheter. After injection, rats with spinal cord injury displayed higher scores on the Basso, Beattie and Bresnahan locomotor scale. Motor function was also well recovered and hematoxylin-eosin staining showed that spinal glial scar hyperplasia was not apparent. Additionally, anterior tibial muscle fibers slowly, but progressively, atrophied. Immu- nohistochemical staining showed that the absorbance values of calcitonin gene related peptide and acetylcholinesterase in anterior tibial muscle and spinal cord were similar, and injection of basic fi- broblast growth factor increased this absorbance. Results showed that after spinal cord injury, the distal motor neurons and motor endplate degenerated. Changes in calcitonin gene related peptide and acetylcholinesterase in the spinal cord anterior horn motor neurons and motor endplate then occurred that were consistent with this regeneration. Our findings indicate that basic fibroblast growth factor can protect the endplate through gene related peptide and acetylcholinesterase cord. attenuating the decreased expression of calcitonin n anterior horn motor neurons of the injured spinal展开更多
In industries DC motor drives are very essential due to their high performance applications such as its reliability, ease of control, low cost and simplicity. And speed control of these motors is very easy due to powe...In industries DC motor drives are very essential due to their high performance applications such as its reliability, ease of control, low cost and simplicity. And speed control of these motors is very easy due to power electronic AC-DC converters. These power electronic converters are with prominent low power factor and higher Total Harmonic Distortion (THD). These converters operate only for short time resulting non-sinusoidal waveform. This problem of harmonic distortion can be mitigated by reshaping the non-sinusoidal waveform to pure sine wave. Different wave shaping techniques have been developed by using different filters among which one is tuned passive filter. This paper proposed power factor improvement and harmonic mitigation of AC-DC converters based on separately excited DC motor using tuned passive filter. In this context experimental model is designed and results are analyzed by power quality analyzer.展开更多
We have been previously reported that disuse muscle atrophy exacerbates both motor neuron (MN) degeneration in caudal regions remote from a spinal cord injury, and decrease in glial cell line-derived neurotrophic fact...We have been previously reported that disuse muscle atrophy exacerbates both motor neuron (MN) degeneration in caudal regions remote from a spinal cord injury, and decrease in glial cell line-derived neurotrophic factor (GDNF) protein level in paralyzed muscle. In this study we found that disuse muscle atrophy exacerbated the decrease in GDNF protein level in the L4/5 spinal cord, which was not immunopositive for GDNF. Our results were consistent with the fact that in the lumbar spinal cord of rats with mid-thoracic contusion, GDNF expression was not detected, while expression of GDNF receptors (GFRα1 and RET) was. Our study showed that administration of exogenous recombinant GDNF into the atrophic muscle partially rescued α-MN degeneration in the L4/5 spinal cord. These results suggest that the depletion of GDNF protein by muscle atrophy exacerbates α-MN degeneration in caudal regions remote from the injury.展开更多
为了改善音圈电机驱动系统的动态性能,课题组提出了一种全局自适应非奇异快速终端滑模控制策略。在非奇异快速终端滑模控制器的基础上,引入全局滑态因子,改善系统的瞬态响应;同时将自适应控制和非奇异快速终端滑模控制相结合,利用自适...为了改善音圈电机驱动系统的动态性能,课题组提出了一种全局自适应非奇异快速终端滑模控制策略。在非奇异快速终端滑模控制器的基础上,引入全局滑态因子,改善系统的瞬态响应;同时将自适应控制和非奇异快速终端滑模控制相结合,利用自适应控制可以根据系统的实时状态和外部干扰自动调整参数的特点,来减小扰动、提高系统的鲁棒性和抗干扰性;将控制律中的符号函数改为一种边界层的饱和函数来削弱振动;通过李亚普诺夫稳定性理论证明所提出的控制器的稳定性;最后,将全局自适应非奇异快速终端滑模控制与比例积分微分控制(proportional integral derivative,PID)和滑模控制(sliding mode control,SMC)进行仿真对比。结果表明:与PID控制和滑模控制相比,所提出的全局自适应非奇异快速终端滑模控制提高了系统的动态响应速度和控制精度,有效改善了系统的动态性能。展开更多
