The main purpose of this study was to investigate the protective actions of captopril and cicaprost on changes of membrane fluidity of cultured neonatal rat myocardial cells exposed to anoxia and sugar deprivation.Lip...The main purpose of this study was to investigate the protective actions of captopril and cicaprost on changes of membrane fluidity of cultured neonatal rat myocardial cells exposed to anoxia and sugar deprivation.Lipid peroxidation level estimated by determining the thiobarbituric acid reactive substance(TBARS)content and lactate dehydrogenase(LDH)released in culture medium was also observed in order to examine other membrane-related changes due to anoxia.Membrane fluidity was monitored by measuring changes in the steady state fluorescence anisotropy(r_s)by fluorescence spectroscopy.The r_s value,TBARS level and LDH release were significantly increased after 3 h anoxia.Captopril(180 μmol/L),cicaprost(30 nmol/L)and indomethacin(1μmol/L)did not alter r_s, TBARS level and LDH activity of normal cultured neonatal rat myocardial cells.However,both captopril and cicaprost significantly prevented the increases of r_s,TBARS content and LDH release in those cells exposed to anoxia and sugar deprivation.lndomethacin abolished the actions of captopril on TBARS production and LDH release,but maintained its membrane fluidity protection.These results indicate that captopril and cicaprost protect membrane fluidity and lipid peroxidation changes in anoxia- injured myocardial cells.The action mechanism of captopril may be due,in part,to stimulation of prostacyclin synthesis and/or release.展开更多
Joyce began his literary career with strong discontent with his social condition. Ulysses is Joyce＇s optimum work, which takes 3 Dublin characters＇ experience in one day as the main line to show the paralysation and...Joyce began his literary career with strong discontent with his social condition. Ulysses is Joyce＇s optimum work, which takes 3 Dublin characters＇ experience in one day as the main line to show the paralysation and crisis of the whole Western society, people＇s emptiness on their minds, loneliness on their feelings and labefaction on their spirits, also, it showed the inextricable perplexity. To treat the theme of inextricable perplexity, this paper is trying to set about the inextricable Catholic Church and identity problems, with the ideas of Alick West-the outstanding English Marxist literary critic of the 20th century.展开更多
A favorable environment for the exchange of information and innovation is able to provide the economic and social progress. Thus, this article aims to propose a study methodology to develop strategies for promoting te...A favorable environment for the exchange of information and innovation is able to provide the economic and social progress. Thus, this article aims to propose a study methodology to develop strategies for promoting technological innovation, to answer the research question： What actions to leverage the innovative potential of a region？ Data were collected through qualitative and quantitative approaches. The study was characterized as exploratory, descriptive, and inventory. The study sample was composed of the industrial spectrum of Francisco Beltrao region. Innovation indexes were identified companies operating in areas of greatest economic importance. Representatives of the companies were interviewed for the researcher could analyze their knowledge of the laws that encourage innovation and actions imposed by the interested parties and the municipal government. Interested parties were also interviewed to verify the effectiveness of actions. The main results indicated a low overall rate of innovation of companies in the Francisco Beltrao region. Another point was the very low number of companies they knew about laws and incentives. The higher content of knowledge of these laws and actions of stakeholders were among the companies participating in the single business hub of the city looking for technological innovation. The main conclusions brought proposed strategies to promote technological innovation.展开更多
The fourth BRICS Healt h Ministers’Meeting was held in Brasilia,Brazil’s capital,on December 5.Brazilian Health Minister Arthur Chioro,South African Health Minister Pakishe Aaron Motsoaledi,Indian Vice-Health Minist...The fourth BRICS Healt h Ministers’Meeting was held in Brasilia,Brazil’s capital,on December 5.Brazilian Health Minister Arthur Chioro,South African Health Minister Pakishe Aaron Motsoaledi,Indian Vice-Health Minister Vishwa Mohan Katoch and Russian ViceHealth Minister Kostennikov Dmitry attended the meeting.展开更多
The Berezovsk coal mine in western Siberia has yielded the most diverse Middle Jurassic limnic and terrestrial vertebrate assemblage of Asia. The vertebrate remains were recovered by screen washing from floodplain dep...The Berezovsk coal mine in western Siberia has yielded the most diverse Middle Jurassic limnic and terrestrial vertebrate assemblage of Asia. The vertebrate remains were recovered by screen washing from floodplain deposits on top of a thick coal seam of the Bathonian Itat Formation. A total of 29 vertebrate taxa has been recorded so far,including hybodontiform sharks,acipenseriforms,palaeonisciforms,amiiforms,dipnoans,anurans,caudates,turtles,squamates,choristoderans,crocodyliforms,pterosaurs,dinosaurs,tritylodontids,and a diverse mammaliaform and mammalian assemblage( eleutherodontids,docodontans,? amphilestids,dryolestids,and zatherians). The caudates are among the oldest in the fossil record and the anurans represent the oldest Asian record of this group. Among the mammals,Anthracolestes is the oldest and most basal known member of Dryolestidae and so far the only record from Asia. The vertebrate assemblage from the Berezovsk coal mine is very similar to that from the British Forest Marble Formation( Bathonian) and suggests a limited provincialism in the Middle Jurassic Laurasian landmass.展开更多
