急性脑血管疾病包括急性出血性卒中和急性缺血性卒中。目前急性缺血性卒中是我国致死及致残的主要原因之一,亦是全球最常见的卒中类型。作为一种重要的病理机制,急性脑梗死发生后炎症免疫反应会被激活。最为常见的炎症指标是外周血中的...急性脑血管疾病包括急性出血性卒中和急性缺血性卒中。目前急性缺血性卒中是我国致死及致残的主要原因之一,亦是全球最常见的卒中类型。作为一种重要的病理机制,急性脑梗死发生后炎症免疫反应会被激活。最为常见的炎症指标是外周血中的白细胞、中性粒细胞、淋巴细胞、单核细胞。本文从神经炎症机制和中性粒细胞、单核细胞、淋巴细胞在发生缺血性卒中后的炎症反应以及炎症相关指标对脑梗死的预测作用进行综述。Acute cerebrovascular diseases include acute hemorrhagic stroke and acute ischemic stroke. At present, acute ischemic stroke is one of the main causes of death and disability in China, and it is also the most common type of stroke worldwide. As an important pathological mechanism, the inflammatory immune response is activated after acute cerebral infarction occurs. The most common inflammatory markers are white blood cells, neutrophils, lymphocytes, and monocytes in peripheral blood. This article reviews the mechanisms of neuroinflammation and the inflammatory responses of neutrophils, monocytes, and lymphocytes after ischemic stroke, as well as the predictive role of inflammation related indicators for cerebral infarction.展开更多
目的:观察分析血常规炎性细胞等相关指标与甲状腺毒症不同病因的相关性,并探讨其在临床中的意义。方法:选取2022年1月至2022年12月于同济大学附属东方医院胶州医院内分泌科门诊就诊的患者49例,包括27例Graves病患者(GD组)、22例桥本甲...目的:观察分析血常规炎性细胞等相关指标与甲状腺毒症不同病因的相关性,并探讨其在临床中的意义。方法:选取2022年1月至2022年12月于同济大学附属东方医院胶州医院内分泌科门诊就诊的患者49例,包括27例Graves病患者(GD组)、22例桥本甲状腺炎患者(HT组)、以及在本院体检中心健康体检的志愿者30名(CON组),比较三组间白细胞(WBC)、中性粒细胞(NC)、淋巴细胞(LC)、单核细胞(MC)、中性粒/淋巴细胞比值(NLR)、单核/淋巴细胞比值(MLR)等实验室资料及相关资料的差异。相关性分析甲状腺毒症不同病因与实验室检查指标的相关性。结果:HT组与CON组相比,WBC、LC、MLR均呈负相关(p Objective: To observe and analyze the correlation between blood routine inflammatory cells and different causes of thyrotoxicosis, and to explore its clinical significance. Methods: A total of 49 patients were selected from the endocrinology outpatient department of Jiaozhou Hospital, East Hospital Affiliated to Tongji University from January 2022 to December 2022, including 27 patients with Graves’ disease (GD group), 22 patients with Hashimoto thyroiditis (HT group), and 30 volunteers (CON group) who underwent physical examination in the physical examination center of our hospital. The laboratory data of leukocyte (WBC), neutrophil (NC), lymphocyte (LC), monocyte (MC), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) and other relevant data were compared between the three groups. The correlation between different etiology of thyrotoxicosis and laboratory test indexes was analyzed. Results: Compared with CON group, WBC, LC and MLR in HT group were negatively correlated (p < 0.05), while there was no correlation between NC and NLR groups. Compared with CON group, NC, MC, NLR, MLR, FT3, FT4, TSH and TRAB in GD group were all negatively correlated (p < 0.05), while no correlation was found between LC and WBC groups. Compared with GD group, WBC, LC, NC, MC, FT3, FT4, TSH and TRAB were all negatively correlated (p < 0.05), while MLR and NLR were not correlated. Conclusion: Blood routine is a simple, inexpensive and widely used clinical indicator, and comparative calculation of relevant inflammatory indicators is helpful to better guide the differential diagnosis of Hashimoto thyroiditis and Graves’ disease.展开更多
文摘急性脑血管疾病包括急性出血性卒中和急性缺血性卒中。目前急性缺血性卒中是我国致死及致残的主要原因之一,亦是全球最常见的卒中类型。作为一种重要的病理机制,急性脑梗死发生后炎症免疫反应会被激活。最为常见的炎症指标是外周血中的白细胞、中性粒细胞、淋巴细胞、单核细胞。本文从神经炎症机制和中性粒细胞、单核细胞、淋巴细胞在发生缺血性卒中后的炎症反应以及炎症相关指标对脑梗死的预测作用进行综述。Acute cerebrovascular diseases include acute hemorrhagic stroke and acute ischemic stroke. At present, acute ischemic stroke is one of the main causes of death and disability in China, and it is also the most common type of stroke worldwide. As an important pathological mechanism, the inflammatory immune response is activated after acute cerebral infarction occurs. The most common inflammatory markers are white blood cells, neutrophils, lymphocytes, and monocytes in peripheral blood. This article reviews the mechanisms of neuroinflammation and the inflammatory responses of neutrophils, monocytes, and lymphocytes after ischemic stroke, as well as the predictive role of inflammation related indicators for cerebral infarction.
文摘目的:观察分析血常规炎性细胞等相关指标与甲状腺毒症不同病因的相关性,并探讨其在临床中的意义。方法:选取2022年1月至2022年12月于同济大学附属东方医院胶州医院内分泌科门诊就诊的患者49例,包括27例Graves病患者(GD组)、22例桥本甲状腺炎患者(HT组)、以及在本院体检中心健康体检的志愿者30名(CON组),比较三组间白细胞(WBC)、中性粒细胞(NC)、淋巴细胞(LC)、单核细胞(MC)、中性粒/淋巴细胞比值(NLR)、单核/淋巴细胞比值(MLR)等实验室资料及相关资料的差异。相关性分析甲状腺毒症不同病因与实验室检查指标的相关性。结果:HT组与CON组相比,WBC、LC、MLR均呈负相关(p Objective: To observe and analyze the correlation between blood routine inflammatory cells and different causes of thyrotoxicosis, and to explore its clinical significance. Methods: A total of 49 patients were selected from the endocrinology outpatient department of Jiaozhou Hospital, East Hospital Affiliated to Tongji University from January 2022 to December 2022, including 27 patients with Graves’ disease (GD group), 22 patients with Hashimoto thyroiditis (HT group), and 30 volunteers (CON group) who underwent physical examination in the physical examination center of our hospital. The laboratory data of leukocyte (WBC), neutrophil (NC), lymphocyte (LC), monocyte (MC), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) and other relevant data were compared between the three groups. The correlation between different etiology of thyrotoxicosis and laboratory test indexes was analyzed. Results: Compared with CON group, WBC, LC and MLR in HT group were negatively correlated (p < 0.05), while there was no correlation between NC and NLR groups. Compared with CON group, NC, MC, NLR, MLR, FT3, FT4, TSH and TRAB in GD group were all negatively correlated (p < 0.05), while no correlation was found between LC and WBC groups. Compared with GD group, WBC, LC, NC, MC, FT3, FT4, TSH and TRAB were all negatively correlated (p < 0.05), while MLR and NLR were not correlated. Conclusion: Blood routine is a simple, inexpensive and widely used clinical indicator, and comparative calculation of relevant inflammatory indicators is helpful to better guide the differential diagnosis of Hashimoto thyroiditis and Graves’ disease.
