A reasonable coordination degree assessment of the social-economic development level and the resource-environment quality level are essential to ident the key factory of the development, and vital to determine the app...A reasonable coordination degree assessment of the social-economic development level and the resource-environment quality level are essential to ident the key factory of the development, and vital to determine the appropriate development strategy and achieve sustainable development. The major function oriented zoning plays a role in spatial coordination mainly＇ by spatial guidance and restriction, so. the proposal of major function oriented zoning gives a new train of thought to generate a coordination evaluation of economy-society and the resource-environment system, From the view of major function oriented zoning that considers resource environmental bearing capacity, existing development density and development potential, this paper constructs an index system and model of coordination evahtation with a case study on Pearl River Delta. The results have shown： （I） It can reveal the conflicts of economic-social development and resource-environment quality to ac- curately consider resource environmental bearing capacity, existing development densio~ and development po- tential; （2） The coordination degree between social-economy system and resource-environment system in Pearl River Delta continued to decline in the past 10 years. The spatial extent of coordination evoh,es.from coordina- tion in the whole Pearl River Delta to imbalance in the core areas, and at present, the uncoordinated areas have already diffused from core areas to the outlying regions： （3） Most regions of the Pearl River Delta are in uncoordinated condition When considering the coordination degree of economic-social development and resollrceenvironment quality, not as coordinated as some scholars considered.展开更多
Objective: To investigate the clinical efficacy and safety of the Ganning formula (肝宁方) for the treatment of liver fibrosis in patients with chronic hepatitis B. Methods: In a multicenter, randomized, controlled cl...Objective: To investigate the clinical efficacy and safety of the Ganning formula (肝宁方) for the treatment of liver fibrosis in patients with chronic hepatitis B. Methods: In a multicenter, randomized, controlled clinical trial, 150 patients with liver fibrosis secondary to hepatitis B virus (HBV) infection were randomly assigned in equal numbers to receive either the Ganning formula (a Chinese herbal decoction; active treatment group) or oral entecavir (control group) for two 3-month courses. Patients were monitored for any treatment-induced changes in liver function test parameters (ALT, AST, and GGT), liver fibrosis markers (LN, HA, IV-C, and PCIII), HBV DNA level, hepatosplenic imaging, quality of life scores, or psychological and social functioning scores. Patients were also observed for any adverse effects. Results: After treatment, patients in both groups experienced significant improvements in liver function, HBV DNA load, hepatosplenic B-mode ultrasonography, quality of life, and psychological and social functioning (P<0.05 or P<0.01). Patients receiving the Ganning formula achieved greater improvements in HA, IV-C, quality of life, and psychological and social functioning compared with those on entecavir (P<0.05 or P<0.01). There were no abnormal changes in blood tests, urine, feces, renal function, or electrocardiogram. Additionally, no adverse effects were observed in any patients in either group. Conclusions: The Ganning formula appears to have the potential to inhibit liver fibrosis and therefore improve liver function by inhibiting HBV replication in patients with chronic hepatitis B. Additionally, this formula is helpful in improving quality of life and psychological and social functioning.展开更多
基金supported by National Social Science Fund(Grant No. 06&ZD038)The 11th Five-Year Planning programme of philosophy and Social Science of Guangdong(Grant NO.07D04)
文摘A reasonable coordination degree assessment of the social-economic development level and the resource-environment quality level are essential to ident the key factory of the development, and vital to determine the appropriate development strategy and achieve sustainable development. The major function oriented zoning plays a role in spatial coordination mainly＇ by spatial guidance and restriction, so. the proposal of major function oriented zoning gives a new train of thought to generate a coordination evaluation of economy-society and the resource-environment system, From the view of major function oriented zoning that considers resource environmental bearing capacity, existing development density and development potential, this paper constructs an index system and model of coordination evahtation with a case study on Pearl River Delta. The results have shown： （I） It can reveal the conflicts of economic-social development and resource-environment quality to ac- curately consider resource environmental bearing capacity, existing development densio~ and development po- tential; （2） The coordination degree between social-economy system and resource-environment system in Pearl River Delta continued to decline in the past 10 years. The spatial extent of coordination evoh,es.from coordina- tion in the whole Pearl River Delta to imbalance in the core areas, and at present, the uncoordinated areas have already diffused from core areas to the outlying regions： （3） Most regions of the Pearl River Delta are in uncoordinated condition When considering the coordination degree of economic-social development and resollrceenvironment quality, not as coordinated as some scholars considered.
基金supported by the Guangxi Medicine Research Grant Program (No.2010095)the Guangxi Science and Technology Research Grant Program (No.2010GXNSFA013217)the Guangxi Natural Science Foundation (No. 0832174)
文摘Objective: To investigate the clinical efficacy and safety of the Ganning formula (肝宁方) for the treatment of liver fibrosis in patients with chronic hepatitis B. Methods: In a multicenter, randomized, controlled clinical trial, 150 patients with liver fibrosis secondary to hepatitis B virus (HBV) infection were randomly assigned in equal numbers to receive either the Ganning formula (a Chinese herbal decoction; active treatment group) or oral entecavir (control group) for two 3-month courses. Patients were monitored for any treatment-induced changes in liver function test parameters (ALT, AST, and GGT), liver fibrosis markers (LN, HA, IV-C, and PCIII), HBV DNA level, hepatosplenic imaging, quality of life scores, or psychological and social functioning scores. Patients were also observed for any adverse effects. Results: After treatment, patients in both groups experienced significant improvements in liver function, HBV DNA load, hepatosplenic B-mode ultrasonography, quality of life, and psychological and social functioning (P<0.05 or P<0.01). Patients receiving the Ganning formula achieved greater improvements in HA, IV-C, quality of life, and psychological and social functioning compared with those on entecavir (P<0.05 or P<0.01). There were no abnormal changes in blood tests, urine, feces, renal function, or electrocardiogram. Additionally, no adverse effects were observed in any patients in either group. Conclusions: The Ganning formula appears to have the potential to inhibit liver fibrosis and therefore improve liver function by inhibiting HBV replication in patients with chronic hepatitis B. Additionally, this formula is helpful in improving quality of life and psychological and social functioning.
