Effects of multidisciplinary exercise management on patients after percutaneous coronary intervention:A randomized controlled study

Objectives To explore the effectiveness of the mobile app-based multidisciplinary exercise management on patients who receive percutaneous coronary intervention(PCI).Methods From January to October 2020,54 patients after PCI were randomly assigned to the intervention group(n=27)and the control group(n=27).The intervention group received the mobile app-based multidisciplinary exercise management,whereas the control group received routine care.The patients after PCI began to take intervention one month after the operation,and the intervention lasted for two months.Before and after the intervention,6-Minute Walking Distance was used to evaluate the patient’s exercise tolerance,and the patient’s exercise compliance was evaluated according to the patient’s exercise status recorded by the mobile app.The cognitive questionnaire on knowledge about PCI treatment for Coronary Heart Disease,the Self-efficacy for Chronic Disease Scale and the Perceived Social Support Scale were used to evaluate patients’disease-related cognition,self-efficacy and perception of social support.This study was registered on Clinical Trials.gov with registration number ChiCTR2000028930.Results Totally 51 patients after PCI who completed this study(25 patients in the intervention group and 26 patients in the control group)were included in the analysis.After 2 months of intervention,the exercise compliance of patients in the intervention group was better than that in the control group.And 6-Minute Walking Distance(469.36±57.48 vs.432.81±67.09),and the scores of knowledge of PCI treatment for coronary heart disease(52.64±9.82 vs.42.42±8.54),Self-efficacy for Chronic Disease Scale(42.40±8.04 vs.36.88±7.73)and Perceived Social Support Scale(74.04±5.73 vs.66.69±6.86)in the intervention group were higher than those in the control group with statistical significance(P<0.05).Conclusions The multidisciplinary exercise management based on the mobile app can effectively improve exercise tolerance,exercise compliance,disease-related cognition,self-efficacy,and perception of social support during exercise training for patients after PCI.

CD133^+ gallbladder carcinoma cells exhibit self-renewal ability and tumorigenicity

AIM： To identify cancer stern cells （CSCs） in human gallbladder carcinomas （GBCs）. METHODS： Primary GBC cells were cultured under serum-free conditions to produce floating spheres. The stem-cell properties of the sphere-forming cells, including self-renewal, differentiation potential, chemoresistance and tumorigenicity, were determined in vitro or in vivo. Cell surface expression of CD133 was investigated in primary tumors and in spheroid cells using flow cytometry. The sphere-colony-formation ability and tumorigenicity of CD133＋ cells were assayed.floating spheroids were generated from primary GBC cells, and these sphere-forming cells could generate new progeny spheroids in serum-free media. Spheroid cells were differentiated under serum-containing conditions with downregulation of the stem cell markers Oct-4, Nanog, and nestin （P 〈 0.05）. The differentiated cells showed lower spheroid-colony-formation ability than the original spheroid cells （P 〈 0.05）. Spheroid ceils were more resistant to chemotherapeutic reagents than the congenetic adherent cells （P 〈 0.05）. Flow cytometry showed enriched CD133＋ population in sphereforming cells （P 〈 0.05）. CD133＋ cells possessed high colony-formation ability than the CD133 population （P 〈 0.01）. CD133＋ cells injected into nude mice revealed higher tumorigenicity than their antigen-negative counterparts （P 〈 0.05）. CONCLUSION： CD133 may be a cell surface marker for CSCs in GBC.

Nursing students'knowledge,willingness,and attitudes toward the first aid behavior as bystanders in traffic accident trauma:A cross-sectional survey

Objectives:The purpose of the study was to investigate the nursing students'levels of the knowledge,willingness,and attitudes toward first aid behavior as bystanders in road traffic accident and the related factors.Methods:A total of 475 nursing students were recruited by convenience choosing in Tianjin University of Traditional Chinese Medicine.The nursing students'self-efficacy,core self-evaluation,knowledge,willingness and attitudes toward first aid behavior as bystanders in traffic accidents were investigated with a self-designed questionnaire.Results:The scores of knowledge,willingness,and attitudes toward first aid behavior in traffic accident trauma were 7.51±1.93,15.54±5.03,and 7.73±1.56,respectively.Students who once gained training of first aid showed lower levels of attitude toward first aid behavior than those untrained(t=-2.345,P=0.019).It was found that self-efficacy was correlated to the knowledge(r=0.150,P<0.001),willingness(r=0.182,P<0.004)and attitudes toward behavior of the first aid(r=0.371,P<0.001)among nursing students.Core self-evaluation was correlated to knowledge(r=0.193,P<0.001)and attitudes toward behavior of the first aid(r=0.199,P<0.001).Conclusions:The first aid knowledge among nursing students was not satisfactory.The study suggested that an unsustainable short first-aid training program may bring negative effects.Countermeasures should be taken to ensure both quality and continuity of first aid training.Meanwhile,more attention should be paid to improving the self-efficacy and core self-evaluation of the nursing students.

