Objective：To assess the diagnostic accuracy of whole-body MRI using diffusion-weighted sequence（WB-DWI）to determine the peritoneal cancer index（PCI）in correlation with surgical and histopathological findings.Meth...Objective：To assess the diagnostic accuracy of whole-body MRI using diffusion-weighted sequence（WB-DWI）to determine the peritoneal cancer index（PCI）in correlation with surgical and histopathological findings.Methods：Twenty-seven patients underwent preoperative WB-MRI,followed by cytoreductive surgery for primary tumors of the appendix（n=15）,colorectum（n=12）,and associated peritoneal disease.A total of 351 regions were retrospectively reviewed.The sensitivity,specificity,and accuracy were calculated at 13 anatomical sites.The WB-DWI PCI and PCI type were compared with surgical and histopathological findings.Results：No statistical difference was found between the WB-DWI PCI and surgical PCI（P=0.574）.WB-DWI correctly predicted the PCI type in 24 of 27 patients with high accuracy（88.9%）,including 10 of 10 patients with small-volume tumor,12 of 14 with moderate-volume tumor,and 2 of 3 with large-volume tumor.WB-DWI correctly depicted tumors in 163 of 203 regions,with 40false-negative and 23 false-positive regions.The overall sensitivity,specificity,and accuracy of WB-DWI for the detection of peritoneal tumors were 80.3%,84.5%,and 82.1%,respectively.For lesions＆lt;0.5 cm in diameter,WB-DWI demonstrated good sensitivity（69.4%）.Conclusions：WB-DWI accurately predicted PCI before surgery in patients undergoing evaluation for cytoreductive surgery.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.81501437)the Shanghai Municipal Planning Commission of Science and Research Fund(Grant No.JGGG1401)
文摘Objective：To assess the diagnostic accuracy of whole-body MRI using diffusion-weighted sequence（WB-DWI）to determine the peritoneal cancer index（PCI）in correlation with surgical and histopathological findings.Methods：Twenty-seven patients underwent preoperative WB-MRI,followed by cytoreductive surgery for primary tumors of the appendix（n=15）,colorectum（n=12）,and associated peritoneal disease.A total of 351 regions were retrospectively reviewed.The sensitivity,specificity,and accuracy were calculated at 13 anatomical sites.The WB-DWI PCI and PCI type were compared with surgical and histopathological findings.Results：No statistical difference was found between the WB-DWI PCI and surgical PCI（P=0.574）.WB-DWI correctly predicted the PCI type in 24 of 27 patients with high accuracy（88.9%）,including 10 of 10 patients with small-volume tumor,12 of 14 with moderate-volume tumor,and 2 of 3 with large-volume tumor.WB-DWI correctly depicted tumors in 163 of 203 regions,with 40false-negative and 23 false-positive regions.The overall sensitivity,specificity,and accuracy of WB-DWI for the detection of peritoneal tumors were 80.3%,84.5%,and 82.1%,respectively.For lesions＆lt;0.5 cm in diameter,WB-DWI demonstrated good sensitivity（69.4%）.Conclusions：WB-DWI accurately predicted PCI before surgery in patients undergoing evaluation for cytoreductive surgery.
