Eu^(3+)和Al^(3+)离子对DPPC人工膜脂双层主相变温度的影响

天然生物膜组成复杂，直接用于研究困难较大．由于天然生物膜中脂分子的行为与人工脂双层膜的行为十分类似，故我们用单一磷脂制备人工脂双层膜来研究金属离子对其主相变温度的影响．膜的动力学性质依靠膜平面内的液体环境，决定膜流动性的膜成分是磷脂分子．磷脂的重要性...

Eu^(3+)对DMPC人工膜脂双层主相变温度的影响

利用付里叶变温红外光谱和核磁共振谱研究了Ｅｕ３＋离子与人膜ＤＭＰＣ脂双层配位作用的影响，实验发现Ｅｕ３＋离子对ＤＭＰＣ脂双层影响不局限于界面区域，而且扩展到整个酰基链，因而使ＤＭＰＣ脂双层的主相变温度提高了６℃。

Surface properties of encapsulating hydrophobic nanoparticles regulate the main phase transition temperature of lipid bilayers： A simulation study

The main phase transition temperature of a lipid membrane, which is vital for its biomedical applications such as controllable drug release, can be regulated by encapsulating hydrophobic nanoparticles into the membrane. However, the exact relationship between surface properties of the encapsulating nanoparticles and the main phase transition temperature of a lipid membrane is far from clear. In the present work we performed coarse-grained molecular dynamics simulations to meet this end. The results show the surface roughness of nanoparticles and the density of surface-modifying molecules on the nanoparticles are responsible for the regulation. Increasing the surface roughness of the nanoparticles increases the main phase transition temperature of the lipid membrane, whereas it can be decreased in a nonlinear way via increasing the density of surface-modifying molecules on the nanoparticles. The results may provide insights for understanding recent experimental studies and promote the applications of nanoparticles in controllable drug release by regulating the main phase transition temperature of lipid vesicles.