In this paper,we introduce the censored composite conditional quantile coefficient(cC-CQC)to rank the relative importance of each predictor in high-dimensional censored regression.The cCCQC takes advantage of all usef...In this paper,we introduce the censored composite conditional quantile coefficient(cC-CQC)to rank the relative importance of each predictor in high-dimensional censored regression.The cCCQC takes advantage of all useful information across quantiles and can detect nonlinear effects including interactions and heterogeneity,effectively.Furthermore,the proposed screening method based on cCCQC is robust to the existence of outliers and enjoys the sure screening property.Simulation results demonstrate that the proposed method performs competitively on survival datasets of high-dimensional predictors,particularly when the variables are highly correlated.展开更多
To investigate the process optimizationof Cu-en/AP composite microspheres preparation via electrostatic spraying,and to reveal the effects of droplet properties and flow rate variations on the experimental results dur...To investigate the process optimizationof Cu-en/AP composite microspheres preparation via electrostatic spraying,and to reveal the effects of droplet properties and flow rate variations on the experimental results during the electrostatic spraying process,the prepared process parameters of Cu-en/AP composite microspheres by electrostatic spray method under the orthogonal experimental design simulated by ANSYS(Fluent).The influence of flow rate,solvent ratio,and solid mass on the experimental results is examined using a controlled variable method.The results indicate that under the conditions of a flow rate of 2.67×10^(-3)kg/s an acetone-to-deionized water ratio of 1.5∶1.0,and a solid mass of 200 mg,the theoretical particle size of the composite microspheres can reach e nanoscale.Droplet trajectories in the electric field remain stable without significant deviation.The simulation results show that particle diameter decreases with increasing flow rate,with the trend leveling off around a flow rate of 1×10^(-3)kg/s.As the solvent ratio increases(with higher acetone content),particle diameter initially decreases,reaching a minimum around a ratio of 1.5∶1.0 before gradually increasing.Increasing the solid mass also reduces the particle diameter,with a linear increase in diameter observed at around 220 mg.Cu-en/AP composite microspheres with nanoscale dimensions were confirmed under these conditions by the final SEM images.展开更多
Some metamorphic relations （MR） are not good at detecting faults in metamorphic testing. In this paper, the method of making compositional MR （CMR） based on the speculative law of proposition logic is presented. T...Some metamorphic relations （MR） are not good at detecting faults in metamorphic testing. In this paper, the method of making compositional MR （CMR） based on the speculative law of proposition logic is presented. This method constructs new MRs by composing existing MRs in a pairwise way. Because CMR contains all the advantages of the MRs that form it, its fault detection performance is wonderful. On the other hand, the number of relations will decrease greatly after composing, so a program can be tested with much fewer test cases when CMRs are used. In order to research the characteristics of a CMR, two case studies are analyzed. The experimental results show that the CMR＇s performance is mostly determined by the central MRs forming it and the sequence of composition. Testing efficiency is improved greatly when CMRs are used.展开更多
In this paper, supose Γ be a boundary of a Jordan domain D and Γ satisfied Альпер condition, the order that rational type interpolating operators at Fejer's points of f(z)∈C(Γ) converge to f(z) in the se...In this paper, supose Γ be a boundary of a Jordan domain D and Γ satisfied Альпер condition, the order that rational type interpolating operators at Fejer's points of f(z)∈C(Γ) converge to f(z) in the sense of uniformly convergence is obtained.展开更多
Massive multiple-input multiple-output provides improved energy efficiency and spectral efficiency in 5 G. However it requires large-scale matrix computation with tremendous complexity, especially for data detection a...Massive multiple-input multiple-output provides improved energy efficiency and spectral efficiency in 5 G. However it requires large-scale matrix computation with tremendous complexity, especially for data detection and precoding. Recently, many detection and precoding methods were proposed using approximate iteration methods, which meet the demand of precision with low complexity. In this paper, we compare these approximate iteration methods in precision and complexity, and then improve these methods with iteration refinement at the cost of little complexity and no extra hardware resource. By derivation, our proposal is a combination of three approximate iteration methods in essence and provides remarkable precision improvement on desired vectors. The results show that our proposal provides 27%-83% normalized mean-squared error improvement of the detection symbol vector and precoding symbol vector. Moreover, we find the bit-error rate is mainly controlled by soft-input soft-output Viterbi decoding when using approximate iteration methods. Further, only considering the effect on soft-input soft-output Viterbi decoding, the simulation results show that using a rough estimation for the filter matrix of minimum mean square error detection to calculating log-likelihood ratio could provideenough good bit-error rate performance, especially when the ratio of base station antennas number and the users number is not too large.展开更多
