The hysteresis control combined with PWM control non-inverting buck-boost was proposed to improve the light load efficiency and power density.The constant inductor current control(CICC)was established to mitigate the ...The hysteresis control combined with PWM control non-inverting buck-boost was proposed to improve the light load efficiency and power density.The constant inductor current control(CICC)was established to mitigate the dependence on the external components and device variation and make smooth transition between hysteresis control loop and pulse width modulation(PWM)control loop.The small signal model was deduced for the buck and boost operation mode.The inductor current slope control(ICSC)was proposed to implement the automatic mode transition between buck and boost mode in one switching cycle.The results show that the converter prototype has good dynamic response capability,achieving 94%efficiency and 95%peak efficiency at full 10 A load current.展开更多
To reasearch on the infrared target perception by pyroelectric infrared (PIR) sensor in network domain measurement,a closed sensing network domain composed of eight-PIR-sensor array is proposed for the minimum sensing...To reasearch on the infrared target perception by pyroelectric infrared (PIR) sensor in network domain measurement,a closed sensing network domain composed of eight-PIR-sensor array is proposed for the minimum sensing cell measurement in network domain and to realize the moving target perception and trajectory prediction. Moreover,the feasibility and accuracy of the proposed method are verified through experiments. The experimental results demonstrate that the maximum error between the real trajectory and the predicted trajectory of the minimum sensing cell measurement method is 0.64 m,which can achieve infrared target perception and moving trajectory prediction.展开更多
In general, it is important to operate the; airgap length uniformly for improving the system efficiency independent of the flatness of the reaction plate in a railway propulsion system by a linear induction motor （LI...In general, it is important to operate the; airgap length uniformly for improving the system efficiency independent of the flatness of the reaction plate in a railway propulsion system by a linear induction motor （LIM）. And it is possible to operate the LIM propulsion system efficiently without a change of the LIM capacity through the airgap length control on the sloped rail. So, in this research, the authors introduce an airgap control system to control the airgap length which depends on the flatness of the secondary reaction plate when the LIM is operated, and design a rotary small-scaled LIM and its airgap control system before manufacturing the real system. Then, the authors analyze some characteristics of the LIM （thrust and normal force, input current, efficiency and power factor）, and through the LIM control modeling, the authors finally analyze an effect of the airgap-length control of the LIM by the airgap control system.展开更多
OBTECTIVE:To explore the role of transient receptor potential vaniiloid subetype 1(TRPV1) in the increase of the thermal pain threshold by moxibustion.METHODS:Forty Kunming mice(20 ± 2) g were randomized into con...OBTECTIVE:To explore the role of transient receptor potential vaniiloid subetype 1(TRPV1) in the increase of the thermal pain threshold by moxibustion.METHODS:Forty Kunming mice(20 ± 2) g were randomized into control group,capsaicin group,capsazepine group,moxibustion group and moxibustion + capsazepine(MC) group with 8 mice in each,and 16 C57BL/6 wild-type mice(18 ± 2) g were randomized into wild-type(WT) control group and WT moxibustion group with 8 mice in each,and 14 TRPV1 knockout mice(18 ± 2) g were randomized into knockout(KO) control group and KO moxibustion group with 7 in each.Each mouse in the capsaicin group was subcutaneously injected with the amount of 0.1 mL/10 g into L5 and L6 spinal cords;each mouse in the capsazepine group was intraperitoneally injected with the amount of0.1 mL/10 g.Similarly,each mouse in the moxibustion group was given a suspended moxibustion with specially-made moxa-stick for 20 min on L5 and L6 spinal cords.Each mouse in MC group was intraperitoneally injected with the amount of 0.1 mL/10 g first,then after 15 min was given a suspended moxibustion for 20 min on L5 and L6 spinal cords.Each mouse in WT moxibustion group and KO moxibustion group was given a suspended moxibustion with specially-made moxa-stick for 20 min on L5 and L6 spinal cords.The control group,WT control group and KO control group were of no treatment in any way.After all treatments were completed,the digital-display measurement instrument for thermal pain was used to measure the