目的了解动脉硬度指数(ASI)能否检测动脉硬化早期与血管内皮功能的关系。方法用 YF-1血管硬度测量仪测量61例高血压病人的 ASI,并用高频超声测量其肱动脉血流介导的血管扩张反应(FMD)和硝酸甘油诱导的血管舒张功能(NID)。结果 ASI 与 F...目的了解动脉硬度指数(ASI)能否检测动脉硬化早期与血管内皮功能的关系。方法用 YF-1血管硬度测量仪测量61例高血压病人的 ASI,并用高频超声测量其肱动脉血流介导的血管扩张反应(FMD)和硝酸甘油诱导的血管舒张功能(NID)。结果 ASI 与 FMD 呈负相关:r=-0.340(P<0.01),ASI 中度升高组和重度升高组的 FMD 值低于正常组(P<0.05)。ASI 正常组、轻度升高组、中度升高组和重度升高组的 NID 差别不大(P>0.05)。结论 ASI 是一个早期发现动脉硬化的指标。展开更多
目的:探讨动脉硬度指数(Arterial stiffness index ASI)与冠状动脉粥样硬化程度的相关性。方法:396例行冠状动脉造影的患者,采用CardioVision MS-2000动脉硬度测量仪测定ASI作为反映动脉弹性的指标。根据ASI水平分为三组:Ⅰ组(ASI0-70,...目的:探讨动脉硬度指数(Arterial stiffness index ASI)与冠状动脉粥样硬化程度的相关性。方法:396例行冠状动脉造影的患者,采用CardioVision MS-2000动脉硬度测量仪测定ASI作为反映动脉弹性的指标。根据ASI水平分为三组:Ⅰ组(ASI0-70,186例),Ⅱ组(ASI71￣140,108例),Ⅲ组(ASI>140,102例)。冠状动脉病变严重程度用冠脉病变支数来评价。结果:三组间年龄、高血压史、糖尿病史、收缩压及冠状动脉病变严重程度有显著的差别,平均病变血管支数Ⅲ组>Ⅱ组>Ⅰ组(P<0.05)。单因素相关分析显示,年龄、收缩压、高血压史、糖尿病史、脂蛋白(a)、尿酸、ASI与病变血管支数呈正相关,高密度脂蛋白胆固醇与病变血管支数呈负相关(P<0.05)。多因素Logistic回归分析结果表明ASI、高密度脂蛋白胆固醇、脂蛋白a是冠心病的独立相关因素。结论:ASI是一种评价动脉弹性功能的良好指标,可以提供冠状动脉病变严重程度的信息。展开更多
Background and objective： Non-alcoholic fatty liver disease（NAFLD） is associated with arterial stiffness in the general population. Age, obesity, hypertension, and diabetics are risk factors for arterial stiffness....Background and objective： Non-alcoholic fatty liver disease（NAFLD） is associated with arterial stiffness in the general population. Age, obesity, hypertension, and diabetics are risk factors for arterial stiffness. In this study, we aimed to investigate the association between NAFLD and arterial stiffness as measured by brachial-ankle pulse wave velocity（baPWV） in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population. Methods： A cross-sectional study with 1296 non-obese, non-hypertensive, and non-diabetic young and middle-aged（20–65 years） subjects undergoing routine medical check-ups in the International Health Care Center of the Second Affiliated Hospital of School of Medicine of Zhejiang University was carried out. Fatty liver was diagnosed by ultrasonography, and baPWV was measured using an automatic waveform analyzer. The subjects were classified into two groups according to the presence of NAFLD, and divided into a further two groups according to their baPWV. Results： The overall incidence of NAFLD was 19.0%, and NAFLD patients had a significantly higher level of baPWV than the controls（（1321±158） cm/s vs.（1244±154） cm/s; P〈0.001）. The incidence of NAFLD was clearly higher in the increased baPWV group than in the normal baPWV group（29.3% vs. 16.9%; P〈0.001）, and the incidence increased in line with the increase of baPWV quartiles in the normal range as well as with the severity of arterial stiffness（both P for trend 〈0.001）. Multiple linear logistic regression analysis showed that the presence of NAFLD was positively and independently associated with baPWV. Conclusions： Our results suggest that the presence of NAFLD is associated with arterial stiffness as measured by baPWV in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population.展开更多
文摘目的了解动脉硬度指数(ASI)能否检测动脉硬化早期与血管内皮功能的关系。方法用 YF-1血管硬度测量仪测量61例高血压病人的 ASI,并用高频超声测量其肱动脉血流介导的血管扩张反应(FMD)和硝酸甘油诱导的血管舒张功能(NID)。结果 ASI 与 FMD 呈负相关:r=-0.340(P<0.01),ASI 中度升高组和重度升高组的 FMD 值低于正常组(P<0.05)。ASI 正常组、轻度升高组、中度升高组和重度升高组的 NID 差别不大(P>0.05)。结论 ASI 是一个早期发现动脉硬化的指标。
文摘目的:探讨动脉硬度指数(Arterial stiffness index ASI)与冠状动脉粥样硬化程度的相关性。方法:396例行冠状动脉造影的患者,采用CardioVision MS-2000动脉硬度测量仪测定ASI作为反映动脉弹性的指标。根据ASI水平分为三组:Ⅰ组(ASI0-70,186例),Ⅱ组(ASI71￣140,108例),Ⅲ组(ASI>140,102例)。冠状动脉病变严重程度用冠脉病变支数来评价。结果:三组间年龄、高血压史、糖尿病史、收缩压及冠状动脉病变严重程度有显著的差别,平均病变血管支数Ⅲ组>Ⅱ组>Ⅰ组(P<0.05)。单因素相关分析显示,年龄、收缩压、高血压史、糖尿病史、脂蛋白(a)、尿酸、ASI与病变血管支数呈正相关,高密度脂蛋白胆固醇与病变血管支数呈负相关(P<0.05)。多因素Logistic回归分析结果表明ASI、高密度脂蛋白胆固醇、脂蛋白a是冠心病的独立相关因素。结论:ASI是一种评价动脉弹性功能的良好指标,可以提供冠状动脉病变严重程度的信息。
文摘Background and objective： Non-alcoholic fatty liver disease（NAFLD） is associated with arterial stiffness in the general population. Age, obesity, hypertension, and diabetics are risk factors for arterial stiffness. In this study, we aimed to investigate the association between NAFLD and arterial stiffness as measured by brachial-ankle pulse wave velocity（baPWV） in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population. Methods： A cross-sectional study with 1296 non-obese, non-hypertensive, and non-diabetic young and middle-aged（20–65 years） subjects undergoing routine medical check-ups in the International Health Care Center of the Second Affiliated Hospital of School of Medicine of Zhejiang University was carried out. Fatty liver was diagnosed by ultrasonography, and baPWV was measured using an automatic waveform analyzer. The subjects were classified into two groups according to the presence of NAFLD, and divided into a further two groups according to their baPWV. Results： The overall incidence of NAFLD was 19.0%, and NAFLD patients had a significantly higher level of baPWV than the controls（（1321±158） cm/s vs.（1244±154） cm/s; P〈0.001）. The incidence of NAFLD was clearly higher in the increased baPWV group than in the normal baPWV group（29.3% vs. 16.9%; P〈0.001）, and the incidence increased in line with the increase of baPWV quartiles in the normal range as well as with the severity of arterial stiffness（both P for trend 〈0.001）. Multiple linear logistic regression analysis showed that the presence of NAFLD was positively and independently associated with baPWV. Conclusions： Our results suggest that the presence of NAFLD is associated with arterial stiffness as measured by baPWV in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population.
