据调查,痔疮在人群中的平均发病率达到40%左右,是影响人们生活、工作与肛功能健康的重要疾病,故而该病备受患者与临床医学关注。手术为重度痔疮疾病的首选疗法,其中,外剥内扎术和21世纪推广于我国的吻合器痔上黏膜环切术（procedure for...据调查,痔疮在人群中的平均发病率达到40%左右,是影响人们生活、工作与肛功能健康的重要疾病,故而该病备受患者与临床医学关注。手术为重度痔疮疾病的首选疗法,其中,外剥内扎术和21世纪推广于我国的吻合器痔上黏膜环切术（procedure for prolapse hemorrhoids,PPH）均为疗效确切的常用术式,为比较二者的临床实践使用情况,现选择116例Ⅲ~Ⅳ期重度痔疮症患者给予不同手术,现报告如下。展开更多
A major susceptibility gene for psoriasis is located in the major histocompatibility complex class I region on chromosome 6 very close to the HLA-Cw6 gene. We collected a cohort of 1,019 patients with chronic plaque p...A major susceptibility gene for psoriasis is located in the major histocompatibility complex class I region on chromosome 6 very close to the HLA-Cw6 gene. We collected a cohort of 1,019 patients with chronic plaque psoriasis. The patients were typed for HLA-C and HLA-B. A total of 654 (64.2%) were HLA-Cw*0602 positive but 365 (35.8%) carried other HLA-C alleles. We confirmed that HLA-Cw*0602 positive patients have younger age of onset (17.5 vs 24.3 years, P< 10-10), higher incidence of guttate and the eruptive type of psoriasis (P< 0.0001), more frequent exacerbations with throat infections (P=0.01), higher incidence of the Koebner’s phenomenon (P=0.01), and more extensive disease (P=0.03). A striking new finding was a diverging pattern of disease severity in HLACw*0602 positive and negative patients depending on the age of onset of the disease (P=0.0006). HLA-Cw*0602 positive women also had more frequent remissions during pregnancy (P< 0.0001). All types of nail changes were, however, more common in the Cw*0602 negative patients (P=0.003) and they more often had multiple types of nail lesions (P< 0.0001). The three ancestral haplotypes of Cw*0602 all conferred an increase in odds ratio but showed no difference in any of the clinical features studied. Our findings indicate that the genetic factor on chromosome 6 has a strong influence on the phenotype of the disease, and underline that differences in clinical features of psoriasis may be to a large extent genetically determined.展开更多
文摘据调查,痔疮在人群中的平均发病率达到40%左右,是影响人们生活、工作与肛功能健康的重要疾病,故而该病备受患者与临床医学关注。手术为重度痔疮疾病的首选疗法,其中,外剥内扎术和21世纪推广于我国的吻合器痔上黏膜环切术（procedure for prolapse hemorrhoids,PPH）均为疗效确切的常用术式,为比较二者的临床实践使用情况,现选择116例Ⅲ~Ⅳ期重度痔疮症患者给予不同手术,现报告如下。
文摘A major susceptibility gene for psoriasis is located in the major histocompatibility complex class I region on chromosome 6 very close to the HLA-Cw6 gene. We collected a cohort of 1,019 patients with chronic plaque psoriasis. The patients were typed for HLA-C and HLA-B. A total of 654 (64.2%) were HLA-Cw*0602 positive but 365 (35.8%) carried other HLA-C alleles. We confirmed that HLA-Cw*0602 positive patients have younger age of onset (17.5 vs 24.3 years, P< 10-10), higher incidence of guttate and the eruptive type of psoriasis (P< 0.0001), more frequent exacerbations with throat infections (P=0.01), higher incidence of the Koebner’s phenomenon (P=0.01), and more extensive disease (P=0.03). A striking new finding was a diverging pattern of disease severity in HLACw*0602 positive and negative patients depending on the age of onset of the disease (P=0.0006). HLA-Cw*0602 positive women also had more frequent remissions during pregnancy (P< 0.0001). All types of nail changes were, however, more common in the Cw*0602 negative patients (P=0.003) and they more often had multiple types of nail lesions (P< 0.0001). The three ancestral haplotypes of Cw*0602 all conferred an increase in odds ratio but showed no difference in any of the clinical features studied. Our findings indicate that the genetic factor on chromosome 6 has a strong influence on the phenotype of the disease, and underline that differences in clinical features of psoriasis may be to a large extent genetically determined.
