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Loading Localization by Small-Diameter Optical Fiber Sensors 被引量:1
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作者 Liu Rongmei Zhu Lujia +1 位作者 Lu Jiyun Liang Dakai 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2018年第2期275-281,共7页
Structural health monitoring(SHM)in service has attracted increasing attention for years.Load localization on a structure is studied hereby.Two algorithms,i.e.,support vector machine(SVM)method and back propagation ne... Structural health monitoring(SHM)in service has attracted increasing attention for years.Load localization on a structure is studied hereby.Two algorithms,i.e.,support vector machine(SVM)method and back propagation neural network(BPNN)algorithm,are proposed to identify the loading positions individually.The feasibility of the suggested methods is evaluated through an experimental program on a carbon fiber reinforced plastic laminate.The experimental tests involve in application of four optical fiber-based sensors for strain measurement at discrete points.The sensors are specially designed fiber Bragg grating(FBG)in small diameter.The small-diameter FBG sensors are arrayed in 2-D on the laminate surface.The testing results indicate that the loading position could be detected by the proposed method.Using SVM method,the 2-D FBG sensors can approximate the loading location with maximum error less than 14 mm.However,the maximum localization error could be limited to about 1 mm by applying the BPNN algorithm.It is mainly because the convergence conditions(mean square error)can be set in advance,while SVM cannot. 展开更多
关键词 small diameter optical fiber sensor structural health monitoring LOADING LOCALIZATION BACK propagation neural network support VECTOR machine
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Online tool-wear measurement of small-diameter end mills based on machine vision 被引量:1
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作者 袁巍 张之敬 +1 位作者 金鑫 刘冰冰 《Journal of Beijing Institute of Technology》 EI CAS 2011年第2期216-220,共5页
The objective of this study was to develop an online tool-wear-measurement scheme for small diameter end-mills based on machine vision to increase tool life and the production efficiency. The geometrical features of w... The objective of this study was to develop an online tool-wear-measurement scheme for small diameter end-mills based on machine vision to increase tool life and the production efficiency. The geometrical features of wear zone of each end mill were analyzed, and three tool wear criterions of small-diameter end mills were defined. With the uEye camera, macro lens and 3-axis micro milling machine, it was proved the feasibility of measuring flank wear with the milling tests on a 45# steel workpiece. The design of experiment (DOE) showed that Vc was the most remarkable effect factor for the flank wear of small-diameter end mill. The wear curve of the experiments of milling was very similar to the Taylor curve. 展开更多
关键词 tool wear end-mills machine vision small diameter flank wear
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Confinement Effect and Diameter Effect on the Non-ideal Detonation Parameters of Small Charge
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作者 徐新春 焦清介 +1 位作者 金兆鑫 杨贵丽 《Journal of Beijing Institute of Technology》 EI CAS 2010年第4期399-404,共6页