In Western Siberia(Russia) there are about 100 Artemia lakes with total area over 1 600 km 2.Geographically these lakes are located between 51°–56°N and 61°–82°E.In general these lakes are shallo...In Western Siberia(Russia) there are about 100 Artemia lakes with total area over 1 600 km 2.Geographically these lakes are located between 51°–56°N and 61°–82°E.In general these lakes are shallow(depth less than 1.5 m),small or medium size(0.1 to 10 km 2);they are chloride;their total salinity is from 40 to 250 g/L.The harvesting of cysts per year is only in 20–40 lakes.In Russia 550 tons of dry Artemia cysts(14%–18% of the world production) were harvested annually.This includes about 350 tons in the Altai region and 200 tons in other regions.During our regular 20-year study period the cyst harvest was:95 tons in Kurgan;65 tons in Omsk,20 tons in Novosibirsk,20 tons in Tyumen.Ways of increasing cyst harvest in Russia are considered in this article.During the last 30 years the harvest of cysts in Russia has increased from 7–20 to 500–600 tons.A significant influence of dryness of the year was found on productivity in selected lakes,but taken for all the lakes together,the relationship was not significant.The optimal salinity for productivity of cysts in the lakes was determined.Analysis of productivity of the lakes and the harvesting results showed that the stocks of cysts are underutilized by approximately 1.7 times.展开更多
Thales of Miletus （640？-546 BC） is famous for his prediction of the total solar eclipse in 585 BC. In this paper, the author demonstrate how Thales may have used the same principle for prediction of solar eclipses ...Thales of Miletus （640？-546 BC） is famous for his prediction of the total solar eclipse in 585 BC. In this paper, the author demonstrate how Thales may have used the same principle for prediction of solar eclipses as that used on the Antikythera Mechanism. At the SEAC conference in Alexandria in 2009, the author presented the paper ＂Ten solar eclipses show that the Antikythera Mechanism was constructed for use on Sicily.＂ The best defined series of exeligmos cycles started in 243 BC during the lifetime of Archimedes （287-212 BC） from Syracuse. The inscriptions on the Antikythera Mechanism were made in 100-150 BC and the last useful exeligmos started in 134 BC. The theory for the motion of the moon was from Hipparchus （ca 190-125 BC）. A more complete investigation of the solar eclipses on the Antikythera Mechanism reveals that the first month in the first saros cycle started with the first new moon after the winter solstice in 542 BC. Four solar eclipses 537-528 BC, from the first saros cycle, and three one exeligmos cycle later, 487-478 BC, are preserved and may have been recorded in Croton by Pythagoras （ca 575-495 BC） and his school.展开更多
基金Supported by a grant for young researcher from Ministry of Public Health of P.R.C.
文摘The main purpose of this study was to investigate the protective actions of captopril and cicaprost on changes of membrane fluidity of cultured neonatal rat myocardial cells exposed to anoxia and sugar deprivation.Lipid peroxidation level estimated by determining the thiobarbituric acid reactive substance(TBARS)content and lactate dehydrogenase(LDH)released in culture medium was also observed in order to examine other membrane-related changes due to anoxia.Membrane fluidity was monitored by measuring changes in the steady state fluorescence anisotropy(r_s)by fluorescence spectroscopy.The r_s value,TBARS level and LDH release were significantly increased after 3 h anoxia.Captopril(180 μmol/L),cicaprost(30 nmol/L)and indomethacin(1μmol/L)did not alter r_s, TBARS level and LDH activity of normal cultured neonatal rat myocardial cells.However,both captopril and cicaprost significantly prevented the increases of r_s,TBARS content and LDH release in those cells exposed to anoxia and sugar deprivation.lndomethacin abolished the actions of captopril on TBARS production and LDH release,but maintained its membrane fluidity protection.These results indicate that captopril and cicaprost protect membrane fluidity and lipid peroxidation changes in anoxia- injured myocardial cells.The action mechanism of captopril may be due,in part,to stimulation of prostacyclin synthesis and/or release.
文摘Joyce began his literary career with strong discontent with his social condition. Ulysses is Joyce＇s optimum work, which takes 3 Dublin characters＇ experience in one day as the main line to show the paralysation and crisis of the whole Western society, people＇s emptiness on their minds, loneliness on their feelings and labefaction on their spirits, also, it showed the inextricable perplexity. To treat the theme of inextricable perplexity, this paper is trying to set about the inextricable Catholic Church and identity problems, with the ideas of Alick West-the outstanding English Marxist literary critic of the 20th century.
