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外周血HMGB1Beclin1表达对多发性硬化急性发作期的诊断价值
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作者 杨芳 朱海生 《中国实用神经疾病杂志》 2024年第9期1136-1140,共5页
目的探究高迁移率族蛋白B1(HMGB1)和Beclin1表达对急性发作期多发性硬化(MS)的诊断价值,分析其表达与病情严重程度的相关性。方法回顾性选取2020-01—2022-12邯郸市中心医院收治的86例急性发作期MS患者为研究组,根据Kurtzke扩展残疾状... 目的探究高迁移率族蛋白B1(HMGB1)和Beclin1表达对急性发作期多发性硬化(MS)的诊断价值,分析其表达与病情严重程度的相关性。方法回顾性选取2020-01—2022-12邯郸市中心医院收治的86例急性发作期MS患者为研究组,根据Kurtzke扩展残疾状态评估量表(EDSS)对患者病情进行评估,选取同期健康体检者95例为对照组,收集2组患者一般资料,采集外周血以酶联免疫吸附法进行HMGB1和Beclin1检测,采用受试者工作特征(ROC)曲线分析HMGB1和Beclin1表达对急性发作期MS的诊断价值,同时采用Pearson相关性分析其表达水平与疾病严重程度的关系。结果2组患者性别、年龄、体重指数(BMI)、淋巴细胞和嗜酸性粒细胞数量差异均无统计学意义(P>0.05),研究组患者白细胞和中性粒细胞均多于对照组(P<0.05)。研究组患者外周血中HMGB1表达水平高于对照组,Beclin1表达水平低于对照组(P<0.05)。经ROC曲线分析,HMGB1和Beclin1诊断急性发作期MS的AUC分别为0.798和0.809,两者联合预测效能最高,灵敏度和特异度分别为78.7%、93.7%。研究组患者EDSS评分为(3.38±1.02)分,随着EDSS评分的上升,HMGB1表达水平上升,Beclin1表达水平下降。经Pearson相关分析,急性发作期MS患者EDSS评分与HMGB1表达呈正相关,与Beclin1表达呈负相关(P<0.05)。结论HMGB1和Beclin1表达对急性发作期MS具有一定的诊断价值,两者联合诊断效能最佳,患者病情严重程度与HMGB1表达水平呈正相关,与Beclin1呈负相关。 展开更多
关键词 多发性硬化 急性发作期 Kurtzke扩展残疾状态评估量表 高迁移率族蛋白B1 BECLIN1
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豆腐柴对面团面筋网络结构劣变影响研究
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作者 张博安 杜文凯 +2 位作者 张亚辉 刘一 张海华 《中国粮油学报》 CAS CSCD 北大核心 2024年第10期52-58,共7页
开发豆腐柴面条是挖掘豆腐柴资源的有效增值途径,但豆腐柴的存在使得面团的形成时间和稳定时间显著缩短。以不同添加量的豆腐柴-小麦粉混粉面团为研究对象,从分子及原子尺度上研究面团面筋网络结构的变化。结果发现,宏观上的劣变归因于... 开发豆腐柴面条是挖掘豆腐柴资源的有效增值途径,但豆腐柴的存在使得面团的形成时间和稳定时间显著缩短。以不同添加量的豆腐柴-小麦粉混粉面团为研究对象,从分子及原子尺度上研究面团面筋网络结构的变化。结果发现,宏观上的劣变归因于分子尺度上谷蛋白高分子聚合体含量的降低和二级结构的变化(α-螺旋结构降低、β-折叠结构的增多、无规则卷曲增多),而分子尺度结构的变化又是由原子尺度上面团中化学作用力所决定,即添加豆腐柴后面团中占优势的疏水作用变成了共价键,而面团中二硫键虽趋于稳定态的g-g-g构型但含量无显著变化,这也是豆腐柴面团稳定时间和形成时间降低的根本原因。 展开更多
关键词 豆腐柴 面团 面筋蛋白 二级结构 共价键
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鲤鱼可溶性蛋白增溶回收工艺优化及营养特性分析
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作者 王远瞩 王晓萱 +3 位作者 左旸 张津海 赵华伟 蒲洋 《鲁东大学学报(自然科学版)》 2024年第2期142-149,共8页
为促进鲤(Cyprinus carpio)的高值化应用,本文运用pH值转换增溶法优化鲤鱼蛋白规模化增溶回收工艺,对鲤鱼鱼糜在不同pH值下的可溶性蛋白溶解度、可溶性蛋白分子量分布及氨基酸组成进行了测量分析。结果表明:不同pH值条件下蛋白溶解度呈... 为促进鲤(Cyprinus carpio)的高值化应用,本文运用pH值转换增溶法优化鲤鱼蛋白规模化增溶回收工艺,对鲤鱼鱼糜在不同pH值下的可溶性蛋白溶解度、可溶性蛋白分子量分布及氨基酸组成进行了测量分析。结果表明:不同pH值条件下蛋白溶解度呈现明显U型曲线,在pH值为1.0~3.0或11.0~13.0条件下溶解度较高;在pH值为2.0条件下,可溶性蛋白溶解度达到62.72%。通过高效液相色谱(HPLC)测得所有样品的可溶性蛋白分子量主要在10~45 kDa范围内,在pH值2.0条件下,这部分低分子量蛋白占比最高为72.6%,进一步测得此工艺条件下回收的可溶性蛋白中呈味氨基酸含量丰富,其中呈鲜味氨基酸,如:谷氨酸占比达到14.7%、天冬氨酸占比达到11.2%;呈甜味氨基酸,如:丙氨酸占比达到6.38%,甘氨酸占比达到5.8%。本研究结果为以鲤鱼或其它低值鱼为原料,规模化回收可溶性蛋白产品及制备后续的生物活性多肽奠定了前期工艺基础,提高了在食品、饲料等领域开发鱼蛋白相关高附加值产品的潜力。 展开更多
关键词 pH值转换增溶法 可溶性蛋白 规模化提取 氨基酸组成分析 高值化应用
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鱼鳞粉对面条品质的影响
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作者 王宇卓 何佳欣 +2 位作者 方恒卓 汪师帅 郑芃园 《农产品加工》 2024年第18期36-39,44,共5页
鱼鳞营养丰富,但常作为下脚料被直接抛弃。为了提高水产品的综合利用价值,将鱼鳞粉添加入面条中,从营养、消化、物性等方面探讨其对面条品质的影响。结果表明,在营养价值上,添加鱼鳞粉会提升面条中蛋白质和氨基酸含量。当面条中鱼鳞粉... 鱼鳞营养丰富,但常作为下脚料被直接抛弃。为了提高水产品的综合利用价值,将鱼鳞粉添加入面条中,从营养、消化、物性等方面探讨其对面条品质的影响。结果表明,在营养价值上,添加鱼鳞粉会提升面条中蛋白质和氨基酸含量。当面条中鱼鳞粉添加量达到10%,面条中蛋白质含量提高45.3%,氨基酸总含量提高47.5%;在消化特性上,鱼鳞粉使面条中快消化淀粉减少,慢消化淀粉增加;在物理性质上,随着鱼鳞粉添加量增加,面条的硬度呈上升趋势;当鱼鳞粉添加量达到10%时,面条的硬度提高26.3%,面条更耐咀嚼。然而,面条的拉伸强度、汤汁透明度、明度却随着鱼鳞粉添加量增大而降低。该研究可为鱼鳞在面制品中的应用提供参考。 展开更多
关键词 鱼鳞 面条 蛋白质 消化 硬度
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促愈消肿汤对运动致肱骨远端骨折患者术后骨生长及功能恢复的影响
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作者 杨柏琦 马金叶 +1 位作者 齐素兰 郭中华 《世界中医药》 CAS 北大核心 2024年第3期383-387,共5页