An expanding model of the confinement of non-ideal detonation of small charge is established on the basis of the nozzle theory.Making use of the expanding model,the analytic relationship of small charge detonation vel... An expanding model of the confinement of non-ideal detonation of small charge is established on the basis of the nozzle theory.Making use of the expanding model,the analytic relationship of small charge detonation velocity and the semi-empirical relationship of detonation pressure that both change with charge diameter and confinement condition are established.The detonation velocity and pressure of small charges are calculated and experimentally verified,and the detonation velocity deviation is less than 7% while the detonation pressure deviation is less than 9%. 展开更多
关键词 explosion mechanics non-ideal detonation small charge diameter effect the nozzle theory
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Electrospun Small Diameter Tubes to Mimic Mechanical Properties of Native Blood Vessels Using Poly (L-lactide-co-ε-caprolactone )and Silk Fibroin: a Preliminary Study
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作者 赵荟菁 吴倩瑶 +1 位作者 王璐 林婧 《Journal of Donghua University(English Edition)》 EI CAS 2013年第5期349-351,共3页
Mismatch in mechanical properties can induce intimal hyperplasia,which is one of the main reasons for the failure of small diameter artificial blood vessels. Electrospun small diameter tubes with tailored mechanical p... Mismatch in mechanical properties can induce intimal hyperplasia,which is one of the main reasons for the failure of small diameter artificial blood vessels. Electrospun small diameter tubes with tailored mechanical properties were fabricated through blending poly( L-lactide-co-ε-caprolactone)( PLCL) and silk fibroin( SF)with the mass ratios of 30 /70,50 /50,and 70 /30 in this study.Scanning electron microscopy( SEM) and mechanical testing were used to characterize morphological and mechanical properties of the tubes. Results showed that tensile strength of the tubes was higher than most of the native blood vessels,and elongations at break of them were improved greatly by blending PLCL. Compliances of the tubes were all higher than 1% /13. 33 kPa( 1% /100 mmHg).Particularly,tubes with blending mass ratio of 50 /50 showed similar compliance with human native femoral arteries,which provided a promising biomaterial that could be applied on small diameter vascular applications. 展开更多
关键词 small diameter silk fibroin poly(L-lactide-co-εcaprolactone) MECHANICAL properties
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Study on energy output rule on attenuation of small diameter charge detonation wave passing by air-gap
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作者 赵海霞 王涑波 +2 位作者 胡双启 焦清介 徐新春 《Journal of Measurement Science and Instrumentation》 CAS 2012年第3期215-218,共4页
In order to study energy output rule on attenuation of small diameter charge detonation wave passing by air-gap,the detonation shock wave pressures of different charge diameters and confinements,which are attenuated i... In order to study energy output rule on attenuation of small diameter charge detonation wave passing by air-gap,the detonation shock wave pressures of different charge diameters and confinements,which are attenuated in air-gap,are measured by using the manganin piezoresistance method.Thus the experiential attenuation rule of X booster explosive is obtained with confinement of 45# steel and polymethyl methacrylate(PMMA),the experiential relational expressions in charge diameter and air-gap thickness are gained.The results indicate that exponential rule is obtained in accordance with attenuation of small diameter charge detonation wave passing by air-gap,and the bigger charge diameter,the smaller modulus decay.By changing air-gap thickness,the detonation pressure is also changed.The detonation performance can be controlled by adjusting charge dimension,confinement and air-gap thickness. 展开更多
