World-Universe Model—Alternative to Big Bang Model

This manuscript provides a comparison of the Hypersphere World-Universe Model (WUM) with the prevailing Big Bang Model (BBM) of the Standard Cosmology. The performed analysis of BBM shows that the Four Pillars of the Standard Cosmology are model-dependent and not strong enough to support the model. The angular momentum problem is one of the most critical problems in BBM. Standard Cosmology cannot explain how Galaxies and Extra Solar systems obtained their substantial orbital and rotational angular momenta, and why the orbital momentum of Jupiter is considerably larger than the rotational momentum of the Sun. WUM is the only cosmological model in existence that is consistent with the Law of Conservation of Angular Momentum. To be consistent with this Fundamental Law, WUM discusses in detail the Beginning of the World. The Model introduces Dark Epoch (spanning from the Beginning of the World for 0.4 billion years) when only Dark Matter Particles (DMPs) existed, and Luminous Epoch (ever since for 13.8 billion years). Big Bang discussed in Standard Cosmology is, in our view, transition from Dark Epoch to Luminous Epoch due to Rotational Fission of Overspinning Dark Matter (DM) Supercluster’s Cores. WUM envisions Matter carried from the Universe into the World from the fourth spatial dimension by DMPs. Ordinary Matter is a byproduct of DM annihilation. WUM solves a number of physical problems in contemporary Cosmology and Astrophysics through DMPs and their interactions: Angular Momentum problem in birth and subsequent evolution of Galaxies and Extrasolar systems—how do they obtain it;Fermi Bubbles—two large structures in gamma-rays and X-rays above and below Galactic center;Diversity of Gravitationally-Rounded Objects in Solar system;some problems in Solar and Geophysics [1]. WUM reveals Inter-Connectivity of Primary Cosmological Parameters and calculates their values, which are in good agreement with the latest results of their measurements.

从HALOE资料看青藏高原上空HCl分布及其与O_3的关系

采用UARS卫星1992—2002年卤素掩星试验(HALOE)的观测资料, 分析了青藏高原上空平流层大气中HCl的分布和随时间的变化, 与同纬度其它地区的对比, 找出它们的差异, 并与青藏高原上空平流层大气中O3 的分布和变化对比, 探讨青藏高原上空HCl对O3 的可能影响。结果表明: 青藏高原上空HCl混合比在垂直方向上随高度递增。在 100 hPa以下 HCl含量较少, 其混合比在 10-10 以下, 在10~0.1 hPa之间达到2~3×10-9 量级。青藏高原上空 HCl混合比与同纬度带相比有不少差异。在夏季, 在100 hPa附近气层, 高原地区的HCl混合比明显小于同纬度带平均的 HCl混合比, 但在25~5 hPa气层, 则高原地区的HCl混合比明显大于同纬度带平均的HCl混合比。冬季的情况与夏季几乎是相反的。HCl混合比的分布和变化与O3混合比的分布和变化的相关关系很明显, 且不同高度有所不同。在25~6 hPa气层, HCl混合比与O3混合比的变化呈明显的反相关。在 30 hPa以下到 70hPa它们的相关关系不明显。而在100 hPa附近为明显的正相关。由于反相关的关系在O3混合比较大的气层25~6 hPa (约25~36 km的高度)最明显, 表明在这个气层中HCl对O3的破坏作用是重要的。

Geochemical Characteristics and Zonation of Primary Halos of Pulang Porphyry Copper Deposit,Northwestern Yunnan Province,Southwestern China

The Pulang （普朗） porphyry copper deposit, located in the southern segment of the Yidun-Zhongdian （义敦-中甸） island arc ore-forming belt of the Tethys-Himalaya ore-forming domain, is a recently discovered large copper deposit. Compared with the composition of granodiorite in China, the porphyry rocks in this area are enriched in W, Mo, Cu, Au, As, Sb, F, V, and Na2O （K1≥1.2）. Compared with the composition of fresh porphyry rocks in this district, the mineralized rocks are enriched in Cu, Au, Ag, Mo, Pb, Zn, W, As, Sb, and K2O （K2≥1.2）. Some elements show clear anomalies, such as Zn, Ag, Cu, Au, W, and Mo, and can be regarded as pathfinders for prospecting new ore bodies in depth. It has been inferred from factor analysis that the Pulang porphyry copper deposit may have undergone the multiple stages of alteration and mineralization： （a） Cu-Au mineralization; （b） W-Mo mineralization; and （c） silicification and potassic metasomatism in the whole ore-forming process. A detailed zonation sequence of indicator elements is obtained using the variability index of indicator elements as follows： Zn→Ag→Cu→Au→W→Mo. According to this zonation, an index such as （Ag＊Zn）D/（Mo×W）D can be constructed and regarded as a significant criterion for predicting the Cu potential at a particular depth.