threshold of thermal pain in each group respectively.RESULTS:Compared with the control group,the thresholds of thermal pain in the moxibustion group and MC group were significantly increased(P <0.01);no significant changes in the thresholds in the capsaicin group and the capsazepine group(P > 0.05);compared with moxibustion group,he threshold of thermal in MC group was obviously decreased(P < 0.01).Compared with WT control group,the threshold of thermal pain in WT moxibustion group was significantly increased(P <0.01);compared with KO control group,no changes in the threshold in KO moxibustion group(P > 0.05).CONCLUSION:TRPV1 participated in the process of increasing the threshold of thermal pain by stimulating L5 and L6 of mice spinal cord with burning mosa-stick.展开更多
The detection of protein/small molecule interactions plays important roles in drug discovery and protein/metabolite interactions in biology. In this work, by coupling the terminal protection of small molecule-linked s...The detection of protein/small molecule interactions plays important roles in drug discovery and protein/metabolite interactions in biology. In this work, by coupling the terminal protection of small molecule-linked ss DNA strategy with the unmodified and positively charged gold nanoparticle((+)Au NP) nanoprobes, we have developed a sensitive and simple colorimetric sensor for the detection of folate receptor, a highly expressed protein in many kinds of malignant tumors. The target folate receptor binds the folate moieties of the folate-linked ss DNA through high affinity interactions and protects the protein-bound ss DNA from digestion by exonuclease I. The protected ss DNA thus adsorbs the((+)Au NP) through electrostatic interactions, leading to a red-to-blue color change of the sensing solution for sensitive colorimetric detection of folate receptor at the sub-nanomolar level. Besides, this colorimetric sensor shows high selectivity toward folate receptor against other control proteins. The developed sensor avoids the modification/conjugation of the Au NP nanoprobes and the involvement of any expensive instruments for signal transduction in protein detection. Featured with these obvious advantages, the colorimetric sensor strategy demonstrated herein can be easily expanded for sensitive and convenient detection of various protein/small molecule interactions.展开更多
文摘The hysteresis control combined with PWM control non-inverting buck-boost was proposed to improve the light load efficiency and power density.The constant inductor current control(CICC)was established to mitigate the dependence on the external components and device variation and make smooth transition between hysteresis control loop and pulse width modulation(PWM)control loop.The small signal model was deduced for the buck and boost operation mode.The inductor current slope control(ICSC)was proposed to implement the automatic mode transition between buck and boost mode in one switching cycle.The results show that the converter prototype has good dynamic response capability,achieving 94%efficiency and 95%peak efficiency at full 10 A load current.
文摘To reasearch on the infrared target perception by pyroelectric infrared (PIR) sensor in network domain measurement,a closed sensing network domain composed of eight-PIR-sensor array is proposed for the minimum sensing cell measurement in network domain and to realize the moving target perception and trajectory prediction. Moreover,the feasibility and accuracy of the proposed method are verified through experiments. The experimental results demonstrate that the maximum error between the real trajectory and the predicted trajectory of the minimum sensing cell measurement method is 0.64 m,which can achieve infrared target perception and moving trajectory prediction.
文摘In general, it is important to operate the; airgap length uniformly for improving the system efficiency independent of the flatness of the reaction plate in a railway propulsion system by a linear induction motor （LIM）. And it is possible to operate the LIM propulsion system efficiently without a change of the LIM capacity through the airgap length control on the sloped rail. So, in this research, the authors introduce an airgap control system to control the airgap length which depends on the flatness of the secondary reaction plate when the LIM is operated, and design a rotary small-scaled LIM and its airgap control system before manufacturing the real system. Then, the authors analyze some characteristics of the LIM （thrust and normal force, input current, efficiency and power factor）, and through the LIM control modeling, the authors finally analyze an effect of the airgap-length control of the LIM by the airgap control system.