目的:探究促愈消肿汤对运动致肱骨远端骨折患者术后血清成纤维细胞生长因子2(FGF-2)、骨形态发生蛋白7(BMP-7)水平及骨愈合状态的影响。方法:选取2021年3月至2022年9月河南省中医院收治的运动致肱骨远端骨折患者86例作为研究对象,采用... 目的:探究促愈消肿汤对运动致肱骨远端骨折患者术后血清成纤维细胞生长因子2(FGF-2)、骨形态发生蛋白7(BMP-7)水平及骨愈合状态的影响。方法:选取2021年3月至2022年9月河南省中医院收治的运动致肱骨远端骨折患者86例作为研究对象,采用随机数字法分为对照组和观察组,每组43例。对照组术后采用常规康复治疗;观察组在对照组基础上服用促愈消肿汤治疗。对比治疗后2组临床疗效及术后恢复情况,术后1 d与术后7 d时2组肘关节功能、关节活动度及血清FGF-2、BMP-7水平差异。结果:观察组临床疗效为93.02%,显著高于对照组的76.74%(P<0.05);治疗后观察组疼痛消除时间、术处消肿时间及骨折愈合时间显著短于对照组(均P<0.05);术后7 d时,观察组Mayo肘关节功能量表,关节活动度(ROM)评分以及血清FGF-2、BMP-7水平显著升高,且高于对照组(均P<0.05);术后7 d时,观察组视觉模拟评分法(VAS)得分较术后1 d时显著降低,且低于对照组(均P<0.05)。结论:运动致肱骨远端骨折患者术后服用促愈消肿汤能有效促进血清FGF-2、BMP-7水平表达上调,改善肘关节活动功能,缓解术后疼痛,加速骨折愈合。 展开更多
关键词 促愈消肿汤 肱骨远端骨折 成纤维细胞生长因子2 骨形态发生蛋白7 骨生长指标 肘关节功能 关节活动度 视觉模拟评分法
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富血小板血浆关节腔注射治疗慢性膝关节骨性关节炎对患者疼痛情况及血清基质金属蛋白酶-3、软骨寡聚基质蛋白水平的影响研究 被引量:1
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作者 余小夏 何仁健 +1 位作者 赵露婷 杨凌 《陕西医学杂志》 CAS 2024年第7期918-921,953,共5页
目的:探究富血小板血浆(PRP)关节腔注射治疗慢性膝关节骨性关节炎(KOA)对患者疼痛情况及血清基质金属蛋白酶-3(MMP-3)、软骨寡聚基质蛋白(COMP)水平的影响。方法:选取86例慢性KOA患者,按随机信封法分为透明质酸(HA)组和PRP组,每组43例... 目的:探究富血小板血浆(PRP)关节腔注射治疗慢性膝关节骨性关节炎(KOA)对患者疼痛情况及血清基质金属蛋白酶-3(MMP-3)、软骨寡聚基质蛋白(COMP)水平的影响。方法:选取86例慢性KOA患者,按随机信封法分为透明质酸(HA)组和PRP组,每组43例。HA组予以关节腔注射HA治疗,每次2 ml, PRP组以相同操作注射PRP,每次3.5 ml,两组均每周1次,连续治疗3周。比较两组治疗前后疼痛评分、症状严重程度、膝关节评分、血清炎症因子水平及不良反应发生情况。结果:治疗后3、6个月PRP组疼痛评分低于HA组(均P<0.05);治疗后3、6个月PRP组疼痛不适、步行能力及日常生活受累程度改善情况均优于HA组(均P<0.05);治疗后3、6个月PRP组膝关节评分显著低于HA组(均P<0.05);治疗后3个月PRP组血清中MMP-3及COMP水平低于HA组(均P<0.05);两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论:注射PRP对慢性KOA的远期疗效明显,可减轻其关节疼痛,改善关节功能,减轻膝关节炎症,安全性高。 展开更多
关键词 富血小板血浆 慢性膝关节骨性关节炎 基质金属蛋白酶-3 软骨寡聚基质蛋白 疼痛视觉模拟评分 透明质酸
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不同抗神经细胞抗体阳性的自身免疫性脑炎临床分析
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作者 张建龙 关肖霄 +2 位作者 赵帅 葛晓敏 李合华 《河南医学研究》 CAS 2024年第13期2323-2328,共6页
目的总结不同抗神经细胞抗体阳性的自身免疫性脑炎(AE)患者临床特点及预后。方法回顾性分析2020年1月至2022年6月新乡医学院第一附属医院神经内科诊治的12例不同抗神经细胞抗体阳性AE患者的临床表现、影像学、抗体检测及治疗,采用改良Ra... 目的总结不同抗神经细胞抗体阳性的自身免疫性脑炎(AE)患者临床特点及预后。方法回顾性分析2020年1月至2022年6月新乡医学院第一附属医院神经内科诊治的12例不同抗神经细胞抗体阳性AE患者的临床表现、影像学、抗体检测及治疗,采用改良Rankin量表(mRS)对预后进行评价。结果男性患者4例,女性患者8例,年龄18~72岁,抗N-甲基-D-天冬氨酸(NMDAR)抗体脑炎3例,抗接触蛋白关联蛋白2(CASPR2)抗体脑炎2例,抗富亮氨酸胶质瘤失活1蛋白(LGI1)抗体脑炎5例,抗谷氨酸脱羧酶65(GAD65)抗体脑炎1例,1例为抗γ氨基丁酸B型受体(GABABR)抗体阳性的抗NMDAR脑炎,同时合并抗Hu抗体IgG阳性。7例表现为癫痫发作,3例为精神症状,2例为面臂肌张力障碍,1例表现为头痛、记忆力下降,1例为腹部抽动。9例影像学头颅MRI异常,累及双侧海马、杏仁体、基底节、大脑半球、脑膜。10例血清及脑脊液AE抗体一致、1例不一致、1例仅脑脊液抗体阳性。12例经免疫治疗均好转,其中1例甲泼尼龙冲击、足量人免疫球蛋白治疗效果差,给予二线免疫药物利妥昔单抗治疗,症状无改善,给予升级免疫药物托珠单抗治疗后症状逐渐好转;1例停药后复发。12例患者预后均较好(mRS≤2分)。结论AE的抗体分类多,临床表现以癫痫发作较常见,影像学以海马受累为主,早期诊断,尽早启动免疫治疗,预后好。 展开更多
关键词 自身免疫性脑炎 改良Rankin量表 N-甲基-D-天冬氨酸 抗接触蛋白关联蛋白2 抗富亮氨酸胶质瘤失活1蛋白
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超声B-Flow联合外周血NLR、CRP对颈动脉粥样硬化斑块易损性的诊断效能研究
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作者 李亮亮 《罕少疾病杂志》 2024年第4期21-23,共3页
目的探讨超声二维灰阶血流显像技术(B-Flow)联合外周血中性粒细胞与淋巴细胞比值(NLR)、C反应蛋白(CRP)诊断颈动脉粥样硬化(CAS)斑块易损性的价值。方法纳入2019年2月至2022年8月在天津市永久医院诊查的152例CAS患者为研究对象,均利用... 目的探讨超声二维灰阶血流显像技术(B-Flow)联合外周血中性粒细胞与淋巴细胞比值(NLR)、C反应蛋白(CRP)诊断颈动脉粥样硬化(CAS)斑块易损性的价值。方法纳入2019年2月至2022年8月在天津市永久医院诊查的152例CAS患者为研究对象,均利用颈动脉斑块超声B-Flow和数字减影血管造影(DSA)检查斑块性质,并检测外周血NLR、CRP水平,以DSA结果为“金标准”,将患者分为易损斑块组和稳定斑块组,统计超声B-Flow检查结果,比较两组外周血NLR、CRP水平,分析超声B-Flow、外周血NLR、CRP水平三者单独及联合诊断CAS斑块易损性的价值。结果DSA检查结果显示,152例CAS患者检出66例易损斑块,86例为稳定斑块;超声B-Flow检查出72例易损斑块,80例稳定斑块,以DSA检查结果作为“金标准”,超声B-Flow诊断易损斑块的灵敏度、特异度、准确度分别为84.85%、81.39%、82.89%;易损斑块组外周血NLR、CRP水平均高于稳定斑块组(P<0.05);超声B-Flow联合外周血NLR、CRP水平诊断CAS易损性斑块的灵敏度、特异度、曲线下面积(AUC)分别为98.48、81.39%、0.907,联合诊断的灵敏度高于单独诊断,AUC高于单独诊断(P<0.05),特异度与单独诊断相近。结论超声B-Flow、外周血NLR、CRP均对CAS斑块易损性具有一定的诊断效能,但三者联合诊断效能更好。 展开更多
关键词 颈动脉粥样硬化 超声二维灰阶血流显像技术 中性粒细胞 淋巴细胞 C反应蛋白 易损斑块
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Nips评分联合血清CRP、降钙素原、脑脊液白细胞计数对新生儿化脓性脑膜炎预后的预测价值
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作者 徐晶磊 周静 吴锫泥 《心电与循环》 2024年第1期20-24,共5页
