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STUDY ON ENHANCING THE WHITENESS OF CALCINED KAOLIN BY USING ADDITIVE
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作者 曹明礼 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 1997年第Z1期42-46,共5页
To meet some special requirements such as paper filler,ceramic titanium white and synthetic 4A zeolite, the raising whiteness of calcined kaolin has become more and more important. The calcined experiments were carrie... To meet some special requirements such as paper filler,ceramic titanium white and synthetic 4A zeolite, the raising whiteness of calcined kaolin has become more and more important. The calcined experiments were carried out with and without additive to increase the whiteness of calcined kaolin. Results show that additive of chloride (A) or oxides can obviously increase the whiteness of calcined kaolin. Meantime,the mechanisms of enhancing the whiteness of calcined kaolin were discussed. 展开更多
关键词 KAOLIN calcining enhancing whiteness ADDITIVE
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Cognitive impairment in cerebral small vessel disease induced by hypertension 被引量:2
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作者 Weipeng Wei Denglei Ma +1 位作者 Lin Li Lan Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1454-1462,共9页
Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular disease.Howeve r,the causal relationship between hypertension a... Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular disease.Howeve r,the causal relationship between hypertension and cerebral small vessel disease remains unclear.Hypertension has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular disease.Chronic hypertension and lifestyle factors are associated with risks for stro ke and dementia,and cerebral small vessel disease can cause dementia and stroke.Hypertension is the main driver of cerebral small vessel disease,which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction,leukoaraiosis,white matter lesions,and intracerebral hemorrhage,ultimately res ulting in cognitive decline and demonstrating that the brain is the to rget organ of hypertension.This review updates our understanding of the pathogenesis of hypertensioninduced cerebral small vessel disease and the res ulting changes in brain structure and function and declines in cognitive ability.We also discuss drugs to treat cerebral small vessel disease and cognitive impairment. 展开更多
关键词 blood-brain barrier cerebral small vessel disease cognitive impairment DEMENTIA endothelial dysfunction enlarged perivascular space HYPERTENSION lacunar infarction NEUROINFLAMMATION TREATMENT white matter high signal intensity
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In vivo 3-photon fluorescence microscopy of white matter in mouse brain excited at the 1700 nm window 被引量:1
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作者 Jie Huang Jincheng Zhong +3 位作者 Shen Tong Yingxian Zhang Ping Qiu Ke Wang 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第5期81-87,共7页
White matter,a densely packed collection of myelinated axons,plays an essential part in neural networks.With high spatial resolution and deep penetration,multi-photon microscopy(MPM)is promising for white matter imagi... White matter,a densely packed collection of myelinated axons,plays an essential part in neural networks.With high spatial resolution and deep penetration,multi-photon microscopy(MPM)is promising for white matter imaging in animal models in vivo.The third harmonic generation(THG)signal can be generated from white matter,but the bottom part of the white matter layer generates weak THG due to its high scattering.Here,we demonstrate an in vivo labeling and imaging technology,capable of visualizing the white matter layer in the mouse brain,combining°uorescence labeling with MitoTracker Red and three-photon°uorescence(3PF)microscopy excited at the 1700 nm window.3PF signals are several times higher than THG signals,resulting in deeper imaging of the white matter layer with the former.Our results indicate that 3PF microscopy is a promising technology for white matter imaging in the deep brain in vivo. 展开更多
关键词 Three-photon microscopy white matter MYELIN MitoTracker Red
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Structural whiteness of the multi-component glaze dependence on amorphous photonic crystals 被引量:3
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作者 Hongquan ZHAN Chuanqi WU +3 位作者 Ce DENG Xiaohong LI Zhipeng XIE Changan WANG 《Frontiers of Materials Science》 SCIE CSCD 2019年第2期206-215,共10页