Assessing Safety of CABG in the Era Post Primary PCI, an Outcome Analysis of STEMI Population

Background: Primary PCI (PPCI) has replaced thrombolysis as the treatment of choice for STEMI. The effect of this change on outcomes of patients referred for subsequent CABG is unknown. Methods: All STEMI patients having thrombolysis or PPCI between 2000 and 2010 were identified. Of these, patients subsequently referred for isolated first time CABG form the cohort for this study. Results: 83 of 2476 (3.4%) patients from the PPCI cohort (median follow-up [FU] 3 years [range 6 m - 7.8 y]) and 49 of 528 (9.2%) from the thrombolysis cohort (median FU 9 y [range 1.5 - 10 y] were referred for subsequent CABG. In this referred group, initial reperfusion success (as defined) was: PPCI = 86%, lysis = 84%, p = 0.69. Surgical waiters with prior PPCI had less post infarct angina (1.2% vs. 25%, p 0.01) and late re-infarction (6% vs. 20%, p = 0.034) prior to surgery. Timing of CABG was: 6 m (PPCI 82%, lysis 73%), 6 m-1 y (PPCI 8.4%, lysis: 9%), >1 y (PPCI 9.6%, lysis 18%).Other than an increased prevalence of diabetes in the thrombolysis group, there were no differences in demographic details or risk profile. There were no post-operative deaths, MIs or CVAs. There were no significant differences in post-op AF (28% vs. 22% p = 0.5), respiratory failure (8% vs. 18%, p = 0.08), renal failure (5% vs. 6%, p = 0.5) or re-openings (0% vs. 6%, p = 0.8). Mortality at 3 years was 2.4% in the PPCI cohort and 4% in the thrombolysis cohort. Overall mortality during follow-up for the PPCI group was 3.6% (n = 3) (median FU 3 years), and for the lysis group was 24.5% (n = 12) (median FU 9 years). Conclusions: In patients awaiting CABG after STEMI, PPCI reduces the risk of post-infarct angina and re-infarction prior to surgery, but early surgical results were equally favorable in both groups. Additional follow-up is needed in the PPCI cohort to determine whether there are any significantly different longer-term outcomes.

ETM study of electroporation influence on cell morphology in human malignant melanoma and human primary gingival fibroblast cells

Objective:To estimate electroporation(EP) influence on malignant and normal cells.Methods: Two cell lines including human malignant melanoma(Me-43) and normal human gingival fibroblast(HCFs) were used.EP parameters were the following:230,1000,1 730,2 300 V/cm;30 μ s by 3 impulses for every case.The viability of cells after EP was estimated by MTT assay. The ullrastructural analysis was observed by transmission electron microscope(Zeiss EM 900). Results:In the current study we observed the intracellular effect following EP on Me-43 and HGF cells.At the conditions applied,we did not observe any significant damage of mitochondrial activity in both cell lines treated by EP.Conversely,we showed that EP in some conditions can stimulate cells to proliferation.Some changes induced by EP were only visible in electron microscopy.In fibroblast cells we observed significant changes in lower parameters of EP(230 and 1 000 V/cm).After applying higher electric field intensities(2 300 V/cm) we detected many vacuoles,myelin-like bodies and swallowed endoplasmic reticulum.In melanoma cells such strong pathological modifications after EP were not observed,in comparison with control cells. The ultrastructure of both treated cell lines was changed according to the applied parameters of EP.Conclusions:We can claim that EP conditions are cell line dependent.In terms of the intracellular morphology,human fibroblasts are more sensitive to electric field as compared with melanoma cells.Optimal conditions should be determined for each cell line.Summarizing our study,we can conclude that EP is not an invasive method for human normal and malignant cells. This technique can be safely applied in chemotherapy for delivering drugs into tumor cells.

