作为一种必需氨基酸,色氨酸(tryptophan,Trp)通过血清素(5-羟色胺)、犬尿氨酸(kynurenine,Kyn)的内源性代谢途径和微生物代谢途径产生5-羟色胺、烟酸、CO2、犬尿喹啉和吲哚衍生物等代谢产物。Trp及其代谢产物在机体内可通过激活芳香烃受...作为一种必需氨基酸,色氨酸(tryptophan,Trp)通过血清素(5-羟色胺)、犬尿氨酸(kynurenine,Kyn)的内源性代谢途径和微生物代谢途径产生5-羟色胺、烟酸、CO2、犬尿喹啉和吲哚衍生物等代谢产物。Trp及其代谢产物在机体内可通过激活芳香烃受体(aromatic hydrocarbon receptor,AhR)、孕烷X受体(progesterone X receptor,PXR),诱导胰高血糖素样肽-1(glucagon like peptide-1,GLP-1)释放,改善肠道抗氧化能力及线粒体功能,促进5-HT释放等机制参与调节机体健康。这里通过阐述Trp、Trp代谢过程以及Trp代谢物的作用机制,探讨Trp及其代谢产物对肠粘膜免疫屏障的调节作用。展开更多
The human gut is the normal habitat of a lot of microorganisms; in the long process of evolution they have developed a symbiotic relationship with the host. Under normal circumstances they do not damage the health, wh...The human gut is the normal habitat of a lot of microorganisms; in the long process of evolution they have developed a symbiotic relationship with the host. Under normal circumstances they do not damage the health, which totally owes to the barrier functions of the integral intestinal mucosa. Intestinal lnucosal barriers are mainly composed of four parts： mechanical barrier, immune barrier, chemical and biological barrier. Each of these functions has corresponding structural basis, an important barrier to prevent harmful substances and pathogens in the gut into the inner environment of the body, and to maintain a stable internal environment.展开更多
文摘作为一种必需氨基酸,色氨酸(tryptophan,Trp)通过血清素(5-羟色胺)、犬尿氨酸(kynurenine,Kyn)的内源性代谢途径和微生物代谢途径产生5-羟色胺、烟酸、CO2、犬尿喹啉和吲哚衍生物等代谢产物。Trp及其代谢产物在机体内可通过激活芳香烃受体(aromatic hydrocarbon receptor,AhR)、孕烷X受体(progesterone X receptor,PXR),诱导胰高血糖素样肽-1(glucagon like peptide-1,GLP-1)释放,改善肠道抗氧化能力及线粒体功能,促进5-HT释放等机制参与调节机体健康。这里通过阐述Trp、Trp代谢过程以及Trp代谢物的作用机制,探讨Trp及其代谢产物对肠粘膜免疫屏障的调节作用。
文摘The human gut is the normal habitat of a lot of microorganisms; in the long process of evolution they have developed a symbiotic relationship with the host. Under normal circumstances they do not damage the health, which totally owes to the barrier functions of the integral intestinal mucosa. Intestinal lnucosal barriers are mainly composed of four parts： mechanical barrier, immune barrier, chemical and biological barrier. Each of these functions has corresponding structural basis, an important barrier to prevent harmful substances and pathogens in the gut into the inner environment of the body, and to maintain a stable internal environment.