文摘A favorable environment for the exchange of information and innovation is able to provide the economic and social progress. Thus, this article aims to propose a study methodology to develop strategies for promoting technological innovation, to answer the research question： What actions to leverage the innovative potential of a region？ Data were collected through qualitative and quantitative approaches. The study was characterized as exploratory, descriptive, and inventory. The study sample was composed of the industrial spectrum of Francisco Beltrao region. Innovation indexes were identified companies operating in areas of greatest economic importance. Representatives of the companies were interviewed for the researcher could analyze their knowledge of the laws that encourage innovation and actions imposed by the interested parties and the municipal government. Interested parties were also interviewed to verify the effectiveness of actions. The main results indicated a low overall rate of innovation of companies in the Francisco Beltrao region. Another point was the very low number of companies they knew about laws and incentives. The higher content of knowledge of these laws and actions of stakeholders were among the companies participating in the single business hub of the city looking for technological innovation. The main conclusions brought proposed strategies to promote technological innovation.
文摘The fourth BRICS Healt h Ministers’Meeting was held in Brasilia,Brazil’s capital,on December 5.Brazilian Health Minister Arthur Chioro,South African Health Minister Pakishe Aaron Motsoaledi,Indian Vice-Health Minister Vishwa Mohan Katoch and Russian ViceHealth Minister Kostennikov Dmitry attended the meeting.
基金Financial support was provided by the Deutsche Forschungsgemeinschaft (DFG) (grant MA 1643 /14-1. 2)the Board of the President of the Russian Federation ( MD-802 . 2009 . 4 )+1 种基金the Russian Foundation for Basic Research ( projects 07 -04 -00393 ,10 -04 -01350 ,13 -04 -01401 ,and 11 -04 -91331 -NNIO)the Program of the Presidium of the Russian Academy of Sciences “Origin of the Life and Establishment of Biosphere
文摘The Berezovsk coal mine in western Siberia has yielded the most diverse Middle Jurassic limnic and terrestrial vertebrate assemblage of Asia. The vertebrate remains were recovered by screen washing from floodplain deposits on top of a thick coal seam of the Bathonian Itat Formation. A total of 29 vertebrate taxa has been recorded so far,including hybodontiform sharks,acipenseriforms,palaeonisciforms,amiiforms,dipnoans,anurans,caudates,turtles,squamates,choristoderans,crocodyliforms,pterosaurs,dinosaurs,tritylodontids,and a diverse mammaliaform and mammalian assemblage( eleutherodontids,docodontans,? amphilestids,dryolestids,and zatherians). The caudates are among the oldest in the fossil record and the anurans represent the oldest Asian record of this group. Among the mammals,Anthracolestes is the oldest and most basal known member of Dryolestidae and so far the only record from Asia. The vertebrate assemblage from the Berezovsk coal mine is very similar to that from the British Forest Marble Formation( Bathonian) and suggests a limited provincialism in the Middle Jurassic Laurasian landmass.
基金Supported by the Federal State Centre for Fisheries(Russia,Tyumen)
文摘In Western Siberia(Russia) there are about 100 Artemia lakes with total area over 1 600 km 2.Geographically these lakes are located between 51°–56°N and 61°–82°E.In general these lakes are shallow(depth less than 1.5 m),small or medium size(0.1 to 10 km 2);they are chloride;their total salinity is from 40 to 250 g/L.The harvesting of cysts per year is only in 20–40 lakes.In Russia 550 tons of dry Artemia cysts(14%–18% of the world production) were harvested annually.This includes about 350 tons in the Altai region and 200 tons in other regions.During our regular 20-year study period the cyst harvest was:95 tons in Kurgan;65 tons in Omsk,20 tons in Novosibirsk,20 tons in Tyumen.Ways of increasing cyst harvest in Russia are considered in this article.During the last 30 years the harvest of cysts in Russia has increased from 7–20 to 500–600 tons.A significant influence of dryness of the year was found on productivity in selected lakes,but taken for all the lakes together,the relationship was not significant.The optimal salinity for productivity of cysts in the lakes was determined.Analysis of productivity of the lakes and the harvesting results showed that the stocks of cysts are underutilized by approximately 1.7 times.
文摘Thales of Miletus （640？-546 BC） is famous for his prediction of the total solar eclipse in 585 BC. In this paper, the author demonstrate how Thales may have used the same principle for prediction of solar eclipses as that used on the Antikythera Mechanism. At the SEAC conference in Alexandria in 2009, the author presented the paper ＂Ten solar eclipses show that the Antikythera Mechanism was constructed for use on Sicily.＂ The best defined series of exeligmos cycles started in 243 BC during the lifetime of Archimedes （287-212 BC） from Syracuse. The inscriptions on the Antikythera Mechanism were made in 100-150 BC and the last useful exeligmos started in 134 BC. The theory for the motion of the moon was from Hipparchus （ca 190-125 BC）. A more complete investigation of the solar eclipses on the Antikythera Mechanism reveals that the first month in the first saros cycle started with the first new moon after the winter solstice in 542 BC. Four solar eclipses 537-528 BC, from the first saros cycle, and three one exeligmos cycle later, 487-478 BC, are preserved and may have been recorded in Croton by Pythagoras （ca 575-495 BC） and his school.
