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丙丁酚抑制氧化型低密度脂蛋白诱导系膜细胞转化生长因子-β_1表达 被引量:9
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作者 王远程 叶志斌 +2 位作者 周钦 张宗梁 吴兆龙 《复旦学报(医学版)》 CAS CSCD 北大核心 2005年第2期151-154,188,共5页
目的 观察丙丁酚对ox- LDL诱导系膜细胞AP -1活性和TGF -β1 表达的作用 ,探讨抗氧化剂治疗脂质肾损伤的分子机制。方法 大鼠系膜细胞随机分为正常细胞组、ox- LDL处理组和ox- LDL +丙丁酚处理组。运用凝胶迁移率实验检测AP-1活性变化... 目的 观察丙丁酚对ox- LDL诱导系膜细胞AP -1活性和TGF -β1 表达的作用 ,探讨抗氧化剂治疗脂质肾损伤的分子机制。方法 大鼠系膜细胞随机分为正常细胞组、ox- LDL处理组和ox- LDL +丙丁酚处理组。运用凝胶迁移率实验检测AP-1活性变化 ,Western杂交检测c- Jun、JNK/SAPK磷酸化及TGF- β1 蛋白表达水平的改变。运用Northern杂交检测TGF- β1- mRNA表达。结果 丙丁酚 5 0 μmol/L预处理系膜细胞 2 0h ,显著降低ox LDL诱导系膜细胞AP 1活性。丙丁酚浓度为 5 0、1 0 0、2 0 0 μmol/L时 ,均显著抑制ox- LDL诱导JNK ,/SAPK磷酸化 ;且ox LDL +丙丁酚处理组的c Jun蛋白表达分别为ox- LDL处理组的 6 0 %、5 1 %和 4 6 %。Northern杂交显示 :ox LDL为 1 0 μg/mL时并不激活TGF- β1 mRNA表达 (P >0 .0 5 ) ;而当ox-LDL浓度增至 5 0、1 0 0 μg/mL时 ,TGF -β1 mRNA表达分别增加 1 .8和 1 .9倍。Western杂交显示ox -LDL呈剂量依赖方式增加TGF β1 蛋白质表达。加入丙丁酚后显著降低ox LDL诱导系膜细胞的TGF -β1- mRNA和蛋白质表达 (P <0 .0 5 )。结论 丙丁酚可能通过抑制JNK1 /SAPK磷酸化和AP 活性下调ox- LDL诱导系膜细胞TGF- β1 表达。 展开更多
关键词 系膜细胞 转化生长因子-β1 丙丁酚 蛋白诱导 氧化型低 抑制 TGF-β1表达 NORTHERN杂交 mRNA表达 Western杂交 JNK/SAPK AP-1活性 mol/L 蛋白质表达 密度 氧化剂治疗 蛋白表达水平 LDL 杂交检测 凝胶迁移率 磷酸化 分子机制 活性变化 实验检测 剂量依赖 Jun
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血液透析患者使用氟伐他汀对其氧化型低密度脂蛋白水平的影响
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作者 常巍 杨毅 《山西医药杂志(上半月)》 CAS 2010年第10期950-951,共2页
关键词 血液透析患者 蛋白水平 氧化型低 氟伐他汀 慢性肾功能衰竭 肾脏移植 密度 持续血液透析
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氢氧化钾型低共熔溶剂用于松木预处理的研究
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作者 詹颖 刘琛 +3 位作者 党哲哲 吴佳昊 孙晓然 赵峥 《广州化工》 2025年第1期47-51,共5页
为了高效去除木质素,增强松木的酶解效率,采用氢氧化钾型低共熔溶剂预处理松木。主要对4种氢氧化钾型低共熔溶剂进行筛选,并优化了预处理的工艺条件。结果表明,氢氧化钾∶单乙醇胺(摩尔比为1∶3)的预处理效果最佳。在温度为110℃、时间... 为了高效去除木质素,增强松木的酶解效率,采用氢氧化钾型低共熔溶剂预处理松木。主要对4种氢氧化钾型低共熔溶剂进行筛选,并优化了预处理的工艺条件。结果表明,氢氧化钾∶单乙醇胺(摩尔比为1∶3)的预处理效果最佳。在温度为110℃、时间为5 h、固液比为1∶15的条件下,木质素去除率达95.31%,预处理残渣酶水解72 h的还原糖产率达82.89%。同时,对比不同低共熔溶剂的pH值和黏度发现,氢氧化钾型低共熔溶剂的预处理效果主要受pH值、黏度影响,其中pH值起主要作用。利用傅里叶转换红外光谱、扫描电子显微镜、X射线衍射表征手段,深入研究氢氧化钾型低共熔溶剂预处理松木的机理。 展开更多
关键词 氧化共熔溶剂 预处理 松木 木质素 酶水解
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某低品位氧化型金矿可选性试验研究 被引量:8
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作者 毛益林 陈晓青 +1 位作者 杨进忠 王秀芬 《矿产综合利用》 CAS 2010年第4期8-11,共4页
该金矿为低品位氧化型金矿。通过活化含金矿物,使其成为浮游性较好的矿物形态,再经浮选富集,金精矿品位达到21.75g/t,回收率78.46%。浮选精矿产品直接氰化浸出,金浸出率达到97.62%;金选冶总回收率76.59%。采用浮选氰化浸出的选冶联合方... 该金矿为低品位氧化型金矿。通过活化含金矿物,使其成为浮游性较好的矿物形态,再经浮选富集,金精矿品位达到21.75g/t,回收率78.46%。浮选精矿产品直接氰化浸出,金浸出率达到97.62%;金选冶总回收率76.59%。采用浮选氰化浸出的选冶联合方案,可使同类型低品位金矿资源的综合开发利用成为可能。 展开更多
关键词 品位氧化金矿 浮选富集 氰化浸出 硫化剂EMH-101
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B113-2/B205-1型一氧化碳变换催化剂应用总结 被引量:3
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作者 裴盈 江志斌 《大氮肥》 CAS 2001年第6期377-381,共5页
总结辽河牌B113 2 /B2 0 5 1型一氧化碳变换催化剂的性能特点、工业应用、运行评价及使用时应注意事项。
关键词 性能 特点 工业应用 运行评价 合成氨工业 B113-2汽气比氧化碳高温变换催化剂 B205-1催化剂
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混合金属氧化物掺杂对锰酸锂性能的影响研究
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作者 李海亮 詹海青 +3 位作者 闫冠杰 吴继相 杨英全 李华成 《中国锰业》 2024年第2期22-26,共5页
以低钠钾型二氧化锰、碳酸锂为原料,以不同量纳米三氧化二铝、二氧化钛为添加剂,采用高温固相法制备电池正极材料锰酸锂,研究混合金属氧化物添加量对锰酸锂的物理性能及电性能的影响。通过粒度分布、振实密度、微观结构、容量及容量衰... 以低钠钾型二氧化锰、碳酸锂为原料,以不同量纳米三氧化二铝、二氧化钛为添加剂,采用高温固相法制备电池正极材料锰酸锂,研究混合金属氧化物添加量对锰酸锂的物理性能及电性能的影响。通过粒度分布、振实密度、微观结构、容量及容量衰减对材料性能进行表征。结果表明,纳米三氧化二铝掺杂量为0.3%和二氧化钛掺杂量为0.5%的条件下合成的锰酸锂材料0.5 C容量为98.2 mAh/g和1.0 C容量为97.9 mAh/g,50次高温循环容量保持率为98.37%,该产品具有高温循环性能优良,对锰酸锂的生产具有一定参考意义。 展开更多