目的探讨新生儿疼痛量表(Nips)评分联合血清C反应蛋白(CRP)、降钙素原、脑脊液白细胞计数对新生儿化脓性脑膜炎(NPM)预后的预测价值。方法选择2015年1月至2021年1月宁波大学附属人民医院收治的NPM患儿70例,以中枢神经感染程度评分标准... 目的探讨新生儿疼痛量表(Nips)评分联合血清C反应蛋白(CRP)、降钙素原、脑脊液白细胞计数对新生儿化脓性脑膜炎(NPM)预后的预测价值。方法选择2015年1月至2021年1月宁波大学附属人民医院收治的NPM患儿70例,以中枢神经感染程度评分标准将其分为轻症感染组45例,重症感染组25例,经治疗后预后良好的52例为预后良好组,预后不良的18例为预后不良组。比较组间Nips评分、血清CRP、降钙素原水平和脑脊液白细胞计数。分析Nips评分、血清CRP、降钙素原水平、脑脊液白细胞计数及联合检测对预后的预测价值。结果重症感染组治疗前后Nips评分、血清CRP、降钙素原水平、脑脊液白细胞计数高于轻症感染组,差异均有统计学意义(均P<0.05)。治疗后预后不良组Nips评分、血清CRP、降钙素原水平、脑脊液白细胞计数高于预后良好组,差异均有统计学意义(均P<0.05)。4项指标联合预测预后的AUC为0.901,高于各单项指标。结论Nips评分联合血清CRP、降钙素原水平及脑脊液白细胞计数有助于对NPM预后的预测。 展开更多
关键词 新生儿 化脓性脑膜炎 新生儿疼痛评分 C反应蛋白 降钙素原 脑脊液白细胞计数
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反向休克指数和格拉斯哥昏迷量表评分的乘积指数联合血清纤维蛋白原和C反应蛋白水平对多发伤患者预后的预测价值
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作者 张明 张宏颖 +2 位作者 杨秋兰 张霞 黄开飞 《中国医药》 2024年第7期1038-1042,共5页
目的探究反向休克指数和格拉斯哥昏迷量表评分的乘积(rSIG)指数联合血清纤维蛋白原(FIB)、C反应蛋白(CRP)水平对多发伤患者预后的预测价值。方法选取2022年2月至2023年3月华北理工大学附属医院急诊科收治的多发伤患者140例,根据患者受伤... 目的探究反向休克指数和格拉斯哥昏迷量表评分的乘积(rSIG)指数联合血清纤维蛋白原(FIB)、C反应蛋白(CRP)水平对多发伤患者预后的预测价值。方法选取2022年2月至2023年3月华北理工大学附属医院急诊科收治的多发伤患者140例,根据患者受伤28 d后的生存情况,分成存活组(120例)和死亡组(20例);另选取同期体检健康者100例作为对照。采用全自动凝血分析仪检测血清FIB水平,免疫散射比浊法检测CRP水平。采用Pearson法分析rSIG指数及血清FIB、CRP水平相关性。采用Cox回归方法分析多发伤患者死亡的影响因素。采用受试者工作特征曲线分析rSIG指数联合血清FIB、CRP水平对多发伤患者预后的预测价值。结果多发伤患者血清FIB水平低于健康体检者[(2.2±0.4)g/L比(2.9±0.5)g/L],CRP水平高于健康体检者[(36±8)mg/L比(7±3)mg/L],差异均有统计学意义(均P<0.001)。存活组患者血清FIB水平高于死亡组[(2.3±0.4)g/L比(1.6±0.4)g/L],CRP水平低于死亡组[(34±8)mg/L比(47±8)mg/L],rSIG指数高于死亡组,差异均有统计学意义(均P<0.05)。Pearson法分析结果显示,血清FIB与CRP水平呈负相关(r=-0.446,P<0.001),与rSIG指数呈正相关(r=0.473,P<0.001);血清CRP水平与rSIG指数呈负相关(r=-0.536,P<0.001)。Cox回归分析结果表明,FIB、CRP、rSIG指数均是多发伤患者死亡的影响因素(均P<0.05)。rSIG指数联合血清FIB、CRP水平预测多发伤患者预后的曲线下面积为0.972,明显高于单项检测(均P<0.05),联合检测敏感度为95.00%,特异度为88.33%。结论多发伤患者血清FIB水平下调,CRP水平上调,二者联合rSIG指数对多发伤患者预后具有一定预测价值。 展开更多
关键词 多发伤 反向休克指数和格拉斯哥昏迷量表评分的乘积指数 纤维蛋白原 C反应蛋白 预后
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光动力疗法辅助龈下刮治及根面平整术治疗慢性牙周炎的临床疗效及对龈沟液中VEGF-D、S100A12、ICAM-1表达水平的影响
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作者 陈星宇 陈芳 +5 位作者 童钰鑫 高瑞 张琳琳 刘芬 白晓帆 安莹 《空军军医大学学报》 CAS 2024年第10期1129-1134,共6页
目的探讨光动力疗法(PDT)辅助龈下刮治和根面平整术(SRP)治疗慢性牙周炎的临床疗效及对龈沟液(GCF)中血管内皮生长因子-D(VEGF-D)、S100钙结合蛋白A12(S100A12)、细胞间黏附分子-1(ICAM-1)表达水平的影响。方法选取2023年9月至2024年4... 目的探讨光动力疗法(PDT)辅助龈下刮治和根面平整术(SRP)治疗慢性牙周炎的临床疗效及对龈沟液(GCF)中血管内皮生长因子-D(VEGF-D)、S100钙结合蛋白A12(S100A12)、细胞间黏附分子-1(ICAM-1)表达水平的影响。方法选取2023年9月至2024年4月于空军军医大学口腔医院牙周病科收治的24例慢性牙周炎患者作为研究对象,采用自身对照试验,每位受试者4个象限,每个象限各选取至少1颗探诊深度(PD)≥6 mm且病损情况相似的同名牙,共104颗患牙,将双侧患牙随机分为对照组(n=52)与试验组(n=52),对照组仅采取单纯SRP治疗,试验组在对照组的基础上辅助PDT,测量并比较两组患牙治疗前(T0)、治疗后1个月(T1)和3个月(T2)的牙周PD、牙龈出血指数(BI)及菌斑指数(PLI)以及治疗前后GCF中VEGF-D、S100A12、ICAM-1的表达水平。结果相较于T0,两组患牙的PD、BI、PLI在T1、T2均有不同程度的降低(P<0.001),试验组患牙的临床指标降低幅度更显著(P<0.001)。对照组中的T1与T2,PLI在统计学上无统计学差异。两组患牙GCF中VEGF-D(P=0.023)、S100A12(P=0.020)、ICAM-1(P=0.010)含量明显低于T0,试验组患牙降低幅度相较于对照组更显著(P<0.01)。结论PDT作为SRP治疗慢性牙周炎的辅助手段,可有效降低PD、BI、PLI等牙周临床指标,并显著降低GCF中VEGF-D、S100A12、ICAM-1的含量,从而减轻牙周炎症反应,改善患者的牙周健康状况。 展开更多
关键词 光动力疗法 根面平整术 慢性牙周炎 血管内皮生长因子 钙结合蛋白 细胞间黏附分子
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揿针配合四黄散外敷治疗急性痛风性关节炎的疗效观察
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作者 金巧丽 马晓芬 +1 位作者 马欢欢 王芳 《上海针灸杂志》 CSCD 2024年第7期779-784,共6页
目的 观察揿针配合四黄散外敷治疗急性痛风性关节炎(acute gouty arthritis, AGA)的临床疗效。方法 将60例AGA患者随机分为治疗组和对照组,每组30例。治疗组采用揿针配合四黄散外敷治疗,对照组采用口服双氯芬酸钠缓释胶囊治疗。观察两... 目的 观察揿针配合四黄散外敷治疗急性痛风性关节炎(acute gouty arthritis, AGA)的临床疗效。方法 将60例AGA患者随机分为治疗组和对照组,每组30例。治疗组采用揿针配合四黄散外敷治疗,对照组采用口服双氯芬酸钠缓释胶囊治疗。观察两组治疗前及治疗第4、7天时视觉模拟评分法(visual analog scale, VAS)评分及各项实验室指标[红细胞沉降(erythrocyte sedimentation rate, ESR)、血尿酸(blood uric acid, BUA)、超敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)]的变化情况,并比较两组临床疗效及不良反应发生率。结果 治疗组总有效率为96.7%,明显高于对照组的80.0%(P<0.05)。两组治疗第4、7天时VAS评分及各项实验室指标均较同组治疗前显著降低,差异均有统计学意义(P<0.05)。治疗组治疗第4天时ESR水平明显低于对照组,治疗第4、7天时VAS评分及各项实验室指标均明显低于对照组,差异均有统计学意义(P<0.05)。治疗组不良反应发生率为3.3%,对照组为10.0%,两组比较差异无统计学意义(P>0.05)。结论 揿针配合四黄散外敷治疗AGA疗效确切,可缓解疼痛,调节ESR、BUA及hs-CRP水平,且安全性较好。 展开更多
