目的制备白头翁总皂苷结肠定位固体分散体。方法采用溶剂法制备白头翁总皂苷固体分散体,以体外累计释放度为评价指标,采用单因素方法筛选制备工艺及处方,并采用电子扫描显微镜(SEM)、红外光谱(IR)对制备的固体分散体进行分析。结果 SEM...目的制备白头翁总皂苷结肠定位固体分散体。方法采用溶剂法制备白头翁总皂苷固体分散体,以体外累计释放度为评价指标,采用单因素方法筛选制备工艺及处方,并采用电子扫描显微镜(SEM)、红外光谱(IR)对制备的固体分散体进行分析。结果 SEM和IR分析结果显示白头翁总皂苷和Eudragit S100形成了固体分散体。体外释放度结果显示载药量在20%时指标成分在p H 1.0溶液中2 h基本不释放,在p H 6.8溶液中4 h累积释放度小于16%,在p H 7.8溶液中2 h累积释放大于86%。结论所制备的固体分散体达到了结肠定位的效果。展开更多
The conducting thin film of charge - transfer salt based upon polyoxometalate[VW 5 O 19 ] 3- and bis(ethyl - enedithio) - tetrathiafulvalene(BEDT - TTF or ET)was fabricated on the gold substrate by electrochemical app...The conducting thin film of charge - transfer salt based upon polyoxometalate[VW 5 O 19 ] 3- and bis(ethyl - enedithio) - tetrathiafulvalene(BEDT - TTF or ET)was fabricated on the gold substrate by electrochemical approach.The sub - micronic grains uniformly covering the gold plate was evidenced by scanning electron microscope(SEM).The film of charge - transfer salt exhibits semiconducting behavior with a room - temperature conductivity4.8 × 10 -3 S·cm -1 .展开更多
文摘目的制备白头翁总皂苷结肠定位固体分散体。方法采用溶剂法制备白头翁总皂苷固体分散体,以体外累计释放度为评价指标,采用单因素方法筛选制备工艺及处方,并采用电子扫描显微镜(SEM)、红外光谱(IR)对制备的固体分散体进行分析。结果 SEM和IR分析结果显示白头翁总皂苷和Eudragit S100形成了固体分散体。体外释放度结果显示载药量在20%时指标成分在p H 1.0溶液中2 h基本不释放,在p H 6.8溶液中4 h累积释放度小于16%,在p H 7.8溶液中2 h累积释放大于86%。结论所制备的固体分散体达到了结肠定位的效果。
文摘The conducting thin film of charge - transfer salt based upon polyoxometalate[VW 5 O 19 ] 3- and bis(ethyl - enedithio) - tetrathiafulvalene(BEDT - TTF or ET)was fabricated on the gold substrate by electrochemical approach.The sub - micronic grains uniformly covering the gold plate was evidenced by scanning electron microscope(SEM).The film of charge - transfer salt exhibits semiconducting behavior with a room - temperature conductivity4.8 × 10 -3 S·cm -1 .
