Five patients (4 males; mean age, 46.4 years) with pain-ful verrucous perianal lesions caused by herpes simplex virus are described. All patients had had AIDS for a long time and were using highly active antiretrovira...Five patients (4 males; mean age, 46.4 years) with pain-ful verrucous perianal lesions caused by herpes simplex virus are described. All patients had had AIDS for a long time and were using highly active antiretroviral therapy. CD4+ counts ranged from 73 to 370/mm3. All lesions were submitted to resection under subdural anesthesia. Histologic examinations revealed epithelial hyperplasia and dense inflammatory process, composed mainly of lymphocytes and plasma cells, extended just to the hypodermis. Immunohistochemistry was positive for herpes simplex virus Type 2 in four patients and for herpes simplex virus Type 1 in one patient, and did not detect human papillomavirus antigens. Three patients had recurrences after 3, 10, and 12 months. Resection was performed on two patients; one had a new recurrence after three months. Oral acyclovir eliminated the lesion in the third patient. The analysis of our patients suggests that herpes simplex virus, Types 1 and 2, may cause verrucous lesions simulating neoplasia in patients with AIDS using antiretroviral therapy.展开更多
最新的两项研究结果显示,两种疫苗有助于妇女对性传播疾病(STDs)和宫颈癌的预防。研究人员在随机的双盲对照试验中发现,人乳头状瘤病毒(HPV)-16疫苗对此前未曾暴露过的妇女的预防效果可高达100％。 Laura A.Koutsky及其同事进行的研究表...最新的两项研究结果显示,两种疫苗有助于妇女对性传播疾病(STDs)和宫颈癌的预防。研究人员在随机的双盲对照试验中发现,人乳头状瘤病毒(HPV)-16疫苗对此前未曾暴露过的妇女的预防效果可高达100％。 Laura A.Koutsky及其同事进行的研究表明,经HPV-16疫苗处理后。展开更多
文摘Five patients (4 males; mean age, 46.4 years) with pain-ful verrucous perianal lesions caused by herpes simplex virus are described. All patients had had AIDS for a long time and were using highly active antiretroviral therapy. CD4+ counts ranged from 73 to 370/mm3. All lesions were submitted to resection under subdural anesthesia. Histologic examinations revealed epithelial hyperplasia and dense inflammatory process, composed mainly of lymphocytes and plasma cells, extended just to the hypodermis. Immunohistochemistry was positive for herpes simplex virus Type 2 in four patients and for herpes simplex virus Type 1 in one patient, and did not detect human papillomavirus antigens. Three patients had recurrences after 3, 10, and 12 months. Resection was performed on two patients; one had a new recurrence after three months. Oral acyclovir eliminated the lesion in the third patient. The analysis of our patients suggests that herpes simplex virus, Types 1 and 2, may cause verrucous lesions simulating neoplasia in patients with AIDS using antiretroviral therapy.
