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奶牛子宫内膜组织α7-nAChR介导的抗炎效应 被引量:1
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作者 阿如娜 刘科 +2 位作者 陈灰 曹金山 贺鹏飞 《中国兽医学报》 CAS CSCD 北大核心 2020年第1期147-152,共6页
产后奶牛子宫内膜炎高发并导致严重的繁殖机能障碍使该病防治成为当前研究重点。胆碱能抗炎症通路为新药开发提供新的靶点,主要通过烟碱乙酰胆碱受体(α7-nAChR)发挥抗炎作用,但α7-nAChR能否成为治疗奶牛子宫内膜炎的潜在药物靶点尚无... 产后奶牛子宫内膜炎高发并导致严重的繁殖机能障碍使该病防治成为当前研究重点。胆碱能抗炎症通路为新药开发提供新的靶点,主要通过烟碱乙酰胆碱受体(α7-nAChR)发挥抗炎作用,但α7-nAChR能否成为治疗奶牛子宫内膜炎的潜在药物靶点尚无数据报道。本研究的目的是调查奶牛子宫内膜组织α7-nAChR是否参与抗炎效应。结果表明,LPS刺激子宫内膜组织8和12 h il-6 mRNA表达量最高,因此选择8和12 h作为本研究炎症模型最佳LPS作用时间;α7-nAChR特异性激动剂PNU-282987在5,10和15mmol/L浓度下可显著下调促炎细胞因子il-1β、il-6、tnf-α及炎症趋化因子il-8 mRNA表达,同时环氧合酶-2(cox-2)和微粒体前列腺素E合成酶-1(mpges-1)表达水平明显下降,这种效应可被α7-nAChR特异性拮抗剂甲基牛扁碱(MLA)逆转。上述结果初步表明激动子宫内膜α7-nAChR具有抑制炎症效应。 展开更多
关键词 奶牛子宫内膜 α-7烟碱乙酰胆碱受体 烟碱抗炎通路 环氧合酶-2
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Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases 被引量:8
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作者 David A Scott Michael Martin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第46期7451-7459,共9页
Discoveries in the first few years of the 21st century have led to an understanding of important interactions between the nervous system and the inflammatory response at the molecular level, most notably the acetylcho... Discoveries in the first few years of the 21st century have led to an understanding of important interactions between the nervous system and the inflammatory response at the molecular level, most notably the acetylcholine (ACh)- triggered,α7-nicotinic acetylcholine receptor (α7nAChR)- dependent nicotinic antinflammatory pathway. Studies using the α7nAChR agonist, nicotine, for the treatment of mucosal inflammation have been undertaken but the efficacy of nicotine as a treatment for inflammatory bowel diseases remains debatable. Further understanding of the nicotinic anti-inflammatory pathway and other endogenous anti-inflammatory mechanisms is required in order to develop refined and specific therapeutic strategies for the treatment of a number of inflammatory diseases and conditions, including periodontitis, psoriasis, sarcoidosis, and ulcerative colitis. 展开更多
关键词 α7-nicotinic acetylcholine receptor Inflammation MUCOSA NICOTINE Nicotinic anti-inflammatory pathway Tobacco smoking
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