The strength model of self-control revisited:Linking acute and chronic effects of exercise on executive functions

Since the 1960＇s, hundreds of articles have been published on the effects of exercise on cognition and more recently on executive functions. A large variety of effects have been observed： acute or long-lasting, facilitating or debilitating. Several theoretical frameworks have been proposed to explain these effects with plausible mechanisms. However, as yet none of these models has succeeded in unifying all the observations in a single framework that subsumes all effects. The aim of the present review is to revisit the strength model of self-control initiated by Baumeister and his colleagues in the 1990＇s in order to extend its assumptions to exercise psychology. This model provides a heuristic framework that can explain and predict the effects of acute and chronic exercise on effortful tasks tapping self-regulation or executive functions. A reconsideration of exercise as a self-control task results from this perspective. A new avenue for future research is delineated besides more traditional approaches.

Comparative Analysis of Five Different Homologous Feeder Cell Lines in the Ability to Support Rhesus Embryonic Stem Cells

In our previous study, five homologous feeder cell lines, Monkey ear skin fibroblasts （MESFs）, clonally derived fibroblasts from the MESFs （CMESFs）, monkey oviductal fibroblasts （MOFs）, monkey follicular granulosa fibroblast-like （MFGs） cells, monkey follicular granulosa epithelium-like （MFGEs） cells, were developed for the maintenance of rhesus embryonic stem cells （rESCs）. We found that MESFs, CMESFs, MOFs and MFGs, but not MFGEs, support the growth of rhesus embryonic stem cells. Moreover, we detected some genes that are upregulated in supportive feeder cell lines by semi-quantitative PCR. In the present study, we applied the GeneChip Rhesus Macaque Genome Array of Affymetrix Corporation to study the expression profiles of these five feeder cell lines, in purpose to find out which cytokines and signaling pathways were important in maintaining the rESCs, mRNAs of eight genes, including GREM2, bFGF, KITLG, DKK3, GREM1, AREG, SERPINF1 and LTBP1, were found to be upregulated in supportive feeder cell lines, but not in MFGE. The results indicate that many signaling pathways may play redundant roles in supporting the undifferentiated growth and maintenance of pluripotency in rESCs.

Side population cells isolated from KATO Ⅲ human gastric cancer cell line have cancer stem cell-like characteristics

AIM: To investigate whether the side population (SP) cells possess cancer stem cell-like characteristics in vitro and the role of SP cells in tumorigenic process in gastric cancer. METHODS: We analyzed the presence of SP cells indifferent human gastric carcinoma cell lines, and then isolated and identified the SP cells from the KATO Ⅲ human gastric cancer cell line by flow cytometry. The clonogenic ability and self-renewal were evaluated by clone and sphere formation assays. The related genes were determined by reverse transcription polymerase chain reaction. To compare tumorigenic ability, SP and non-side population (NSP) cells from the KATO Ⅲ human gastric cancer cell line were subcutaneously injected into nude mice. RESULTS: SP cells from the total population accounted for 0.57% in KATO Ⅲ, 1.04% in Hs-746T, and 0.02% in AGS (CRL-1739). SP cells could grow clonally and have self-renewal capability in conditioned media. The expression of ABCG2, MDRI, Bmi-1 and Oct-4 was different between SP and NSP cells. However, there was no apparent difference between SP and NSP cells when they were injected into nude mice. CONCLUSION: SP cells have some cancer stem celllike characteristics in vitro and can be used for studying the tumorigenic process in gastric cancer.