A kind of enhancing mechanism of structural whiteness dependence on amorphous photonic crystal (APC) structure is introduced in this paper. In the glaze system composed of albite, kaolin, talc, calcite, quartz, titani... A kind of enhancing mechanism of structural whiteness dependence on amorphous photonic crystal (APC) structure is introduced in this paper. In the glaze system composed of albite, kaolin, talc, calcite, quartz, titanium dioxide and zinc oxide, the APC structure will be produced by using quartz as a variable to induce the phase separation. Under different polarities between Ti, Zn etc. and Siion, the separated spheres with the core-shell structure can be obtained and then make up opal-like APCs in the glaze layer. In addition to inner and outer layers of core-shell spheres, the calculated results of refractive indices clearly show the great difference between the particles and the matrix. As a result of different refractive indices, the multiple scatting of visible light plays a key rote in the structural whiteness. However, due to the decrease of the cationic content, APCs with the reverse opal structure would be formed in the interface between glaze and body. Ultimately, the glaze appearance reveals extremely high structural whiteness due to the special APC structure. 展开更多
关键词 STRUCTURAL whiteness AMORPHOUS photonic crystal CORE-SHELL structure
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尿路上皮肿瘤新型可视化成像技术研究进展
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作者 郭子豪 曾晓勇 《现代泌尿生殖肿瘤杂志》 2024年第3期129-132,共4页
白光膀胱镜(white light cystoscopy,WLC)、白光输尿管肾镜(white light ureterorenoscopy,WLURS)是目前诊断尿路上皮肿瘤最常用的腔镜成像技术,尽管应用广泛,但对检测肉眼难以察觉的病变存在局限,影响了尿路上皮恶性肿瘤的早期诊断和... 白光膀胱镜(white light cystoscopy,WLC)、白光输尿管肾镜(white light ureterorenoscopy,WLURS)是目前诊断尿路上皮肿瘤最常用的腔镜成像技术,尽管应用广泛,但对检测肉眼难以察觉的病变存在局限,影响了尿路上皮恶性肿瘤的早期诊断和完整切除。尿路上皮肿瘤可发生于肾盂、输尿管、膀胱、尿道等部位,其中以膀胱癌(bladder cancer,BC)最为多见。 展开更多
关键词 尿路上皮肿瘤 输尿管肾镜 膀胱镜 早期诊断 膀胱癌 WHITE 成像技术
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Premature axon-oligodendrocyte interaction contributes to stalling of experimental axon regeneration after injury to the white matter
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作者 Ephraim F.Trakhtenberg 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期469-470,共2页
Studies from nearly 3 decades ago suggested that,in the central nervous system(CNS),myelination of axons by oligodendrocytes not only helps improve axonal conductivity but also stabilizes circuitry(Colello and Schwab,... Studies from nearly 3 decades ago suggested that,in the central nervous system(CNS),myelination of axons by oligodendrocytes not only helps improve axonal conductivity but also stabilizes circuitry(Colello and Schwab,1994).Over the years,myelin sheaths produced by oligodendrocytes have been found to contain multiple molecules that are inhibitory to axonal growth(e.g.,MAG,NogoA,OMgp,Semaphorins)(Yiu and He,2006;Silver et al.,2014).After white matter injury in the adult CNS,myelin debris from damaged axons and dead oligodendrocytes accumulates in the forming glial scar and exposes these myelin-associated axon growth-inhibitory molecules to the injured axonal stumps,thereby contributing to the inhibition of axonal regrowth.During development,CNS axons reach their postsynaptic targets and stop growing before oligodendrocytes appear and myelinate them(Foran and Peterson,1992;Dangata et al.,1996).Therefore,myelin-associated axon growth-inhibitory molecules interacting with already grown axons during myelination were thought to block axons from promiscuous sprouting and miswiring,thereby stabilizing neural circuitry in the CNS(Colello and Schwab,1994). 展开更多
关键词 thereby white INJURY
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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n
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作者 Sheng-Da Tang Yong-Hao Chen +72 位作者 Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第1期178-187,共10页
Nondestructive and noninvasive neutron assays are essential applications of neutron techniques.Neutron resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental compositi... Nondestructive and noninvasive neutron assays are essential applications of neutron techniques.Neutron resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an object.The back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test experiments.The results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at Back-n.This study reveals its potential future applications. 展开更多
关键词 CSNS White neutron beam NRTA Nuclide identification Nondestructive method
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Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions
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作者 Narek Manukjan Daniel Fulton +2 位作者 Zubair Ahmed WMatthijs Blankesteijn Sébastien Foulquier 《Neural Regeneration Research》 SCIE CAS 2025年第1期191-192,共2页
As the population ages,the burden of age-related diseases becomes greater.Currently,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common form.However,it is becoming cle... As the population ages,the burden of age-related diseases becomes greater.Currently,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common form.However,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of cSVD.The term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018). 展开更多
关键词 PATHOLOGY BECOMING WHITE
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A real-time calibration method based on time-to-digital converter for accelerator timing system
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作者 Qi-Hao Duan Liang Ge +2 位作者 Yan-Hao Jia Jie-Yu Zhu Wei Zhang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第9期127-140,共14页
The high-intensity heavy-ion accelerator facility(HIAF)is a scientific research facility complex composed of multiple cas-cade accelerators of different types,which pose a scheduling problem for devices distributed ov... The high-intensity heavy-ion accelerator facility(HIAF)is a scientific research facility complex composed of multiple cas-cade accelerators of different types,which pose a scheduling problem for devices distributed over a certain range of 2 km,involving over a hundred devices.The white rabbit,a technology-enhancing Gigabit Ethernet,has shown the capability of scheduling distributed timing devices but still faces the challenge of obtaining real-time synchronization calibration param-eters with high precision.This study presents a calibration system based on a time-to-digital converter implemented on an ARM-based System-on-Chip(SoC).The system consists of four multi-sample delay lines,a bubble-proof encoder,an edge controller for managing data from different channels,and a highly effective calibration module that benefits from the SoC architecture.The performance was evaluated with an average RMS precision of 5.51 ps by measuring the time intervals from 0 to 24,000 ps with 120,000 data for every test.The design presented in this study refines the calibration precision of the HIAF timing system.This eliminates the errors caused by manual calibration without efficiency loss and provides data support for fault diagnosis.It can also be easily tailored or ported to other devices for specific applications and provides more space for developing timing systems for particle accelerators,such as white rabbits on HIAF. 展开更多
关键词 HIAF White rabbit Calibration system Time-to-digital converter(TDC)
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Ash removal from inferior coal via ammonium fluoride roasting and simultaneous yield of white carbon black
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作者 Xuqin Duan Shuaiyu Lu +3 位作者 Yuxiao Fu Jiazhe Zhang Tong Liu Jian Ma 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第2期261-279,共19页
The quality upgrading and deashing of inferior coal by chemical method still faces great challenges.The dangers of strong acid,strong alkali,waste water and exhaust gas as well as high cost limit its industrial produc... The quality upgrading and deashing of inferior coal by chemical method still faces great challenges.The dangers of strong acid,strong alkali,waste water and exhaust gas as well as high cost limit its industrial production.This paper systematically investigates the ash reduction and desilicification of two typical inferior coal utilizing ammonium fluoride roasting method.Under the optimal conditions,for fat coal and gas coal,the deashing rates are 69.02%and 54.13%,and the desilicification rates are 92.64%and 90.27%,respectively.The molar dosage of ammonium fluoride remains consistent for both coals;however,the gas coal,characterized by a lower ash and silica content(less than half that of the fat coal),achieves optimum deashing effect at a reduced time and temperature.The majority of silicon in coal transforms into gaseous ammonium fluorosilicate,subsequently preparing nanoscale amorphous silica with a purity of 99.90%through ammonia precipitation.Most of the fluorine in deashed coal are assigned in inorganic minerals,suggesting the possibility of further fluorine and ash removal via flotation.This research provides a green and facile route to deash inferior coal and produce nano-scale white carbon black simultaneously. 展开更多
