Time trends in myopia and high myopia prevalence in young university adults in China

AIM:To investigate time trends in myopia and high myopia prevalence over 6y among young university adults in China.METHODS:This is a 6-year series cross-sectional study from 2016 to 2021.Totally 4910 freshmen were enrolled and completed a questionnaire concerning age,gender,and disease history.Students with eye diseases were excluded after a detailed eye examination.The refractive status was measured by non-cycloplegic objective refraction and ocular parameters were measured by Lenstar 900.The examination followed the same protocol each year.Trends over time in myopia and high myopia prevalence,as well as ocular biometry parameters,were analyzed.RESULTS:From 2016 to 2021,the axial length(AL)and corneal radius(CR)increased significantly(P=0.002 for AL;P=0.04 for CR).However,the spherical equivalent(SE)and the ratio of axial length to the corneal radius(AL/CR)did not change significantly(P=0.59 for SE;P=0.24 for AL/CR).The frequency of AL≥26.0 mm increased from 26.6%in 2016 to 29.3%in 2021(P=0.05 for trend).The prevalence of myopia and high myopia did not change significantly in our study(P≥0.18).Compared to a similar cross-sectional study conducted 10 years ago,the prevalence of myopia decreased significantly(94.9%vs 91.8%,P<0.001).Whereas the prevalence of high myopia increased largely(18.12%vs 27.6%,P<0.001).CONCLUSION:The prevalence of high myopia increases in young university adults during 10y period.Myopia control should begin earlier in childhood.However,these interventions are still needed for high myopia even in young adulthood.

Increasing pancreatic cancer is not paralleled by pancreaticoduodenectomy volumes in Brazil:A time trend analysis

Background: Currently, surgical resection represents the only curative treatment for pancreatic cancer(PC), however, the majority of tumors are no longer resectable by the time of diagnosis. The aim of this study was to describe time trends and distribution of pancreaticoduodenectomies(PDs) performed for treating PC in Brazil in recent years. Methods: Data were retrospectively obtained from Brazilian Health Public System(namely DATASUS) regarding hospitalizations for PC and PD in Brazil from January 2008 to December 2015. PC and PD rates and their mortalities were estimated from DATASUS hospitalizations and analyzed for age, gender and demographic characteristics. Results: A total of 2364 PDs were retrieved. Albeit PC incidence more than doubled, the number of PDs increased only 37%. Most PDs were performed in men(52.2%) and patients between 50 and 69 years old(59.5%). Patients not surgically treated and those 70 years or older had the highest in-hospital mortality rates. The most developed regions(Southeast and South) as well as large metropolitan integrated municipalities registered 76.2% and 54.8% of the procedures, respectively. LMIM PD mortality fluctuated, ranging from 13.6% in 2008 to 11.8% in 2015. Conclusions: This study suggests a trend towards regionalization and volume-outcome relationships for PD due to PC, as large metropolitan integrated municipalities registered most of the PDs and more stable mortality rates. The substantial differences between PD and PC increasing rates reveals a limiting step on the health system resoluteness. Reduction in the number of hospital beds and late access to hospitalization, despite improvement in diagnostic methods, could at least in part explain these findings.

Trend and Periodicity of Temperature Time Series in Ontario

The trends and periodicities in the annual and seasonal temperature time series at fifteen weather stations within Ontario Great Lakes Basins have been analyzed, for the period 1941-2005, using the statistical analyses (Fourier series analysis, t-test, and Mann-Kendall test). The stations were spatially divided into three regions: northwest (NW), southwest (SW), and southeast (SE) to evaluate spatial variability in temperature. The results of the study reveal that the annual maximum mean temperature showed increasing trend for NW, and mixed trends for SW and SE regions. The variability was found to be more for northern stations as compared to southern stations for annual extreme minimum temperature. In addition, the trend slope per 100 years for the average annual extreme minimum temperature increased within the range of -0.8°C (Stratford) to 15°C (Porcupine). The seasonal analysis demonstrated that extreme maximum temperature has an increasing trend and maximum mean temperature has a decreasing trend during summer and winter. The extreme minimum temperature for winter illustrated an increasing trend (90%) with 22% statistically significant for NW region. For the SW region, the trend is also increasing (80%) for most of the temperature variables and 25% of temperature data were significantly increased in the SW region. The SE region stations showed overall very clear increasing trends (95%) for all the temperature variables. The data also showed that 47% of data were statistically significant in the SE region. The analysis of variance accounted for by trend, significant periodicities, and random component show that the pattern is similar for the percent of variance accounted for periodicities, and random component contribute dominantly for the four temperature variables and frost free days (FFD) for all three regions. Overall, the study reveals that the extreme minimum temperature is increasing annually and seasonally, with statistically significant at many stations.

