The present study was aimed to examine changes of extracellular concentration of dopamin e and its metabolite homovanillic acid in the striatum, the periaqueductal gray matter and the dorsal horn of lumbar spinal cord...The present study was aimed to examine changes of extracellular concentration of dopamin e and its metabolite homovanillic acid in the striatum, the periaqueductal gray matter and the dorsal horn of lumbar spinal cord following intraplantar injecti on of ca rrageenan. In vivo microdialysis and high performance liquid chromatography wit h electrochemical detection were performed. The results showed that intraplantar injection of carrageenan significantly increased dopamine or homovanillic acid l evels in the different central regions. The present study suggested that the cen tral dopamine system (at least including ascending nigrostriatal pathway and des cending A 11 --the dorsal horn fibers) could be activated following intrap lantar injection of carrageenan, while the resultant activation probably mediate d antinociception.展开更多
Fragile X syndrome （FXS） is the most common form of inherited mental retardation, characterized by moderate-to- severe mental retardation, attention deficits, and hyperactivity. This disease results from the expansi...Fragile X syndrome （FXS） is the most common form of inherited mental retardation, characterized by moderate-to- severe mental retardation, attention deficits, and hyperactivity. This disease results from the expansion of a trinucleotide repeat （CGG） within the X-linked fragile X mental retardation l （FMR1） gene, which leads to the lack of the product of the FMR1 gene--fragile X mental retardation protein. Many mental disorders such as FXS and Rett syndrome are thought to originate during early developmental period, but recent findings have suggested the involvement of the processes in the adult nervous system. Here we outline our recent studies and initial clinical trials that may provide an approach to treat FXS in the adulthood.展开更多
文摘The present study was aimed to examine changes of extracellular concentration of dopamin e and its metabolite homovanillic acid in the striatum, the periaqueductal gray matter and the dorsal horn of lumbar spinal cord following intraplantar injecti on of ca rrageenan. In vivo microdialysis and high performance liquid chromatography wit h electrochemical detection were performed. The results showed that intraplantar injection of carrageenan significantly increased dopamine or homovanillic acid l evels in the different central regions. The present study suggested that the cen tral dopamine system (at least including ascending nigrostriatal pathway and des cending A 11 --the dorsal horn fibers) could be activated following intrap lantar injection of carrageenan, while the resultant activation probably mediate d antinociception.
基金supported by the National Natural Science Foundation of China (No. 30670684,30770686)
文摘Fragile X syndrome （FXS） is the most common form of inherited mental retardation, characterized by moderate-to- severe mental retardation, attention deficits, and hyperactivity. This disease results from the expansion of a trinucleotide repeat （CGG） within the X-linked fragile X mental retardation l （FMR1） gene, which leads to the lack of the product of the FMR1 gene--fragile X mental retardation protein. Many mental disorders such as FXS and Rett syndrome are thought to originate during early developmental period, but recent findings have suggested the involvement of the processes in the adult nervous system. Here we outline our recent studies and initial clinical trials that may provide an approach to treat FXS in the adulthood.
