多发性硬化(multiple sclerosis,MS)是一种中枢神经系统的免疫介导性慢性炎症疾病,其主要特征包括脱髓鞘、轴突损伤以及神经退行性变。慢性活动性病灶(chronic active lesion,CAL)是疾病进展和神经退行的重要因素,对于MS的诊断和治疗选...多发性硬化(multiple sclerosis,MS)是一种中枢神经系统的免疫介导性慢性炎症疾病,其主要特征包括脱髓鞘、轴突损伤以及神经退行性变。慢性活动性病灶(chronic active lesion,CAL)是疾病进展和神经退行的重要因素,对于MS的诊断和治疗选择有重要指导作用。近年来,随着影像技术的不断进步,MRI成为MS诊断和预后评估的重要工具,如磁敏感加权成像(susceptibility-weighted imaging,SWI)能有效显示病灶的铁沉积。此外,正电子发射断层扫描(positron emission tomography,PET)可提供CAL的代谢活动信息,进一步揭示炎症活动,并为多维度评估提供支持。本文将综述MRI检测技术在CAL中的研究进展和临床价值,旨在为MS患者的早期诊断、治疗决策和预后评估提供新的影像学依据。展开更多
目的:总结1例慢性活动性EB病毒感染相关性噬血细胞综合征患儿的临床特点及诊疗经过,提高对该疾病的认识。方法:回顾性分析2022年10月山东大学附属威海市立医院儿科收治的1例慢性活动性EB病毒感染相关性噬血细胞综合征患儿的临床特点及...目的:总结1例慢性活动性EB病毒感染相关性噬血细胞综合征患儿的临床特点及诊疗经过,提高对该疾病的认识。方法:回顾性分析2022年10月山东大学附属威海市立医院儿科收治的1例慢性活动性EB病毒感染相关性噬血细胞综合征患儿的临床特点及诊疗经过,并进行相关文献复习。结果:患儿以发热、反复肝损害、全血细胞减少、凝血功能紊乱为突出表现,病情发展迅速,短时间内死亡,结合相关检查,诊断为慢性活动性EB病毒感染相关性噬血细胞综合征。结论:对于慢性活动性EB病毒感染患儿,在明确诊断后应积极采取有效治疗措施,一旦引起相关噬血细胞综合征,死亡率极高。Objective: To summarize the clinical characteristics and diagnosis and treatment process of a child with chronic active EB virus infection associated hemophagocytic syndrome, and improve the understanding of this disease. Methods: Retrospective analysis of the clinical characteristics and diagnosis and treatment process of a child with chronic active EB virus infection associated hemophagocytic syndrome admitted to the pediatrics department of Weihai Municipal Hospital affiliated with Shandong University in October 2022, and relevant literature review. Results: The child presented with prominent symptoms such as fever, repeated liver damage, decreased whole blood cells, and coagulation dysfunction. The condition developed rapidly and died within a short period of time. Combined with relevant examinations, the diagnosis was chronic active EB virus infection associated hemophagocytic syndrome. Conclusions: For children with chronic active EB virus infection, effective treatment measures should be actively taken after a clear diagnosis. Once it causes related hemophagocytic syndrome, the mortality rate is extremely high.展开更多
慢性活动性EB病毒感染(Chronic active EBV infection,CAEBV)是一种少见的发生在无明确免疫缺陷个体的综合征,临床表现多种多样,其病理改变几乎可涉及到各个器官。主要表现为EBV感染后出现慢性或复发性传单样症状,伴随EBV抗体的异常改...慢性活动性EB病毒感染(Chronic active EBV infection,CAEBV)是一种少见的发生在无明确免疫缺陷个体的综合征,临床表现多种多样,其病理改变几乎可涉及到各个器官。主要表现为EBV感染后出现慢性或复发性传单样症状,伴随EBV抗体的异常改变或病毒载量的升高,病程中可出现严重的或致死的并发症。文章就其发病机制、临床表现、实验室检查及诊治方案进展作一介绍,以提高临床对慢性活动性EBV的诊治水平。展开更多
文摘目的:总结1例慢性活动性EB病毒感染相关性噬血细胞综合征患儿的临床特点及诊疗经过,提高对该疾病的认识。方法:回顾性分析2022年10月山东大学附属威海市立医院儿科收治的1例慢性活动性EB病毒感染相关性噬血细胞综合征患儿的临床特点及诊疗经过,并进行相关文献复习。结果:患儿以发热、反复肝损害、全血细胞减少、凝血功能紊乱为突出表现,病情发展迅速,短时间内死亡,结合相关检查,诊断为慢性活动性EB病毒感染相关性噬血细胞综合征。结论:对于慢性活动性EB病毒感染患儿,在明确诊断后应积极采取有效治疗措施,一旦引起相关噬血细胞综合征,死亡率极高。Objective: To summarize the clinical characteristics and diagnosis and treatment process of a child with chronic active EB virus infection associated hemophagocytic syndrome, and improve the understanding of this disease. Methods: Retrospective analysis of the clinical characteristics and diagnosis and treatment process of a child with chronic active EB virus infection associated hemophagocytic syndrome admitted to the pediatrics department of Weihai Municipal Hospital affiliated with Shandong University in October 2022, and relevant literature review. Results: The child presented with prominent symptoms such as fever, repeated liver damage, decreased whole blood cells, and coagulation dysfunction. The condition developed rapidly and died within a short period of time. Combined with relevant examinations, the diagnosis was chronic active EB virus infection associated hemophagocytic syndrome. Conclusions: For children with chronic active EB virus infection, effective treatment measures should be actively taken after a clear diagnosis. Once it causes related hemophagocytic syndrome, the mortality rate is extremely high.
文摘慢性活动性EB病毒感染(Chronic active EBV infection,CAEBV)是一种少见的发生在无明确免疫缺陷个体的综合征,临床表现多种多样,其病理改变几乎可涉及到各个器官。主要表现为EBV感染后出现慢性或复发性传单样症状,伴随EBV抗体的异常改变或病毒载量的升高,病程中可出现严重的或致死的并发症。文章就其发病机制、临床表现、实验室检查及诊治方案进展作一介绍,以提高临床对慢性活动性EBV的诊治水平。
