目的探讨瑞舒伐他汀片对急性脑梗死患者血脂、踝肱指数和颈动脉粥样硬化斑块的影响。方法选择2014年1月至2015年1月宜昌市第一人民医院神经内科收治的120例急性脑梗死患者为研究对象,按照随机数字法分为观察组和对照组,各60例。对照组...目的探讨瑞舒伐他汀片对急性脑梗死患者血脂、踝肱指数和颈动脉粥样硬化斑块的影响。方法选择2014年1月至2015年1月宜昌市第一人民医院神经内科收治的120例急性脑梗死患者为研究对象,按照随机数字法分为观察组和对照组,各60例。对照组采用常规的缺血性脑卒中治疗,血栓通冻干粉500 mg,加入5%葡萄糖注射液250 m L中静脉滴注,每日1次;观察组在常规治疗的基础上加用瑞舒伐他汀片治疗,每日10 mg。分别观察两组患者治疗前、治疗后6个月血脂、踝肱指数、颈动脉粥样硬化斑块变化情况。结果治疗后,观察组患者总胆固醇、三酰甘油、低密度脂蛋白胆固醇均低于对照组[(2.7±0.3)mmol/L比(5.0±1.1)mmol/L,(1.7±0.6)mmol/L比(2.9±0.7)mmol/L,(1.9±0.4)mmol/L比(3.6±0.6)mmol/L],差异有统计学意义(P<0.05)。治疗后,观察组患者踝肱指数高于对照组(0.75±0.24比0.59±0.21),差异有统计学意义(P<0.05)。治疗后,观察组颈总动脉的内中膜厚度低于对照组[(1.5±0.7)mm比(2.6±0.7)mm],低回声斑块、混合回声斑块比例低于对照组[26.7%(16/60)比53.3%(32/60),51.7%(31/60)比75.0%(45/60)],差异有统计学意义(P<0.05)。结论瑞舒伐他汀片可以降低急性脑梗死患者血脂水平,升高踝肱指数,并抑制颈动脉粥样硬化斑块的形成,疗效显著,值得在临床推广应用。展开更多
Objective：To observe the effect of warm needling plus oral administration of rosuvastatin calcium tablets on blood lipids in cerebral infarction patients. Methods：A total of 125 eligible cases were randomly allocate...Objective：To observe the effect of warm needling plus oral administration of rosuvastatin calcium tablets on blood lipids in cerebral infarction patients. Methods：A total of 125 eligible cases were randomly allocated into group A （n=42）, group B （n=40） and group C （n=43）. Cases in group A received warm needling plus oral administration of rosuvastatin calcium tablets, cases in group B received warm needling, whereas cases in group C received oral administration of rosuvastatin calcium tablets. Results：After treatment, the total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C） all dropped obviously in the three groups, with significant differences （allP〈0.05）, modified Barthel index （BI） scores all significantly rise （allP〈0.05）, and high-density lipoprotein cholesterol （HDL-C） remained unchanged （allP〉0.05）. After treatment, the changes of TC, TG and LDL-C in group A were significantly different from those in group B and group C （allP〈0.05）, while the changes showed no statistical significance between group B and group C （P〉0.05）. There were no between-group differences in HDL-C among the three groups （allP〉0.05）; the modified BI scores in groupA and groupB were significantly higher than that in group C （bothP〈0.05）, while there was no significant difference between group A and group B （P〉0.05）.After treatment, the total effective rate was significantly higher in group A than that in group B and group C （bothP〈0.05）, there was no significant difference between group B and group C （P〉0.05）. Conclusion：Warm needling and oral administration of rosuvastatin calcium tablets both can adjust blood lipids effectively in cerebral infarction patients with a similar therapeutic efficacy, while the effect gets better based upon combining both methods; acupuncture-moxibustion plays an important role in the recovery of nerve functions in cerebral infarction patients.展开更多
文摘目的探讨瑞舒伐他汀片对急性脑梗死患者血脂、踝肱指数和颈动脉粥样硬化斑块的影响。方法选择2014年1月至2015年1月宜昌市第一人民医院神经内科收治的120例急性脑梗死患者为研究对象,按照随机数字法分为观察组和对照组,各60例。对照组采用常规的缺血性脑卒中治疗,血栓通冻干粉500 mg,加入5%葡萄糖注射液250 m L中静脉滴注,每日1次;观察组在常规治疗的基础上加用瑞舒伐他汀片治疗,每日10 mg。分别观察两组患者治疗前、治疗后6个月血脂、踝肱指数、颈动脉粥样硬化斑块变化情况。结果治疗后,观察组患者总胆固醇、三酰甘油、低密度脂蛋白胆固醇均低于对照组[(2.7±0.3)mmol/L比(5.0±1.1)mmol/L,(1.7±0.6)mmol/L比(2.9±0.7)mmol/L,(1.9±0.4)mmol/L比(3.6±0.6)mmol/L],差异有统计学意义(P<0.05)。治疗后,观察组患者踝肱指数高于对照组(0.75±0.24比0.59±0.21),差异有统计学意义(P<0.05)。治疗后,观察组颈总动脉的内中膜厚度低于对照组[(1.5±0.7)mm比(2.6±0.7)mm],低回声斑块、混合回声斑块比例低于对照组[26.7%(16/60)比53.3%(32/60),51.7%(31/60)比75.0%(45/60)],差异有统计学意义(P<0.05)。结论瑞舒伐他汀片可以降低急性脑梗死患者血脂水平,升高踝肱指数,并抑制颈动脉粥样硬化斑块的形成,疗效显著,值得在临床推广应用。
基金supported by Key Discipline Funded Project of Chongqing City No.2008-47~~
文摘Objective：To observe the effect of warm needling plus oral administration of rosuvastatin calcium tablets on blood lipids in cerebral infarction patients. Methods：A total of 125 eligible cases were randomly allocated into group A （n=42）, group B （n=40） and group C （n=43）. Cases in group A received warm needling plus oral administration of rosuvastatin calcium tablets, cases in group B received warm needling, whereas cases in group C received oral administration of rosuvastatin calcium tablets. Results：After treatment, the total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C） all dropped obviously in the three groups, with significant differences （allP〈0.05）, modified Barthel index （BI） scores all significantly rise （allP〈0.05）, and high-density lipoprotein cholesterol （HDL-C） remained unchanged （allP〉0.05）. After treatment, the changes of TC, TG and LDL-C in group A were significantly different from those in group B and group C （allP〈0.05）, while the changes showed no statistical significance between group B and group C （P〉0.05）. There were no between-group differences in HDL-C among the three groups （allP〉0.05）; the modified BI scores in groupA and groupB were significantly higher than that in group C （bothP〈0.05）, while there was no significant difference between group A and group B （P〉0.05）.After treatment, the total effective rate was significantly higher in group A than that in group B and group C （bothP〈0.05）, there was no significant difference between group B and group C （P〉0.05）. Conclusion：Warm needling and oral administration of rosuvastatin calcium tablets both can adjust blood lipids effectively in cerebral infarction patients with a similar therapeutic efficacy, while the effect gets better based upon combining both methods; acupuncture-moxibustion plays an important role in the recovery of nerve functions in cerebral infarction patients.
