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多组学数据驱动的机器学习模型在乳腺癌生存及治疗响应预测中的应用 被引量:1
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作者 章子怡 王棨临 +4 位作者 张俊有 段迎迎 刘家欣 刘赵硕 李春燕 《遗传》 CAS CSCD 北大核心 2024年第10期820-832,共13页
乳腺癌的高度异质性导致其治疗及预后评估较为复杂。治疗方案的选择受到肿瘤亚型、病变分级、基因型等多种因素的影响,因此需要制定个体化治疗策略。患者的预后效果因病情不同而产生显著差异。作为人工智能的一个重要分支,机器学习能高... 乳腺癌的高度异质性导致其治疗及预后评估较为复杂。治疗方案的选择受到肿瘤亚型、病变分级、基因型等多种因素的影响,因此需要制定个体化治疗策略。患者的预后效果因病情不同而产生显著差异。作为人工智能的一个重要分支,机器学习能高效处理海量数据,并实现决策过程的自动化。机器学习方法的引入将为乳腺癌治疗的选择和预后评估提供新的解决方案。在癌症治疗领域,传统方法预测生存与治疗效果往往依赖于单一或少量的生物标志物,难以全面捕捉复杂的生物学过程。机器学习通过分析患者的多组学数据以及它们在疾病发生发展过程中复杂的变化趋势,预测患者的生存和治疗响应效果,从而选择适合的治疗措施,实施早期干预,改善患者的治疗效果。本文首先介绍了常用的机器学习方法,在此基础上分别从评估生存情况和预测治疗效果这两方面展开,详细分析了机器学习在乳腺癌患者生存预测及预后领域中的应用,以期为乳腺癌患者提供精准医疗治疗策略,提高治疗效果和生存质量。 展开更多
关键词 乳腺癌 机器学习 多组学数据整合分析 生存预测 治疗响应
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细胞外基质刚度诱导CCL5合成以提高非小细胞肺癌免疫治疗响应
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作者 张天 杨雅儒 +2 位作者 张恩永 郭卉 刘梦洁 《西安交通大学学报(医学版)》 CAS CSCD 北大核心 2024年第3期396-404,共9页
目的探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)细胞外基质刚度调控趋化因子配体5(C-C motif chemokine ligand 5,CCL5)的机制,揭示CCL5对NSCLC的免疫治疗响应的影响。方法通过TCGA数据库分析NSCLC细胞外基质刚度与CCL5表达... 目的探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)细胞外基质刚度调控趋化因子配体5(C-C motif chemokine ligand 5,CCL5)的机制,揭示CCL5对NSCLC的免疫治疗响应的影响。方法通过TCGA数据库分析NSCLC细胞外基质刚度与CCL5表达的相关性;根据NSCLC细胞外基质刚度设计不同刚度的聚丙烯酰胺水凝胶,获得响应水凝胶基质刚度力学加载的H1299细胞并对其进行转录组测序,利用q-PCR验证高基质刚度对CCL5表达的影响;进一步利用NSCLC患者转录组数据探究CCL5与免疫治疗响应的相关性。结果高细胞外基质刚度可以上调CCL5的表达,并且干扰素-γ(interferonγ,IFN-γ)介导的信号通路可能参与了该过程;CCL5高表达的NSCLC患者,肿瘤组织中细胞毒性T细胞的丰度更高,与抗程序性死亡受体-1(programmed cell death protein 1,PD-1)治疗响应性有关。结论细胞外基质刚度增加可促进CCL5合成,CCL5可通过增加肿瘤组织中细胞毒性T细胞浸润提升NSCLC的免疫治疗响应性。 展开更多
关键词 非小细胞肺癌(NSCLC) 细胞外基质刚度 趋化因子配体5(CCL5) 免疫治疗响应
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低Tim-3表达水平与肝癌氩氦刀冷冻消融联合TACE治疗响应的相关性
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作者 张剑 杨荟玉 +3 位作者 张自森 王利娟 张红巧 郭彦伟 《实用癌症杂志》 2023年第2期235-239,共5页
目的探讨肝癌浸润免疫细胞中Tim-3表达含量与氩氦刀冷冻消融(AHCS)联合肝动脉化疗栓塞术(TACE)治疗响应以及预后的相关性。方法使用免疫组化方法检测肿瘤活检组织免疫细胞中Tim-3表达水平。Tim-3高表达被定义为TILs上的染色>5%,依据T... 目的探讨肝癌浸润免疫细胞中Tim-3表达含量与氩氦刀冷冻消融(AHCS)联合肝动脉化疗栓塞术(TACE)治疗响应以及预后的相关性。方法使用免疫组化方法检测肿瘤活检组织免疫细胞中Tim-3表达水平。Tim-3高表达被定义为TILs上的染色>5%,依据Tim-3表达情况将患者分为Tim-3低表达组、Tim-3高表达组。2组患者均接受AHCS-TACE联合治疗。为期3年的随访,观察指标包括总生存期(OS),肿瘤进展时间(TTP)以及客观反应率(ORR)。治疗3月后应用ELISA试验方法检测患者CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)T淋巴细胞亚群水平。结果2组患者在性别、ECOG评分、Child-Pugh分级、肿瘤大小、AFP水平、有无门静脉侵犯相关指标均无统计学差异。经AHCS-TACE联合治疗后,Tim-3低表达组患者的ORR显著高于Tim-3高表达组。Tim-3低表达组的中位OS为27.07月,Tim-3高表达组为19.79个月,差异具有统计学意义(P<0.05)。Tim-3低表达组的中位TTP为16.41个月,而Tim-3高表达组为11.49个月。Tim-3低表达组患者的CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)T细胞水平均显著高于Tim-3高表达组患者。多因素分析显示,有无门静脉瘤栓和肝内肿瘤的最大直径以及Tim-3表达含量是OS和TTP的预后因素。结论肿瘤浸润免疫细胞中Tim-3含量对TACE+AHCS联合治疗患者预后具有预测价值。基于Tim-3的高表达模式,应用Tim-3的免疫检查点抑制剂进行维持治疗,可能会改善接受AHCS-TACE联合治疗的患者的预后和完全反应率。 展开更多
关键词 Tim-3表达水平 氩氦刀冷冻消融 TACE 治疗响应 预后
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清金化痰汤联合支气管镜下肺泡灌洗术治疗社区获得性肺炎的临床疗效观察
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作者 郭钢强 《中国科技期刊数据库 医药》 2024年第3期0138-0141,共4页
