Based on a macroscopic mean-field model associating with the thalamus and cerebral cortex, we investigate how the newly proposed coordinated reset stimulation(CRS) strategy controls the absence seizures as some key pa...Based on a macroscopic mean-field model associating with the thalamus and cerebral cortex, we investigate how the newly proposed coordinated reset stimulation(CRS) strategy controls the absence seizures as some key parameters are changed.Different from the previous stimulation processes, CRS represents the intermittent pulse current administered to different structures including cortex, specific relay nuclei(SRN) and thalamus reticular nucleus(TRN) at different time by using three different micro-electrodes. In particular, we first simulate a typical absence epilepsy activity under the combined effect of the coupling strength between inhibitory interneurons(IIN)-excitatory pyramidal neurons(EPN) and EPN-TRN pathway. And then we explore the control mechanism of different parameters of 3:2 ON-OFF CRS on spike and slow-wave discharges(SWDs)region. Through analyzing the corresponding two-dimensional bifurcation diagrams, we find CRS is effective on controlling absence seizures in proper ranges of stimulation parameters. Especially, the combination of frequency and positive input duration can inhibit the pathological area more effectively. The obtained results might be helpful to study the pathophysiology mechanism of epilepsy, although the CRS's feasibility still needs further exploration in clinical experiments.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.11325208 and 11572015)
文摘Based on a macroscopic mean-field model associating with the thalamus and cerebral cortex, we investigate how the newly proposed coordinated reset stimulation(CRS) strategy controls the absence seizures as some key parameters are changed.Different from the previous stimulation processes, CRS represents the intermittent pulse current administered to different structures including cortex, specific relay nuclei(SRN) and thalamus reticular nucleus(TRN) at different time by using three different micro-electrodes. In particular, we first simulate a typical absence epilepsy activity under the combined effect of the coupling strength between inhibitory interneurons(IIN)-excitatory pyramidal neurons(EPN) and EPN-TRN pathway. And then we explore the control mechanism of different parameters of 3:2 ON-OFF CRS on spike and slow-wave discharges(SWDs)region. Through analyzing the corresponding two-dimensional bifurcation diagrams, we find CRS is effective on controlling absence seizures in proper ranges of stimulation parameters. Especially, the combination of frequency and positive input duration can inhibit the pathological area more effectively. The obtained results might be helpful to study the pathophysiology mechanism of epilepsy, although the CRS's feasibility still needs further exploration in clinical experiments.