关键词 针刺疗法 揿针 皮肤针疗法 关节炎 痛风性 视觉模拟评分 超敏C反应蛋白 针药并用
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反向休克指数和格拉斯哥昏迷量表评分的乘积指数联合血清指标对多发伤合并多器官功能障碍综合征患者预后的预测价值分析
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作者 张明 张宏颖 +2 位作者 杨秋兰 张霞 黄开飞 《中国医药》 2024年第10期1504-1508,共5页
目的探讨反向休克指数和格拉斯哥昏迷量表评分的乘积(rSIG)指数联合血清D-二聚体、纤维蛋白原、C反应蛋白对多发伤合并多器官功能障碍综合征(MODS)患者预后的预测价值。方法选取2020年1月至2022年1月在华北理工大学附属医院急诊抢救室... 目的探讨反向休克指数和格拉斯哥昏迷量表评分的乘积(rSIG)指数联合血清D-二聚体、纤维蛋白原、C反应蛋白对多发伤合并多器官功能障碍综合征(MODS)患者预后的预测价值。方法选取2020年1月至2022年1月在华北理工大学附属医院急诊抢救室治疗的194例多发伤患者作为研究对象。根据治疗过程中有无发生MODS将其分为无MODS组(98例)和MODS组(96例);MODS组再根据患者受伤后28 d时的生存情况分为存活组(52例)和死亡组(44例)。比较各组血清D-二聚体、纤维蛋白原、C反应蛋白水平以及rSIG指数;多因素Logistic回归方法分析多发伤合并MODS患者预后的影响因素;受试者工作特征(ROC)曲线分析rSIG指数联合血清D-二聚体、纤维蛋白原、C反应蛋白对多发伤合并MODS患者预后的预测价值。结果MODS组血清D-二聚体、纤维蛋白原、C反应蛋白水平高于无MODS组[(14±3)mg/L比(9±3)mg/L、(4.5±1.0)g/L比(3.0±1.0)g/L、(32±6)mg/L比(21±6)mg/L],差异均有统计学意义(t=10.352、10.079、12.883,均P<0.001)。死亡组多发伤合并MODS患者血清D-二聚体、纤维蛋白原、C反应蛋白水平显著高于存活组,rSIG指数显著低于存活组(均P<0.001)。多因素Logistic回归分析结果显示D-二聚体、纤维蛋白原、C反应蛋白、rSIG指数是多发伤合并MODS患者预后的独立影响因素(均P<0.05)。ROC曲线分析结果显示D-二聚体、纤维蛋白原、C反应蛋白、rSIG指数联合检测预测多发伤合并MODS患者预后的曲线下面积为0.964,敏感度为84.09%,特异度为96.15%,优于各指标单独预测(均P<0.05)。结论多发伤合并MODS死亡组患者血清D-二聚体、纤维蛋白原、C反应蛋白显著上升,rSIG指数显著下降,以上指标联合对多发伤合并MODS患者的预后具有较好的预测价值。 展开更多
关键词 多发伤 多器官功能障碍综合征 反向休克指数和格拉斯哥昏迷量表评分的乘积指数 D-二聚体 纤维蛋白原 C反应蛋白 预后
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Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation: A randomly controlled study 被引量:11
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作者 Zeyu Xie Minghua Zhuang +3 位作者 Lan Lin Hongwu Xu Linxing Chen Lina Hu 《Neural Regeneration Research》 SCIE CAS CSCD 2007年第5期314-317,共4页
Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation: A randomly controlled study BACKGROUND: Plasma inflammatory factor, such as C-reactive prot... Changes of plasma C-reactive protein in patients with craniocerebral injury before and after hyperbaric oxygenation: A randomly controlled study BACKGROUND: Plasma inflammatory factor, such as C-reactive protein, whose content is regarded as a sensitively pathological marked protein and quantitative indexes of central nervous system injury, has been paid more and more attention in clinic. OBJECTIVE: To observe the effects and clinical significance of C-reactive protein in patients with craniocerebral injury after hyperbaric oxygenation. DESIGN: Randomized controlled study. SETTING: Departments of Neurosurgery, Laboratory and Hyperbaric Oxygen, the Second Affiliated Hospital, Medical College of Shantou University. PARTICIPANTS: A total of 60 patients with craniocerebral injury were selected from Department of Neurosurgery, the Second Affiliated Hospital, Medical College of Shantou University from October 2006 to April 2007. There were 37 males and 23 females and the mean age was 26 years. All subjects were certainly diagnosed as history of craniocerebral injury. Patients hospitalized at 24 hours after injury, Glasgow Coma Score ranged from 3 to 12 points, and all patients were certainly diagnosed with CT or MR scanning. Patients and their relatives provided confirmed consent. All the subjects were randomly divided into hyperbaric oxygenation group and control group with 30 in each group. METHODS: Patients in the control group were treated with routinely neurosurgical therapy after hospitalization; however, based the same basic treatment in the control group, patients in the hyperbaric oxygenation