AIM:To explain the role of Monocyte chemotactic protein-1 (MCP-1) and soluble adhesion molecules in chronic hepatitis C during the treatment of interferon alpha (IFNα) 2 b and ribavirin (RBV). METHODS:Concentrations ...AIM:To explain the role of Monocyte chemotactic protein-1 (MCP-1) and soluble adhesion molecules in chronic hepatitis C during the treatment of interferon alpha (IFNα) 2 b and ribavirin (RBV). METHODS:Concentrations of MCP-1,soluble adhesion molecules intercellular adhesion molecule-1 (sICAM-1),sP- selectin,interleukin (IL) 6,and IL10 in serum were estimated in the group of 40 patients with chronic hepatitis C treated with IFNalpha2 b and RBV in 0,16,32,48 wk of the therapy, RESULTS:In chronic hepatitis C,before and during the treatment,the serum levels of MCP-1 and sP-selectin in responders were similar to those of healthy subjects.In non- responders (NR),MCP-1 increased in the course of IFNc^+RBV treatment,differences were statistically significant as compared to responders.MCP-1 correlated statistically with the activity of periportal inflammation (r=0.35,P<0.05) but not with staging of liver fibrosis,sICAM-1 positively correlated with inflammatory activity and fibrosis in NR.sP-selectin did not correlate with histological findings in the liver.The MCP-1 correlated with the soluble form of sP-selectin concentrations (r= 6,P<0.001) and with IL-10 level in NR (r=0.4,P<0.05).There was no correlation observed between the concentration of MCP-1 and sICAM-1,IL-6 during the treatment. CONCLUSION:MCP-1 concentration may be a prognostic marker of the efficacy of IFN+RBV therapy in patients with chronic hepatitis C.展开更多
Traditional information retrieval systems respond to user queries with ranked lists of relevant documents. Since, XML （Extensible Markup Language） documents separate content and structure; XML-IR （information retri...Traditional information retrieval systems respond to user queries with ranked lists of relevant documents. Since, XML （Extensible Markup Language） documents separate content and structure; XML-IR （information retrieval） systems are able to retrieve only the relevant portions of documents. Therefore, users who utilize an XML-IR system could potentially receive highly relevant and precise material. We have developed the XML information retrieval system by using MySQL and Sphinx, which we call MEXIR. In our system, XML documents are stored into one table that has fixed relational schema. The schema is independent of the logical structure of XML documents. Each node in XML documents is represented by labels that express the positions in XML tree, namely ADXPI scheme. Our system has performance experiments on INEX collections and shown an average up to four seconds better than GPX. In addition, it has been reduced the size of the data down by 82.29 % compare to GPX system.展开更多
文摘AIM:To explain the role of Monocyte chemotactic protein-1 (MCP-1) and soluble adhesion molecules in chronic hepatitis C during the treatment of interferon alpha (IFNα) 2 b and ribavirin (RBV). METHODS:Concentrations of MCP-1,soluble adhesion molecules intercellular adhesion molecule-1 (sICAM-1),sP- selectin,interleukin (IL) 6,and IL10 in serum were estimated in the group of 40 patients with chronic hepatitis C treated with IFNalpha2 b and RBV in 0,16,32,48 wk of the therapy, RESULTS:In chronic hepatitis C,before and during the treatment,the serum levels of MCP-1 and sP-selectin in responders were similar to those of healthy subjects.In non- responders (NR),MCP-1 increased in the course of IFNc^+RBV treatment,differences were statistically significant as compared to responders.MCP-1 correlated statistically with the activity of periportal inflammation (r=0.35,P<0.05) but not with staging of liver fibrosis,sICAM-1 positively correlated with inflammatory activity and fibrosis in NR.sP-selectin did not correlate with histological findings in the liver.The MCP-1 correlated with the soluble form of sP-selectin concentrations (r= 6,P<0.001) and with IL-10 level in NR (r=0.4,P<0.05).There was no correlation observed between the concentration of MCP-1 and sICAM-1,IL-6 during the treatment. CONCLUSION:MCP-1 concentration may be a prognostic marker of the efficacy of IFN+RBV therapy in patients with chronic hepatitis C.
文摘Traditional information retrieval systems respond to user queries with ranked lists of relevant documents. Since, XML （Extensible Markup Language） documents separate content and structure; XML-IR （information retrieval） systems are able to retrieve only the relevant portions of documents. Therefore, users who utilize an XML-IR system could potentially receive highly relevant and precise material. We have developed the XML information retrieval system by using MySQL and Sphinx, which we call MEXIR. In our system, XML documents are stored into one table that has fixed relational schema. The schema is independent of the logical structure of XML documents. Each node in XML documents is represented by labels that express the positions in XML tree, namely ADXPI scheme. Our system has performance experiments on INEX collections and shown an average up to four seconds better than GPX. In addition, it has been reduced the size of the data down by 82.29 % compare to GPX system.