关键词 small diameter charge detonation pressure confinement condition ATTENUATION
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Study of drying of small diameter Larch lumbers with intermittent heating
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作者 郭明辉 赵西平 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2006年第4期431-434,共4页
Intermittent heating for drying of small diameter Larch lumbers is investigated experimentally. The lumbers were dried using an experimental drying schedule. Moisture content (MC) of the lumber was continuously record... Intermittent heating for drying of small diameter Larch lumbers is investigated experimentally. The lumbers were dried using an experimental drying schedule. Moisture content (MC) of the lumber was continuously recorded and final drying defects were examined. The drying curves showed that the drying rate was a constant in the early stage of intermittent heating drying and decreased evidently when the MC was about 18% (intermittent 2h) and 20% (intermittent 6h). The drying quality reached the second (intermittent 2h) and first grade (intermittent 6h) of the Chinese National Standard. The visual drying defects, especially the check extent along grains were reduced with intermittent heating. When the intermittent time increased, the effect was more obvious. 展开更多
关键词 small diameter lumber LARCH intermittent heating drying curve drying quality
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A numerical simulation of unsteady flow in small diameter helical grafts
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作者 Tinghui Zheng2,Yubo Fan1,Weizhong Wang2,Wentao Jiang2,Xiaoyan Deng1(1.School of Biological Science and Medical Engineering,Beihang University,Beijing,China 2.Department of Applied Mechanics,Sichuan University,Chengdu,Chin 《医用生物力学》 EI CAS CSCD 2009年第S1期40-41,共2页
The application of small diameter arterial grafts is limited due to the fact of relatively poor long-time patency which is caused by thrombosis formation in the short term and intimal hyperplasia(IH) in the medium and... The application of small diameter arterial grafts is limited due to the fact of relatively poor long-time patency which is caused by thrombosis formation in the short term and intimal hyperplasia(IH) in the medium and long term.Thrombosis,obstructing the flow of blood 展开更多
关键词 A numerical simulation of unsteady flow in small diameter helical grafts FLOW
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The Primary Study of the Construction of Small Diameter Tissue-engineered Blood Vessel
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作者 Huai-Qing CHEN Xi-Xun YU Yi ZHANG Min CHENG(Institute of Biomedical Engineering, West China Center of Medical Science, Sichuan University, Chengdu 610041, China) 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2005年第S1期19-20,共2页
关键词 The Primary Study of the Construction of small diameter Tissue-engineered Blood Vessel HUVECS