group received hyperbaric oxygenation by using iced-wheel four-door 2-cabin air-compression chamber (made in Yantai) from 24 hours to 10 days after operation or injury. After entering the cabin, patients who had a clear consciousness breathed the oxygen by using face mask; contrarily, patients directly breathed the oxygen. Therapeutic project: Expression was increased for about 15–20 minutes, maintained for about 70–80 minutes, and decreased for 20 minutes. Otherwise, pressure was maintained from 0.2 to 0.25 MPa. Hyperbaric oxygenation took an hour for once a day and 10 times were regarded as a course. Venous blood was collected before treatment and on the next day of the first course end. Content of C-reactive protein in plasma was measured with immune turbidimetry in hyperbaric oxygenation group; in addition, content of C-reactive protein in plasma was directly measured with the same method at the corresponding time in the control group. If the content was less or equal to 8 mg/L, it was regarded as normal value. Effects of the two groups were evaluated based on Glasgow Coma Score before and after treatment. MAIN OUTCOME MEASURES: Content of plasma C-reactive protein and Glasgow Coma Score in the two groups before and after treatment. RESULTS: All 60 patients were involved in the final analysis. ① Content of plasma C-reactive protein: The two contents were obviously higher than normal value after craniocerebral injury. There was no significant difference in the two groups before treatment (P 〉 0.05), but both contents were decreased after treatment, and there was significant difference between HBOT group and control group after treatment (t =4.756, P 〈 0.01). In addition, there was significant difference in hyperbaric oxygen therapy group before and after treatment (t =5.236, P 〈 0.01). ② Glasgow Coma Score: There was no significant difference in the two groups before treatment (P 〉 0.05), but scores were increased in both groups after treatment (t =9.92, 2.51, P 〈 0.01, 0.05); on the other hand, therefore, there was significant difference between the two groupsafter treatment (t =9.21, P 〈 0.01). CONCLUSION: Hyperbaric oxygenation can remarkably decrease content of plasma C-reactive protein in patients with craniocerebral injury at the phase of stress. 展开更多
关键词 craniocerebral trauma hyperbaric oxygenation C-reactive protein Glasgow Coma scale
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Local injection of bone morphogenetic protein 7 promotes neuronal regeneration and motor function recovery after acute spinal cord injury 被引量:6
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作者 Chen Chen Guang-Chao Bai +2 位作者 Hong-Liang Jin Kun Lei Kuan-Xin Li 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第6期1054-1060,共7页
After spinal cord injury,the number of glial cells and motor neurons expressing bone morphogenetic protein 7(BMP7)increases,indicating that upregulation of BMP7 can promote nerve repair.We,therefore,tested whether d... After spinal cord injury,the number of glial cells and motor neurons expressing bone morphogenetic protein 7(BMP7)increases,indicating that upregulation of BMP7 can promote nerve repair.We,therefore,tested whether direct injection of BMP7 into acutely injured ratalalo createrywith 50 ng BMP7(BMP7 group)or physiological saline(control group)for 7 consecutive days.Electrophysiological examination showed that the amplitude of N1 in motor evoked potentials(MEP)decreased after spinal cord injury.At 8 weeks post-operation,the amplitude of N1 in the BMP7 group was remarkably higher than that at 1 week post-operation