OBJECTIVE: To evaluate the effect of Huadananshen mistura in clinical treatment of Chinese patients with insomnia. METHODS: In this randomized, double-blind, placebo-controlled, multi-center study, 244 patients with i...OBJECTIVE: To evaluate the effect of Huadananshen mistura in clinical treatment of Chinese patients with insomnia. METHODS: In this randomized, double-blind, placebo-controlled, multi-center study, 244 patients with insomnia were randomly assigned to a placebo group, a low-dose (10 mL/day), or a high-dose (20 mL/day) mistura group. Efficacy was assessed by using the sleep dysfunction rating scale (SDRS) and Clinical Global Impression-Improvement (CGI-I) scores. Safety and tolerability assessments included emergent adverse events, laboratory tests, and electrocardiograms. RESULTS: Total SDRS scores decreased in all three groups, and there were significant differences between the placebo group and the lowand high-dose mistura groups (P=0.000). CGI-I ratings in the lowand high-dose mistura groups were sig-nificantly better than that of the placebo group (P= 0.000). Incidences of rebound insomnia were similar in all three groups (placebo group: 6.94% , low-dose mistura group: 12.99% , and high-dose mistura group: 10.96% ; P=0.475). The efficacy of Huadananshen mistura in the lowor high-dose group was significantly better than that of the placebo group (P=0.000), but with no significant difference found between the lowand high-dose mistura groups (P=0.887). The rates of adverse events were similar in the three groups (placebo 2.44% , low-dose mistura 0%, and high-dose mistura 5%; P=0.088). CONCLUSION: Huadananshen mistura is an effective and generally well-tolerated hypnotic medicine for the treatment of Chinese patients with insomnia.展开更多
Objective To observe the influence of acupuncture on sleep disorders and anxiety.Methods This is a descriptive study of correlation type.Sixty patients and 60 common people aged from 20 to 40 in Yazd City were selecte...Objective To observe the influence of acupuncture on sleep disorders and anxiety.Methods This is a descriptive study of correlation type.Sixty patients and 60 common people aged from 20 to 40 in Yazd City were selected to answer the questions of Pittsburgh Sleep Quality Index(PSQI) and Beck Anxiety Inventory(BAI) questionnaires.The data were analyzed using correlation coefficient and multiple regressions.Results The results showed that treatment by acupuncture outperforms drug-based medication in decreasing the level of anxiety in people.The medication using chemical drugs has lower effect over the quality of sleeping.The acupuncture method has the best prediction from the sleep quality(53%).Also acupuncture method has the best prediction from lowering anxiety among people(62%).Conclusion Due to the effect of acupuncture on the patients suffering sleep disorders and anxiety,acupuncture can open promising horizons for these patients.Nowadays acupuncture has a special status on treatment of sleep disorders and anxiety.展开更多
基金Supported by the Grants from National Major Project for IND(2012ZX09303-003)Shanghai Health Talent Professional Project(XBR2011049)
文摘OBJECTIVE: To evaluate the effect of Huadananshen mistura in clinical treatment of Chinese patients with insomnia. METHODS: In this randomized, double-blind, placebo-controlled, multi-center study, 244 patients with insomnia were randomly assigned to a placebo group, a low-dose (10 mL/day), or a high-dose (20 mL/day) mistura group. Efficacy was assessed by using the sleep dysfunction rating scale (SDRS) and Clinical Global Impression-Improvement (CGI-I) scores. Safety and tolerability assessments included emergent adverse events, laboratory tests, and electrocardiograms. RESULTS: Total SDRS scores decreased in all three groups, and there were significant differences between the placebo group and the lowand high-dose mistura groups (P=0.000). CGI-I ratings in the lowand high-dose mistura groups were sig-nificantly better than that of the placebo group (P= 0.000). Incidences of rebound insomnia were similar in all three groups (placebo group: 6.94% , low-dose mistura group: 12.99% , and high-dose mistura group: 10.96% ; P=0.475). The efficacy of Huadananshen mistura in the lowor high-dose group was significantly better than that of the placebo group (P=0.000), but with no significant difference found between the lowand high-dose mistura groups (P=0.887). The rates of adverse events were similar in the three groups (placebo 2.44% , low-dose mistura 0%, and high-dose mistura 5%; P=0.088). CONCLUSION: Huadananshen mistura is an effective and generally well-tolerated hypnotic medicine for the treatment of Chinese patients with insomnia.
文摘Objective To observe the influence of acupuncture on sleep disorders and anxiety.Methods This is a descriptive study of correlation type.Sixty patients and 60 common people aged from 20 to 40 in Yazd City were selected to answer the questions of Pittsburgh Sleep Quality Index(PSQI) and Beck Anxiety Inventory(BAI) questionnaires.The data were analyzed using correlation coefficient and multiple regressions.Results The results showed that treatment by acupuncture outperforms drug-based medication in decreasing the level of anxiety in people.The medication using chemical drugs has lower effect over the quality of sleeping.The acupuncture method has the best prediction from the sleep quality(53%).Also acupuncture method has the best prediction from lowering anxiety among people(62%).Conclusion Due to the effect of acupuncture on the patients suffering sleep disorders and anxiety,acupuncture can open promising horizons for these patients.Nowadays acupuncture has a special status on treatment of sleep disorders and anxiety.
