利用膦腈碱(t-BuP4)为催化剂在室温下催化甲基丙烯酸烯丙酯(AMA)的进行基团转移聚合(GTP)反应,制备含悬垂双键的线型聚合物,并通过核磁(1 H NMR)、红外(FTIR)、凝胶渗透色谱(GPC)等对其进行分析和表征。结果表明t-BuP4催化AMA的GTP反应1...利用膦腈碱(t-BuP4)为催化剂在室温下催化甲基丙烯酸烯丙酯(AMA)的进行基团转移聚合(GTP)反应,制备含悬垂双键的线型聚合物,并通过核磁(1 H NMR)、红外(FTIR)、凝胶渗透色谱(GPC)等对其进行分析和表征。结果表明t-BuP4催化AMA的GTP反应1h内,单体转化率就接近100%;聚合反应是通过AMA上的甲基丙烯酸酯双键进行,烯丙基双键不参与聚合反应;所得聚合物Mark-Houwink常数为0.75;使用极性溶剂更有利于加强聚合反应的可控性。展开更多
In this article, poly（2-hydroxyethylmethacrylate-co-acrylamide） hydrogels were synthesized by bulk free-radical copolymerization of 2-hydroxyethylmethacrylate （HEMA） and acrylamide （AAm） for soft contact lens（...In this article, poly（2-hydroxyethylmethacrylate-co-acrylamide） hydrogels were synthesized by bulk free-radical copolymerization of 2-hydroxyethylmethacrylate （HEMA） and acrylamide （AAm） for soft contact lens（SCL）-based ophthalmic drug delivery system. The copolymer was characterized with FT-IR and SEM, the swelling property of the hydrogels were studied by gravimetrical method, and chloramphenicol was used as a model drug to investigate drug release profile of the hydrogels. The results showed that poly（2-hydroxyethylmethacrylateco-acrylamide） hydrogels were transparent and useful SCL biomaterial, the water content increased as AAm content increase and pH decrease, and in the same way, hydrogel composition affected chloramphenicol release process too. Migration rate of chloramphenicol increased as the AAm content in the hydrogels increased in the first stage of diffusion process, whereas there was no significant difference thereafter.展开更多
文摘利用膦腈碱(t-BuP4)为催化剂在室温下催化甲基丙烯酸烯丙酯(AMA)的进行基团转移聚合(GTP)反应,制备含悬垂双键的线型聚合物,并通过核磁(1 H NMR)、红外(FTIR)、凝胶渗透色谱(GPC)等对其进行分析和表征。结果表明t-BuP4催化AMA的GTP反应1h内,单体转化率就接近100%;聚合反应是通过AMA上的甲基丙烯酸酯双键进行,烯丙基双键不参与聚合反应;所得聚合物Mark-Houwink常数为0.75;使用极性溶剂更有利于加强聚合反应的可控性。
基金Supported by the Natural Science Foundation of Guangdong Province （5300978） and Zhongkai University of Agriculture and Engineering （G2360221）.
文摘In this article, poly（2-hydroxyethylmethacrylate-co-acrylamide） hydrogels were synthesized by bulk free-radical copolymerization of 2-hydroxyethylmethacrylate （HEMA） and acrylamide （AAm） for soft contact lens（SCL）-based ophthalmic drug delivery system. The copolymer was characterized with FT-IR and SEM, the swelling property of the hydrogels were studied by gravimetrical method, and chloramphenicol was used as a model drug to investigate drug release profile of the hydrogels. The results showed that poly（2-hydroxyethylmethacrylateco-acrylamide） hydrogels were transparent and useful SCL biomaterial, the water content increased as AAm content increase and pH decrease, and in the same way, hydrogel composition affected chloramphenicol release process too. Migration rate of chloramphenicol increased as the AAm content in the hydrogels increased in the first stage of diffusion process, whereas there was no significant difference thereafter.