and was higher than that of the control group.Basso,Beattie,Bresnahan scale(BBB)scores,hematoxylin-eosin staining,and western blot assay showed that at 1,2,4 and 8 weeks post-operation,BBB scores were increased;Nissl body staining was stronger;the number of Nissl-stained bodies was increased;the number of vacuoles gradually decreased;the number of synapses was increased;and the expression of neuronal marker,neurofilament protein 200,was increased in the hind limbs of the BMP7 group compared with the control group.Western blot assay showed that the expression of GFAP protein in BMP7 group and control group did not change significantly and there was no significant difference between the BMP7 and control groups.These data confirmed that local injection of BMP7 can promote neuronal regeneration after spinal cord injury and promote recovery of motor function in rats. 展开更多
关键词 nerve regeneration BEHAVIOR Basso Beattie Bresnahan scale score motor evoked potential wave Nissl staining NEURONS glial cells neurofilament protein 200 glial fibrillary acidic protein neural regeneration
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Statistical interior properties of globular proteins
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作者 姜舟婷 章林溪 +1 位作者 孙婷婷 吴太权 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第10期4580-4590,共11页
The character of forming long-range contacts affects the three-dimensional structure of globular proteins deeply. As the different ability to form long-range contacts between 20 types of amino acids and 4 categories o... The character of forming long-range contacts affects the three-dimensional structure of globular proteins deeply. As the different ability to form long-range contacts between 20 types of amino acids and 4 categories of globular proteins, the statistical properties are thoroughly discussed in this paper. Two parameters NC and ND are defined to confine the valid residues in detail. The relationship between hydrophobieity scales and valid residue percentage of each amino acid is given in the present work and the linear functions are shown in our statistical results. It is concluded that the hydrophobicity scale defined by chemical derivatives of the amino acids and nonpolar phase of large unilamellar vesicle membranes is the most effective technique to characterise the hydrophobic behavior of amino acid residues. Meanwhile, residue percentage Pi and sequential residue length Li of a certain protein i are calculated under different conditions. The statistical results show that the average value of Pi as well as Li of all-α proteins has a minimum among these 4 classes of globular proteins, indicating that all-α proteins are hardly capable of forming long-range contacts one by one along their linear amino acid sequences. All-β proteins have a higher tendency to construct long-range contacts along their primary sequences related to the secondary configurations, i.e. parallel and anti-parallel configurations of/3 sheets. The investigation of the interior properties of globular proteins give us the connection between the three-dimensional structure and its primary sequence data or secondary configurations, and help us to understand the structure of protein and its folding process well. 展开更多
关键词 globular proteins long-range contact hydrophobicity scale
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Folding rate prediction using complex network analysis for proteins with two- and three-state folding kinetics 被引量:2
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作者 Hai-Yan Li Ji-Hua Wang 《Journal of Biomedical Science and Engineering》 2009年第8期644-650,共7页