Conforming to the Trend at An Appropriate Time——My Thoughts on the Building of the Silk Road Economic Belt

During his state visit to Kazakhstan this September,President Xi Jinping made a concrete proposal to build a Silk Road Economic Belt(SREB for short in the following paragraphs)from the aspects of policy communication,road connectivity,

Analysis of the Main Factors Influencing Food Production in China Based on Time Series Trend Chart

Based on the annual sample data on food production in China since the reform and opening up,we select 8 main factors influencing the total food production( growing area,application rate of chemical fertilizer,effective irrigation area,the affected area,total machinery power,food production cost index,food production price index,financial funds for supporting agriculture,farmers and countryside),and put them into categories of material input,resources and environment,and policy factors. Using the factor analysis,we carry out the multi-angle analysis of these typical influencing factors one by one through the time series trend chart. It is found that application rate of chemical fertilizer,the growing area of food crops and drought-affected area become the key factors affecting food production. On this basis,we set forth the corresponding recommendations for improving the comprehensive food production capacity.

Piecewise linear representation of time series based on mean trend in sliding window

Seismic data show some important characteristics, such as big volume and strong timeliness. Specific to the time series data of earthquake precursory observations, a piecewise linear representation based on the sliding window mean value （PLR_MTSW） algorithm is proposed. With this algorithm, the mutation points can be identified accurately according to the rate Of mean value change, while the main features of time series are maintained well. This algorithm can also smooth the noise and improve the compression accuracy with sliding window. Meanwhile the local extreme points can be identified effectively according to the change of mean value trend within window.

Strengthening Exchanges and Cooperation in the Northeast Asia Region Follows the Trend of the Times——Sidelights of the 10^(th) Northeast Asia Youth Forum

The 10thNortheast Asia Youth Forum,with the theme of China-ROK-Japan Youth Employment Guidance,sponsored by Moral Re-Armament/Initiatives of Change(MRA/IC)-Korea was held in Seoul and Cheonan from August 12 to 17.Seventy five college students from 37 universities sent by China International Youth Exchange Center,Moral Re-Armament/Initiatives of Change(MRA/IC)-Korea and Japan Society attended the Forum.Lee Boksil,Vice-Minister of Ministry of

Statistical Analysis for Assessing Randomness, Shift and Trend in Rainfall Time Series under Climate Variability and Change: Case of Senegal

The main purpose of this study is to assess the climate variability and change through statistical processing tools that able to highlight annual and monthly rainfall behavior between 1970 and 2010 in six strategical raingauges located in northern (Saint-Louis, Bakel), central (Dakar, Kaolack), and southern (Ziguinchor, Tambacounda) part of Senegal. Further, differences in sensitivity of statistical tests are also exhibited by applying several tests rather than a single one to check for one behavior. Dependency of results from statistical tests on studied sequence in time series is also shown comparing results of tests applied on two different periods (1970-2010 and 1960-2010). Therefore, between 1970 and 2010, exploratory data analysis is made to give in a visible manner a first idea on rainfall behavior. Then, Statistical characteristics such as the mean, variance, standard deviation, coefficient of variation, skewness and kurtosis are calculated. Subsequently, statistical tests are applied to all retained time series. Kendall and Spearman rank correlation tests allow verifying whether or not annual rainfall observations are independent. Hubert’s procedures of segmentation, Pettitt, Lee Heghinian and Buishand tests allow checking rainfall homogeneity. Trend is undertaken by first employing the annual and seasonal Mann-Kendall trend test, and in case of significance, magnitude of trend is calculated by Sen’s slope estimator tests. All statistical tests are applied in the period of 1960-2010. Explanatory analysis data indicates upwards trends for records in northern and central and trend free for southern records. Application of multiple tests shows that the Kendall and spearman ranks correlation tests lead to same conclusion. The difference in tests sensitivity was shown by outcomes of homogeneity tests giving different results either in dates of the shift occurrence or in the significance of an eventual shift. A synthesis analysis of results of tests was carried out to conclude about rainfall behaviors. Tests for homogeneity show that southern rainfall is homogeneous, while northern and central ones are not. According to trend test, upwards trends in Northern and central rainfall trend free in southern assumption in exploratory data analysis have been confirmed. The Sen’s slop estimator shows that all retained trend can be assumed to linear type. The same test over the period 1960-2010 shows independence of observations in all raingauges and exhibits neither trends nor breaks. This seems to show a return to a wet period.

