Using an available compound 3 pentanone(1) as starting material, the key intermediate compound 4,6 dimethyl 3,7 nonandione(5) was synthesized through the addition elimination of silylenol ether and Michael addition of...Using an available compound 3 pentanone(1) as starting material, the key intermediate compound 4,6 dimethyl 3,7 nonandione(5) was synthesized through the addition elimination of silylenol ether and Michael addition of α methylene 3 pentanone(4) with silylenol ether(2). In the presence of chiral reagent 6 β phenyl amino 3 β,5α chlorestandiol(7), compound (5) was reduced by KBH 4 directly to give Tobacco Beetle Pheromone (7S) (-) 4,6 dimethyl 7 hydroxyl 3 nonanone(6). 25 D=-35 87°( c =0 23, CHCl 3), overall yield 23 9%.展开更多
The stereoselective synthesis of oxazolidine derivatives was accomplished,starting from ephedrine,pseudo-ephedrine and substituted benzaldehyde.Seven kinds of new substituted phenyl-3,4-dimethyl-5 phenyloxazolidine we...The stereoselective synthesis of oxazolidine derivatives was accomplished,starting from ephedrine,pseudo-ephedrine and substituted benzaldehyde.Seven kinds of new substituted phenyl-3,4-dimethyl-5 phenyloxazolidine were first reported.At the same time,the stereochemical structures and the spectral characteristics were studied for these oxazolidines.展开更多
α-N-(S-1-phenylethyl)-β-(4’-methoxyl)benzoyl-L-alanine had been synthesized by combination of Friedal-Craft reaction and stereo-selective Michael reaction.The structure was confirmed by 1H NMR,13C NMR and X-Ray sin...α-N-(S-1-phenylethyl)-β-(4’-methoxyl)benzoyl-L-alanine had been synthesized by combination of Friedal-Craft reaction and stereo-selective Michael reaction.The structure was confirmed by 1H NMR,13C NMR and X-Ray single crystal diffraction.The steady-state fluorescence property of the title compound was also investigated.It was found that the maximum emission wavelength was longer and the quantum yield was less in solvents with larger dielectric constant.The title compound displayed recognition ability to environmental state.展开更多
文摘Using an available compound 3 pentanone(1) as starting material, the key intermediate compound 4,6 dimethyl 3,7 nonandione(5) was synthesized through the addition elimination of silylenol ether and Michael addition of α methylene 3 pentanone(4) with silylenol ether(2). In the presence of chiral reagent 6 β phenyl amino 3 β,5α chlorestandiol(7), compound (5) was reduced by KBH 4 directly to give Tobacco Beetle Pheromone (7S) (-) 4,6 dimethyl 7 hydroxyl 3 nonanone(6). 25 D=-35 87°( c =0 23, CHCl 3), overall yield 23 9%.
文摘The stereoselective synthesis of oxazolidine derivatives was accomplished,starting from ephedrine,pseudo-ephedrine and substituted benzaldehyde.Seven kinds of new substituted phenyl-3,4-dimethyl-5 phenyloxazolidine were first reported.At the same time,the stereochemical structures and the spectral characteristics were studied for these oxazolidines.
文摘α-N-(S-1-phenylethyl)-β-(4’-methoxyl)benzoyl-L-alanine had been synthesized by combination of Friedal-Craft reaction and stereo-selective Michael reaction.The structure was confirmed by 1H NMR,13C NMR and X-Ray single crystal diffraction.The steady-state fluorescence property of the title compound was also investigated.It was found that the maximum emission wavelength was longer and the quantum yield was less in solvents with larger dielectric constant.The title compound displayed recognition ability to environmental state.
