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侵袭性催乳素垂体瘤经内镜切除术后早期催乳素缓解因素分析
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作者 董峻东 裴玉康 +4 位作者 纪培志 苗发安 张慧 张桐 范月超 《徐州医科大学学报》 CAS 2024年第3期169-174,共6页
目的 探讨侵袭性催乳素垂体瘤经内镜切除术后早期催乳素缓解的影响因素。方法 回顾性收集2017年1月至2022年12月徐州医科大学附属医院经内镜下行垂体病损切除手术的141例侵袭性催乳素垂体瘤患者的临床资料,根据术后2周催乳素水平,分为... 目的 探讨侵袭性催乳素垂体瘤经内镜切除术后早期催乳素缓解的影响因素。方法 回顾性收集2017年1月至2022年12月徐州医科大学附属医院经内镜下行垂体病损切除手术的141例侵袭性催乳素垂体瘤患者的临床资料,根据术后2周催乳素水平,分为术后早期缓解组与未缓解组。采用单因素分析2组患者的临床资料,并采用多因素logistic回归对术后早期催乳素缓解的独立预测因素进行分析。结果 在141例手术治疗的侵袭性催乳素垂体瘤患者中,有121例(85.82%)患者获得早期缓解,20例(14.18%)未缓解。早期缓解组与未缓解组在性别、肿瘤大小、肿瘤切除程度、术前催乳素水平、术后首日催乳素水平方面比较,差异具有统计学意义(P<0.05)。多因素logistic回归分析显示侵袭性催乳素垂体瘤术后首日催乳素水平是影响术后早期催乳素缓解的独立预测因素。结论 侵袭性催乳素垂体瘤的患者中,满足术后首日催乳素水平达到正常值的因素,且肿瘤侵袭性越低,肿瘤直径越小,术前测定催乳素<200μg/L,通过经神经内镜下手术治疗,做到肿瘤完全切除,患者术后2周催乳素水平更易达到早期缓解。 展开更多
关键词 催乳素垂体瘤 早期缓解 内镜手术 催乳素水平 多变量分析
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Expression of Prolactin Gene in Rat Prolactinoma Induced by 17-β-Estradiol
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作者 许荣焜 郭传海 +3 位作者 黄曼影 韩小四 周远征 单惠敏 《Developmental and Reproductive Biology》 1995年第2期46-52,共7页
Rats were implanted subcutaneously with silastic capsules containing 10 mg 17-β-estradiol. After 30, 60 and 120 days, their pituitary weights and plasma PRL levels were found to increase significantly. The administra... Rats were implanted subcutaneously with silastic capsules containing 10 mg 17-β-estradiol. After 30, 60 and 120 days, their pituitary weights and plasma PRL levels were found to increase significantly. The administration of β-estradiol also produced a marked rise of PRL mRNA concentrations in the rat total RNA, but the sharper rise of serum PRL levels indicates that estradiol not only promotes transcription of prolactin gene, but also improves the efficiency of translation of the transcription product. 展开更多
关键词 ESTRADIOL PROLACTINOMA Prolactin Gene expression
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Pituitary prolactin adenoma with Toxoplasma gondii infection
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作者 张晓晖 李青 +2 位作者 程虹 阎庆国 黄高昇 《Journal of Medical Colleges of PLA(China)》 CAS 2003年第1期48-50,共3页
Objective: To report two recent cases of pituitary adenoma associated with Toxoplasma gondii (T.Gondii) infection.Methods: Histological changes were observed in H & E and PAS staining sections microscopically.Immu... Objective: To report two recent cases of pituitary adenoma associated with Toxoplasma gondii (T.Gondii) infection.Methods: Histological changes were observed in H & E and PAS staining sections microscopically.Immunohistochemistry was performed to classify the pituitary tumors and to confirm the diagnosis of T.gondii.Results: The cases were 43- and 19-year-old females, in which the latter one was a recurring case, and radiology examination showed that tumors existed in sellar region.Microscopically, the tumors consisted of small homogenous polygonal or round cells with abundant eosinophilic granular cytoplasm.Immunohistochemistry revealed they were prolactin-producing adenomas.Interestingly, we found toxoplasma infection in the tumor tissues, being confirmed by T.gondii sepicific antibody immunohistochemistry.Conclusion: The association of pituitary adenoma with toxoplasma raises the possibility that T.gondii may be involved in the development of certain cases of pituitary adenoma. 展开更多
关键词 pituitary adenoma Toxoplasma gondii ETIOLOGY
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