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Study of an Ultrasonic Probe Installed into a Small Diameter-Pipe Using an Electromagnetic Acoustic Transducer
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作者 Riichi Murayama Benjie Wang +1 位作者 Koutarou Shindou Koudai Katsunaga 《Engineering(科研)》 2020年第8期549-562,共14页
Metal pipes having an inner diameter of about 25 mm or less are frequently used as heat exchangers for power plants, gas pipes, and water pipes. However, erosion and corrosion due to long-term use may cause serious ac... Metal pipes having an inner diameter of about 25 mm or less are frequently used as heat exchangers for power plants, gas pipes, and water pipes. However, erosion and corrosion due to long-term use may cause serious accidents, such as steam leaks, resulting in economic loss and environmental pollution. Therefore, inspection of the entire length and thickness before shipping or monitoring during operation are important technologies. However, no inspection technology including the inside of the wall thickness has been developed. The purpose was to develop an ultrasonic probe that can inspect the inner and outer surfaces from the inside of the pipe at the same time. The developed ultrasonic probe is based on an electromagnetic ultrasonic transducer (EMAT) that does not require a couplant and is then easy to install in a pipe. The EMAT for the longitudinal and for the transverse vibration mode guided wave are connected in series in order to take into account the variety of defects. First, the EMAT was successfully developed for each mode. That is, it was conducted by using the magnetostrictive effect for the longitudinal mode type and by using the Lorentz force for the transverse mode type, and evaluated to improve the performance. The reflected signal from a notch defect was then evaluated in the state that each EMAT was connected in series using any artificial defects and found to be able to detect any notches with about 10% depth or about 15% circumferential length. 展开更多
关键词 EMAT small diameter Pipe Nondestructive Inspection Guide Wave
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SMALL-DIAMETER KOREAN PINES AND THEIR ROLES INNATURAL KOREAN PINE FOREST
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作者 王树力 李凤山 李瑛 《Journal of Northeast Forestry University》 SCIE CAS CSCD 1996年第3期1-7,共7页
Korean pine population strueture in natural Korean pine forest was studied through massive field investigation and indoor analvsis. Small-diameter Korean pines origination, growth charaeter and their roles in stand we... Korean pine population strueture in natural Korean pine forest was studied through massive field investigation and indoor analvsis. Small-diameter Korean pines origination, growth charaeter and their roles in stand were discussed from the view of population origination and tree growth. The results show that small-diameter Korean pines origination and growth havc close relations to the overstory canopy structure dynamics and play an important role in the maintenance and development of Korean pine forest. The process from small-diameter trees to dominant canopy is a selfmaintenance phase, with diffieulty, in Korean pine population. To complete this phase, it not only demands some morphological characters and physiological conditions, but severe forest strueture conditions as well. The time for complating this phase needs separation from overstory Korean pines and converge with overstory broad-leaf trees. In vertical space, it needs to fell overstory canopy or reduce the layers of overstory canopy, and in horizontal space it should be separated from Korean pines but accompanied by broad-leaf trees. 展开更多