AIM： To develop a conditionally replicative gene-viral vector system called CNHK500-p53, which contains dual promoters within the E1 region, and combines the advantages of oncolytic virus and gene therapies for hepat...AIM： To develop a conditionally replicative gene-viral vector system called CNHK500-p53, which contains dual promoters within the E1 region, and combines the advantages of oncolytic virus and gene therapies for hepatocellular carcinoma （HCC）. METHODS： CNHK500-p53 was constructed by using human telomerase reverse transcriptase （hTERT） promoter to drive adenovirus E1a gene and hypoxia response element （HRE） promoter to drive adenovirus E1b gene. p53 gene expressing cassette was inserted into the genome of replicative virus. Viral replication experiments, cytopathic effect （CPE） and methyl thiazolyl tetrazolium （MTT） assay were performed to test the selective replication and oncolytic efficacy of CNHK500-p53. RESULTS： Immunohistochemistry verified that infection with CNHK500-p53 was associated with selective replication of adenovirus and production of p53 protein in telomerase-positive and hypoxia-inducible factordependent HCC cells, p53 protein secreted from HepG2, infected with CNHK500-p53 was significantly higher than that infected with nonreplicative adenovirus Ad-p53 in vitro （388 ± 34.6 μg/L vs 76.3 ± 13.17 μg/L）. Viral replication experiments showed that replication of CNHK500-p53 and CNHK500 or WtAd5, was much stronger than that of Ad-p53 in tested HCC cell lines. CPE and H1-F assay indicated that CNHK500-p53 selectively replicated in and killed HCC cells while leaving normal cells unaffected. CONCLUSION： A more efficient gene-viral system is developed by combining selective oncolysis with exogenous expression of p53 against HCC cells.展开更多
We present an extension of the Common Reflection Surface （CRS） stack that provides support for an arbitrary top surface topography. CRS stacking can be applied to the original prestack data without the need for any ...We present an extension of the Common Reflection Surface （CRS） stack that provides support for an arbitrary top surface topography. CRS stacking can be applied to the original prestack data without the need for any elevation statics. The CRS-stacked zero- offset section can be corrected （redatumed） to a given planar level by kinematic wave field attributes. The seismic processing results indicate that the CRS stacked section for rugged surface topography is better than the conventional stacked section for S/N ratio and better continuity of reflection events. Considering the multiple paths of zero-offset rays, the method deals with reflection information coming from different dips and performs the stack using the method of dip decomposition, which improves the kinematic and dynamic character of CRS stacked sections.展开更多
Piezoelectric composite material (PCM) is an important branch of modernsensor and actuator materials with wide applications in smart structures. In this paper, based onpiezoelectric ceramic, composite and experimental...Piezoelectric composite material (PCM) is an important branch of modernsensor and actuator materials with wide applications in smart structures. In this paper, based onpiezoelectric ceramic, composite and experimental mechanics theories, a kind of 1-3 orthogonalanisotropic PCM (OAPCM) sensor is developed, and the sensing principle is analyzed to describesensor behaviors. In order to determine strain and stress on isotropic or orthogonal anisotropiccomponent surface, the relationships between strain and stress are established. The experimentalresearch on 1-3 OAPCM sensor is carried out in uniaxial and biaxial stress states. The results showthat 1-3 OAPCM sensors offer orthotropic properties of piezoelectricity, and sensing equations canbe used for strain or stress measurement with good accuracy.展开更多
Climate change has altered locally singletype disasters to large-scale compound disasters because of increasing intensity and frequency of extreme rainfall events.The compound disasters can combine small-scale floods,...Climate change has altered locally singletype disasters to large-scale compound disasters because of increasing intensity and frequency of extreme rainfall events.The compound disasters can combine small-scale floods,debris flows,shallow landslides,deep-seated landslides,and landslide lakes into a large-scale single disaster event.Although simulation models and evaluation tools are available for single-type disasters,no single model is well developed for compound disasters due to the difficulty of handling the interrelationship between two successive single-type disasters.This study proposes a structure for linking available single-type simulation models to evaluate compound disasters and provides a useful tool of decision making for warning and planning of disaster reduction.展开更多
基金Outstanding Youth Foundation of Hunan Provincial Department of Education(Grant No.22B0911)。
文摘In this paper,we introduce the censored composite conditional quantile coefficient(cC-CQC)to rank the relative importance of each predictor in high-dimensional censored regression.The cCCQC takes advantage of all useful information across quantiles and can detect nonlinear effects including interactions and heterogeneity,effectively.Furthermore,the proposed screening method based on cCCQC is robust to the existence of outliers and enjoys the sure screening property.Simulation results demonstrate that the proposed method performs competitively on survival datasets of high-dimensional predictors,particularly when the variables are highly correlated.