It is a challenging task to investigate the different in- fluence of long-range and short-range interactions on two-state and three-state folding kinetics of protein. The networks of the 30 two-state proteins and 15 t... It is a challenging task to investigate the different in- fluence of long-range and short-range interactions on two-state and three-state folding kinetics of protein. The networks of the 30 two-state proteins and 15 three-state proteins were constructed by complex networks analysis at three length scales: Protein Contact Networks, Long-range Interaction Networks and Short-range Interaction Networks. To uncover the relationship between structural properties and folding kinetics of the proteins, the correlations of protein network parameters with protein folding rate and topology parameters contact order were analyzed. The results show that Protein Contact Networks and Short-range Interaction Networks (for both two-state and three-state proteins) exhibit the “small-world” property and Long-range Interaction networks indicate “scale-free” behavior. Our results further indicate that all Protein Contact Networks and Short- range Interaction networks are assortative type. While some of Long-range Interaction Networks are of assortative type, the others are of disassortative type. For two-state proteins, the clustering coefficients of Short-range Interaction Networks show prominent correlation with folding rate and contact order. The assortativity coefficients of Short-range Interaction Networks also show remarkable correlation with folding rate and contact order. Similar correlations exist in Protein Contact Networks of three-state proteins. For two-state proteins, the correlation between contact order and folding rate is determined by the numbers of local contacts. Short- range interactions play a key role in determining the connecting trend among amino acids and they impact the folding rate of two-state proteins directly. For three-state proteins, the folding rate is determined by short-range and long-range interactions among residues together. 展开更多
关键词 protein CONTACT Networks SMALL-WORLD scale-FREE Assortative Type FOLDING RATE
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Evolutionary Relationship of Protein Sequences of SARS-CoV-2 and Other Viruses through Chaos Game Representation
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作者 Matthew D. Hill Kevin E. Simmons Dipendra C. Sengupta 《Computational Molecular Bioscience》 CAS 2022年第3期123-143,共21页
Comparison between different biological sequences is a key step in bioinformatics when analyzing similarities of sequences and phylogenetic relationships. A method of graphically representing biological sequences know... Comparison between different biological sequences is a key step in bioinformatics when analyzing similarities of sequences and phylogenetic relationships. A method of graphically representing biological sequences known as Chaos Game Representation (CGR) has achieved many applications in the studies of bioinformatics. The key issue in the application of CGR is to extract as many useful features as possible from CGR. Initially, CGR was applied to DNA sequences, but in this paper, a CGR-based approach is used to extract suitable features for comparing protein sequences of SARS-CoV-2 and other viruses. For this aim, several viral protein sequences from 12 groups are considered and CGR centroid, amino acid frequency, compounded frequency, Shannon entropy, and Kullback-Lieber Discrimination Information are applied to find the inter-relationship among the sequences. The experimental results demonstrate the potential strengths of CGR-based method for examining the evolutionary relationship of protein sequences. Our method is powerful for extracting effective features from protein sequences, and therefore important in classifying proteins and inferring the phylogeny of viruses. 展开更多