本次研究是为了探讨清金化痰汤联合支气管镜下肺泡灌洗术在社区获得性肺炎(CAP)治疗中的临床疗效及其可行性。方法 采用前瞻性非随机对照研究,共分为两组。研究组包括15例肺炎计分指数(PSI)为71-130分的CAP患者,在常规使用抗生素治疗的... 本次研究是为了探讨清金化痰汤联合支气管镜下肺泡灌洗术在社区获得性肺炎(CAP)治疗中的临床疗效及其可行性。方法 采用前瞻性非随机对照研究,共分为两组。研究组包括15例肺炎计分指数(PSI)为71-130分的CAP患者,在常规使用抗生素治疗的基础上,施行清金化痰汤联合支气管镜下肺泡灌洗术。对照组共30例CAP患者,这些患者的PSI分数也在71-130之间,但其中15名患者仅接受了常规的抗生素治疗,数据收集自2019年1月至2021年6月。另外15例患者,在常规使用抗生素治疗的基础上接受了支气管镜下肺泡灌洗术。本次研究时间为2021年10月至2022年12月期间。结果 结果显示,研究组的治疗效果在白介素6和白细胞水平上显著优于对照组(P<0.05)。结论 清金化痰汤联合支气管镜下肺泡灌洗术治疗CAP具有较好的疗效,能改善临床症状,缩短治病周期,并且具有较高的安全性。本研究为清金化痰汤在现代医学中应用提供了一定的临床依据,并为CAP的综合治疗提供了一个新的思路,值得进一步的探讨与研究。 展开更多
关键词 社区获得性肺炎 清金化痰汤 支气管镜下肺泡灌洗术 临床疗效 可行性 肺炎计分指数 治疗响应时间
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^(18)F-FDG PET/CT预测弥漫大B细胞淋巴瘤化疗后无进展生存期 被引量:2
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作者 林少春 黎恩廷 +2 位作者 陈志丰 张冰 李周雷 《中山大学学报(医学科学版)》 CAS CSCD 北大核心 2023年第2期262-270,共9页
[目的]评估^(18)F-FDG PET/CT不同代谢参数在分析弥漫性大B细胞淋巴瘤(DLBCL)治疗响应中的预测价值。[方法]回顾性地选取2015年6月至2020年10月收治^(18)F-FDG PET/CT的81例DLBCL患者。通过多元逻辑回归分析确定DLBCL治疗反应的预测因素... [目的]评估^(18)F-FDG PET/CT不同代谢参数在分析弥漫性大B细胞淋巴瘤(DLBCL)治疗响应中的预测价值。[方法]回顾性地选取2015年6月至2020年10月收治^(18)F-FDG PET/CT的81例DLBCL患者。通过多元逻辑回归分析确定DLBCL治疗反应的预测因素,并根据这些因素创建预测模型。之后,通过特性曲线和校准图验证此预测模型的性能。[结果]首次化疗后2年内,23例患者(28.3%,23/81)疾病复发,58例患者(71.7%,58/81)无进展。本文分析了PET/CT特征的二元逻辑回归模型的预测能力。结果显示,化疗后^(18)F-FDG PET/CT的定量值是无进展生存期(PFS)的独立预后因素。其中,SUV_(THR-mean)2是预测DLBCL患者化疗后治疗反应的最重要因素,临界值为2.00(AUC=0.81)。[结论]我们建立的影像学特征预测模型显示出对DLBCL化疗无进展生存期的良好预测效能。其中,化疗后的影像学特征SUV_(THR-mean)2是DLBCL患者PSF预后的最佳独立预测因素。我们的预测模型将能提示疾病进展风险,有利于建议临床选择适当的治疗及随访方案,提高诊治效能,节省医疗成本。 展开更多
关键词 弥漫大B细胞淋巴瘤 PET/CT 治疗响应 预测模型
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Effect of b value on monitoring therapeutic response by diffusion-weighted imaging 被引量:13
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作者 Zhao-Xia Jiang Wei-Jun Peng +5 位作者 Wen-Tao Li Feng Tang Shi-Yuan Liu Xu-Dong Qu Jian-Hua Wang Hong-Feng Lu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第38期5893-5899,共7页
AIM: To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (T... AIM: To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (TACE) in a rabbit model. METHODS: Twelve New Zealand white rabbits bearing VX2 tumors in the liver were treated with TACE. Diffusion-weighted imaging (DWI) with various b values was performed using the same protocol before and 3 d after treatment with TACE. ADC values and CNR of each tumor pre- and post-treatment with different b factors were analyzed. Correlation between ADC values and extent of necrosis in histological specimens was analyzed by a Pearson's correlation test.RESULTS: The quality of diffusion-weighted images diminished as the b value increased. A substantial decrease in the mean lesion-to-liver CNR was observed on both pre- and post-treatment DW images, the largest difference in CNR pre- and post-treatment was manifested at a b value of 1000 s/mm^2 (P = 0.036 ). The effect of therapy on diffusion early after treatment was shown by a significant increase in ADCs (P = 0.007), especially with large b factors (≥ 600 s/mm^2). The mean percentage of necrotic cells present within the tumor was 76.3%-97.5%. A significant positive correlation was found between ADC values and the extent of necrosis with all b values except for b200, a higher relative coefficient between ADC values and percentage of necrosis was found on DWI with bl000 and b2000 (P = 0.002 and 0.006, respectively). CONCLUSION: An increasing b value of up to 600 s/mm^2 would increase ADC contrast pre- and post-treatment, but decrease image quality. Taking into account both CNR and ADC measurement, diffusion-weighted imaging obtained with a b value of 1000 s/mm^2 is recommended for monitoring early hepatic tumor response to TACE. 展开更多