基金Supported by National Key Basic Research Program 973(Dual Effects of Acupuncture on Functional Intestinal Disease and Its Relationship with Autonomic Nervous Function,No.2011cb505206)2013 Jiangsu Province Education Department of Natural Science Research of Major Projects(Research on The Role of Trpv1 About Anti-inflammation And Analgesia Effect of Moxibustion Treatment,No.13kja360001)Academic Propagate Project on Scientific And Technical Innovation Team,Nanjing University Of Chinese Medicine 2013 Scientific And Technical Innovation Team Project
文摘OBTECTIVE:To explore the role of transient receptor potential vaniiloid subetype 1(TRPV1) in the increase of the thermal pain threshold by moxibustion.METHODS:Forty Kunming mice(20 ± 2) g were randomized into control group,capsaicin group,capsazepine group,moxibustion group and moxibustion + capsazepine(MC) group with 8 mice in each,and 16 C57BL/6 wild-type mice(18 ± 2) g were randomized into wild-type(WT) control group and WT moxibustion group with 8 mice in each,and 14 TRPV1 knockout mice(18 ± 2) g were randomized into knockout(KO) control group and KO moxibustion group with 7 in each.Each mouse in the capsaicin group was subcutaneously injected with the amount of 0.1 mL/10 g into L5 and L6 spinal cords;each mouse in the capsazepine group was intraperitoneally injected with the amount of0.1 mL/10 g.Similarly,each mouse in the moxibustion group was given a suspended moxibustion with specially-made moxa-stick for 20 min on L5 and L6 spinal cords.Each mouse in MC group was intraperitoneally injected with the amount of 0.1 mL/10 g first,then after 15 min was given a suspended moxibustion for 20 min on L5 and L6 spinal cords.Each mouse in WT moxibustion group and KO moxibustion group was given a suspended moxibustion with specially-made moxa-stick for 20 min on L5 and L6 spinal cords.The control group,WT control group and KO control group were of no treatment in any way.After all treatments were completed,the digital-display measurement instrument for thermal pain was used to measure the threshold of thermal pain in each group respectively.RESULTS:Compared with the control group,the thresholds of thermal pain in the moxibustion group and MC group were significantly increased(P <0.01);no significant changes in the thresholds in the capsaicin group and the capsazepine group(P > 0.05);compared with moxibustion group,he threshold of thermal in MC group was obviously decreased(P < 0.01).Compared with WT control group,the threshold of thermal pain in WT moxibustion group was significantly increased(P <0.01);compared with KO control group,no changes in the threshold in KO moxibustion group(P > 0.05).CONCLUSION:TRPV1 participated in the process of increasing the threshold of thermal pain by stimulating L5 and L6 of mice spinal cord with burning mosa-stick.
基金supported by the National Natural Science Foundation of China (21505010, 21173274)Chongqing Research Program of Basic Research and Frontier Technology (cstc2015jcyj A1357)Scientific Research Innovation Team of Chongqing University of Technology (2015TD22)
文摘The detection of protein/small molecule interactions plays important roles in drug discovery and protein/metabolite interactions in biology. In this work, by coupling the terminal protection of small molecule-linked ss DNA strategy with the unmodified and positively charged gold nanoparticle((+)Au NP) nanoprobes, we have developed a sensitive and simple colorimetric sensor for the detection of folate receptor, a highly expressed protein in many kinds of malignant tumors. The target folate receptor binds the folate moieties of the folate-linked ss DNA through high affinity interactions and protects the protein-bound ss DNA from digestion by exonuclease I. The protected ss DNA thus adsorbs the((+)Au NP) through electrostatic interactions, leading to a red-to-blue color change of the sensing solution for sensitive colorimetric detection of folate receptor at the sub-nanomolar level. Besides, this colorimetric sensor shows high selectivity toward folate receptor against other control proteins. The developed sensor avoids the modification/conjugation of the Au NP nanoprobes and the involvement of any expensive instruments for signal transduction in protein detection. Featured with these obvious advantages, the colorimetric sensor strategy demonstrated herein can be easily expanded for sensitive and convenient detection of various protein/small molecule interactions.