关键词 钠钾氧化 混合金属氧化 锰酸锂 高温循环性能
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通心络对实验性家兔主动脉粥样斑块内血管内皮生长因子表达的影响 被引量:50
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作者 张路 吴宗贵 +1 位作者 廖德宁 潘晓明 《中国动脉硬化杂志》 CAS CSCD 2004年第2期177-182,共6页
通过构建实验性家兔主动脉粥样硬化模型 ,观察通心络及辛伐他汀对血清氧化型低密度脂蛋白、一氧化氮、一氧化氮合酶和乳酸脱氢酶及血管形态学的影响 ,并采用免疫组织化学、逆转录—聚合酶链反应及WesternBlot蛋白印迹等方法 ,从不同水... 通过构建实验性家兔主动脉粥样硬化模型 ,观察通心络及辛伐他汀对血清氧化型低密度脂蛋白、一氧化氮、一氧化氮合酶和乳酸脱氢酶及血管形态学的影响 ,并采用免疫组织化学、逆转录—聚合酶链反应及WesternBlot蛋白印迹等方法 ,从不同水平观察通心络及辛伐他汀对动脉粥样斑块血管内皮生长因子表达的影响。结果发现 ,通心络减少动脉粥样斑块血管内皮生长因子表达 ,降低血清氧化型低密度脂蛋白及乳酸脱氢酶浓度 ,提示通心络可增加粥样斑块稳定性 ,延缓动脉粥样硬化的进程。 展开更多
关键词 药理学 通心络对动脉粥样癍块稳定性的影响 免疫组织化学 血管内皮生长因子 氧化型低 密度脂蛋白 通心络 动脉粥样硬化
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血浆ox-LDL与急性缺血性脑卒中合并颈动脉斑块患者预后的关系 被引量:3
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作者 王春阳 李艳玲 +4 位作者 戴丽叶 杨光 王翠兰 杨斌 石秋艳 《山东医药》 CAS 2018年第21期55-57,共3页
目的探讨血浆氧化型低密度脂蛋白(ox-LDL)与急性缺血性脑卒中合并颈动脉斑块患者预后的关系。方法选取急性缺血性卒中患者氧化应激(SOS-Stroke)研究数据库中合并颈动脉斑块的患者2 188例,依据急性中风治疗组织10172试验分型标准分为大... 目的探讨血浆氧化型低密度脂蛋白(ox-LDL)与急性缺血性脑卒中合并颈动脉斑块患者预后的关系。方法选取急性缺血性卒中患者氧化应激(SOS-Stroke)研究数据库中合并颈动脉斑块的患者2 188例,依据急性中风治疗组织10172试验分型标准分为大动脉粥样硬化型(LAA)1 297例、心源性栓塞型(CE)112例、小动脉闭塞型(SAO)685例、其他病因型(SOE)及原因不明型(SUE)40例。用酶联免疫吸附法检测患者血浆ox-LDL水平,并计算其四分位数。纳入SOS-Stroke研究12个月用改良Rankin量表对患者预后进行评价。用多变量回归分析ox-LDL与脑卒中后预后不良的关系,将ox-LDL四分位数中值(Q1、Q2、Q3、Q4)输入模型并作为连续变量进行处理,在Logistic回归模型中进行趋势检验;用回归模型分析ox-LDL与脑卒中亚型患者预后的关系。结果 2 188例患者血浆ox-LDL水平为(566.1±206.9)μg/L。具有高ox-LDL水平(Q4)患者脑卒中后的不良结局较低四分位数风险高。调整潜在的混杂因素(年龄、性别、体质量指数、吸烟史、饮酒史、收缩压、舒张压和降脂药物),Q2、Q3和Q4亚组的比值比分别为1.58(95%CI 1.14~2.20)、1.58(95%CI 1.14~2.19)和1.89(95%CI 1.36~2.61)。Ox-LDL水平每升高10个单位,预后不良风险增加15.69%。血浆ox-LDL水平对LAA型、SAO型脑卒中不良预后有影响(P均<0.05),对其他类型脑卒中不良预后无明显影响(P均>0.05)。结论血浆ox-LDL是急性缺血性脑卒中合并颈动脉斑块患者预后的影响因素,尤其对LAA型、SAO型脑卒中患者预后有影响;血浆ox-LDL水平越高,患者预后越差。 展开更多
关键词 脑卒中 氧化型低密底脂蛋白 颈动脉斑块 预后
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Baicalin and geniposide inhibit the development of atherosclerosis by increasing Wntl and inhibiting dickkopf-related protein-1 expression 被引量:8
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作者 Bin WANG Ping-Ping LIAO +3 位作者 Li-Hua LIU Xin FANG Wei LI Si-Ming GUAN 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第10期846-854,共9页
Background Our previous study showed that the combined Chinese herbs containing scutellaria baicalensis georgi and gardenia jasminoids ellis inhibited atherosclerosis. In this study, we sought to determine if baicalin... Background Our previous study showed that the combined Chinese herbs containing scutellaria baicalensis georgi and gardenia jasminoids ellis inhibited atherosclerosis. In this study, we sought to determine if baicalin and geniposide could inhibit atherosclerosis through Wntl and dickkopf-related protein-1 (DKK1). Methods The wild-type and ApoE-/- mice were treated with baicalin, geniposide, and baicalin plus geniposide daily by gavage for 12 weeks. Blood lipid levels were measured with an automatic biochemistry analyzer. Aortic atherosclerotic lesion areas were analyzed with Image-ProPlus software. The mRNA and protein expression of DKK1, Wntt and nuclear factor-r,B (NF-κB) were measured with RT-PCR and Westem Blot. Serum levels of interleukin-12 (IL-12) were quantified