关键词 Hepatic carcinoma Diffusion-weighted MR Treatment response Apparent diffusion coefficient
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Second-line therapy for gemcitabine-pretreated advanced or metastatic pancreatic cancer 被引量:1
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作者 Romain Altwegg Marc Ychou +8 位作者 Vanessa Guillaumon Simon Thezenas Pierre Senesse Nicolas Flori Thibault Mazard Ludovic Caillo Stéphanie Faure Emmanuelle Samalin Eric Assenat 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第12期1357-1364,共8页
AIM: To investigate second-line chemotherapy in gemcitabine-pretreated patients with advanced or metastat- ic pancreatic cancer [(frequency, response, outcome, course of carbohydrate antigen 19-9 (CA 19-9)].METHOD... AIM: To investigate second-line chemotherapy in gemcitabine-pretreated patients with advanced or metastat- ic pancreatic cancer [(frequency, response, outcome, course of carbohydrate antigen 19-9 (CA 19-9)].METHODS: This retrospective study included all patients with advanced or metastatic pancreatic cancer (adenocarcinoma or carcinoma) treated with secondline chemotherapy in our center between 2000 and 2008. All patients received first-line chemotherapy with gemcitabine, and prior surgery or radiotherapy was permitted. We analyzed each chemotherapy protocol for second-line treatment, the number of cycles and the type of combination used. The primary endpoint was overall survival. Secondary endpoints included progression-free survival, response rate, grade 3-4 toxicity, dosage modifications and CA 19-9 course.a second-line therapy among 206 patients who had initially received first-line treatment with a gemcitabi- ne-based regimen. Median number of cycles was 4 (range: 1-12) and the median duration of treatment was 2.6 mo (range: 0.3-7.4). The overall disease control rate was 40.0%. The median overall survival and progression-free survival from the start of second-line therapy were 5.8 (95% CI: 4.1-6.6) and 3.4 mo (95% CI: 2.4-4.2), respectively. Toxicity was generally acceptable. Median overall survival of patients with a CA 19-9 level declining by more than 20% was 10.3 mo (95% CI: 4.5-11.6) vs 5.2 mo (95% CI: 4.0-6.4) for others (P = 0.008).CONCLUSION: A large proportion of patients could benefit from second-line therapy, and CA 19-9 allows efficient treatment monitoring both in first and secondline chemotherapy. 展开更多
关键词 SECOND-LINE CHEMOTHERAPY Pancreatic can-cer GEMCITABINE Carbohydrate antigen 19-9
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pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment 被引量:8
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作者 Ke-Ni Yang Chun-Qiu Zhang +3 位作者 Wei Wang Paul C.Wang Jian-Ping Zhou Xing-Jie Liang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2014年第1期34-43,共10页
In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles (MSNs) with a func... In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles (MSNs) with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanopartides, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. These categories will be described in detail. 展开更多