Turkish validity and reliability of the Diabetes Self-Efficacy Scale

Purpose:The aim of this methodological study was to determine the validity and reliability of the Diabetes Self-Efficacy Scale adapted to the Turkish community.Methods:The study sample was completed with 319 patients who had been diagnosed at least 1 year before and hospitalized in the Malatya Turgut Ozal Health Center and Malatya State Hospital in Turkey.A questionnaire that consists of items on sociodemographic characteristics,drug use and information about the disease of patients and the Diabetes Self-Efficacy Scale were used for data collection in the study.In reliability analysis of the scale,the Cronbach'sαcoefficient was calculated and item analysis method was utilized.Factor analysis was used for the construct validity,and Principal Component Analysis and Varimax Rotation method were used for analyzing the factor structures.Results:According to data obtained in the study,item-total correlation of the items of the scale was found to be at an adequate level(0.297-0.803).The scale's Cronbach'sαreliability coefficient was found to be 0.86,and there was one factor that explains 52.38%of the total variance with an eigenvalue was greater than 1.0.As a result of the analysis,the factor loadings of the items of the scale were found to bebetween 0.59 and 0.81.Conclusion:Diabetes Self-Efficacy Scale is a valid and reliable instrument for determining the self-efficacy of patients and providing a proper care.It can be suggested to investigate and evaluate the consistency of the scale by applying it to broader sample groups representing different socioeconomic levels.

Effect of continuing nursing on self-care ability of diabetic patients:A meta-analysis

Objective:To evaluate the effect of continuing nursing on self-care ability of diabetic patients.Methods:Meta-analysis was used to search multiple Chinese and English databases,and relevant randomized controlled trials were collected.After reviewing the literature quality,RevMan 5.2 software was used for data analysis.Results:A total of 8 randomized controlled trials(RCTs)were included.The results showed that the self-care ability of the continuing care observation group was significantly higher than that of the control group [WMD = 17.88,95%CI(17.30,18.47),P<0.001].Conclusion:Continuing nursing shows superiority in improving self-care ability of diabetic patients.

Therapeutic application of stem cells in gastroenterology:An up-date

Adult stem cells represent the self-renewing progenitors of numerous body tissues, and they are currently classified according to their origin and differentiation ability. In recent years, the research on stem cells has expanded enormously and holds therapeutic promises for many patients suffering from currently disabling diseases. This paper focuses on the possible use of stem cells in the two main clinical settings in gastro-enterology, i.e., hepatic and intestinal diseases, which have a strong impact on public health worldwide. Despite encouraging results obtained in both regenerative medicine and immunemediated conditions,further studies are needed to fully understand the biology of stem cellsand carefully assess their put ativeonco- genicproperties.Moreover,there searchonstemcellsarousesferventethical,socialandpoliticaldebate.TheItalianSocietyofGastroenterologysponsoredaworkshoponstemcellsheldinVeronaduringtheⅩⅥCongressoftheFederationofItalianSocietiesofDigestiveDiseases(March 6-9,2010).Here,we report on the issues discussed,including liver and intestinal diseases that may benefit from stemcell therapy,the biology of hepatic and intestinal tissue repair,and stem cell usage inclinical trials.

c-Met in pancreatic cancer stem cells: Therapeutic implications

Pancreatic cancer is the deadliest solid cancer and currently the fourth most frequent cause of cancer-related deaths. Emerging evidence suggests that cancer stem cells (CSCs) play a crucial role in the development and progression of this disease. The identification of CSC markers could lead to the development of new therapeutic targets. In this study, the authors explore the functional role of c-Met in pancreatic CSCs, by analyzing self-renewal with sphere assays and tumorigenicity capacity in NOD SCID mice. They concluded that c-Met is a novel marker for identifying pancreatic CSCs and c-Met high in a higher tumorigenic cancer cell population. Inhibition of c-Met with XL184 blocks self-renewal capacity in pancreatic CSCs. In pancreatic tumors established in NOD SCID mice, c-Met inhibition slowed tumor growth and reduced the population of CSCs, along with preventing the development of metastases.

Self-renewal Capacity of Several Species of the Genus Sternbergia Possessing Medicinal Properties

The present work dealt with sexual reproduction capacity of three relic species of the genus Sternbergia （family AmaryUidaceae） distributed in the Caucasus, i.e., Sternbergia lutea （L.） Ker Gawl. ex Spreng., Sternbergiafischeriana （Herb.） Roem and Sternbergia colchiciflora Waldst. ＆ Kit.. Under this study, the natural populations of species, which possess valuable medicinal and ornamental properties, have been assessed by experts as vulnerable, and S. colchiciflora is included in the red list of endemic plants of the Caucasus, as having status of the critically endangered species. The situation is aggravated by the poor self-regeneration capacity of these species, which is one of the main factors responsible for the sustainability of the population of this or that species in the wild. Self-regeneration capacity for sexual reproduction was investigated in the listed species of the genus Sternbergia using common methods of embryology and reproduction biology. In conditions of the National Botanical Garden of Georgia （NBGG）, the species S. lutea and S. fischeriana prove to be completely infertile and propagate vegetatively by bulblets, while S. colchiciflora revealed the ability for propagation by seed. Long-term conservation of seeds of the studied species S. colchiciflora in the Caucasus Regional Seed Bank （CRSB） and establishing of living collections of this species at the experimental plot were chosen as the method for safeguarding this critically endangered species.