关键词 Inferior coal Deashing treatment Silicon recycling Ammonium fluoride roasting White carbon black
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Clinical features and possible pathogenesis of multiple evanescent white dot syndrome with different retinal diseases and events:a narrative review
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作者 Chun-Li Chen Yi-Zhe Cheng +2 位作者 Zhi-Han Zhang Ge Wang Xiao-Yan Peng 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第3期583-595,共13页
●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field defects.Many previous studies have explained the possible pathogenesis and clinical features ... ●Multiple evanescent white dot syndrome(MEWDS)is a rare fundus disease,characterized by acute vision loss and visual field defects.Many previous studies have explained the possible pathogenesis and clinical features of primary MEWDS.However,as the number of reported cases increases,secondary MEWDS occurs in other related retinal diseases and injuries,exhibiting some special characteristics.The associated retinal diseases include multifocal choroiditis/punctate inner choroidopathy(MFC/PIC),acute zonal occult outer retinopathy,best vitelliform macular dystrophy,pseudoxanthoma elasticum,and ocular toxoplasmosis.The related retinal injury is laser photocoagulation,surgery,and trauma.Although primary MEWDS often have a self-limiting course,secondary MEWDS may require treatment in some cases,according to the severity of concomitant diseases and complications.Notably,MEWDS secondary to MFC/PIC that is prone to forming choroidal neovascularization and focal choroidal excavation,needs positive treatment with corticosteroids.The possible underlying pathogenesis of secondary MEWDS is the exposure of choroidal antigen after the disruption of Bruch’s membrane.The MEWDS-related features in secondary MEWDS are still evanescent under most circumstances.Its prognosis and treatment depend on the severity of complications.Current studies propose that the etiology is associated with immune factors,including viral infection,inflammation in choroid and Bruch’s membrane,and antigen exposure caused by retinal and/or choroidal insults.More pathogenic studies should be conducted in the future.Accurate diagnosis for secondary MEWDS could benefit patients in aspects of management and prognosis. 展开更多
关键词 multiple evanescent white dot syndrome punctate inner choroidopathy multifocal choroiditis secondary multiple evanescent white dot syndrome
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Barley chitinase genes expression revamp resistance against whitefly (Bemisia Tabaci) in transgenic cotton (Gossypium hirsutum L.)
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作者 BASHIR Samina YAQOOB Amina +7 位作者 BASHIR Rohina BUKHARI Shanila SHAHID Naila AZAM Saira BAKHSH Allah HUSNAIN Tayyab SHAHID Ahmad Ali RAO Abdul Qayyum 《Journal of Cotton Research》 CAS 2024年第1期90-100,共11页
Background Chitinase is an enzyme that hydrolyzes chitin,a major component of the exoskeleton of insects,including plant pests like whiteflies.The present study aimed to investigate the expression of chemically synthe... Background Chitinase is an enzyme that hydrolyzes chitin,a major component of the exoskeleton of insects,including plant pests like whiteflies.The present study aimed to investigate the expression of chemically synthesized barley ch1 and chi2 genes in cotton(Gossypium hirsutum)through Agrobacterium-mediated transformation.Fifty-five putative transgenic cotton plants were obtained,out of which fifteen plants successfully survived and were shifted to the field.Using gene-specific primers,amplification of 447 bp and 401 bp fragments confirmed the presence of the ch1 and chi2 genes in five transgenic cotton plants of the T0 generation.These five plants were further evalu-ated for their mRNA expression levels.The T0 transgenic cotton plants with the highest mRNA expression level and better yield performance in field,were selected to raise their subsequent progenies.Results The T1 cotton plants showed the highest mRNA expression levels of 3.5-fold in P10(2)for the ch1 gene and 3.7-fold in P2(1)for the chi2 gene.Fluorescent in situ hybridization(FISH)confirmed a single copy number of ch1 and chi2(hemizygous)on chromosome no.6.Furthermore,the efficacy of transgenes on whitefly was evaluated through an insect bioassay,where after 96 h of infestation,mortality rates of whitefly were calculated to be 78%–80%in transgenic cotton plants.The number of eggs on transgenic cotton plants were calculated to be 0.1%–0.12 per plant compared with the non-transgenic plants where egg number was calculated to be 0.90–1.00 per plant.Conclusion Based on these findings,it can be concluded that the chemically synthesized barley chitinase genes(ch1 and chi2)have the potential to be effective against insects with chitin exoskeletons,including whiteflies.The transgenic cotton plants expressing these genes showed increased resistance to whiteflies,resulting in reduced egg numbers and higher mortality rates. 展开更多