关键词 small-diameter KOREAN PINES KOREAN PINE population KOREAN PINE FOREST
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Effects of process parameters on numerical control bending process for large diameter thin-walled aluminum alloy tubes 被引量:16
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作者 李成 杨合 +2 位作者 詹梅 许旭东 李光俊 《中国有色金属学会会刊:英文版》 CSCD 2009年第3期668-673,共6页
Numerical control(NC) bending experiments with different process parameters were carried out for 5052O aluminum alloy tubes with outer diameter of 70 mm, wall thickness of 1.5 mm, and centerline bending radius of 105 ... Numerical control(NC) bending experiments with different process parameters were carried out for 5052O aluminum alloy tubes with outer diameter of 70 mm, wall thickness of 1.5 mm, and centerline bending radius of 105 mm. And the effects of process parameters on tube wall thinning and cross section distortion were investigated. Meanwhile, acceptable bending of the 5052O aluminum tubes was accomplished based on the above experiments. The results show that the effects of process parameters on bending process for large diameter thin-walled aluminum alloy tubes are similar to those for small diameter thin-walled tubes, but the forming quality of the large diameter thin-walled aluminum alloy tubes is much more sensitive to the process parameters and thus it is more difficult to form. 展开更多
关键词 小口径薄壁管 工艺参数 铝合金管 弯曲过程 大直径 数控 弯曲试验 数字控制
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Improved Circularity Metrology of Small Cylindrical Workpieces by the Segmenting-stitching Technique
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作者 ZHAO Jiali ZHANG Liang +2 位作者 WU Dan SHEN Bobo LI Qiaolin 《Instrumentation》 2023年第4期39-49,共11页
To address the alignment and measuring force problem in the segmenting-stitching technique for the circularity metrology of small cylindrical workpieces(diameter less than 1.5 mm and length less than 10 mm),a magnet c... To address the alignment and measuring force problem in the segmenting-stitching technique for the circularity metrology of small cylindrical workpieces(diameter less than 1.5 mm and length less than 10 mm),a magnet combination jig method is proposed.A small round magnet is attached between the round magnetic jig and small cylinder,and the other end of the small cylindrical workpiece is attached to some cylindrical magnets.Thus,the smaller cylinder can be put in the V-groove and measured successfully with the magnet combination.For verifying the advantage of the magnet combination jig,four measurement quality evaluations are proposed:the circumferential deviation of neighbor arc contours,radial deviation of neighbor arc contours,angle of inclination between the V-groove and small cylinder,and curvature of the obtained arc.The results show that the matching coefficient is enhanced by 98%,the Euclidean distance of overlap parts of neighbor arc contours is reduced by 68%,the position error is reduced 27%,and the average curvature of the arc contours is improved.It can be concluded that the measuring quality can be enhanced prominently by this magnet combination method for the segmenting-stitching method. 展开更多