Double-Moduli Gaussian Encryption/Decryption with Primary Residues and Secret Controls

In this paper an encryption-decryption algorithm based on two moduli is described: one in the real field of integers and another in the field of complex integers. Also the proper selection of cryptographic system parameters is described. Several numeric illustrations explain step-by-step how to precondition a plaintext, how to select secret control parameters, how to ensure feasibility of all private keys and how to avoid ambiguity in the process of information recovery. The proposed cryptographic system is faster than most of known public key cryptosystems, since it requires a small number of multiplications and additions, and does not require exponentiations for its implementation.

Effects of ginger moxibustion combined with Chinese medicine iontophoresis on patients with primary dysmenorrhea

Objective:To observe the effects of Ginger moxibustion combined with iontophoresis with traditional Chinese medicine on the improvement of symptoms, serum platelet activating factor (PAF) level and uterine artery pulsation index in patients with primary dysmenorrhea.Methods 114 patients with primary dysmenorrhea who were treated in our hospital from August 2017 to February 2019 were divided into two groups according to the different treatment schemes. 57 patients in the control group were treated with ibuprofen capsules, and 57 patients in the study group were treated with Ginger moxibustion combined with iontophoresis with traditional Chinese medicine. After three menstrual cycles of treatment, the curative effect was evaluated and the improvement of symptoms was counted. PAF, PAF-AH and platelet adhesion rate were compared, uterine artery hemodynamics was measured, and levels of serum hs-CRP and IL-6 were measured.Results The overall response rate of the study group was significantly higher than that of the control group (P < 0.05). After treatment, the scores of different symptoms in the two groups were significantly lower than those before treatment (P < 0.05), and the scores of different symptoms in the study group were significantly lower than those in the control group (P < 0.05). After treatment, PAF and platelet adhesion rate in the two groups were significantly lower than those before treatment (P < 0.05), PAF-AH was significantly higher than that before treatment (P < 0.05), and PAF and platelet adhesion rate in the study group were significantly lower than those in the control group (P < 0.05), PAF-AH was significantly higher than that in the control group (P < 0.05). After treatment, the pulsation index, resistance index and peak systolic-diastolic ratio in the study group were significantly lower than those before treatment (P < 0.05), and the pulsation index, resistance index and peak systolic-diastolic ratio in the study group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of serum hs-CRP and IL-6 in the two groups were significantly lower than those before treatment (P < 0.05), and the levels of serum hs-CRP and IL-6 in the study group were significantly lower than those in the control group (P < 0.05).Conclusions Ginger moxibustion combined with iontophoresis with traditional Chinese medicine is helpful to improve the overall response rate of primary dysmenorrhea treatment, reduce the score levels of different symptoms, rationally improve PAF, PAF-AH, platelet adhesion rate, and the pulse index, resistance index, peak systolic-diastolic ratio are decreased significantly, and serum hs-CRP and IL-6 levels tend to be normal.

World-Universe Model Predictions

In 2013, World-Universe Model (WUM) proposed a principally different way to solve the problem of Newtonian Constant of Gravitation measurement precision. WUM revealed a self-consistent set of time-varying values of Primary Cosmological parameters of the World: Gravitation parameter, Hubble’s parameter, Age of the World, Temperature of the Microwave Background Radiation, and the concentration of Intergalactic plasma. Based on the inter-connectivity of these parameters, WUM solved the Missing Baryon problem and predicted the values of the following Cosmological parameters: gravitation G, concentration of Intergalactic plasma, relative energy density of protons in the Medium, and the minimum energy of photons, which were experimentally confirmed in 2015-2018. Between 2013 and 2018, the relative standard uncertainty of G measurements decreased x6. The set of values obtained by WUM was recommended for consideration in CODATA Recommended Values of the Fundamental Physical Constants 2014.

