目的:评估超声睫状体成形术(Ultrasonic Cycloplasty, UCP)治疗青光眼的有效性和安全性。方法:从Pubmed、Embae、Web of sience数据库搜索相关文献,纳入符合纳入标准的文献,使用Review Manage 5.4 (Cochrane Collaboration)和Stata Corp...目的:评估超声睫状体成形术(Ultrasonic Cycloplasty, UCP)治疗青光眼的有效性和安全性。方法:从Pubmed、Embae、Web of sience数据库搜索相关文献,纳入符合纳入标准的文献,使用Review Manage 5.4 (Cochrane Collaboration)和Stata Corp LLC (version 17, USA)进行Meta分析。结果:检索得到305篇文献,经过筛查后最终有18篇文章被纳入本次Meta分析。总的来说,超声睫状体成形术(UCP)治疗青光眼是有效、安全的。UCP治疗青光眼的成功率高,[相对危险度(Relative Risk, RR):2.21 95% CI, (1.59, 2.80),P 2 = 77%]。UCP治疗青光眼术后IOP降低的效果明显,[加权平均差值(Weighted Mean Difference, WMD):10.09 95% CI, (8.74, 11.44),P 2 = 75%]。UCP手术是安全可靠的,长期或严重并发症较少,且明显少于短期或轻度并发症,[相对危险度(RR):0.23 95% CI,(0.11, 0.48),P 2 = 91%]。其次,UCP治疗青光眼术后降眼压药物的使用数量减少[加权平均差值(WMD):1.11 95% CI, (0.67, 1.55),P 2 = 91%]。但是,UCP治疗青光眼对最佳矫正视力(Best Corrected Visual Acuity, BCVA)无明显改善,[加权平均差值(WMD):−0.01 95% CI,(−0.08, 0.05),P = 0.91,I2 = 0%]。结论:UCP治疗青光眼是安全可靠、舒适、有效的,它可以有效降低青光眼患者的IOP及降压眼药物的数量,术后长期或严重并发症较少。Objective: To evaluate the efficacy and safety of ultrasonic cycloplasty (UCP) in the treatment of glaucoma. Methods: The relevant literature was searched from Pubmed, Embae and Web of sience databases. After Literature screening, a Meta-analysis was performed by Review Manage 5.4 (Cochrane Collaboration) and Stata Corp LLC (version 17, USA) and software. Results: A total of 305 articles were retrieved, and 18 articles met the inclusion criteria were included in the Meta-analysis. In general, ultrasonic cycloplasty (UCP) is effective and safe for the treatment of glaucoma. UCP had a high success rate in the treatment of glaucoma [Relative Risk (RR): 2.21 95% CI, (1.59, 2.80), P 2 = 77%]. UCP significantly reduced IOP [Weighted Mean Difference (WMD): 10.09 95% CI, (8.74, 11.44), P 2 = 75%]. Secondly, UCP is safe and reliable with few long-term or serious complications [Relative Risk (RR): 0.23 95% CI, (0.11, 0.48), P 2 = 91%]. UCP can effectively reduce the number of postoperative anti-glaucoma medications [Weighted Mean Difference (WMD): 1.11 95% CI, (0.67, 1.55), P 2 = 91%]. However, UCP did not significantly improve the best corrected visual acuity (BCVA) [weighted mean difference (WMD): −0.01 95% CI, (−0.08, 0.05), P = 0.91, I2 = 0%]. Conclusion: UCP is safe, reliable, comfortable and effective in the treatment of glaucoma. It can effectively reduce IOP and the number of postoperative antihypertensive eye drugs, with fewer long-term or serious complications.展开更多
文摘目的:评估超声睫状体成形术(Ultrasonic Cycloplasty, UCP)治疗青光眼的有效性和安全性。方法:从Pubmed、Embae、Web of sience数据库搜索相关文献,纳入符合纳入标准的文献,使用Review Manage 5.4 (Cochrane Collaboration)和Stata Corp LLC (version 17, USA)进行Meta分析。结果:检索得到305篇文献,经过筛查后最终有18篇文章被纳入本次Meta分析。总的来说,超声睫状体成形术(UCP)治疗青光眼是有效、安全的。UCP治疗青光眼的成功率高,[相对危险度(Relative Risk, RR):2.21 95% CI, (1.59, 2.80),P 2 = 77%]。UCP治疗青光眼术后IOP降低的效果明显,[加权平均差值(Weighted Mean Difference, WMD):10.09 95% CI, (8.74, 11.44),P 2 = 75%]。UCP手术是安全可靠的,长期或严重并发症较少,且明显少于短期或轻度并发症,[相对危险度(RR):0.23 95% CI,(0.11, 0.48),P 2 = 91%]。其次,UCP治疗青光眼术后降眼压药物的使用数量减少[加权平均差值(WMD):1.11 95% CI, (0.67, 1.55),P 2 = 91%]。但是,UCP治疗青光眼对最佳矫正视力(Best Corrected Visual Acuity, BCVA)无明显改善,[加权平均差值(WMD):−0.01 95% CI,(−0.08, 0.05),P = 0.91,I2 = 0%]。结论:UCP治疗青光眼是安全可靠、舒适、有效的,它可以有效降低青光眼患者的IOP及降压眼药物的数量,术后长期或严重并发症较少。Objective: To evaluate the efficacy and safety of ultrasonic cycloplasty (UCP) in the treatment of glaucoma. Methods: The relevant literature was searched from Pubmed, Embae and Web of sience databases. After Literature screening, a Meta-analysis was performed by Review Manage 5.4 (Cochrane Collaboration) and Stata Corp LLC (version 17, USA) and software. Results: A total of 305 articles were retrieved, and 18 articles met the inclusion criteria were included in the Meta-analysis. In general, ultrasonic cycloplasty (UCP) is effective and safe for the treatment of glaucoma. UCP had a high success rate in the treatment of glaucoma [Relative Risk (RR): 2.21 95% CI, (1.59, 2.80), P 2 = 77%]. UCP significantly reduced IOP [Weighted Mean Difference (WMD): 10.09 95% CI, (8.74, 11.44), P 2 = 75%]. Secondly, UCP is safe and reliable with few long-term or serious complications [Relative Risk (RR): 0.23 95% CI, (0.11, 0.48), P 2 = 91%]. UCP can effectively reduce the number of postoperative anti-glaucoma medications [Weighted Mean Difference (WMD): 1.11 95% CI, (0.67, 1.55), P 2 = 91%]. However, UCP did not significantly improve the best corrected visual acuity (BCVA) [weighted mean difference (WMD): −0.01 95% CI, (−0.08, 0.05), P = 0.91, I2 = 0%]. Conclusion: UCP is safe, reliable, comfortable and effective in the treatment of glaucoma. It can effectively reduce IOP and the number of postoperative antihypertensive eye drugs, with fewer long-term or serious complications.