An optically active rod coil rod triblock copolymer containing poly(ethylene oxide)(PEO) as the flexible segment and poly{(+) 2,5 bis[4′ ((s) 2 methyl butoxy) phenyl]styrene} (PMBPS) as the rigid segment,PMBPS b PEO ...An optically active rod coil rod triblock copolymer containing poly(ethylene oxide)(PEO) as the flexible segment and poly{(+) 2,5 bis[4′ ((s) 2 methyl butoxy) phenyl]styrene} (PMBPS) as the rigid segment,PMBPS b PEO b PMBPS,was synthesized via atom transfer radical polymerization.The PMBPS block had a stable helical conformation with an excess of screw sense in solution.The self assembly behavior of the triblock copolymer in dioxane/water mixed solvents was examined by means of TEM and turbidity measurements.The triblock copolymer molecules aggregated when water content in the system was about 2wt%. The higher the initial polymer concentrations,the lower the critical water content.They formed vesicles with highly dispersed outside diameters,but they had a relatively uniform wall thickness of (27±3) nm.展开更多
以3,4-二羟基苯丙烯酸（咖啡酸）为原料,经酯化和仿生氧化偶联反应得到苯并呋喃类化合物2-（3′,4′-二羟基苯基）-3-甲氧羰基-5-甲氧羰基乙烯基-7-羟基-2,3-二氢苯并呋喃（1）和苯并二氧六环类化合物2-（3′,4′-二羟基苯基）-3-甲氧羰...以3,4-二羟基苯丙烯酸（咖啡酸）为原料,经酯化和仿生氧化偶联反应得到苯并呋喃类化合物2-（3′,4′-二羟基苯基）-3-甲氧羰基-5-甲氧羰基乙烯基-7-羟基-2,3-二氢苯并呋喃（1）和苯并二氧六环类化合物2-（3′,4′-二羟基苯基）-3-甲氧羰基-6-甲氧羰基乙烯基-2,3-二氢-1,4-苯并二氧六环（2）,然后经乙酰化、DDQ氧化脱氢、Pd/C 催化氢化、氢化铝锂还原、碱性条件下脱乙酰基等反应,合成了一系列苯并呋喃新木脂素类化合物3~7和苯并二氧六环新木脂素类化合物8~10.所合成化合物的结构已由核磁共振法（1 H NMR,13 C NMR）、质谱法（MS）进行了表征.其中5~7,9和10是未见文献报道的新化合物,8为天然产物异美商陆醇A.采用MTT法对所合成的苯并呋喃新木脂素类化合物1,3~5进行了生物活性测试.结果表明：化合物1,3,4和5对白血病细胞（HL-60）、肺癌细胞（A-549）、乳腺癌细胞（MCF-7）、结肠癌细胞（SW-480）、肝癌细胞（SMMC-7721）有良好的体外生长抑制活性.展开更多
An enantioselective and regioselective total synthesis approach to chiral 1,4-benzodioxane lignans(2R,3R)- and (2S,3S)-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyde was reported firstly.
文摘An optically active rod coil rod triblock copolymer containing poly(ethylene oxide)(PEO) as the flexible segment and poly{(+) 2,5 bis[4′ ((s) 2 methyl butoxy) phenyl]styrene} (PMBPS) as the rigid segment,PMBPS b PEO b PMBPS,was synthesized via atom transfer radical polymerization.The PMBPS block had a stable helical conformation with an excess of screw sense in solution.The self assembly behavior of the triblock copolymer in dioxane/water mixed solvents was examined by means of TEM and turbidity measurements.The triblock copolymer molecules aggregated when water content in the system was about 2wt%. The higher the initial polymer concentrations,the lower the critical water content.They formed vesicles with highly dispersed outside diameters,but they had a relatively uniform wall thickness of (27±3) nm.
文摘以3,4-二羟基苯丙烯酸（咖啡酸）为原料,经酯化和仿生氧化偶联反应得到苯并呋喃类化合物2-（3′,4′-二羟基苯基）-3-甲氧羰基-5-甲氧羰基乙烯基-7-羟基-2,3-二氢苯并呋喃（1）和苯并二氧六环类化合物2-（3′,4′-二羟基苯基）-3-甲氧羰基-6-甲氧羰基乙烯基-2,3-二氢-1,4-苯并二氧六环（2）,然后经乙酰化、DDQ氧化脱氢、Pd/C 催化氢化、氢化铝锂还原、碱性条件下脱乙酰基等反应,合成了一系列苯并呋喃新木脂素类化合物3~7和苯并二氧六环新木脂素类化合物8~10.所合成化合物的结构已由核磁共振法（1 H NMR,13 C NMR）、质谱法（MS）进行了表征.其中5~7,9和10是未见文献报道的新化合物,8为天然产物异美商陆醇A.采用MTT法对所合成的苯并呋喃新木脂素类化合物1,3~5进行了生物活性测试.结果表明：化合物1,3,4和5对白血病细胞（HL-60）、肺癌细胞（A-549）、乳腺癌细胞（MCF-7）、结肠癌细胞（SW-480）、肝癌细胞（SMMC-7721）有良好的体外生长抑制活性.
文摘An enantioselective and regioselective total synthesis approach to chiral 1,4-benzodioxane lignans(2R,3R)- and (2S,3S)-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-1,4-benzodioxan-6-carbaldehyde was reported firstly.
