目的:探讨太冲透刺涌泉治疗肝阳上亢型偏头痛的效果及机制。方法:本试验60例诊断为肝阳上亢型偏头痛患者选于2023年2月至2024年2月在本院就诊的患者,根据随机数字表法分为2组,各30例。对照组参照“十四五”规划教材《针灸学》取穴;观察...目的:探讨太冲透刺涌泉治疗肝阳上亢型偏头痛的效果及机制。方法:本试验60例诊断为肝阳上亢型偏头痛患者选于2023年2月至2024年2月在本院就诊的患者,根据随机数字表法分为2组,各30例。对照组参照“十四五”规划教材《针灸学》取穴;观察组以对照组取穴为基础,选取涌泉穴,给予太冲透刺涌泉针法。分别观察两组治疗前、后的偏头痛综合量化评分、中医证候积分、VAS疼痛评分,及对比两组的临床疗效。结果:两组治疗前的一般资料差异无统计学意义(P > 0.05);治疗后的各项观察指标积分与治疗前相比均有减小,观察组的临床疗效改善更加显著,观察组的各积分均低于对照组,以上差异均有统计学意义(P Objective: To explore the effect and mechanism of Taichong penetrating Yongquan in the treatment of migraine with hyperactivity of liver yang. Methods: 60 patients with migraine diagnosed as hyperactivity of liver yang were selected from February 2023 to February 2024 in our hospital. According to the random number table method, they were divided into two groups, 30 cases in each group. The control group referred to the “14th Five-Year Plan” textbook “Acupuncture” to select acupoints;on the basis of acupoint selection in the control group, the observation group selected Yongquan acupoint and gave Taichong penetration acupuncture. The migraine comprehensive quantitative score, TCM syndrome score and VAS pain score of the two groups before and after treatment were observed, and the clinical efficacy of the two groups was compared. Results: There was no significant difference in general data between the two groups before treatment (P > 0.05);The scores of each observation index after treatment were lower than those before treatment, and the clinical efficacy of the observation group was more significant. The scores of the observation group were lower than those of the control group, and the above differences were statistically significant (P < 0.05). Conclusion: The effect of Taichong penetrating Yongquan in the treatment of migraine with hyperactivity of liver yang is better than that of conventional acupuncture.展开更多
目的:探讨内关、太冲穴位埋线对自发性高血压(SHR)前期大鼠心肌能量代谢的影响及其潜在作用机制。方法:选择16只3周龄SHR大鼠,适应性喂养1周后,随机分为埋线组与模型组( n =8),另取8只同龄的京都种Wistar(WKY)大鼠为对照组;埋线组大鼠...目的:探讨内关、太冲穴位埋线对自发性高血压(SHR)前期大鼠心肌能量代谢的影响及其潜在作用机制。方法:选择16只3周龄SHR大鼠,适应性喂养1周后,随机分为埋线组与模型组( n =8),另取8只同龄的京都种Wistar(WKY)大鼠为对照组;埋线组大鼠定位内关、太冲穴位并进行穴位埋线干预,模型组及对照组仅予以抓取固定,实验周期为2周。在干预前1小时及干预2、7、14天后,测定各组大鼠收缩压(SBP)和舒张压(DBP)水平,并于末次检测后处死大鼠,取心肌组织,采用ATP试剂盒测定各组大鼠左心室心肌组织中ATP水平,免疫组织化学实验及免疫蛋白印迹实验测定左室前壁心肌组织AMPK、p-AMPK的蛋白表达。结果:模型组大鼠的SBP和DBP均高于对照组( P <0.05);干预2、7和14天后,埋线组大鼠的DBP低于模型组( P <0.05);干预7和14天后,埋线组大鼠SBP低于模型组( P <0.05)。模型组大鼠的ATP低于对照组,埋线组高于模型组( P <0.05)。免疫组织化学实验结果显示各组大鼠的AMPK表达水平差异不明显( P >0.05),p-AMPK表达水平明显不同,模型组低于对照组,埋线组高于模型组( P <0.05);免疫蛋白印迹实验结果显示模型组大鼠p-AMPK/AMPK表达比低于对照组,埋线组高于模型组( P <0.05)。结论:在自发性高血压前期大鼠模型中,内关、太冲穴位埋线可调节AMPK信号通路介导的心肌能量代谢,从而改善高血压状态,这对预防心肌高压状态下的损伤可能有帮助。展开更多