关键词 Mesoporous silica nanoparticles PH-RESPONSIVE controlled drug release drug delivery systems antineoplastic protocols
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Research of the relationship between radiotherapy and microRNAs
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作者 Jiao yang Ximing Xu Yanrong Hao 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第5期285-289,共5页
MicroRNAs(miRNAs) are endogenous short non-coding RNAs,and play a pivotal role in regulating a variety of cellular processes,including proliferation and apoptosis,both of which are cellular responses to radiation trea... MicroRNAs(miRNAs) are endogenous short non-coding RNAs,and play a pivotal role in regulating a variety of cellular processes,including proliferation and apoptosis,both of which are cellular responses to radiation treatment.In response to radiation,multiple miRNAs show altered expression,which act as oncogenes or tumor suppressors.Recent evidence has also shown that some miRNAs have radiotherapy sensitization or radiation resistance role in malignant tumors.This review focuses on analysis of these characteristics and mechanisms of miRNAs,and will provide some insight into the therapeutic application of radiation. 展开更多
关键词 microRNAs (miRNAs) radiotherapy sensitization radiotherapy resistance dysregulation mechanism
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SEN virus does not affect treatment response in hepatitis C virus coinfected patients but SEN virus response depends on SEN virus DNA concentration 被引量:2
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作者 Abdurrahman Sagin Ortwin Adams +3 位作者 OliverKirschberg AndreasErhardt TobiasHeintges Dieter Hussinger 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第13期1893-1897,共5页
AIM: To clarify the effect of SEN virus (SENV) infection on a combination therapy including interferon alfa (IFN-α) or pegylated-IFN with ribavirin in patients with chronic hepatitis and the effect of a combination t... AIM: To clarify the effect of SEN virus (SENV) infection on a combination therapy including interferon alfa (IFN-α) or pegylated-IFN with ribavirin in patients with chronic hepatitis and the effect of a combination therapy on SENV.METHODS: SENV DNA was determined by polymerase chain reaction in serum samples from 95 patients with chronic hepatitis C. Quantitative analysis was done for SENV H DNA.RESULTS: Twenty-one (22%) of 95 patients were positive for SENV DNA. There was no difference in clinical and biochemical parameters between patients with HCV infection alone and coinfected patients. The sustained response rate for HCV clearance after combination therapy did not differ between patients with SENV (52%) and without SENV(50%, n.s.). SENV DNA was undetectable in 76% of the initially SENV positive patients at the end of follow-up. SENV H response to combination therapy was significantly correlated with SENV DNA level (P=-0.05).CONCLUSION: SENV infection had no influence on the HCV sustained response rate to the combination therapy.Response rate of SENV to the combination therapy depends on SENV DNA level. 展开更多
