目的通过分析影像学和实验室检查与慢性乙肝患者肝硬化临床分期的关系,探讨影像学和实验室检查对慢性乙肝患者肝硬化临床分期的价值。方法回顾性收集2018年10月至2021年9月就诊的慢性乙肝患者240例,分别按照两期分期法和Child-Pugh评分...目的通过分析影像学和实验室检查与慢性乙肝患者肝硬化临床分期的关系,探讨影像学和实验室检查对慢性乙肝患者肝硬化临床分期的价值。方法回顾性收集2018年10月至2021年9月就诊的慢性乙肝患者240例,分别按照两期分期法和Child-Pugh评分进行分组,比较在不同的分期方法下,瞬时弹性成像测量的肝硬度值(liver stiffness measurement,LSM)、磁共振磁敏感加权成像的肝肌信号强度比(liver to muscle ratio,LMR)、纤维化-4指数(fibrosis 4 score,FIB-4)、天冬氨酸转氨酶和血小板比率指数(aspartate aminotransferase to platelet ratio index,APRI)的组间差异,分析LSM、LMR、FIB-4、APRI与不同分期方法的相关性,并绘制LSM、LMR、FIB-4、APRI判断临床肝硬化与Child-Pugh评分B级、C级的受试者工作特征曲线(receiver operating characteristic curve,ROC)。结果使用两期分期法进行分组和Child-Pugh评分进行分组时,3组间的LSM、LMR、FIB-4、APRI均存在显著差异(P<0.05)。LSM、FIB-4、APRI与不同的分期方法均具有显著的正相关性,LMR与不同的分期方法均具有显著的负相关性(P<0.05)。使用两期法进行分组时,LSM、LMR、FIB-4、APRI判断临床肝硬化的受试者工作特征曲线下面积(area under the ROC,AUROC)分别为0.805、0.587、0.789、0.704,差异均有统计学意义(P<0.05)。使用Child-Pugh评分进行分组时,LSM、LMR、FIB-4、APRI判断Child-Pugh评分B级、C级的AUROC分别为0.924、0.691、0.921、0.940,差异均有统计学意义(P<0.05)。结论影像学和实验室检查(LSM、LMR、FIB-4、APRI)与肝硬化临床分期密切相关,在诊断肝硬化临床分期中具有一定的价值,可以作为辅助检查帮助临床工作者更好地识别和诊断肝硬化的临床分期。展开更多
布鲁氏杆菌病(Brucellosis)是由布鲁杆菌引起的以动物为传染源的人畜共患病。布鲁氏菌感染人体后可累及多器官、多系统,其中骨关节系统病变为其最常见并发症,且常见于脊柱。布氏杆菌性脊柱炎又称布病脊柱炎(Brucella Spondylitis, BS),...布鲁氏杆菌病(Brucellosis)是由布鲁杆菌引起的以动物为传染源的人畜共患病。布鲁氏菌感染人体后可累及多器官、多系统,其中骨关节系统病变为其最常见并发症,且常见于脊柱。布氏杆菌性脊柱炎又称布病脊柱炎(Brucella Spondylitis, BS),是由布鲁氏菌侵犯脊柱(椎间盘、椎体、肌肉)导致的脊柱感染性疾病,约占布病患者的2%~53%。主要临床表现为发热、乏力、夜间盗汗、厌食、头痛、肝脾肿大、关节疼痛、腰背痛等全身及局部症状。本文旨在深入阐述BS的致病机制、分型技术及实验室检查的最新进展。Brucellosis is a zoonotic disease caused by Brucella, which is transmitted from animals. Brucella infection in the human body can affect multiple organs and systems, among which bone and joint system lesions are the most common complications, and are common in the spine. Brucella spondylitis, also known as brucella spondylitis (BS), is a spinal infectious diseases caused by brucella invading the spine (intervertebral disc, vertebral body, muscle), accounting for 2% to 53% of patients with brucellosis. The main clinical manifestations include fever, fatigue, night sweats, anorexia, headache, hepatosplenomegaly, joint pain, lower back pain, and other systemic and local symptoms. This article aims to provide an in-depth explanation of the pathogenesis, typing techniques, and latest developments in laboratory testing of BS.展开更多
百日咳是一种可预防的急性呼吸道疾病,主要表现为阵发性痉咳、咳嗽末尾声和咳嗽伴呕吐。百日咳临床表现受诸多因素影响,婴幼儿、青少年和成人可表现不典型,这使百日咳难以识别,易导致诊断和治疗延误,采用实验室检查方法辅助诊断可提高...百日咳是一种可预防的急性呼吸道疾病,主要表现为阵发性痉咳、咳嗽末尾声和咳嗽伴呕吐。百日咳临床表现受诸多因素影响,婴幼儿、青少年和成人可表现不典型,这使百日咳难以识别,易导致诊断和治疗延误,采用实验室检查方法辅助诊断可提高百日咳诊断率,本文就国内外百日咳实验室检查研究进展进行综述。Pertussis (whooping cough) is a preventable acute respiratory disease, mainly manifested as paroxysmal convulsive cough, cough ending and cough with vomiting. The clinical manifestations of pertussis are affected by many factors, and infants, adolescents and adults may show atypical manifestations, which makes it difficult to identify pertussis and easily leads to delayed diagnosis and treatment. The use of laboratory examination to assist diagnosis can improve the diagnosis rate of pertussis. This paper reviews the research progress in laboratory examination of pertussis at home and abroad.展开更多