文摘目的:探讨太冲透刺涌泉治疗肝阳上亢型偏头痛的效果及机制。方法:本试验60例诊断为肝阳上亢型偏头痛患者选于2023年2月至2024年2月在本院就诊的患者,根据随机数字表法分为2组,各30例。对照组参照“十四五”规划教材《针灸学》取穴;观察组以对照组取穴为基础,选取涌泉穴,给予太冲透刺涌泉针法。分别观察两组治疗前、后的偏头痛综合量化评分、中医证候积分、VAS疼痛评分,及对比两组的临床疗效。结果:两组治疗前的一般资料差异无统计学意义(P > 0.05);治疗后的各项观察指标积分与治疗前相比均有减小,观察组的临床疗效改善更加显著,观察组的各积分均低于对照组,以上差异均有统计学意义(P Objective: To explore the effect and mechanism of Taichong penetrating Yongquan in the treatment of migraine with hyperactivity of liver yang. Methods: 60 patients with migraine diagnosed as hyperactivity of liver yang were selected from February 2023 to February 2024 in our hospital. According to the random number table method, they were divided into two groups, 30 cases in each group. The control group referred to the “14th Five-Year Plan” textbook “Acupuncture” to select acupoints;on the basis of acupoint selection in the control group, the observation group selected Yongquan acupoint and gave Taichong penetration acupuncture. The migraine comprehensive quantitative score, TCM syndrome score and VAS pain score of the two groups before and after treatment were observed, and the clinical efficacy of the two groups was compared. Results: There was no significant difference in general data between the two groups before treatment (P > 0.05);The scores of each observation index after treatment were lower than those before treatment, and the clinical efficacy of the observation group was more significant. The scores of the observation group were lower than those of the control group, and the above differences were statistically significant (P < 0.05). Conclusion: The effect of Taichong penetrating Yongquan in the treatment of migraine with hyperactivity of liver yang is better than that of conventional acupuncture.
文摘目的:探讨内关、太冲穴位埋线对自发性高血压(SHR)前期大鼠心肌能量代谢的影响及其潜在作用机制。方法:选择16只3周龄SHR大鼠,适应性喂养1周后,随机分为埋线组与模型组( n =8),另取8只同龄的京都种Wistar(WKY)大鼠为对照组;埋线组大鼠定位内关、太冲穴位并进行穴位埋线干预,模型组及对照组仅予以抓取固定,实验周期为2周。在干预前1小时及干预2、7、14天后,测定各组大鼠收缩压(SBP)和舒张压(DBP)水平,并于末次检测后处死大鼠,取心肌组织,采用ATP试剂盒测定各组大鼠左心室心肌组织中ATP水平,免疫组织化学实验及免疫蛋白印迹实验测定左室前壁心肌组织AMPK、p-AMPK的蛋白表达。结果:模型组大鼠的SBP和DBP均高于对照组( P <0.05);干预2、7和14天后,埋线组大鼠的DBP低于模型组( P <0.05);干预7和14天后,埋线组大鼠SBP低于模型组( P <0.05)。模型组大鼠的ATP低于对照组,埋线组高于模型组( P <0.05)。免疫组织化学实验结果显示各组大鼠的AMPK表达水平差异不明显( P >0.05),p-AMPK表达水平明显不同,模型组低于对照组,埋线组高于模型组( P <0.05);免疫蛋白印迹实验结果显示模型组大鼠p-AMPK/AMPK表达比低于对照组,埋线组高于模型组( P <0.05)。结论:在自发性高血压前期大鼠模型中,内关、太冲穴位埋线可调节AMPK信号通路介导的心肌能量代谢,从而改善高血压状态,这对预防心肌高压状态下的损伤可能有帮助。