关键词 CHITINASE Cotton White fly TRANSGENE BIOASSAY
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Finely regulated luminescent Ag-In-Ga-S quantum dots with green-red dual emission toward white light-emitting diodes
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作者 Zhi Wu Leimeng Xu +1 位作者 Jindi Wang Jizhong Song 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第9期54-63,共10页
Ag-In-Ga-S(AIGS)quantum dots(QDs)have recently attracted great interests due to the outstanding optical properties and eco-friendly components,which are considered as an alternative replacement for toxic Pb-and Cd-bas... Ag-In-Ga-S(AIGS)quantum dots(QDs)have recently attracted great interests due to the outstanding optical properties and eco-friendly components,which are considered as an alternative replacement for toxic Pb-and Cd-based QDs.However,enormous attention has been paid to how to narrow their broadband spectra,ignoring the application advantages of the broadband emission.In this work,the AIGS QDs with controllable broad green-red dual-emission are first reported,which is achieved through adjusting the size distribution of QDs by controlling the nucleation and growth of AIGS crystals.Resultantly,the AIGS QDs exhibit broad dual-emission at green-and red-band evidenced by photoluminescence(PL)spectra,and the PL relative intensity and peak position can be finely adjusted.Furthermore,the dual-emission is the intrinsic characteristics from the difference in confinement effect of large particles and tiny particles confirmed by temperature-dependent PL spectra.Accordingly,the AIGS QDs(the size consists of 17 nm and 3.7 nm)with 530 nm and 630 nm emission could successfully be synthesized at 220°C.By combining the blue light-emitting diode(LED)chips and dual-emission AIGS QDs,the constructed white light-emitting devices(WLEDs)exhibit a continuous and broad spectrum like natural sunlight with the Commission Internationale de l’Eclairage(CIE)chromaticity coordinates of(0.33,0.31),a correlated color temperature(CCT)of 5425 K,color rendering index(CRI)of 90,and luminous efficacy of radiation(LER)of 129 lm/W,which indicates that the AIGS QDs have huge potential for lighting applications. 展开更多
关键词 quantum dots Ag-In-Ga-S dual emission white light-emitting diodes
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Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats
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作者 Vahideh Abbasnia Mohsen Foadoddini +2 位作者 Delaram Eslimi Esfahani Mohammad Reza Khazdair Shahrbanoo Oryan 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2024年第3期100-105,共6页
Objective:To evaluate the effect of rosmarinic acid on tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats.Methods:Rats were randomly divided into six groups:the control gr... Objective:To evaluate the effect of rosmarinic acid on tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats.Methods:Rats were randomly divided into six groups:the control group,the asthmatic group,and the asthmatic groups treated with dexamethasone(1 mg/kg;oral gavage)or three doses of rosmarinic acid(0.5,1,and 2 mg/kg;oral gavage).For induction of asthma,rats received intraperitoneal injections and inhalation of ovalbumin.After 21 days,bronchoalveolar lavage fluid and lung samples were collected for histopathological analyses.Moreover,total and differential white blood cell counts were determined.Results:The rosmarinic acid-treated group had significantly lower tracheal smooth muscle responses to methacholine than the asthmatic group.In addition,rosmarinic acid reduced white blood cell count and the percentages of eosinophils,monocytes,and neutrophils while increasing the percentage of lymphocytes.Ovalbumin-induced lung pathological changes were significantly improved by treatment with rosmarinic acid.Conclusions:Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats. 展开更多
关键词 Rosmarinic acid ASTHMA OVALBUMIN Tracheal responsiveness Inflammation White blood cell
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Synergistic effects of the entomopathogenic fungus Isaria javanica and low doses of dinotefuran on the efficient control of the rice pest Sogatella furcifera