with ELISA. Results The baicalin or geniposide monotherapy as well as combination therapy inhibited the development of atherosclerotic lesions, increased Wntl and decreased DKKI expression and elevated the ratio of Wntl/DKK1 compared with high-lipid diet group. However, only baicalin or geniposide monotherapy decreased NF-κB expression. Moreover, baicalin and geniposide monoor combination therapy lowered IL-12 levels. Geniposide reduced both serum total cholesterol and low density lipoprotein levels, while baicalin either alone or in combination with geniposide did not affect serum lipid levels. In human, umbilical vein endothelial ceils stimulated by oxidized low density lipoprotein, baicalin and geniposide also increased Wntl and decreased DKK1 expression and elevated the ratio of Wntl/DKK1. Condusions Baicalin and geniposide exert inflammation-regulatory effects and may prevent atherosclerotic lesions through enhancing Wntl and inhibit- ing DKK1 expression. 展开更多
关键词 ATHEROSCLEROSIS BAICALIN DKK1 GENIPOSIDE Wntl
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Reversion of severe hepatopulmonary syndrome in a non cirrhotic patient after corticosteroid treatment for granulomatous hepatitis:A case report and review of the literature 被引量:3
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作者 Nikolaos Tzovaras Aggelos Stefos +6 位作者 Sarah P Georgiadou Nikolaos Gatselis Georgia Papadamou Eirini Rigopoulou Maria Ioannou Ioannis Skoularigis Georgios N Dalekos 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第2期336-339,共4页
Hepatopulmonary syndrome (HPS) is defined as a clinical triad including liver disease, abnormal pulmonary gas exchange and evidence of intrapulmonary vascular dilatations. We report a 61-year-old male presented with... Hepatopulmonary syndrome (HPS) is defined as a clinical triad including liver disease, abnormal pulmonary gas exchange and evidence of intrapulmonary vascular dilatations. We report a 61-year-old male presented with fatigue, long-lasting fever, loss of weight, signs of portal hypertension, hepatosplenomegaly, cholestasis and progressive dyspnoea over the last year. Clinical, laboratory and histological findings confirmed the diagnosis of granulomatous hepatitis. HPS due to hepatic granulomainduced portal hypertension was proved to be the cause of severe hypoxemia of the patient as confirmed by contrast-enhanced echocardiography. Reversion of HPS after corticosteroid therapy was confirmed by a new contrastenhanced echocardiography along with the normalization of cholestatic enzymes and improvement of the patient' s conditions. This is the first case of complete reversion of HPS in a non-cirrhotic patient with hepatic granuloma, indicating that intrapulmonary shunt in liver diseases is a functional phenomenon and HPS can be developed even in miscellaneous liver involvement as in this case. 展开更多
关键词 Hepatopulmonary syndrome Granulomatous hepatitis Liver cirrhosis Orthodeoxia Platypnoea
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云南某金矿浮选工艺研究 被引量:1
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作者 郑金庆 《云南冶金》 2017年第1期33-36,共4页
介绍了一种无氰、无毒、无污染的用于处理云南某低氧化型金矿单一浮选工艺,该工艺流程简单、投入成本低,经过探索试验,确定了药剂制度及工艺流程,最终可获得品位为38.65 g/t,回收率为75.33%的金精矿,试验指标较好。
关键词 无氰 氧化金矿 单一浮选 金精矿
