自制和国外的6-OH-BTA-0放射性核素标记效果的比较

目的:观察放射性核素标记的不同来源的6-OH-BTA-0,比较制备的阿尔茨海默病(AD)PET显像剂[11C]6-OH-BTA-1的效果。方法:分别使用两种来源的6-OH-BTA-0,以同样的反应条件,通过11C-Triflate-CH3行放射性核素11C标记成[11C]6-OH-BTA-1,应用C18cartridge柱提纯产品。结果:两种不同来源的6-OH-BTA-0,标记出产品[11C]6-OH-BTA-1的效果没有明显差异。按照加速器生产925MBq11C-Triflate-CH3计算,未校正11C衰变的情况下,无色澄清[11C]6-OH-BTA-1注射液的产率均在36%￣44%,放化纯92%￣93%。结论:自制的6-OH-BTA-0可以在ADPET显像剂[11C]6-OH-BTA-1研究中使用。

Carbon Composites for the Immobilization of Long-Lived Radio-Nuclides for the Purpose Their Disposal and Transmutation, Part 1

There is presented the review of publications connecting with creation of matrices for the immobilization of long-lived radionuclides and radioactive waste for storage and disposal, as well as for the transmutation. This paper substantiates the practicability and feasibility of obtaining the carbon matrces by carbonization of imidoderivatives.