Effective Learner-Lecturer Interaction Working With a Virtual Learning Environment

Using the Internet to learn a language creates wide opportunities to enhance learning （Association of teachers of English in Catalonia （APAC）, 2010）. The Internet activities promote learners＇ self-monitoring ability, encourage the use of multimedia and network technology, and develop students＇ cooperation and participation. During the latest years, there have been many changes in education as these new technologies, including VLEs （Virtual Learning Environments）, which have become an important part in the teaching/learning process. According to Tech Terms Computer Dictionary （2012）, VLE is a virtual classroom where teachers and students communicate. VLEs have evolved as at an early stage, they were only ways of transmitting information： Teachers uploaded the multimedia resources and students read this information. At a higher stage, VLEs have become interactive. This means that students become active. We have designed a virtual environment where students, weekly, must contribute their opinions and comments in response to a required activity uploaded by the teacher. In this paper, we describe this weekly task and analyze students＇ opinion about this planned activity. The students become an active subject in this field. In this paper, we show how VLEs are no longer a means of transmitting information but a means of interaction as well as a way of motivating our students to be involved in their learning process

Study on the Scaffolding Teaching of Three-dimensional Animation Foundation based on Modularization

In this paper, the teaching of course Three-dimensional Animation Foundation is designed mainly based on teaching content modularization and scaffolding teaching model. The modularized content design for Three-dimensional Animation Foundation is specifically expounded, and also the ideas for developing the scaffolding teaching model are analyzed. How to integrate the scaffolding teaching model into course teaching is introduced in details. Finally, new methods for guiding students to think independently in course teaching and improve students＇ self-awareness and self-learning ability are proposed.

On Translator＇s Subjectivity in the Chinese Version of Pride and Prejudice Translated by Wang Keyi

As the center and subject of the translation, translator＇ s subjectivity plays a great role in translation research and more and more attention has been aroused. Since the first version of Pride and Prejudice came into being, Chinese translators have begun to show great interest in translating this novel, and there are more than ten translated Chinese versions now. Scholars have conducted a lot of research about this novel and its various translated versions. Among all these Chinese versions, Wang Keyi＇ s version is relatively earlier and is also the most popular one. Thus, it attracts many readers＇ eyes and there are increasing comments and studies on this version. There are also studies analyzing or comparing several versions from the perspective of translator＇ s subjectivity. While, few articles are published to analyze this version from the three elements of translator＇ s subjectivity： initiatives, passiveness, and purposiveness. They are also three basic features of translator＇ s subjectivity, in which translator＇ s subjectivity reflects. It is also the three features that consist of the translator＇ s subjectivity. Therefore, the comprehensive and intensive research of translator＇ s subjectivity in the Chinese version of Pride and Prejudice has great realistic meaning and practical values.

Self-adapting Scalable Differential Evolution Algorithm

Differential evolution(DE) demonstrates good convergence performance,but it is difficult to choose trial vector generation strategies and associated control parameter values.An improved method,self-adapting scalable DE(SSDE) algorithm,is proposed.Trial vector generation strategies and crossover probability are respectively self-adapted by two operators in this algorithm.Meanwhile,to enhance the convergence rate,vectors selected randomly with the optimal fitness values are introduced to guide searching direction.Benchmark problems are used to verify this algorithm.Compared with other well-known DE algorithms,experiment results indicate that this algorithm is better than other DE algorithms in terms of convergence rate and quality of optimization.

Emerging Research Efficacy Through Scaffolded Research Practice: An EFL Preservice Teacher Autobiographical Narrative

EFL preservice teachers ’ research efficacy, as perceived competence to perform tasks in research, is crucial to their research engagement. This autobiographical narrative inquiry investigates the contribution of scaffolded research practice to a female EFL preservice teacher ’s research efficacy.The data were collected through conversations, notes, journals, and portfolios. The findings suggest that teacher research efficacy was pliable through scaffolded research practice. It emerged gradually over time, in different places with social and personal interaction. The factors contributing to the emerging research efficacy were: teacher educators ’ support, peers ’ support,and research participation. The study sheds light on teacher educators and EFL preservice teachers,with the intention of establishing an inquiry-based pedagogy for M.Ed. programs.