基金National Natural Science Foundation of China(No.2275150)。
文摘To investigate the process optimizationof Cu-en/AP composite microspheres preparation via electrostatic spraying,and to reveal the effects of droplet properties and flow rate variations on the experimental results during the electrostatic spraying process,the prepared process parameters of Cu-en/AP composite microspheres by electrostatic spray method under the orthogonal experimental design simulated by ANSYS(Fluent).The influence of flow rate,solvent ratio,and solid mass on the experimental results is examined using a controlled variable method.The results indicate that under the conditions of a flow rate of 2.67×10^(-3)kg/s an acetone-to-deionized water ratio of 1.5∶1.0,and a solid mass of 200 mg,the theoretical particle size of the composite microspheres can reach e nanoscale.Droplet trajectories in the electric field remain stable without significant deviation.The simulation results show that particle diameter decreases with increasing flow rate,with the trend leveling off around a flow rate of 1×10^(-3)kg/s.As the solvent ratio increases(with higher acetone content),particle diameter initially decreases,reaching a minimum around a ratio of 1.5∶1.0 before gradually increasing.Increasing the solid mass also reduces the particle diameter,with a linear increase in diameter observed at around 220 mg.Cu-en/AP composite microspheres with nanoscale dimensions were confirmed under these conditions by the final SEM images.
基金The National Natural Science Foundation of China(No.60425206,60633010,60773104,60503033)the Excellent Talent Foundation of Teaching and Research of Southeast University
文摘Some metamorphic relations （MR） are not good at detecting faults in metamorphic testing. In this paper, the method of making compositional MR （CMR） based on the speculative law of proposition logic is presented. This method constructs new MRs by composing existing MRs in a pairwise way. Because CMR contains all the advantages of the MRs that form it, its fault detection performance is wonderful. On the other hand, the number of relations will decrease greatly after composing, so a program can be tested with much fewer test cases when CMRs are used. In order to research the characteristics of a CMR, two case studies are analyzed. The experimental results show that the CMR＇s performance is mostly determined by the central MRs forming it and the sequence of composition. Testing efficiency is improved greatly when CMRs are used.
文摘In this paper, supose Γ be a boundary of a Jordan domain D and Γ satisfied Альпер condition, the order that rational type interpolating operators at Fejer's points of f(z)∈C(Γ) converge to f(z) in the sense of uniformly convergence is obtained.
文摘Massive multiple-input multiple-output provides improved energy efficiency and spectral efficiency in 5 G. However it requires large-scale matrix computation with tremendous complexity, especially for data detection and precoding. Recently, many detection and precoding methods were proposed using approximate iteration methods, which meet the demand of precision with low complexity. In this paper, we compare these approximate iteration methods in precision and complexity, and then improve these methods with iteration refinement at the cost of little complexity and no extra hardware resource. By derivation, our proposal is a combination of three approximate iteration methods in essence and provides remarkable precision improvement on desired vectors. The results show that our proposal provides 27%-83% normalized mean-squared error improvement of the detection symbol vector and precoding symbol vector. Moreover, we find the bit-error rate is mainly controlled by soft-input soft-output Viterbi decoding when using approximate iteration methods. Further, only considering the effect on soft-input soft-output Viterbi decoding, the simulation results show that using a rough estimation for the filter matrix of minimum mean square error detection to calculating log-likelihood ratio could provideenough good bit-error rate performance, especially when the ratio of base station antennas number and the users number is not too large.