Comparative Analysis of Climatic Change Trend and Change-Point Analysis for Long-Term Daily Rainfall Annual Maximum Time Series Data in Four Gauging Stations in Niger Delta

The aim of this study is to establish the prevailing conditions of changing climatic trends and change point dates in four selected meteorological stations of Uyo, Benin, Port Harcourt, and Warri in the Niger Delta region of Nigeria. Using daily or 24-hourly annual maximum series (AMS) data with the Indian Meteorological Department (IMD) and the modified Chowdury Indian Meteorological Department (MCIMD) models were adopted to downscale the time series data. Mann-Kendall (MK) trend and Sen’s Slope Estimator (SSE) test showed a statistically significant trend for Uyo and Benin, while Port Harcourt and Warri showed mild trends. The Sen’s Slope magnitude and variation rate were 21.6, 10.8, 6.00 and 4.4 mm/decade, respectively. The trend change-point analysis showed the initial rainfall change-point dates as 2002, 2005, 1988, and 2000 for Uyo, Benin, Port Harcourt, and Warri, respectively. These prove positive changing climatic conditions for rainfall in the study area. Erosion and flood control facilities analysis and design in the Niger Delta will require the application of Non-stationary IDF modelling.

Cancer burden in China:trends,risk factors and prevention

As the most populous country in the world,China has made strides in health promotion in the past few decades.With the aging population,the burden of cancer in China continues to grow.Changes in risk factors for cancer,especially diet,obesity,diabetes,and air pollution,continue to fuel the shift of cancer transition in China.The burden of upper gastrointestinal cancer in China is decreasing,but still heavy.The rising burden of colorectal,prostate,and breast cancers is also significant.Lung cancer became the top cause of cancer-related deaths,together with smoking as the most important contributor to cancer deaths.The Chinese government has taken several approaches to control cancer and cancer-related risk factors.Many achievements have been made,but some challenges remain.Health China 2030 is ambitious and depicts a bright vision of the future for cancer control in China.The decrease in the cancer burden in China will require cross-sector collaboration and coordinated efforts on primary and secondary preventions by governments,public health organizations,and individuals.In this review,we describe the trends of cancer burden and discuss cancer-related risk factors in China,identifying strategies to reduce the burden of cancer in China.

Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China

BACKGROUND Through analyzing the data from a single institution in Northeast China,this study revealed the possible clinicopathologic characteristics that influence the prognosis of patients with gastric cancer(GC).AIM To evaluate the changing trends of clinicopathologic features and survival duration after surgery in patients with GC in Northeast China,which is a highprevalence area of GC.METHODS The study analyzed the difference in clinicopathologic features and survival duration after surgery of 5887 patients who were histologically diagnosed with GC at the Harbin Medical University Cancer Hospital.The study mainly analyzed the data in three periods,2000 to 2004(Phase 1),2005 to 2009(Phase 2),and 2010 to 2014(Phase 3).RESULTS Over time,the postoperative survival rate significantly increased from 2000 to 2014.In the past 15 years,compared with Phases 1 and 2,the tumor size was smaller in Phase 3(P<0.001),but the proportion of high-medium differentiated tumors increased(P<0.001).The proportion of early GC gradually increased from 3.9%to 14.4%(P<0.001).A surprising improvement was observed in the mean number of retrieved lymph nodes,ranging from 11.4 to 27.5(P<0.001).The overall 5-year survival rate increased from 24%in Phase 1 to 43.8%in Phase 3.Through multivariate analysis,it was found that age,tumor size,histologic type,tumor-node-metastasis stage,depth of invasion,lymph node metastasis,surgical approach,local infiltration,radical extent,number of retrieved lymph nodes,and age group were independent risk factors that influenced the prognosis of patients with GC.CONCLUSION The clinical features of GC in Northeast China changed during the observation period.The increasing detection of early GC and more standardized surgical treatment effectively prolonged lifetimes.