Rare presentation of primary (AL) amyloidosis as gastrointestinal hemorrhage without systemic involvement

We are reporting a rare case of a patient with primary(AL) amyloidosis presenting with an acute non-varicealupper gastrointestinal hemorrhage in the absence ofother systemic involvement. The case report involves a58-year-old woman with significant cardiac history andhereditary blood disorder who came in complaining ofabdominal pain and coffee-ground emesis for two days.Computed tomography(CT) scan of the abdomen andpelvis with contrast revealed segmental wall thickeningof the proximal jejunum with hyperdense, heterog-enous luminal content. Similar findings were evident inthe left lower small bowel region, suspicious for smallbowel hematoma and the possibility of intraluminalclots. Esophagogastroduodenoscopy performed postresuscitation showed punctate, erythematous lesionsthroughout the stomach as well as regions of smallbowel mucosa that appeared scalloped, ulcerated, andhemorrhaged on contact. Despite initial treatment for immunostain-positive focal cytomegalovirus gastritis, follow-up esophagogastroduodenoscopy after two months continued to demonstrate friable and irregular duodenal mucosa hinting at a different underlying etiol-ogy. Pathology reports from analyses of biopsy samples highlighted infiltration and expansion of the lamina pro-pria and submucosa. Subsequent staining with congo red/crystal violet and appropriate subtyping established the diagnosis of AL(kappa)-type amyloidosis. The sig-nificance of this case lies in the fact that our patient did not have the typically seen diagnostic systemic involvements-namely of heart and kidneys-usually seen in primary(AL) amyloidosis patients. It was the persis-tent endoscopic findings and biopsy results which gave clues to the physicians regarding the possibility of an abnormal protein-deposition entity.

植入物与Halo-vest内外固定联合治疗下颈椎骨折脱位

背景:对于外伤性下颈椎骨折脱位及脊髓损伤,选择何种治疗方式目前尚存争议。目的:评价植入物内固定与Halo-vest外固定联合应用治疗下颈椎骨折脱位后稳定性的临床效果。方法:回顾分析汕头大学医学院第二附属医院骨科2009年1月至2011年12月收治下颈椎骨折脱位的17例患者,男13例,女4例,年龄21-65岁,平均年龄41.6岁,高处坠落伤6例,重物压砸伤3例,道路交通伤8例,伤后入院时间2h-5d,平均2.5d,所有患者均在局麻下行Halo-vest外固定,然后逐步撑开,在复位情况下,行前路减压植骨、钛板螺钉内固定,通过Frankel分级与影像学检查评价治疗效果。结果与结论:所有患者获得随访,随访12-24个月,平均15.4个月,常规X射线正侧位片显示骨折脱位均复位,恢复颈椎的正常序列及生理弧度,CT显示植骨融合,未发现内固定断裂及松动,按Frankel分级,显效(降低2级)5例,有效(降低1级)10例,无效2例。植入物与Halo-vest内外固定联合对下颈椎骨折脱位失稳固定的效果不仅安全可靠,并且能更好的恢复脊柱的矢状位对线。

人脑初级体感皮质M_(20)反应的性别差异-脑磁图研究

目的:应用脑磁图(MEG)研究健康受试者初级体感皮质反应M20的潜伏期、波幅及位置的性别差异。方法:对40例受试者给予双侧腕部正中神经电刺激,固定电流脉冲0.3ms,刺激间期0.5s,诱发初级体感皮质兴奋。脑磁图检查后进行MR扫描,层厚1.5mm。大脑初级体感皮质反应由等电流偶极(ECD)评价。将脑磁图所获得的M20反应叠加到MRI上,形成磁源性影像(MSI)。结果:依照给予电刺激后反应潜伏期不同分别称为M20、M35及M60,因M35及M60易受刺激间期(ISI)的影响,只对M20的潜伏期、波幅及反应位置的性别差异进行分析。结果为(1)M20左、右半球潜伏期男性20.6±1.0ms和20.7±1.2ms,女性20.1±0.9ms和20.2±0.9ms,男女性同侧半球潜伏期无显著性差异(P>0.05);(2)M20左、右半球波幅男性23.6±11.2nAm和25.4±11.2nAm,女性25.8±10.5nAm和27.6±7.8nAm,男女性同侧半球波幅无显著性差异(P>0.05);(3)左半球男女性M20偶极位置在X轴位存在显著性差异(P<0.05),显示男性X轴上与女性相比稍偏外侧,右半球男女性M20偶极位置在X轴位无显著性差异(P>0.05),Y,Z轴无显著性差异(P>0.05);(4)磁源性影像显示所有受试者M20反应峰值均位于中央后回。结论:脑磁图可明确不同性别的大脑初级体感皮质反应M20潜伏期、波幅及位置。磁源性影像显示M20峰值位于?