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作者 Tingting Zhou Qian Zhao +4 位作者 Chengzhou Li Lu Ye Yanfang Li Nemat OKeyhani Zhen Huang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第2期621-638,共18页
The rice planthopper,Sogatella furcifera,is a piercing-sucking insect pest of rice,Oryza sativa.It is responsible for significant crop yield losses,and has developed moderate to high resistance to several commonly use... The rice planthopper,Sogatella furcifera,is a piercing-sucking insect pest of rice,Oryza sativa.It is responsible for significant crop yield losses,and has developed moderate to high resistance to several commonly used chemical insecticides.We investigated the effects of the insect fungal pathogen Isaria javanica,alone and in combination with the chemical insecticide dinotefuran,on S.furcifera under both laboratory and field conditions.Our results show that I.javanica displays high infection efficiency and mortality for different stages of S.furcifera,reducing adult survival,female oviposition and ovary development.Laboratory bioassays showed that the combined use of I.javanica with a low dose(4-16 mg L^(-1))of dinotefuran resulted in higher mortality in S.furcifera than the use of I.javanica or dinotefuran alone.The combined treatment also had more significant effects on several host enzymes,including superoxide dismutase,catalase,peroxidase,and prophenol oxidase activities.In field trials,I.javanica effectively suppressed populations of rice planthoppers to low levels(22-64%of the level in untreated plots).Additional field experiments showed synergistic effects,i.e.,enhanced efficiency,for the control of S.furcifera populations using the combination of a low dose of I.javanica(1×10^(4) conidia mL^(-1))and a low dose of dinotefuran(~4.8-19.2%of normal field use levels),with control effects of>90%and a population level under 50 insects per 100 hills at 3-14 days post-treatment.Our findings indicate that the entomogenous fungus I.javanica offers an attractive biological control addition as part of the integrated pest management(IPM)practices for the control of rice plant pests. 展开更多
关键词 Isaria javanica Sogatella furcifera entomopathogenic fungus white planthopper RICE synergistic effect on pest control
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MicroRNAs as potential biomarkers for diagnosis of attention deficit hyperactivity disorder
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作者 Bridget Martinez Philip V.Peplow 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期557-562,共6页
Inappropriate levels of hyperactivity,impulsivity,and inattention characterize attention deficit hyperactivity disorder,a common childhood-onset neuropsychiatric disorder.The cognitive function and learning ability of... Inappropriate levels of hyperactivity,impulsivity,and inattention characterize attention deficit hyperactivity disorder,a common childhood-onset neuropsychiatric disorder.The cognitive function and learning ability of children with attention deficit hyperactivity disorder are affected,and these symptoms may persist to adulthood if they are not treated.The diagnosis of attention deficit hyperactivity disorder is only based on symptoms and objective tests for attention deficit hyperactivity disorder are missing.Treatments for attention deficit hyperactivity disorder in children include medications,behavior therapy,counseling,and education services which can relieve many of the symptoms of attention deficit hyperactivity disorder but cannot cure it.There is a need for a molecular biomarker to distinguish attention deficit hyperactivity disorder from healthy subjects and other neurological conditions,which would allow for an earlier and more accurate diagnosis and appropriate treatment to be initiated.Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of attention deficit hyperactivity disorder.The recent studies reviewed had performed microRNA profiling in whole blood,white blood cells,blood plasma,and blood serum of children with attention deficit hyperactivity disorder.A large number of microRNAs were dysregulated when compared to healthy controls and with some overlap between individual studies.From the studies that had included a validation set of patients and controls,potential candidate biomarkers for attention deficit hyperactivity disorder in children could be miR-140-3p,let-7g-5p,-30e-5p,-223-3p,-142-5p,-486-5p,-151a-3p,-151a-5p,and-126-5p in total white blood cells,and miR-4516,-6090,-4763-3p,-4281,-4466,-101-3p,-130a-3p,-138-5p,-195-5p,and-106b-5p in blood serum.Further studies are warranted with children and adults with attention deficit hyperactivity disorder,and consideration should be given to utilizing rat models of attention deficit hyperactivity disorder.Animal studies could be used to confirm microRNA findings in human patients and to test the effects of targeting specific microRNAs on disease progression and behavior. 展开更多
