Objective To observe the serum level of non-high density lipoprotein cholesterol(non-HDLC),and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people...Objective To observe the serum level of non-high density lipoprotein cholesterol(non-HDLC),and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people(7369 males,4299 females) who took physical examination in our hospital during 2006.1-2007.6 were detected the fast serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) according to standard operating procedure.And then non-HDLC and atherogenic index of plasma(AIP) were calculated according to the formulae non-HDL-C =TC-HD-C and AIP=log(TG/HDL-C).Statistical analysis was performed to evaluate the correlation between non-HDLC and atherosclerosis.Results There was a significant difference of LDL-C between by direct assay and by Friedewald formula calculation(P<0.001).When TG<4.5mmol/L and TG without grouping,LDL-C calculated by Friedewald formula was higher than that by direct assay.When TG≧4.5mmol/L,LDL-C calculated by Friedewald formula was obviously lower than that by direct assay.Non-HDLC was more closely related to AIP than LDLC as comparing TC and TG on different levels.Conclusions Non-HDLC was more closely related to AIP,and it could be used to judge the chanciness of atherosclerosis.Therefore,we suggest that the value of non-HDLC and AIP should be combined on analyzing routine blood fat to elevate the accuracy of artherosclerosis evaluation and non-HDLC as the second target in blood fat treatment.展开更多
目的探讨SREBP2基因的常见多态rs4822063与胆固醇水平的关系。方法在948个研究对象中采用PCR-限制性片段长度多态方法进行基因分型,分析rs4822063不同基因型间胆固醇水平的相关关系。结果与常见G等位基因的携带者(GG+GC基因型)相比,少...目的探讨SREBP2基因的常见多态rs4822063与胆固醇水平的关系。方法在948个研究对象中采用PCR-限制性片段长度多态方法进行基因分型,分析rs4822063不同基因型间胆固醇水平的相关关系。结果与常见G等位基因的携带者(GG+GC基因型)相比,少见等位基因纯合子CC携带者的高总胆固醇(Total cholesterol,TC)及高低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)的危险增加;CC基因型携带者TC和LDL-C的水平高于常见G等位基因的携带者(GG+GC)。结论SREBP2基因的常见多态rs4822063与胆固醇水平相关。展开更多
文摘Objective To observe the serum level of non-high density lipoprotein cholesterol(non-HDLC),and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people(7369 males,4299 females) who took physical examination in our hospital during 2006.1-2007.6 were detected the fast serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) according to standard operating procedure.And then non-HDLC and atherogenic index of plasma(AIP) were calculated according to the formulae non-HDL-C =TC-HD-C and AIP=log(TG/HDL-C).Statistical analysis was performed to evaluate the correlation between non-HDLC and atherosclerosis.Results There was a significant difference of LDL-C between by direct assay and by Friedewald formula calculation(P<0.001).When TG<4.5mmol/L and TG without grouping,LDL-C calculated by Friedewald formula was higher than that by direct assay.When TG≧4.5mmol/L,LDL-C calculated by Friedewald formula was obviously lower than that by direct assay.Non-HDLC was more closely related to AIP than LDLC as comparing TC and TG on different levels.Conclusions Non-HDLC was more closely related to AIP,and it could be used to judge the chanciness of atherosclerosis.Therefore,we suggest that the value of non-HDLC and AIP should be combined on analyzing routine blood fat to elevate the accuracy of artherosclerosis evaluation and non-HDLC as the second target in blood fat treatment.
文摘目的探讨SREBP2基因的常见多态rs4822063与胆固醇水平的关系。方法在948个研究对象中采用PCR-限制性片段长度多态方法进行基因分型,分析rs4822063不同基因型间胆固醇水平的相关关系。结果与常见G等位基因的携带者(GG+GC基因型)相比,少见等位基因纯合子CC携带者的高总胆固醇(Total cholesterol,TC)及高低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)的危险增加;CC基因型携带者TC和LDL-C的水平高于常见G等位基因的携带者(GG+GC)。结论SREBP2基因的常见多态rs4822063与胆固醇水平相关。