关键词 Adult Antiviral Agents DNA Virus Infections DNA Viruses purification DNA Viral Drug Therapy Combination Female HEPACIVIRUS Hepatitis C Chronic Humans Interferon Alfa-2a INTERFERON-ALPHA Male Middle Aged Polyethylene Glycols Prevalence RNA Viral RIBAVIRIN
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A Novel Regimen for Perioral Dermatitis by Photodynamic Therapy
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作者 Smadar Schreiber 《Journal of Pharmacy and Pharmacology》 2016年第10期559-563,共5页
Some patients with perioral dermatitis are not relieved despite many medications. These patients confront pain, psychological bother and social/occupational limitations. Being efficient for a wide variety of diseases ... Some patients with perioral dermatitis are not relieved despite many medications. These patients confront pain, psychological bother and social/occupational limitations. Being efficient for a wide variety of diseases including infectious inflammative degenerative or tumoral, photodynamic therapy holds a good chance to cure diseases of unknown origin, such as perioral dermatitis. This study presents the results of three women with chronic perioral dermatitis that persisted for years with partial response to medical regimen. They asked for photodynamic treatment to ease off their suffering. The duration of follow-up was up to five years. Following PDT (photodynamic therapy), the patients discontinued medications, redness decreased and eruption disappeared. In these patients, a single PDT treatment provided prolonged relief of perioral dermatitis for up to three years. These data are encouraging but not sufficient. Further study is warranted. 展开更多
关键词 PDT (photodynamic therapy) perioral dermatitis periorificial dermatitis face rash.
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Comparison of two different kinds of regimens in treatment of advanced non-small cell lung cancer
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作者 Wenwu Wang Xuenong Ouyang 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第10期563-566,共4页
Objective: The aim of this study was to analyze and compare the recent efficacy and toxicity of a three-drug platinum-based regimen (A regimen): [cisplatin (DDP) + gemcitabine (GEM) + vinorelbine (NVB)] an... Objective: The aim of this study was to analyze and compare the recent efficacy and toxicity of a three-drug platinum-based regimen (A regimen): [cisplatin (DDP) + gemcitabine (GEM) + vinorelbine (NVB)] and a two-drug combination without a platinum drug (B regimen): GEM + NVB, which were used to treat 55 advanced non-small cell lung cancer (NSCLC) patients, in a bid to provide a guidance for clinical treatment. Methods: Twenty-four cases of advanced NSCLC (stage Ill-IV) patients were treated with A regimen (DDP 35 mg/m^2 d1-3; GEM 1250 mg/m^2 d1, 8 ). The other 31 cases were treated with B (GEM 1250 mg/m^2 d1,8; NVB 25 mg/m^2 d1, 8 ). Repeat every 3 weeks for 6 courses. Results: In A regimen group, the overall response rate was 45.8% (CR + PR = 11), median response time was 5.5 months, median survival time was 11 months and 1-year survival rate was 41.7%. In B regimen group, the overall response rate was 48.4% (CR + PR = 15) and median response time, survival time and 1-year survival rate were respectively 6.5 and 10 months and 41.9%. The major toxicities were nausea/vomiting, myelosuppression in A regimen group, myelosuppression and phlebitis in B regimen group, respectively. Conclusion: A regimen and B regimen for advanced NSCLC have similar response rate (P 〉 0.05). B regimen, a two-drug combination without a platinum drug is of less toxicity and more safety than A regimen, a three-drug platinum-based regimen and is recommended to be a regimen in the first-line treatment for advanced NSCLC. 展开更多
