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中药口服结肠靶向递药系统的研究进展 被引量:1
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作者 杨志欣 刘佳佳 +3 位作者 王海威 王祺茹 张蕾 王鑫 《中国药房》 CAS 北大核心 2017年第22期3143-3146,共4页
目的:为进一步开发中药口服结肠靶向递药系统(OCDDS)提供参考。方法:以"中药""口服结肠定位""结肠靶向递药系统""Chinese herbal medicine""Colon-specific delivery system""O... 目的:为进一步开发中药口服结肠靶向递药系统(OCDDS)提供参考。方法:以"中药""口服结肠定位""结肠靶向递药系统""Chinese herbal medicine""Colon-specific delivery system""Oral colon-specific drug delivery system"等为关键词,组合查询1990-2016年在Pub Med、Web of Science、中国知网、万方、维普等数据库中的相关文献,对各种类型中药OCDDS的研究进展进行综述。结果与结论:共检索到相关文献196篇,其中有效文献35篇。传统的单触发性OCDDS有pH依赖型、时滞型、酶触发型、压力型、生物黏附型、特异型等;随着研究的深入,发展为pH-时滞型、pH-酶依赖型、酶降解-时滞型等多触发性OCDDS。OCDDS虽基础研究较多,但因临床实际情况较复杂,影响因素较多,实际产品上市并于临床应用的较少。目前唯一应用于临床的是pH依赖型,研究热度较高的是酶触发型及多触发性OCDDS。结合更新的现代药物传递技术,开发新型口服结肠靶向制剂是今后的研究方向。 展开更多
关键词 中药 口服结肠靶向递药系统 触发 多触发性 PH依赖型 时滞型 酶依赖型
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Finite element investigation of the poroelastic effect on the Xinfengjiang Reservoir-triggered earthquake 被引量:16
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作者 CHENG HuiHong ZHANG Huai +4 位作者 ZHU BoJing SUN YuJun ZHENG Liang YANG ShaoHua SHI YaoLin 《Science China Earth Sciences》 SCIE EI CAS 2012年第12期1942-1952,共11页
Coulomb failure stress changes (ΔCFS) are used in the study of reservoir-induced seismicity (RIS) generation.The threshold value of ΔCFS that can trigger earthquakes is an important issue that deserves thorough rese... Coulomb failure stress changes (ΔCFS) are used in the study of reservoir-induced seismicity (RIS) generation.The threshold value of ΔCFS that can trigger earthquakes is an important issue that deserves thorough research.The M s 6.1 earthquake in the Xinfengjiang Reservoir in 1962 is well acknowledged as the largest reservoir-induced earthquake in China.Therefore, it is a logical site for quantitative calculation of ΔCFS induced by the filling of the reservoir and for investigating the magnitude of CFS that can trigger reservoir seismic activities.To better understand the RIS mechanism, a three-dimensional poroelastic finite element model of the Xinfengjiang Reservoir is proposed here, taking into consideration of the precise topography and dynamic water level.We calculate the instant changes of stress and pore pressure induced by water load, and the time variation of effective stresses due to pore water diffusion.The CFS on the seismogenesis faults and the accumulation of strain energy in the reservoir region are also calculated.Primary results suggest that the reservoir impoundment increases both pore pressure and CFS on the fault at the focal depth.The diffusion of pore pressure was likely the main factor that triggered the main earthquake, whereas the elastic stress owing to water load was relatively small.The magnitude of CFS on seismogenesis fault can reach approximately 10 kPa, and the ΔCFS values at the hypocenter can be about 0.7-3.0 kPa, depending on the fault diffusion coefficient.The calculated maximum vertical subsidence caused by the water load in the Xinfengjiang Reservoir is 17.5 mm, which is in good agreement with the observed value of 15 mm.The accumulated strain energy owing to water load was only about 7.3×10 11 J, even less than 1% of the seismic wave energy released by the earthquake.The reservoir impoundment was the only factor that triggered the earthquake. 展开更多
关键词 Xinfengjiang Reservoir reservoir triggered seismicity Coulomb failure stress poroelasticity model finite element method
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