Alefacept is a dimeric fusion protein that consists of the extracellular CD2-binding portion of human lymphocyte function-associated antigen-3, which is linked to the Fc segment of human IgG1.1 Alefacept inhibits T-ce...Alefacept is a dimeric fusion protein that consists of the extracellular CD2-binding portion of human lymphocyte function-associated antigen-3, which is linked to the Fc segment of human IgG1.1 Alefacept inhibits T-cell activation and proliferation, and induces apoptosis of memory-effector (CD45RO+) T cells in vitro,2 limiting the inflammatory and uncontrolled keratinocyte proliferation seen in psoriatic lesions. Alefacept is the first biologic approved in the United States for the treatment of moderate to severe chronic plaque psoriasis. This report describes the use of alefacept in 2 patients with extensive and recalcitrant palmoplantar psoriasis who achieved significant improvements on alefacept therapy.展开更多
掌跖脓疱病(Pustular psoriasis of the palma and soles,PPP)是一种慢性复发性皮肤疾病,有人称该病为局限性脓疱型银屑病,也有人认为这是银屑病的变种或亚型,但现在不少学者又认为它是一种独立的疾病。本病主要由于脾虚生湿,湿热内蕴,...掌跖脓疱病(Pustular psoriasis of the palma and soles,PPP)是一种慢性复发性皮肤疾病,有人称该病为局限性脓疱型银屑病,也有人认为这是银屑病的变种或亚型,但现在不少学者又认为它是一种独立的疾病。本病主要由于脾虚生湿,湿热内蕴,或外感湿热邪毒,以致邪毒循经外越蕴于掌跖而发;另有部分金属过敏体质者,亦可发生此病,但在具体病理不明时一般作为第三种独立的疾病来诊断。该病包括:包括掌跖脓疱性银屑病(Pustular psoriasis of the palma andsoles)和脓疱性细菌疹(Pustular bacterid),其鉴别如下:1.掌跖脓疱性银屑病:多数人认为是局限性脓疱型银屑病,以掌跖多见,损害常见于手掌的大小鱼际及跖弓部位,也可发展到指(趾)背侧;初起时为对称性红斑,很快出现若干无菌的小脓疱,表面并不隆起,脓疱位于表皮内,逐渐扩大而互相融合,一两周内干涸结成痂,皮痂脱落后出现小鳞屑,但又可出新脓疱,如此反复并指甲受累而变色或变形,呈混浊肥厚,有脊状突起自觉疼痛;身体其它部位可有不典型寻常型银屑病的皮损,或有成片脓疱性银屑病的表现,有的病人可见沟状舌。2.脓疱性细菌疹:损害往往先发生于手掌或足底的中央逐渐蔓延至整个手掌和足底,也可蔓延到手足的侧面,初起时为水疱,迅速变成不含细菌的脓疱,几天以后脓疱干涸结痂变成棕色鳞屑,鳞屑脱落以后又有新的脓疱出现。如此反复持续若干年掌跖皮肤可以发红,增厚,表面有鳞屑,有些患者局部有瘙痒和疼痛,脓疱细菌培养阴性。展开更多
文摘Alefacept is a dimeric fusion protein that consists of the extracellular CD2-binding portion of human lymphocyte function-associated antigen-3, which is linked to the Fc segment of human IgG1.1 Alefacept inhibits T-cell activation and proliferation, and induces apoptosis of memory-effector (CD45RO+) T cells in vitro,2 limiting the inflammatory and uncontrolled keratinocyte proliferation seen in psoriatic lesions. Alefacept is the first biologic approved in the United States for the treatment of moderate to severe chronic plaque psoriasis. This report describes the use of alefacept in 2 patients with extensive and recalcitrant palmoplantar psoriasis who achieved significant improvements on alefacept therapy.
文摘掌跖脓疱病(Pustular psoriasis of the palma and soles,PPP)是一种慢性复发性皮肤疾病,有人称该病为局限性脓疱型银屑病,也有人认为这是银屑病的变种或亚型,但现在不少学者又认为它是一种独立的疾病。本病主要由于脾虚生湿,湿热内蕴,或外感湿热邪毒,以致邪毒循经外越蕴于掌跖而发;另有部分金属过敏体质者,亦可发生此病,但在具体病理不明时一般作为第三种独立的疾病来诊断。该病包括:包括掌跖脓疱性银屑病(Pustular psoriasis of the palma andsoles)和脓疱性细菌疹(Pustular bacterid),其鉴别如下:1.掌跖脓疱性银屑病:多数人认为是局限性脓疱型银屑病,以掌跖多见,损害常见于手掌的大小鱼际及跖弓部位,也可发展到指(趾)背侧;初起时为对称性红斑,很快出现若干无菌的小脓疱,表面并不隆起,脓疱位于表皮内,逐渐扩大而互相融合,一两周内干涸结成痂,皮痂脱落后出现小鳞屑,但又可出新脓疱,如此反复并指甲受累而变色或变形,呈混浊肥厚,有脊状突起自觉疼痛;身体其它部位可有不典型寻常型银屑病的皮损,或有成片脓疱性银屑病的表现,有的病人可见沟状舌。2.脓疱性细菌疹:损害往往先发生于手掌或足底的中央逐渐蔓延至整个手掌和足底,也可蔓延到手足的侧面,初起时为水疱,迅速变成不含细菌的脓疱,几天以后脓疱干涸结痂变成棕色鳞屑,鳞屑脱落以后又有新的脓疱出现。如此反复持续若干年掌跖皮肤可以发红,增厚,表面有鳞屑,有些患者局部有瘙痒和疼痛,脓疱细菌培养阴性。