关键词 ADULTS attention deficit hyperactivity disorder biomarkers blood plasma blood serum CHILDREN MICRORNA total white blood cells whole blood
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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage
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作者 Wenjing Ning Shi Lv +1 位作者 Qian Wang Yuzhen Xu 《Neural Regeneration Research》 SCIE CAS 2025年第7期1829-1848,共20页
Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter injury.Microglia,which are the key immune cells... Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter injury.Microglia,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective effects.Increasing evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid hemorrhage.Moreover,microglia play certain neuroprotective roles in the recovery phase of subarachnoid hemorrhage.Several approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage injury.This provides new targets and ideas for the treatment of subarachnoid hemorrhage.However,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still lacking.This review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter lesions.It also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid hemorrhage.Currently,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese medicine.However,most of these are still being evaluated at the laboratory stage.More clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemorrhage. 展开更多
关键词 apoptosis blood–brain barrier brain edema MICROGLIA NEUROINFLAMMATION neuron NEUROPROTECTION subarachnoid hemorrhage VASOCONSTRICTION white matter injury
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Similarities and differences in inherent mechanism and characteristic frequency between the one-dimensional poroelastic model and the layered White model
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作者 Li-Ming Zhao Cai-Ping Lu +1 位作者 Yang Liu Chao-Chao Li 《Petroleum Science》 SCIE EI CAS CSCD 2024年第4期2383-2392,共10页
The similarities and differences in inherent mechanism and characteristic frequency between the onedimensional(1D)poroelastic model and the layered White model were investigated.This investigation was conducted under ... The similarities and differences in inherent mechanism and characteristic frequency between the onedimensional(1D)poroelastic model and the layered White model were investigated.This investigation was conducted under the assumption that the rock was homogenous and isotropic at the mesoscopic scale.For the inherent mechanism,both models resulted from quasi-static flow in a slow P-wave diffusion mode,and the differences between them originated from saturated fluids and boundary conditions.On the other hand,for the characteristic frequencies of the models,the characteristic frequency of the 1D poroelastic model was first modified because the elastic constant and formula for calculating it were misused and then compared to that of the layered White model.Both of them moved towards higher frequencies with increasing permeability and decreasing viscosity and diffusion length.The differences between them were due to the diffusion length.The diffusion length for the 1D poroelastic model was determined by the sample length,whereas that for the layered White model was determined by the length of the representative elementary volume(REV).Subsequently,a numerical example was presented to demonstrate the similarities and differences between the models.Finally,published experimental data were interpreted using the 1D poroelastic model combined with the Cole-Cole model.The prediction of the combined model was in good agreement with the experimental data,thereby validating the effectiveness of the 1D poroelastic model.Furthermore,the modified characteristic frequency in our study was much closer to the experimental data than the previous prediction,validating the effectiveness of our modification of the characteristic frequency of the 1D poroelastic model.The investigation provided insight into the internal relationship between wave-induced fluid flow(WIFF)models at macroscopic and mesoscopic scales and can aid in a better understanding of the elastic modulus dispersion and attenuation caused by the WIFF at different scales. 展开更多