基于seasonal-trend-loess方法的符号化时间序列网络

为了有效控制海量数据时间序列网络的规模并使得网络更贴近实际,符号化时间序列网络成为研究热点.结合周期性时间序列的seasonal-trend-loess方法和符号化转化方法,本文提出一种新的符号化时间序列建网方法.该方法考虑了单个数据值的状态又结合了序列的长远变化趋势.以符号模式为节点;依时间顺序推移,以节点间的邻接转换关系定义连边;根据转换方向和转换频次确定连边的方向和权重,建立有向加权网络.分别以航空旅客吞吐量时间序列和因特网流量时间序列为实验数据构建的两个时间序列网络,有明显差异的拓扑特征;进一步对移动通信语音时间序列做了实证分析,挖掘时间序列数据的本质规律.

肺结核发病的时空分布特征和气象因素分析

通过对2015—2019年全国肺结核发病率数据(不含香港地区、澳门地区和台湾地区)可视化,探究全国肺结核发病的时空分布特征;通过空间自相关分析和拉格朗日乘数(LM)检验,选取面板数据空间杜宾模型探究有关气象因素对肺结核发病的影响。研究结果表明,每年的1月和3月是全国肺结核的高发期,且全国肺结核发病率存在空间聚集性,高发区域是新疆、西藏和青海等西北部地区;气温和湿度与当地肺结核发病是负相关关系,与周边地区的肺结核发病是正相关关系。

Trends in the survival of patients with nasopharyngeal carcinoma between 1976 and 2005 in Sihui, China: a population-based study

Both the incidence a nd mortality of nasopharyngeal carcinoma(NPC) have decreased in Hong Kong and Taiwan but not in China's Mainland. The goal of this study was to analyze trends in NPC patient survival between 1976 and 2005 in Sihui, an area of China's Mainland with a population at high risk for NPC. A total of 1,761 patients diagnosed with NPC between 1976 and 2005 according to the records of Sihui Cancer Registry were followed to the end of 2006. We determined their observed and relative survival rates and used Cox proportional hazards regression analysis to predict prognosis. Our results showed that the 5-year and 10-year observed survival rates of NPC patients in Sihui were 50.5% and 36.9% , respectively, and the median survival time was 5.1 years. The 5-year observed survival rate of NPC patients diagnosed after 2000 was 69.8%, significantly higher than that of patients diagnosed between 1976 and 1985 (42.5% ; P<0.001, relative risk=0.28). Similarly, the 5-year relative survival rate was 84.8% between 2000 and 2005 but 51.8% between 1976 and 1985. Besides date of diagnosis, other prognostic factors included patient sex and age and NPC clinical stage and histologic type. The relative risks of death from NPC were 0.76 [95% confidence interval (CI): 0.65-0.90] for female comparing to male and 1.28 (95% CI: 1.00-1.64) for WHO type I comparing to WHO types II and III. For the eldest age group and the latest clinical stage group, the relative risks were 2.22 (95% CI: 1.73-2.84) and 3.41 (95% CI: 2.34-4.49), respectively. Our results indicate that the survival of NPC patients in Sihui has significantly increased in recent years and this increase is not influenced by patient's sex, age, histologic type, and clinical stage. A reduction in mortality rate is expected in coming years.