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Construction of a macromolecular structural model of Chinese lignite and analysis of its low-temperature oxidation behavior 被引量:11
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作者 Xianliang Meng Mingqiang Gao +6 位作者 Ruizhi Chu Zhenyong Miao Guoguang Wu Lei Bai Peng Liu Yuanfang Yan Pengcheng Zhang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2017年第9期1314-1321,共8页
The aim of this paper is to analyze the change in the active structure of lignite during the process of lowtemperature oxidation by constructing a molecular structure model for lignite. Using quantum computation combi... The aim of this paper is to analyze the change in the active structure of lignite during the process of lowtemperature oxidation by constructing a molecular structure model for lignite. Using quantum computation combined with experimental results of proximate analysis, ultimate analysis, Fourier transform infrared spectroscopy(FTIR) and X-ray photoelectron spectroscopy(XPS), a structural model for the large molecular structure was constructed. By analyzing the bond lengths in the model molecule, the evolution law for the active structure of lignite was predicted for the process of low-temperature oxidation. In low-temperature oxidation,alkanes and hydroxyls are the primary active structures observed in lignite, though ether may also react. These active functional groups react with oxygen to release heat, thereby speeding up the reaction between coal and oxygen. Finally, the content of various functional groups in the process of lignite low-temperature oxidation was analyzed by infrared analysis, and the accuracy of the model was verified. 展开更多
关键词 Chinese lignite Coal combustion Molecular simulation Low-temperature oxidation process Environment
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A 0.18μm CMOS GAIN-SWITCHED LNA AND MIXER WITH LARGE DYNAMIC RANGE 被引量:2
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作者 Yang Jinlin Yang Haigang Xue Bing 《Journal of Electronics(China)》 2008年第5期679-684,共6页
A 2.4GHz 0.18μm CMOS gain-switched single-end Low Noise Amplifier (LNA) and a passive mixer with no external balun for near-zero-IF (Intermediate Frequency)/RF (Radio Frequency) applications are described. The ... A 2.4GHz 0.18μm CMOS gain-switched single-end Low Noise Amplifier (LNA) and a passive mixer with no external balun for near-zero-IF (Intermediate Frequency)/RF (Radio Frequency) applications are described. The LNA, fabricated in the 0.18μm 1P6M CMOS technology, adopts a gain-switched technique to increase the linearity and enlarge the dynamic range. The mixer is an IQ-based passive topology. Measurements of the CMOS chip are performed on the FR-4 PCB and the input is matched to 50Ω. Combining LNA and mixer, the front-end measured performances in high gain state are: -15dB of Sll, 18.5dB of voltage gain, 4.6dB of noise figure, 15dBm of IIP3, 85dBm to -10dBm dynamic range. The full circuit drains 6mA from a 1.8V supply. 展开更多
关键词 CMOS Low Noise Amplifier (LNA) MIXER Front-end Noise figure Gain-switched Dynamic range
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Green aerobic oxidative desulfurization of diesel by constructing an Fe-Anderson type polyoxometalate and benzene sulfonic acid-based deep eutectic solvent biomimetic cycle 被引量:5