改进基本医疗(初级保健)研究报告内容的CRISP共识声明

基本医疗(初级保健)是一门独特的临床专业和研究学科,具有其自身的视角和方法。该领域的研究使用多种研究方法和研究设计来调查各种主题。基本医疗(初级保健)的多样性对其研究内容的报告提出了挑战,尽管已有大量报告指南问世,但没有一项指南专门针对基本医疗(初级保健)学科的需求而设。基本医疗(初级保健)研究报告内容的条目共识(CRISP)清单,旨在指导基本医疗(初级保健)研究的报告,包括提供基本医疗(初级保健)相关人群(从业者、患者和社区)所需的信息。CRISP清单完善了现有指南,有利于基本医疗(初级保健)研究结果的报告、传播和应用。先前的CRISP研究,探索了在该领域改善研究内容报告的可能性。工作组通过对国际化、跨学科和跨专业的基本医疗(初级保健)社区的调查,确定了基本医疗(初级保健)研究报告中需要包含的基本条目。工作组开展了一项包含两轮德尔菲的研究,对必要的条目达成了共识,并汇总成清单。CRISP清单包含24个条目,涵盖了基本医疗(初级保健)研究报告中的研究团队、患者、研究参与者、健康状况、临床接触、护理团队、干预、研究测量、照护环境,以及研究结果的实施等方面。并非全部条目都适用于每种研究设计或主题。CRISP指南为设计和报告以下三类研究提供了参考信息:(1)基本医疗(初级保健)研究人员开展的研究,(2)其他研究人员在基本医疗(初级保健)人群和环境中开展的研究,(3)旨在应用于基本医疗(初级保健)实践中的研究,从而改进对临床服务和研究过程背景的报告。这对于解释研究结果并将其应用于基本医疗(初级保健)的不同人群和环境至关重要。

Environmentally Benign Electrophilic Halogenation of Naphthalenes by H₂O₂—Alkali Metal Halides in An Aqueous Cationic Micellar Media

An efficient and greener protocol for the synthesis of 1-halo-naphthols by the action of hydrogen peroxide and alkali metal halides in aqueous micellar media is been described in the present work. This is an environmentally clean and safe procedure, which involved insitu generation of the active halogen in presence of alkali halides. Cationic surfactants such as cetyltrimethylammoniumbromide (CTAB) and cetyltrimethylammoniumchloride (CTAC) were found to facilitate efficiency of halogenation in aqueous media.

The Role of Serum Ceruloplasmin and Oxidative Stress Markers in Primary Open Angle Glaucoma

Purpose: The study aimed at evaluation of the role of ceruloplasmin (A protein involved in iron homeostasis and can inactivate free radicals) and other oxidative stress markers as superoxide dismutase (SOD), malondialdehyde (MDA) and catalase activity (CAT) in primary open angle glaucoma (POAG). Methods: This observational case control study included 90 persons divided into 3 equal groups: group A of 30 normal persons as a control group, group B of 30 patients of untreated (POAG) (firstly diagnosed) by the clinical characters including measuring intraocular pressure (IOP), optic disc cupping and visual field changes and group C of 30 patients of POAG under medical treatment by topical anti-glaucomatous drugs. Serum ceruloplasmin, superoxide dismutase, malondialdehyde and catalase activity were measured in all groups, statistical analysis of the data was performed. Results: In a comparison to group A of control, serum ceruloplasmin decreased significantly in group B of untreated POAG (20.95 ± 6.01) mg-dl and in group C of POAG under treatment (22.15 ± 6.14) mg-dl (P 0.05). Also, serum superoxide dismutase increased significantly in group B (2.23 ± 0.4) and in group C (2.19 ± 0.38) U-ml (P 0.05). Serum malondialdehyde increased significantly in group B (3.82 ± 0.74) nmol-ml and in group C (3.55 ± 0.73) nmol-ml (P 0.05). Serum catalase decreased significantly in group B (17.97 ± 2.75) U-ml and in group C (18.75 ± 2.33) U-ml in a comparison to the control group A (22.67 ± 3.05) U-ml (P 0.05). Conclusions: Serum ceruloplasmin level and the antioxidant (CAT) activity significantly decreased, while serum levels of SOD, MDA significantly increased in cases of POAG. This may indicate the need for addition of anti-oxidative stress therapy in combination with the anti-glaucomatous drugs. Monitoring these markers can be considered good indicators for determination of the oxidative stress condition in such cases.