基金Supported by the Major State Basic Research Development Program (973 Program) of China, No. 2003CB515507
文摘AIM： To develop a conditionally replicative gene-viral vector system called CNHK500-p53, which contains dual promoters within the E1 region, and combines the advantages of oncolytic virus and gene therapies for hepatocellular carcinoma （HCC）. METHODS： CNHK500-p53 was constructed by using human telomerase reverse transcriptase （hTERT） promoter to drive adenovirus E1a gene and hypoxia response element （HRE） promoter to drive adenovirus E1b gene. p53 gene expressing cassette was inserted into the genome of replicative virus. Viral replication experiments, cytopathic effect （CPE） and methyl thiazolyl tetrazolium （MTT） assay were performed to test the selective replication and oncolytic efficacy of CNHK500-p53. RESULTS： Immunohistochemistry verified that infection with CNHK500-p53 was associated with selective replication of adenovirus and production of p53 protein in telomerase-positive and hypoxia-inducible factordependent HCC cells, p53 protein secreted from HepG2, infected with CNHK500-p53 was significantly higher than that infected with nonreplicative adenovirus Ad-p53 in vitro （388 ± 34.6 μg/L vs 76.3 ± 13.17 μg/L）. Viral replication experiments showed that replication of CNHK500-p53 and CNHK500 or WtAd5, was much stronger than that of Ad-p53 in tested HCC cell lines. CPE and H1-F assay indicated that CNHK500-p53 selectively replicated in and killed HCC cells while leaving normal cells unaffected. CONCLUSION： A more efficient gene-viral system is developed by combining selective oncolysis with exogenous expression of p53 against HCC cells.
基金This research work is sponsored by National Natural Science Foundation of China （40474041）, the Special Fund of the National ＂863＂ Project （2006AA06Z206）, and the CNPC Invention Foundation for Young- and Middle-aged Scientists （04E7040）, Postdoctoral Scientific Workstation in Zhongyuan 0il Field and the CNPC key Lab of Geophysical Exploration in China University of Petroleum （East China）.
文摘We present an extension of the Common Reflection Surface （CRS） stack that provides support for an arbitrary top surface topography. CRS stacking can be applied to the original prestack data without the need for any elevation statics. The CRS-stacked zero- offset section can be corrected （redatumed） to a given planar level by kinematic wave field attributes. The seismic processing results indicate that the CRS stacked section for rugged surface topography is better than the conventional stacked section for S/N ratio and better continuity of reflection events. Considering the multiple paths of zero-offset rays, the method deals with reflection information coming from different dips and performs the stack using the method of dip decomposition, which improves the kinematic and dynamic character of CRS stacked sections.
文摘Piezoelectric composite material (PCM) is an important branch of modernsensor and actuator materials with wide applications in smart structures. In this paper, based onpiezoelectric ceramic, composite and experimental mechanics theories, a kind of 1-3 orthogonalanisotropic PCM (OAPCM) sensor is developed, and the sensing principle is analyzed to describesensor behaviors. In order to determine strain and stress on isotropic or orthogonal anisotropiccomponent surface, the relationships between strain and stress are established. The experimentalresearch on 1-3 OAPCM sensor is carried out in uniaxial and biaxial stress states. The results showthat 1-3 OAPCM sensors offer orthotropic properties of piezoelectricity, and sensing equations canbe used for strain or stress measurement with good accuracy.
基金supported by National Science Council,Taiwan,China.The project name is Numerical Approach to Estimate the Stability and Deformation Response of Landslide Dams(NSC99-2625-M-006-004)and Modeling of The Compound Disaster in Hsiaolin Village(NSC99-2218-E-006-238)
文摘Climate change has altered locally singletype disasters to large-scale compound disasters because of increasing intensity and frequency of extreme rainfall events.The compound disasters can combine small-scale floods,debris flows,shallow landslides,deep-seated landslides,and landslide lakes into a large-scale single disaster event.Although simulation models and evaluation tools are available for single-type disasters,no single model is well developed for compound disasters due to the difficulty of handling the interrelationship between two successive single-type disasters.This study proposes a structure for linking available single-type simulation models to evaluate compound disasters and provides a useful tool of decision making for warning and planning of disaster reduction.