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作者 Jiajia Xu Zhiguo Zhu +6 位作者 Ting Su Weiping Liao Changliang Deng Dongmei Hao Yuchao Zhao Wanzhong Ren Hongying Lü 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2020年第5期868-876,共9页
A unique redox-coupled biomimetic system was developed, in which Fe-Anderson type polyoxometalates(POMs) were employed as electron transfer mediators(ETMs) and benzenesulfonic acid(BSA)-based deep eutectic solvents(DE... A unique redox-coupled biomimetic system was developed, in which Fe-Anderson type polyoxometalates(POMs) were employed as electron transfer mediators(ETMs) and benzenesulfonic acid(BSA)-based deep eutectic solvents(DESs) were used as electron-donors for aerobic oxidative desulfurization(AODS) of diesel fuel. Different compositions of DESs were used and the polyethylene glycol 2000(PEG2000)/2.5 BSA system showed the highest desulfurization activity, with the removal of dibenzothiophene(DBT) at 60 ℃ reaching 95% in 60 min. The excellent desulfurization activity of the system is due to the in situ formation of peroxysulfonate via a biomimetic process. By constructing a coupled redox system, Fe-Anderson type POMs as ETMs reduce the activation energy of oxygen-activated sulfonate. The physical characteristics of four different DESs were tested. The results show that the conductivity of DESs is correlated with the composition of BSA-based DESs. However, there is no similar trend in viscosity testing at the same temperature, and the maximum viscosity value is obtained for the PEG2000/2.5 BSA system at 60 ℃, which may be associated with the stronger hydrogen bonds. It is worth noting that the PEG2000/2.5 BSA system also possesses the best desulfurization activity, which suggests that the activity of the desulfurization system is related to the strength of the hydrogen bond in DESs. Finally, the biomimetic desulfurization system exhibits excellent performance and good stability under mild reaction conditions(60 ℃, atmospheric pressure, oxygen as the oxidant). 展开更多
关键词 Aerobic oxidative desulfurization Fe-Anderson type polyoxometalate Deep eutectic solvents DIBENZOTHIOPHENE Physical characteristics Electron transfer mediators
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Low temperature doping of anatase nano TiO2
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作者 ZHU Tang-long WANG Li-ming SHEN Yong WANG Ping SHEN Yang-yang 《International English Education Research》 2015年第9期104-112,共9页
In this paper. Glucose, nitrate, and urea were respectively used as C, B, and N sources doped TiO2 at low temperature sol gel method, The obtained nano TiO2 was characterized by DRS, FIRT, TG-DTG. The photocatalytic p... In this paper. Glucose, nitrate, and urea were respectively used as C, B, and N sources doped TiO2 at low temperature sol gel method, The obtained nano TiO2 was characterized by DRS, FIRT, TG-DTG. The photocatalytic properties and the optical response range of the natase nanocrystalline were analyzed and studied with the hybrid orbital theory. The results show that the band gap of the doped TiO2 was narrow, and the photocatalytic ability could be excited by the visible lighL and the doping of non metallic elements broadens the application range of TiO2, so that it could be excited under the visible light and obtained better use value. 展开更多