Using Speech Recognition in Learning Primary School Mathematics via Explain, Instruct and Facilitate Techniques

The application of Information and Communication Technologies has transformed traditional Teaching and Learning in the past decade to computerized-based era. This evolution has resulted from the emergence of the digital system and has greatly impacted on the global education and socio-cultural development. Multimedia has been absorbed into the education sector for producing a new learning concept and a combination of educational and entertainment approach. This research is concerned with the application of Window Speech Recognition and Microsoft Visual Basic 2008 Integrated/Interactive Development Environment in Multimedia-Assisted Courseware prototype development for Primary School Mathematics contents, namely, single digits and the addition. The Teaching and Learning techniques—Explain, Instruct and Facilitate are proposed and these could be viewed as instructors’ centered strategy, instructors’—learners’ dual communication and learners' active participation. The prototype is called M-EIF and deployed only users' voices;hence the activation of Window Speech Recognition is required prior to a test run.

Risk factors for hepatic decompensation in patients with primary biliary cirrhosis

AIM:To examine the clinical features and analyze prognostic factors in a prospective study of primary biliary cirrhosis(PBC) patients.METHODS:From 1995 to 2010,PBC patients without hepatic decompensation seen at the Peking Union Medical College Hospital were enrolled.Clinical signs and manifestations(pruritus,persistent fatigue,jaundice and pain in the right hypochondrium),laboratory parameters(auto-antibodies for autoimmune hepatic disease,biliary and hepatic enzymes,immunoglobulin,bilirubin,and albumin) and imaging findings were recorded at entry and at specific time points during follow-up.Cox regression and Kaplan-Meier analyses,respectively,assessed the risk factors for hepatic decompensation and survival.RESULTS:Two hundred and sixty-two PBC patients were enrolled with a median follow-up of 75.2 mo(range,21-201 mo).The 240 patients were aged 51.5 ± 10.2 years at diagnosis and 91.6% were female.Two hundred and forty-five(93.5%) were seropositive for anti-mitochondrial antibodies.At presentation,170 patients(64.9%) were symptomatic,while 96 patients(36.6%) had extra-hepatic autoimmune disease.During the follow-up period,62(23.7%) patients developed hepatic decompensation of whom four underwent liver transplantation and 17 died.The cumulative survival rate and median survival time were 83.9% and 181.7 mo,respectively.Cox regression analysis revealed that an incomplete ursodeoxycholic acid(UDCA) response or inconsistent treatment [P < 0.001;hazard risk(HR) 95%CI = 2.423-7.541],anti-centromere antibodies(ACA) positivity(P < 0.001;HR 95%CI = 2.516-7.137),alanine aminotransferase ratio(AAR) elevations(P < 0.001;HR 95%CI = 1.357-2.678),and histological advanced liver disease(P = 0.006;HR 95%CI = 1.481-10.847) were predictors of hepatic decompensation.The clinical features and survival of PBC in China are consistent with those described in Western countries.CONCLUSION:Incomplete UDCA response or inconsistent treatment,ACA positivity,AAR elevations,and advanced histological stage are predictors of decompensation.

Mathematical Overview of Hypersphere World-Universe Model

The Hypersphere World-Universe Model (WUM) provides a mathematical framework that allows calculating the primary cosmological parameters of the World which are in good agreement with the most recent measurements and observations. WUM explains the experimental data accumulated in the field of Cosmology and Astroparticle Physics over the last decades: the age of the World and critical energy density;the gravitational parameter and Hubble’s parameter;temperatures of the cosmic microwave background radiation and the peak of the far-infrared background radiation;the concentration of intergalactic plasma and time delay of Fast Radio Bursts. Additionally, the model predicts masses of dark matter particles, photons, and neutrinos;proposes new types of particle interactions (Super Weak and Extremely Weak);shows inter-connectivity of primary cosmological parameters of the World. WUM proposes to introduce a new fundamental parameter Q in the CODATA internationally recommended values. This paper is the summary of the mathematical results obtained in [1]-[4].