A Phenomenological Understanding of Digital Processes of Subjectification： The Example of Lifelogging

By lifelogging, we understand a specific, very recent phenomenon of digital technology, which falls within the range of practices of the quantified self. It is a complex form of self-management through self-monitoring and self-tracking practices, which combines the use of wearable computers for measuring psycho-physical performances through specific apps for the processing, selecting and describing of the data collected, possibly in combination with video recordings. Given that lifelogging is becoming increasingly widespread in technologically advanced societies and that practices related to it are becoming part of most people＇s everyday lives, it is more important than ever to gain an understanding of the phenomenon. In this paper, I am interested in particular in exploring the issue of the transformations in the perception, comprehension, and construction of self, and hence in subjectification practices, deriving from the new digital technologies, and especially lifelogging.

Psychometric testing of the cross-culturally adapted Thai version of the Self-Care Self-Efficacy Scale version 3.0 in individuals with chronic illnesses

Objective:To assess the psychometric properties of the Thai version of the Self-Care Self-Efficacy Scale version 3.0(SCSES-v3.0)in individuals with chronic illnesses.Although originally developed and tested in a Western context,its applicability in Asian populations,including Thailand,remains inadequately explored.Methods:Psychometric tests were guided by COSMIN principles.This included the translation of the English version into Thai based on the ISPOR framework.Nine nursing experts evaluated the content validity.Data were obtained from a multicenter cross-sectional study conducted between July and November 2022.This study included individuals with chronic conditions from 16 primary care centers in Thailand.We tested the structural validity using exploratory factor analysis(EFA)and confirmatory factor analysis(CFA),and concurrent validity in relation to the Self-Care of Chronic Illness Inventory version 4.c(SC-CII-v4.c).We tested the scale’s reliability with McDonald’s u,Cronbach’s a,and the intraclass correlation coefficient(ICC).Results:The Thai SCSES-v3.0 demonstrated excellent content validity(k¼1.00).Thefinal analysis included a total of 385 participants.The EFA with thefirst split-half subsample(n¼193)extracted a twofactor structure.One reflected SCSES for maintenance and monitoring behaviors and another captured SCSES for management behaviors(item 6e10).CFA with the second split-half subsample(n¼192)and the overall sample(n¼385)supported the scale’s two-factor model with high factor loadings.Each dimension and the overall SCSES-v3.0 positively correlated with each scale and the overall SC-CII-v4.c.McDonald’s u and Cronbach’s a(both ranged 0.91e0.94)and ICC(ranged 0.95e0.96),indicated excellent internal reliability and test-retest reliability,respectively.Conclusions:The identification of a valid and reliable two-factor model for the Thai SCSES-v3.0 renders it a valuable tool for clinicians and investigators,facilitating the assessment of self-efficacy in self-care across diverse contexts.

The Effects of Positive Self-evaluation on Senior High School Students' English Writing Performance and Writing Self-efficacy

This study examined the effectiveness of positive self-evaluation used as an intervention to cultivate students＇ English writing self-efficacy and improve their writing performance. Multiple sources of data were collected from 90 students of grade 10 at a high school in Beijing, including the pretest and posttest writings, writing self-efficacy questionnaires, interviews, and follow-up questionnaires over one semester. Data analyses showed that the experimental group excelled the control group in writing performance and became more confident in writing at the end of positive self-evaluation practices. This study also found that writing self-efficacy and writing performance were positively related. The students with high writing self-efficacy tended to perform better in their writing than those with low writing self-efficacy.

The Justification of Teacher-guided Error Correction of Chinese College Students' English Writing

本文通过为期12周的实证研究旨在突出自主学习环境下教师主导作用在中国大学生英语作文纠错处理方面的发挥。通过实验组与控制组,实验前与实验后的对比分析,研究显示尽管实验前两组学生在作文自我修改能力及整体作文质量方面均无显著差异,行文准确度即流利度方面,控制组甚至强于实验组,经过12周的纠错处理,实验组学生在自我改错能力,文章表达准确度及作文整体质量方面明显优于控制组。在行文流利程度方面两组无明显差异,但两组在实验后作文流利程度均有显著提高。该研究丰富了已有的纠错研究并倡导自主学习环境下教师主导进行学生作文纠错处理。