基金supported by a grant from the Hunan Provincial Science and Technology Ministry in China, No. 2012SK3222Funding for New Teachers by the Ministry of Education in China, No. 200805331166
文摘The distal end of the spinal cord and neuromuscular junction may develop secondary degeneration and damage following spinal cord injury because of the loss of neural connections. In this study, a rat model of spinal cord injury, established using a modified Allen＇s method, was injected with basic fibroblast growth factor solution via subarachnoid catheter. After injection, rats with spinal cord injury displayed higher scores on the Basso, Beattie and Bresnahan locomotor scale. Motor function was also well recovered and hematoxylin-eosin staining showed that spinal glial scar hyperplasia was not apparent. Additionally, anterior tibial muscle fibers slowly, but progressively, atrophied. Immu- nohistochemical staining showed that the absorbance values of calcitonin gene related peptide and acetylcholinesterase in anterior tibial muscle and spinal cord were similar, and injection of basic fi- broblast growth factor increased this absorbance. Results showed that after spinal cord injury, the distal motor neurons and motor endplate degenerated. Changes in calcitonin gene related peptide and acetylcholinesterase in the spinal cord anterior horn motor neurons and motor endplate then occurred that were consistent with this regeneration. Our findings indicate that basic fibroblast growth factor can protect the endplate through gene related peptide and acetylcholinesterase cord. attenuating the decreased expression of calcitonin n anterior horn motor neurons of the injured spinal
文摘In industries DC motor drives are very essential due to their high performance applications such as its reliability, ease of control, low cost and simplicity. And speed control of these motors is very easy due to power electronic AC-DC converters. These power electronic converters are with prominent low power factor and higher Total Harmonic Distortion (THD). These converters operate only for short time resulting non-sinusoidal waveform. This problem of harmonic distortion can be mitigated by reshaping the non-sinusoidal waveform to pure sine wave. Different wave shaping techniques have been developed by using different filters among which one is tuned passive filter. This paper proposed power factor improvement and harmonic mitigation of AC-DC converters based on separately excited DC motor using tuned passive filter. In this context experimental model is designed and results are analyzed by power quality analyzer.
文摘We have been previously reported that disuse muscle atrophy exacerbates both motor neuron (MN) degeneration in caudal regions remote from a spinal cord injury, and decrease in glial cell line-derived neurotrophic factor (GDNF) protein level in paralyzed muscle. In this study we found that disuse muscle atrophy exacerbated the decrease in GDNF protein level in the L4/5 spinal cord, which was not immunopositive for GDNF. Our results were consistent with the fact that in the lumbar spinal cord of rats with mid-thoracic contusion, GDNF expression was not detected, while expression of GDNF receptors (GFRα1 and RET) was. Our study showed that administration of exogenous recombinant GDNF into the atrophic muscle partially rescued α-MN degeneration in the L4/5 spinal cord. These results suggest that the depletion of GDNF protein by muscle atrophy exacerbates α-MN degeneration in caudal regions remote from the injury.
文摘为了改善音圈电机驱动系统的动态性能,课题组提出了一种全局自适应非奇异快速终端滑模控制策略。在非奇异快速终端滑模控制器的基础上,引入全局滑态因子,改善系统的瞬态响应;同时将自适应控制和非奇异快速终端滑模控制相结合,利用自适应控制可以根据系统的实时状态和外部干扰自动调整参数的特点,来减小扰动、提高系统的鲁棒性和抗干扰性;将控制律中的符号函数改为一种边界层的饱和函数来削弱振动;通过李亚普诺夫稳定性理论证明所提出的控制器的稳定性;最后,将全局自适应非奇异快速终端滑模控制与比例积分微分控制(proportional integral derivative,PID)和滑模控制(sliding mode control,SMC)进行仿真对比。结果表明:与PID控制和滑模控制相比,所提出的全局自适应非奇异快速终端滑模控制提高了系统的动态响应速度和控制精度,有效改善了系统的动态性能。