青年肝炎、肝硬化患者中肝癌早期诊断的相关因素

目的探讨青年慢性肝炎(CAH)、肝硬化(HLC)患者中肝癌(PHC)早期诊断的相关因素。方法对324例年龄<39岁的青年CAH、HLC、PHC患者进行调查,从家族史、过去史、饮酒史、临床症状、体征、肝功生化指标、AFP、HBVM进行比较分析,并进行相对危险度(OR值)计算。结果(1)PHC组的男女之比4.16∶1;(2)PHC组72.63%的患者合并肝硬化;(3)HLC组,有明确的家族肿瘤史及肝癌史者,发生肝癌的相对危险度(OR)分别为26.78和2.27;(4)PHC组中,16.84%有长期大量饮酒史,OR值为3.78;(5)PHC组AFP(+)率68.36%,>400ng/ml者占44.89%,而CAH及HLC组AFP(+)率则为12.26%、15.00%,仅0、1.67%(>400ng/ml);(6)HBV感染标记随CAH→HLC→PHC的发展呈递减关系。结论男性青年CAH、HLC是PHC的高危人群;肝炎的病程与反复发作及PHC的发生密切相关;家族肝癌及其他肿瘤史在青年肝癌的发生中相对危险度较高,长期大量饮酒对乙肝病毒确有加速和加重作用,为肝癌的一个促发因素;腹泻是肝癌患者常见的、较早出现的一个临床症状,应引起医务人员重视。

Efficacy of Combined Phacoemulsification and Goniosynechialysis in the Treatment of Patients with Primary Angle Closure Disease and Concomitant Cataract at Preah Ang Duong Hospital in Cambodia

Background: Goniosynechialysis is a surgical procedure that has been shown to slow the progression of glaucoma in oriental eyes with chronic angle closure glaucoma. This procedure was successful in 80% of cases, and the peripheral anterior syenchiae did not exist until one year later. Nonetheless, there is little evidence of its efficacy in our context. Our study aims to investigate the efficacy of goniosynechialysis during phacoemulsification in patients with primary angle closure disease and concomitant cataract. Methods: This was an observational, prospective study. The intra-ocular pressure, need for anti-glaucoma drugs, visual acuity, the extent of synechiae, anterior chamber depth, surgical success rate, and other indicators were monitored for at least three months following surgery. Results: This study included 114 patients (118 eyes), 61 with chronic angle closure glaucoma (51.69%), 33 with primary angle closure (27.97%), and 24 with acute attack angle closure (20.34%), who were surgically treated with phacoemulsification and goniosynechialysis (Phaco-GSL). The mean intra-ocular pressure had significantly decreased three months after surgery (pre- vs post-op: 22.04 ± 10.86 vs 15.41 ± 6.06 mmHg, p-value p-value p-value p-value p-value Conclusion: Regardless of the type of glaucoma, combined phacoemulsification-goniosynechialysis is effective in lowering pressure, restoring vision, reducing the need for anti-glaucoma drugs, and preventing the synechial recurrence. Success was higher in eyes with less extensive synechiae. Phaco-GSL is safe and effective in the treatment of primary angle closure diseases with co-existing cataract.

The Relationship Between Mean Platelet Volume and In-Hospital Mortality in Geriatric Patients with ST Segment Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary Intervention

Objective:We planned to investigate the effect of mean platelet volume(MPV)on in-hospital mortality and coronary risk factors in geriatric patients with ST segment elevation myocardial infarction(STEMI)who underwent primary percutaneous coronary intervention(PCI).Methods:We enrolled 194 consecutive STEMI patients.The study population was divided into two groups on the basis of admission MPVs.The high-MPV group(n=49)included patients in the highest tertile(>8.9 fL),and the low-MPV group(n=145)included patients with a value in the lower two tertiles(≤8.9 fL).Clinical characteristics,in-hospital mortality,cardiovascular risk factors,and outcomes of primary PCI were analyzed.Results:The patients in the high-MPV group were older,more of them had three-vessel disease,and they had higher in-hospital mortality.Patients with in-hospital death were older,had higher Gensini score,creatinine concentration,and MPV,and had lower HDL cholesterol concentration.MPV,age,HDL cholesterol concentration,creatinine concentration,and Gensini score were found to be independent predictors of in-hospital death.Conclusion:These results suggest that high admission MPV levels are associated with increased in-hospital mortality in geriatric patients with STEMI undergoing primary PCI.