关键词 Circularity and diameter Measurement Magnets Combination Jig small Cylinder Segmenting-stitching Method
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颅内动脉直径与脑小血管病患者认知功能的关系
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作者 邢媛媛 路畅 +3 位作者 白宏英 姚燕雯 陈静 李彩霞 《中国实用神经疾病杂志》 2024年第9期1093-1097,共5页
目的探讨颅内动脉直径与脑小血管病(CSVD)患者认知功能之间可能存在的关系,以求为血管性认知功能障碍(VCI)患者的早期识别、诊断及预后提供新的思路。方法回顾性分析2022-01—2023-12在郑州大学第二附属医院及新郑市公立人民医院住院的... 目的探讨颅内动脉直径与脑小血管病(CSVD)患者认知功能之间可能存在的关系,以求为血管性认知功能障碍(VCI)患者的早期识别、诊断及预后提供新的思路。方法回顾性分析2022-01—2023-12在郑州大学第二附属医院及新郑市公立人民医院住院的151例CSVD患者,采用蒙特利尔认知量表(MoCA)评估受试者的认知功能情况,分为认知功能正常组88例和认知功能障碍组63例,使用3D-Slicer软件对患者原始MRI图像进行处理,得出颅内动脉重塑(BAR)评分。根据BAR评分将患者分为颅内大动脉直径缩窄组(58例)、颅内大动脉直径平均组(37例)、颅内大动脉直径扩张组(56例)。应用Logistic回归分析颅内动脉直径与认知功能障碍的关系,Pearson相关性分析颅内动脉直径与MoCA总分及MoCA各子项得分的关系。结果Logistic回归分析提示颅内动脉直径扩张(OR=1.214,95%CI:1.127~1.307,P<0.01)是认知功能障碍的危险因素。颅内动脉直径扩张与MoCA总分(r=-0.306,P<0.001)、视空间与执行功能(r=-0.237,P=0.003)、语言(r=-0.238,P=0.003)、抽象(r=-0.160,P=0.049)、延迟回忆(r=-0.180,P=0.027)、定向(r=-0.163,P=0.046)呈负相关。结论颅内动脉直径扩张是CSVD患者认知功能障碍的危险因素,颅内动脉直径扩张与MoCA校正后总分、视空间与执行功能、语言、抽象、延迟回忆、定向力呈负相关。 展开更多
关键词 脑小血管病 颅内动脉直径 认知功能障碍 脑萎缩 线性测量 危险因素
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基于机器学习的水泥基灌浆料强度预测方法
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作者 李其廉 陈佳尧 +2 位作者 敦彦茹 曹宪锋 刘毅 《河北科技大学学报》 CAS 北大核心 2024年第3期308-317,共10页
针对采用小直径芯样法准确预测水泥基灌浆料抗压强度的问题,使用压力试验机分别对水泥基灌浆料标准尺寸试块和小直径芯样进行抗压强度试验,并基于试验数据,采用支持向量机回归(SVR)和随机森林回归(RFR)对水泥基灌浆料抗压强度进行回归... 针对采用小直径芯样法准确预测水泥基灌浆料抗压强度的问题,使用压力试验机分别对水泥基灌浆料标准尺寸试块和小直径芯样进行抗压强度试验,并基于试验数据,采用支持向量机回归(SVR)和随机森林回归(RFR)对水泥基灌浆料抗压强度进行回归预测。结果表明:标准尺寸试块均呈正反相接的四角锥体破坏形态,而高径比为0.7和1.0的小直径芯样呈正反相接的圆锥体破坏形态,高径比为1.2的小直径芯样呈斜裂缝剪切破坏形态;标准尺寸试块和小直径芯样的抗压强度值均服从正态分布,且无离群值;随着龄期的增长,标准尺寸试块和小直径芯样的抗压强度提高,且具有早期强度较高的特性;直径46 mm芯样的抗压强度较小,且更易受加工精度的影响;在给定的龄期和直径下,高径比为0.7的芯样抗压强度值最大,抗压强度离散程度最小;RFR预测模型对水泥基灌浆料抗压强度的预测效果更优。所提方法可较准确预测水泥基灌浆料抗压强度,为水泥基灌浆料抗压强度的预测研究提供了参考。 展开更多
关键词 非金属建筑材料 水泥基灌浆料 机器学习 小直径芯样 抗压强度
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高性能高精度铜合金带材六辊冷轧机组的研发与应用
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作者 尤磊 刘云飞 +2 位作者 王恬 魏维刚 袁欢媚 《中国重型装备》 2024年第4期32-37,共6页
针对高性能高精度铜带材生产的技术难点,首次开发了800 mm小辊径六辊可逆中精轧机组。介绍了机组的工艺设备组成、主要工艺技术参数配置和装机水平;重点阐述了开发的新技术:紧凑式弯辊小辊径六辊轧机、高精度自动厚度控制技术、高精度... 针对高性能高精度铜带材生产的技术难点,首次开发了800 mm小辊径六辊可逆中精轧机组。介绍了机组的工艺设备组成、主要工艺技术参数配置和装机水平;重点阐述了开发的新技术:紧凑式弯辊小辊径六辊轧机、高精度自动厚度控制技术、高精度板形自动控制系统以及高效除油装置。机组投入使用后,产品质量得到有效提高,对于厚度为0.175 mm,宽度为620 mm的铜带,成品厚差不大于±1μm,板形均方差不大于0.55I。 展开更多
关键词 铜带 高精度 板形 板厚 六辊冷轧机 小辊径
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基于改进自适应遗传算法的小径短绳自动打捆机步进电机PID控制 被引量:2
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作者 代健超 孟婥 +1 位作者 孙志军 杜诚杰 《东华大学学报(自然科学版)》 CAS 北大核心 2024年第1期63-69,共7页
为提高小径短绳自动打捆机步进电机的控制精度,在分析经典遗传算法和经典自适应遗传算法的基础上,引入进化代数和个体适应值排名来指导自适应交叉率和自适应变异率,设计了一个基于改进自适应遗传算法的PID控制器,以削弱进化过程中优良... 为提高小径短绳自动打捆机步进电机的控制精度,在分析经典遗传算法和经典自适应遗传算法的基础上,引入进化代数和个体适应值排名来指导自适应交叉率和自适应变异率,设计了一个基于改进自适应遗传算法的PID控制器,以削弱进化过程中优良参数的退化现象。MATLAB仿真结果表明,改进的自适应遗传PID提高了收敛精度,并具有更快的收敛速度。针对步进电机的实际测试结果表明,与经典遗传算法相比,改进的自适应遗传PID调整时间更短、超调量更低。 展开更多
关键词 改进自适应遗传算法 小径短绳 自动打捆机 步进电机PID控制 绳缆包装
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小径管X射线焊缝图像缺陷识别算法 被引量:1
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作者 肖扬 高炜欣 邓国浩 《焊接学报》 EI CAS CSCD 北大核心 2024年第2期82-88,I0007,I0008,共9页
针对小径管X射线焊缝图像缺陷检测精确率低的现状,通过对图像进行特征分析并结合稀疏字典学习,提出一种基于图像分割的小径管焊缝图像缺陷检测算法.首先,对小径管焊缝图像进行两步图像分割获得感兴趣区域;其次,提取焊缝缺陷,得到缺陷疑... 针对小径管X射线焊缝图像缺陷检测精确率低的现状,通过对图像进行特征分析并结合稀疏字典学习,提出一种基于图像分割的小径管焊缝图像缺陷检测算法.首先,对小径管焊缝图像进行两步图像分割获得感兴趣区域;其次,提取焊缝缺陷,得到缺陷疑似局部图像;最后,提出以不同类型原子间相关性最小为目标的小径管焊缝缺陷字典矩阵数学模型并使用K-SVD算法进行求解,利用该字典矩阵实现圆形缺陷、线形缺陷和噪声的分类鉴别.为提高系统实时性,使用并行编程对图像分割算法进行加速.结果表明,改进后缺陷字典矩阵对圆形缺陷识别成功率为0.974,线形缺陷识别成功率为0.967,且具有较快的识别速度,实现了小径管焊缝图像缺陷的有效识别. 展开更多
