Purpose: To investigate visual function and ocular morphology in children born after intracytoplasmic sperm injection (ICSI)-and compare them with visual function and ocular morphology in matched children born after s...Purpose: To investigate visual function and ocular morphology in children born after intracytoplasmic sperm injection (ICSI)-and compare them with visual function and ocular morphology in matched children born after spontaneous conception. Methods: A total of 137 children born after ICSI and 159 control children were examined at the age of 5 years in a blinded study. The two groups were matched for age, gender and maternal age. The children underwent a detailed ophthalmological investigation by an ophthalmologist and an orthoptist. Results: A total of 90.4% of the ICSI children had a visual acuity (VA) in the better eye of ≥ 0.8, compared with 93.7% of the controls (NS). No significant differences were found between ICSI children and controls with regard to hyperopia, myopia, astigmatism, heterotropia, stereoscopic vision and convergence. One child with Goldenhar syndrome and one with Marcus Gunn syndrome were observed in the ICSI group. One child in the ICSI group was treated for retinopathy of prematurity. Conclusion: In this limited study group, no significant differences in visual function and/or ocular morphology were found between children born after ICSI and matched control children at the age of 5 years.展开更多
To determine the necessity for the heightened level of monitoring for cataract development in patients taking quetiapine (Seroquel, AstraZeneca Pharmaceutical s, Wilmington, Delaware) dictated by the Physicians’Desk ...To determine the necessity for the heightened level of monitoring for cataract development in patients taking quetiapine (Seroquel, AstraZeneca Pharmaceutical s, Wilmington, Delaware) dictated by the Physicians’Desk Reference. Also, to ex plore the possibility of cataractogenesis because of quetiapine therapy. Observa tional case series. Data were garnered from a series of 80 case reports collecte d at the National Registry of Drug Induced Ocular Side Effects (Portland, Orego n). The World Health Organization (WHO) causality assessment guidelines were use d to assess the relationship between quetiapine and cataractogenesis. There were 34 reports of cataracts associated with quetiapine therapy. Average age was 44 years with 23 females and 11 males studied. Average duration of therapy was 29.3 weeks on standard doses. Cataractogenesis secondary to quetiapine is unlikely b y WHO guidelines. This probably makes it unnecessary to require biannual ophthal mic examinations as routine eye examinations are sufficient to screen for this c ondition.展开更多
文摘Purpose: To investigate visual function and ocular morphology in children born after intracytoplasmic sperm injection (ICSI)-and compare them with visual function and ocular morphology in matched children born after spontaneous conception. Methods: A total of 137 children born after ICSI and 159 control children were examined at the age of 5 years in a blinded study. The two groups were matched for age, gender and maternal age. The children underwent a detailed ophthalmological investigation by an ophthalmologist and an orthoptist. Results: A total of 90.4% of the ICSI children had a visual acuity (VA) in the better eye of ≥ 0.8, compared with 93.7% of the controls (NS). No significant differences were found between ICSI children and controls with regard to hyperopia, myopia, astigmatism, heterotropia, stereoscopic vision and convergence. One child with Goldenhar syndrome and one with Marcus Gunn syndrome were observed in the ICSI group. One child in the ICSI group was treated for retinopathy of prematurity. Conclusion: In this limited study group, no significant differences in visual function and/or ocular morphology were found between children born after ICSI and matched control children at the age of 5 years.
文摘To determine the necessity for the heightened level of monitoring for cataract development in patients taking quetiapine (Seroquel, AstraZeneca Pharmaceutical s, Wilmington, Delaware) dictated by the Physicians’Desk Reference. Also, to ex plore the possibility of cataractogenesis because of quetiapine therapy. Observa tional case series. Data were garnered from a series of 80 case reports collecte d at the National Registry of Drug Induced Ocular Side Effects (Portland, Orego n). The World Health Organization (WHO) causality assessment guidelines were use d to assess the relationship between quetiapine and cataractogenesis. There were 34 reports of cataracts associated with quetiapine therapy. Average age was 44 years with 23 females and 11 males studied. Average duration of therapy was 29.3 weeks on standard doses. Cataractogenesis secondary to quetiapine is unlikely b y WHO guidelines. This probably makes it unnecessary to require biannual ophthal mic examinations as routine eye examinations are sufficient to screen for this c ondition.