关键词 1D poroelastic model Layered White model Quasi-static flow Slow P-wave diffusion Characteristic frequency Diffusion length
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Measurement of the neutron-induced total cross sections of ^(nat)Pb from 0.3 eV to 20 MeV on the Back-n at CSNS
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作者 Jie-Ming Xue Song Feng +14 位作者 Yong-Hao Chen Han Yi Min Xiao Pin-Jing Cheng Xin-Xiang Li Rong Liu Yi-Wei Yang Zi-Jie Han Da-Jun Zhao Hao-Qiang Wang Bao-Qian Li Ji-Rong Zhao Lei-Xun Tang Wen Luo Bo Zheng 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第2期85-93,共9页
The neutron-induced total cross sections of natural lead have been measured in a wide energy range(0.3 eV-20 MeV)on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron Source.Neutron energ... The neutron-induced total cross sections of natural lead have been measured in a wide energy range(0.3 eV-20 MeV)on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron Source.Neutron energy was determined by the neutron total cross-section spectrometer using the time-of-flight technique.A fast multi-cell fission chamber was used as the neutron detector,and a 10-mm-thick high-purity natural lead sample was employed for the neutron transmission measurements.The on-beam background was determined using Co,In,Ag,and Cd filters.The excitation function of ^(nat)Pb(n,tot)reaction below 20 MeV was calculated using the TALYS-1.96 nuclear-reaction modeling program.The present results were compared with previous results,the evaluated data available in the five major evaluated nuclear data libraries(i.e.,ENDF/B-VIII.0,JEFF-3.3,JENDL-5,CENDL-3.2,and BROND-3.1),and the theoretical calculation curve.Good agreement was found between the new results and those of previous experiments and with the theoretical curves in the corresponding region.This measurement obtained the neutron total cross section of natural lead with good accuracy over a wide energy range and added experimental data in the resonance energy range.This provides more reliable experimental data for nuclear engineering design and nuclear data evaluation of lead. 展开更多
关键词 Neutron-induced total cross section Natural lead TIME-OF-FLIGHT TALYS-1.96 CSNS Back-n white neutron beamline
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White Matter Lesions in Young-Middle Aged Migraineurs with Patent Foreman Ovale: A Case-Control Study
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作者 Yang Hua Jinyu Sun +3 位作者 Yuxuan Lou Hao Zhang Jing Shi Wei Sun 《Congenital Heart Disease》 SCIE 2024年第3期279-291,共13页
Background:White matter lesion(WML)is common in aging brain and is associated with cognitive impairment and dementia.However,recent studies reported an association between patent foramen ovale(PFO)and WML in migraineu... Background:White matter lesion(WML)is common in aging brain and is associated with cognitive impairment and dementia.However,recent studies reported an association between patent foramen ovale(PFO)and WML in migraineurs,especially in young,middle-aged migraineurs.Our retrospective,case-control study aims to describe the clinical characteristics of WML in this population and to explore potential risk factors.Methods:226 patients with migraine and PFO were consecutively initially screened.Relevant factors were selected by the least absolute shrinkage and selection operator(LASSO)regression and multivariable logistic regression model.A Nomogram was employed to visualize the prediction model conveniently.The discrimination and calibration abilities were evaluated using the Receiver Operating Characteristic(ROC)curve,the Hosmer-Lemeshow test,and calibration curves.Results:One hundred and nineteen participants were ultimately enrolled in our study,with a median age of 36.9±12.7 years and 80.7%of females.Brain magnetic resonance imaging MRI showed 67(56.3%)patients had WML,whereas 52(43.7%)patients were categorized into the non-WML group.LASSO regression screened out potential variables and subsequent multivariate analysisfinally identified age,mean platelet volume,andfibri-nogen(FIB)as independent predictive factors of WML.The area under the ROC curve(AUC)was 0.807.Hos-mer-Lemeshow test and calibration curve verified a consistency between the predicted and actual probability.Conclusion:The predictive nomogram established and validated in our study may assist clinicians in screening WML among young middle-aged migraineurs with PFO and developing individualized preventive and treatment strategies. 展开更多
关键词 White matter lesion MIGRAINE patent foreman ovale NOMOGRAM predictive model
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