关键词 小径管 焊缝缺陷 图像分割 稀疏字典学习
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小口径组合桩在滑坡抢险中的设计方法探讨 被引量:2
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作者 薛海洋 赵青海 姚裕春 《路基工程》 2024年第1期191-197,共7页
为适应滑坡抢险工程的时效性和安全性,在分析小口径组合桩加固机理的基础上,提出设计流程、计算方法及具体参数取值,并应用于某铁路大临道路工程修建期间诱发的一处滑坡整治工程中,通过监控量测和数值模拟分析,验证该设计方法在抢险工... 为适应滑坡抢险工程的时效性和安全性,在分析小口径组合桩加固机理的基础上,提出设计流程、计算方法及具体参数取值,并应用于某铁路大临道路工程修建期间诱发的一处滑坡整治工程中,通过监控量测和数值模拟分析,验证该设计方法在抢险工程中的可行性。工程效果证明,计算方法及具体参数取值较为合理。 展开更多
关键词 工程滑坡 抢险整治措施 小口径组合桩 设计方法 参数取值
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不同静电纺丝膜上骨髓间充质干细胞的黏附、增殖与成血管平滑肌分化 被引量:2
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作者 孙现娟 王秋花 +3 位作者 张锦艺 杨杨杨 王文双 张晓晴 《中国组织工程研究》 CAS 北大核心 2025年第4期661-669,共9页
背景:临床上迫切需要小口径人工血管来治疗冠状动脉和外周动脉疾病,目前,血管组织工程已成为制备小口径人工血管的主要方法,选择合适的生物材料和细胞来源是小口径组织工程血管构建成功的关键因素。目的:观察4种静电纺丝膜材料对骨髓间... 背景:临床上迫切需要小口径人工血管来治疗冠状动脉和外周动脉疾病,目前,血管组织工程已成为制备小口径人工血管的主要方法,选择合适的生物材料和细胞来源是小口径组织工程血管构建成功的关键因素。目的:观察4种静电纺丝膜材料对骨髓间充质干细胞增殖、黏附及分化为血管平滑肌细胞的影响。方法:分离提取SD大鼠骨髓间充质干细胞。将骨髓间充质干细胞分别接种于聚己内酯(PCL)、聚己内酯-透明质酸(PCL-HA)、聚己内酯-丝素蛋白(PCL-SF)、聚己内酯-明胶(PCL-GEL)静电纺丝膜材料上,培养1,3,7 d后,扫描电镜下观察材料上的细胞排布,鬼笔环肽染色观察材料上的细胞增殖与黏附,qRT-PCR检测材料上细胞分泌的CD90、Meflin、转化生长因子βmRNA表达;向血管平滑肌细胞诱导分化7 d后,qRT-PCR检测材料上细胞ɑ-平滑肌肌动蛋白mRNA表达。结果与结论:①扫描电镜下可见骨髓间充质干细胞在4种静电纺丝膜上均沿着静电纺丝膜的纤维走向排列;②鬼笔环肽染色显示,骨髓间充质干细胞在4种静电纺丝膜上分布规律,均沿着纤维走向呈现平行分布,并且PCL-HA、PCL-SF、PCL-GEL静电纺丝膜较PCL静电纺丝膜更有利于骨髓间充质干细胞的增殖、黏附,PCL-SF静电纺丝膜相较于PCL-HA、PCL-GEL静电纺丝膜更有利于骨髓间充质干细胞的增殖、黏附;③qRT-PCR检测显示,4种静电纺丝膜材料均可维持骨髓间充质干细胞CD90和Meflin的mRNA表达,组间比较差异无显著性意义(P>0.05);PCL-HA、PCL-SF、PCL-GEL组培养1,7 d的转化生长因子βmRNA表达高于PCL组(P<0.05),PCL-SF组培养3,7 d的转化生长因子βmRNA表达高于其他3组(P<0.05),PCL-HA组培养7 d的转化生长因子βmRNA表达高于PCL-GEL组(P<0.05);④qRT-PCR检测显示,PCL-SF组ɑ-平滑肌肌动蛋白mRNA表达高于其他3组(P<0.05),PCL-HA组ɑ-平滑肌肌动蛋白mRNA表达高于PCL组(P<0.05);⑤结果表明:相较于PCL、PCL-HA、PCL-GEL静电纺丝膜,PCL-SF静电纺丝膜与骨髓间充质干细胞结合更适合制备小口径组织工程血管。 展开更多
关键词 骨髓间充质干细胞 小口径组织工程血管 静电纺丝 聚己内酯 聚己内酯-透明质酸 聚己内酯-丝素蛋白 聚己内酯-明胶
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非小细胞肺癌软脑膜转移患者MR测量与脑脊液压力的相关性研究
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作者 何雪颖 林永娟 +4 位作者 尹震宇 田传帅 张鑫 梁雪 张冰 《南京医科大学学报(自然科学版)》 CAS 北大核心 2024年第6期812-817,共6页
目的:探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)软脑膜转移(leptomeningeal metastases,LM)患者磁共振(magnetic resonance,MR)测量视神经鞘直径(optic nerve sheath diameter,ONSD)和头颅外周脑脊液体积/全脑容积(periphera... 目的:探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)软脑膜转移(leptomeningeal metastases,LM)患者磁共振(magnetic resonance,MR)测量视神经鞘直径(optic nerve sheath diameter,ONSD)和头颅外周脑脊液体积/全脑容积(peripheral cerebrospinal fluid volume/intracranial volume,PCSFV/ICV)比值与脑脊液压力(cerebrospinal fluid pressure,CSFP)的相关性,评估ONSD和PCSFV/ICV联合诊断CSFP升高的准确性。方法:共收集63例NSCLC-LM患者,所有患者同时进行视神经和颅脑MR扫描,测量双眼ONSD、颅脑PCSFV和ICV。随后对所有患者行腰椎穿刺测量CSFP,并定期进行鞘内化疗。采用Pearson相关分析法分析CSFP与MR表现的相关性。通过受试者工作特征(receiver operating characteristic,ROC)曲线评估ONSD和PCSFV/ICV联合诊断CSFP升高的准确性。结果:所有NSCLC-LM患者双眼平均ONSD与CSFP呈正相关(r=0.567,P<0.001),PCSFV/ICV与CSFP呈负相关(r=-0.365,P=0.003)。ROC曲线分析显示ONSD、PCSFV/ICV及ONSD联合PCSFV/ICV诊断颅内高压(CSFP>15 mmHg)的性能分别为0.81(95%CI:0.71~0.91)、0.76(95%CI:0.64~0.89)和0.91(95%CI:0.84~0.99)。ONSD、PCSFV/ICV及ONSD联合PCSFV/ICV诊断颅内高压(CSFP>20 mmHg)的性能分别为0.70(95%CI:0.58~0.82)、0.72(95%CI:0.57~0.88)和0.81(95%CI:0.70~0.93)。结论:经MR测量ONSD和PCSFV/ICV可以评估NSCLC-LM患者CSFP的变化,二者联合能够提高诊断颅内高压的准确性,有较好的临床应用价值。 展开更多
关键词 脑脊液压力 非小细胞肺癌 软脑膜转移 视神经鞘直径 磁共振
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