文摘目的通过分析影像学和实验室检查与慢性乙肝患者肝硬化临床分期的关系,探讨影像学和实验室检查对慢性乙肝患者肝硬化临床分期的价值。方法回顾性收集2018年10月至2021年9月就诊的慢性乙肝患者240例,分别按照两期分期法和Child-Pugh评分进行分组,比较在不同的分期方法下,瞬时弹性成像测量的肝硬度值(liver stiffness measurement,LSM)、磁共振磁敏感加权成像的肝肌信号强度比(liver to muscle ratio,LMR)、纤维化-4指数(fibrosis 4 score,FIB-4)、天冬氨酸转氨酶和血小板比率指数(aspartate aminotransferase to platelet ratio index,APRI)的组间差异,分析LSM、LMR、FIB-4、APRI与不同分期方法的相关性,并绘制LSM、LMR、FIB-4、APRI判断临床肝硬化与Child-Pugh评分B级、C级的受试者工作特征曲线(receiver operating characteristic curve,ROC)。结果使用两期分期法进行分组和Child-Pugh评分进行分组时,3组间的LSM、LMR、FIB-4、APRI均存在显著差异(P<0.05)。LSM、FIB-4、APRI与不同的分期方法均具有显著的正相关性,LMR与不同的分期方法均具有显著的负相关性(P<0.05)。使用两期法进行分组时,LSM、LMR、FIB-4、APRI判断临床肝硬化的受试者工作特征曲线下面积(area under the ROC,AUROC)分别为0.805、0.587、0.789、0.704,差异均有统计学意义(P<0.05)。使用Child-Pugh评分进行分组时,LSM、LMR、FIB-4、APRI判断Child-Pugh评分B级、C级的AUROC分别为0.924、0.691、0.921、0.940,差异均有统计学意义(P<0.05)。结论影像学和实验室检查(LSM、LMR、FIB-4、APRI)与肝硬化临床分期密切相关,在诊断肝硬化临床分期中具有一定的价值,可以作为辅助检查帮助临床工作者更好地识别和诊断肝硬化的临床分期。
文摘布鲁氏杆菌病(Brucellosis)是由布鲁杆菌引起的以动物为传染源的人畜共患病。布鲁氏菌感染人体后可累及多器官、多系统,其中骨关节系统病变为其最常见并发症,且常见于脊柱。布氏杆菌性脊柱炎又称布病脊柱炎(Brucella Spondylitis, BS),是由布鲁氏菌侵犯脊柱(椎间盘、椎体、肌肉)导致的脊柱感染性疾病,约占布病患者的2%~53%。主要临床表现为发热、乏力、夜间盗汗、厌食、头痛、肝脾肿大、关节疼痛、腰背痛等全身及局部症状。本文旨在深入阐述BS的致病机制、分型技术及实验室检查的最新进展。Brucellosis is a zoonotic disease caused by Brucella, which is transmitted from animals. Brucella infection in the human body can affect multiple organs and systems, among which bone and joint system lesions are the most common complications, and are common in the spine. Brucella spondylitis, also known as brucella spondylitis (BS), is a spinal infectious diseases caused by brucella invading the spine (intervertebral disc, vertebral body, muscle), accounting for 2% to 53% of patients with brucellosis. The main clinical manifestations include fever, fatigue, night sweats, anorexia, headache, hepatosplenomegaly, joint pain, lower back pain, and other systemic and local symptoms. This article aims to provide an in-depth explanation of the pathogenesis, typing techniques, and latest developments in laboratory testing of BS.
文摘百日咳是一种可预防的急性呼吸道疾病,主要表现为阵发性痉咳、咳嗽末尾声和咳嗽伴呕吐。百日咳临床表现受诸多因素影响,婴幼儿、青少年和成人可表现不典型,这使百日咳难以识别,易导致诊断和治疗延误,采用实验室检查方法辅助诊断可提高百日咳诊断率,本文就国内外百日咳实验室检查研究进展进行综述。Pertussis (whooping cough) is a preventable acute respiratory disease, mainly manifested as paroxysmal convulsive cough, cough ending and cough with vomiting. The clinical manifestations of pertussis are affected by many factors, and infants, adolescents and adults may show atypical manifestations, which makes it difficult to identify pertussis and easily leads to delayed diagnosis and treatment. The use of laboratory examination to assist diagnosis can improve the diagnosis rate of pertussis. This paper reviews the research progress in laboratory examination of pertussis at home and abroad.