关键词 Chaos Game Representation (CGR) protein Multi-Dimensional Scaling (MDS)
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Study on the relationship between syndrome characteristics degree and inflammatory factor and negative emotional scale in"double heart disease"patients with Qi stagnation blood stasis and heart gallbladder heat stagnation
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作者 Di Ma Jing Chen +1 位作者 Chao Ye Hai-Bin Zhao 《Journal of Hainan Medical University》 2021年第21期12-16,共5页
Objective:To Discuss the correlation between Hypersensitivity C-reactive Protein(Hs-CRP),Total Cholesterol(TC),Triglyceride(TG),negative emotion scale and TCM syndrome scores in“Double Heart Disease”patients with Qi... Objective:To Discuss the correlation between Hypersensitivity C-reactive Protein(Hs-CRP),Total Cholesterol(TC),Triglyceride(TG),negative emotion scale and TCM syndrome scores in“Double Heart Disease”patients with Qi stagnation blood stasis and heart gallbladder heat stagnation.Method:Fifty-two patients in Western Medicine Diagnosis of Double Heart Disease,in TCM syndrome identified as Qi stagnation blood stasis Heart gallbladder heat stagnation syndrome,detects it Hs-CRP,TC,TG levels by ELISA,use TCM Syndromes Scale to evaluate TCM Syndrome,use the Pittsburgh Sleep Quality Index(PSQI)and Self-rating symptom scale(SCL-90)to assess anxiety and sleep levels,analyze the correlation between TCM syndrome scores and Hs-CRP,TC,TG level,PSQI index,SCL-90 index.Result:There was a significant positive correlation between Hs-CRP,TG level and TCM Syndrome scores(P<0.05);TC level was postively correlated with TCM Syndrome scores,but there was no statistical significance(P>0.05);There was a significant positive correlation between PSQI index,SCL-90 index and TCM Syndrome scores(P<0.05).Conclusion:In“Double Heart Disease”patients with Qi stagnation blood stasis and heart gallbladder heat stagnation,there have characteristic syndrome changes in terms of inflammatory factor level,blood lipid level and negative emotion score;Which the above indexes can reflect the severity of TCM syndromes to a certain extent and provide the basis for the effective intervention treatment of TCM. 展开更多
关键词 Double heart disease Qi stagnation blood stasis and heart gallbladder heat stagnation SYNDROMES Negative emotion scale High sensitivity C-reactive protein
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糖尿病前期脑出血患者的临床特征及预后分析 被引量:3
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作者 李玲 朱磊 +2 位作者 侯稳 王竹亭 任晓梅 《实用临床医药杂志》 CAS 2023年第5期119-122,127,共5页
目的 探讨糖尿病前期脑出血患者的临床特征及远期预后。方法 回顾性分析165例脑出血患者的资料,依据血糖结果分为糖尿病前期组56例和糖代谢正常组109例,比较2组基线资料及临床特征,依据改良Rankin量表(mRS)评估发病后1年的预后情况。结... 目的 探讨糖尿病前期脑出血患者的临床特征及远期预后。方法 回顾性分析165例脑出血患者的资料,依据血糖结果分为糖尿病前期组56例和糖代谢正常组109例,比较2组基线资料及临床特征,依据改良Rankin量表(mRS)评估发病后1年的预后情况。结果 脑出血预后不良与年龄、血肿量、破入脑室、血肿扩大、美国国立卫生研究院卒中量表(NIHSS)评分、并发感染、C反应蛋白(CRP)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)等有关。与糖代谢正常组相比,糖尿病前期组除了入院后的HbA1c外,其他基线资料比较差异均无统计学意义(P>0.05)。脑出血后,糖尿病前期组更容易出现血肿量增大、NIHSS评分升高、破入脑室及并发感染状况。糖尿病前期组脑出血预后不良发生率为71.43%,高于糖代谢正常组的32.11%,差异有统计学意义(P<0.05)。结论 糖尿病前期脑出血患者病情更重,预后更差,临床需关注糖尿病前期脑出血患者的临床表现。 展开更多
关键词 脑出血 糖尿病前期 临床特征 预后 C反应蛋白 空腹血糖 糖化血红蛋白 美国国立卫生研究院卒中量表
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