致癌物评估实验中的Time-adjusted趋势检验

在致癌物评估实验中 ,随药物剂量的增加 ,动物死亡率变化呈现某种趋势 .本文给出分组评估实验中的 time-adjusted趋势检验和相关参数的极大似然估计 。

Space-time analysis of the changing patterns of population pressure on the ecological environment in China

This paper examines the temporal change and spatial variation of population pressure on the ecological environment in China.We have collected sufficient data from the statistical yearbooks of 31 provincial administrative areas in 1990,1995,2000,2005,and 2010.Using a geographic information system(GIS) and relevant models,we analyzed the trend of the population pressure on ecological environment and the change of the gravity center of ecological environment quality.We conclude that:(1) generally,population pressure on the ecological environment in China was becoming higher during1990-2010,especially in some areas where the population and environment were in serious imbalance and the ecological environment experienced severe pollution;(2) during a certain period,population pressure on the ecological environment was becoming lower in some areas,but the ecological environment was getting worse;(3) the areas with super-high population pressure on the ecological environment were Beijing,Tianjin,and Shanghai;(4) the gravity center of population pressure on the ecological environment and the center of ecological environment quality move differently during the study time period,but the general trend was similar- both of them were moving from west to east.Based on the analysis,this paper also provides some policy suggestions on the control of ecological environment quality.

Time-Series Modeling and Prediction of Global Monthly Absolute Temperature for Environmental Decision Making

A generalized, structural, time series modeling framework was developed to analyze the monthly records of absolute surface temperature, one of the most important environmental parameters, using a deterministicstochastic combined （DSC） approach. Although the development of the framework was based on the characterization of the variation patterns of a global dataset, the methodology could be applied to any monthly absolute temperature record. Deterministic processes were used to characterize the variation patterns of the global trend and the cyclic oscillations of the temperature signal, involving polynomial functions and the Fourier method, respectively, while stochastic processes were employed to account for any remaining patterns in the temperature signal, involving seasonal autoregressive integrated moving average （SARIMA） models. A prediction of the monthly global surface temperature during the second decade of the 21st century using the DSC model shows that the global temperature will likely continue to rise at twice the average rate of the past 150 years. The evaluation of prediction accuracy shows that DSC models perform systematically well against selected models of other authors, suggesting that DSC models, when coupled with other ecoenvironmental models, can be used as a supplemental tool for short-term （10-year） environmental planning and decision making.

GPS time-series and its response to M_S=8.1 Kunlunshan earthquake

In this paper, observation data in 25 GPS reference stations of China have been analyzed by calculating GPS position coordinate time-series with GIPSY. Result shows there is an obvious trend variation in such time-series. The trend variations of time series along the longitude and latitude coordinate reflect the motion of each position in the global-plate, in which the trend variation in the vertical direction reveals some large-scale construction information or reflects the local movement around the positions. The analysis also shows that such time-series have a variation cycle of nearly 1.02 a, but the reason still remains to be further studied. At the end of this paper, response of the time-series to MS=8.1 Kunlunshan earthquake was analyzed, and the seismogenic process of MS=8.1 Kunlunshan earthquake, according to the time proceeding and the feature of anomaly, was divided into 3 phases-changes in blocks with forces, strain accumulation, quick accumulation and slow release of energy. At the initial stage of seismogenic process of MS=8.1 earthquake and at the imminent earthquake, coseismic process as well as during the post earthquake recovery, anomaly in vertical direction is always in a majority. The anomalous movement in vertical direction at the initial stage resulted in a blocking between faults, while at the middle stage of seismogenic process, the differential movement between blocks are in a majority, which is the major reason causing energy accumulating at the blocking stage of faults.

Time Series Econometrics: A Critique

This is a critical note regarding the currently established econometrics of time series. The criticism involves commonly practiced mechanistic modeling and testing of relationships, taking econometrics away from economics. Among others, modeling economic trends as simple functions of time is extremely naive and testing for cointegration lacks a proper economic foundation.

考虑谐波严重程度的长时间尺度谐波责任划分方法

针对现有谐波责任划分方法未考虑不同谐波严重程度下责任所造成的实际影响差异,提出一种考虑谐波严重程度的长时间尺度谐波责任划分方法。考虑谐波数值分布与变化趋势两方面因素划分工况,并计算各工况综合权重量化谐波严重程度;基于典型相关性分析原理筛选长时间尺度数据,并根据谐波责任定义式估算谐波责任;结合上述综合权重获取长时间尺度综合谐波责任划分指标;采用仿真算例与实测数据进行验证,与传统方法相比,所提方法可反映各谐波源在长时间尺度下不同次数谐波造成的累计影响,更适用于谐波精准治理与公平奖惩工作。