关键词 non-small cell lung cancer (NSCLC) gemcitabine (GEM) vinorelbine (NVB) cisplatin (DDP) combined chemotherapy
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阿齐沙坦酯治疗原发性高血压安全性和有效性的Meta分析 被引量:2
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作者 曹旺 刘永军 《中国新药杂志》 CAS CSCD 北大核心 2020年第11期1313-1320,共8页
目的:评价阿齐沙坦酯(azilsartan medoxomil,AZL-M)治疗原发性高血压的安全性及有效性。方法:检索PubMed、Embase、Cochrane、Web of Science、中国知网、万方、维普等数据库中关于阿齐沙坦酯治疗原发性高血压的随机对照试验,筛选符合... 目的:评价阿齐沙坦酯(azilsartan medoxomil,AZL-M)治疗原发性高血压的安全性及有效性。方法:检索PubMed、Embase、Cochrane、Web of Science、中国知网、万方、维普等数据库中关于阿齐沙坦酯治疗原发性高血压的随机对照试验,筛选符合纳入标准的文献并进行文献质量评价,采用RevMan 5.3软件进行Meta分析。结果:共纳入8篇RCT,6148例患者。阿齐沙坦酯治疗组不良事件的发生率无显著性差异(OR=1.03,95%CI:0.94~1.14,P=0.51),导致停药的不良事件发生率也无显著性差异(OR=1.09,95%CI:0.84~1.41,P=0.52)。与其他药物相比,阿齐沙坦酯治疗有更高的收缩压响应率(OR=1.34,95%CI:1.02~1.74,P<0.00001)和血压响应率(OR=2.2,95%CI:1.82~2.66,P<0.00001)。结论:阿齐沙坦酯治疗原发性高血压疗效显著,且不良反应事件的发生率与其他现有治疗药物相当。 展开更多
关键词 阿齐沙坦酯 原发性高血压 治疗响应 安全性 META分析
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A pH-responsive zinc(Ⅱ) metalated porphyrin for enhanced photodynamic/photothermal combined cancer therapy 被引量:1
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作者 Pingpine Liang Hao Tang +6 位作者 Rui Gu Lei Xue Dapeng Chen Wenjun Wang Zhou Yang Weili Si Xiaochen Dong 《Science China Materials》 SCIE EI CSCD 2019年第8期1199-1209,共11页
The acidic tumor microenvironment is triggered by glycolysis in hypoxic condition, which can motivate the pHresponsive system to build certain triggers for efficiently tumor-targeted phototherapy. Additionally, the me... The acidic tumor microenvironment is triggered by glycolysis in hypoxic condition, which can motivate the pHresponsive system to build certain triggers for efficiently tumor-targeted phototherapy. Additionally, the metalated porphyrin structures are widely studied in biomedical applications due to the favorable properties of high singlet oxygen quantum yield as well as strong fluorescence imaging ability. Herein, a pH-responsive zinc(II) metalated porphyrin(P-4) was designed and synthesized for amplifying cancer photodynamic/photothermal therapy with excellent fluorescence quantum yield(67.4%), superb singlet oxygen quantum yield(84.3%) and desired photothermal conversion efficiency(30.0%). In vitro, the self-assembled P-4 nanoparticles can specifically target to lysosome subcellular site and realize protonated process of dibutaneaminophenyl(DBAP) groups with high photo toxicity. Under single 660 nm laser illumination, the tumor can be ablated completely with no side effects in vivo. This work demonstrates that the p H-responsive P-4 nanoparticles provide a new avenue for highly efficient cancer combination therapy. 展开更多
关键词 PH-RESPONSIVE PORPHYRIN NIR absorbance photodynamic therapy photothermal therapy
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