关键词 Sol-gel metho& Natase nanocrystalline Low temperature Non-metallic doping Visible light
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南化集团研究院三催化剂产品被认定为国家重点新产品
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《气体净化》 2003年第1期21-21,共1页
关键词 南化集团研究院 认定 国家重点新产品 C306压甲醇合成催化剂 B207氧化浊变换催化剂 DH021环己醇脱氯制环己酮催化剂
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Effect of Danhong injection on expressions of macrophage scavenger receptor 1 and sub-family A member 1 in human U937 cells 被引量:6
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作者 Xianming Su Wei Yang Xiaowen Zhi 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2013年第3期384-387,共4页
OBJECTIVE: To study the effects of Danhong injec- tion (DHI) on expression of the macrophage scaven- ger receptor 1 (MSR1) and ATP-binding cassette, sub-family A member 1 (ABCA1) genes, which en- code scavenger... OBJECTIVE: To study the effects of Danhong injec- tion (DHI) on expression of the macrophage scaven- ger receptor 1 (MSR1) and ATP-binding cassette, sub-family A member 1 (ABCA1) genes, which en- code scavenger receptor-A I (SR-AI) and ATP-bind- ing cassette transporter 1 (ABCA1), respectively, as a potential anti-atherosclerotic mechanism. METHODS: Human U937 cells were stimulated by in- cubation with 100 nM phorbo112-myristate 13-ace- tate (PMA) for 48 h.These stimulated, monocyte-like cells were then incubated for 24 h with 50 mg/L oxi- dized low-density lipoprotein (ox-LDL, to induce foam cell formation), together with a liver X recep- tor (LXR) agonist or with different DHI concentra- tions. MSR1 and ABCA1 mRNA levels were mea- sured by fluorescence-based quantitative PCR. RESULTS: Compared with control cells (which re- ceived only ox-LDL), cells treated with both ox-LDL and 10 IJmol/L LXR agonist showed lower MSR1 ex-pression (but this effect was not statistically signifi- cant, P〉0.05) and higher ABCA1 expression (P〈 0.01). Cells that received ox-LDL and 3 mL/L DHI possessed higher MSR1 mRNA levels than the con- trols, whereas cells treated with ox-LDL and higher DHI concentrations (10, 30 or 60 mL/L) showed low- er MSR1 expression levels (but the differences ob- served between DHI concentration groups were not statistically significant, P〉0.05). ABCA1 expression in cells treated with ox-LDL and 3, 10 or 30 mL/L DHI was higher than in the control cells, and increased with increasing DHI concentration (P〈0.05). ABCA1 expression in cells treated with ox-LDL and the highest DHI concentration tested (60 mL/L) was not significantly different from that in the controls. ABCA1 mRNA levels in cells treated with ox-LDL and DHI were similar to, or lower than, those in cells treated with ox-LDL and the LXR agonist. CONCLUSION: DHI does not affect MSR1 mRNA lev- els in ox-LDL-treated U937 cells. However, at certain concentrations (10 and 30 mL/L), DHI significantly increases ABCA1 mRNA levels. Therefore, the an- ti-atherosclerotic action of DHI might be mediated by an increased expression of ABCA1. 展开更多
关键词 Receptors scavengers Class A ATP-binding cassette transporters Cholesterol me-tabolism U937 cells Danhong injection
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