正1、引言安全是相对的,所以有人把安全定义为能将人员伤亡或财产损失控制在可接受的水平状态,对安全程度的高要求往往意味着昂贵的成本,但另一方面安全又是降低成本的最好方式。ALARP准则认为,任何工业活动都具有风险,不可能通过预防...正1、引言安全是相对的,所以有人把安全定义为能将人员伤亡或财产损失控制在可接受的水平状态,对安全程度的高要求往往意味着昂贵的成本,但另一方面安全又是降低成本的最好方式。ALARP准则认为,任何工业活动都具有风险,不可能通过预防措施来彻底消除风险,必须在风险水平与利益之间做出平衡,因此它也被称为最低合理可行(As Low As ReasonablyPracticale)准则,剑桥大学Fischhoff在1981年出版的《可接受风险》(Acceptable Risk)一书中就专门探讨了可接受风险,主张接受风险不是无条件的,仅仅在获得利益可以补偿所带来的损失时才是可以接受的。展开更多
The transmitting models of ultrasonic vibration in ultrasonic transducer and capillary were presented according to the propagating mechanism of ultrasonic wave in elastic body. The coupling characteristics of ultrason...The transmitting models of ultrasonic vibration in ultrasonic transducer and capillary were presented according to the propagating mechanism of ultrasonic wave in elastic body. The coupling characteristics of ultrasonic longitudinal-complex transverse vibration system were simulated by Matlab software. The ultrasonic vibration displacement and the velocity of high frequency were measured by using the PSV-400-M2(1.5MHz) laser Doppler vibrometer. The vibration locus shapes driven by the same frequency and different frequencies were tested by using GDS-820S dual channel digital oscilloscope. The microstructures at bonding interface were observed by means of KYKY2800 scanning electron microscope. The results show that ultrasonic vibration displacement or velocity and energy density increase with the decrease of section area in the transmitting process. The vibration locus shapes driven simultaneously by the same frequency and different frequencies are elliptical (or circular) loci and rectangular (or square) loci, respectively. And the characteristics at bonding interface are improved by coupling loci.展开更多
Four episodes of granitic rocks at 517, 501-496, 462-451, and 426-385 Ma occurred in the South Altyn subduction-collision complex. The first episode of granite emplacement predates the formation of the ophiolite type ...Four episodes of granitic rocks at 517, 501-496, 462-451, and 426-385 Ma occurred in the South Altyn subduction-collision complex. The first episode of granite emplacement predates the formation of the ophiolite type mafic rock （〉500 Ma）, and the three subsequent episodes can be temporally correlated to high-pressure （HP） to ultrahigh-pressure （UHP） metamorphism at ca 500 Ma, retrograde granulite-facies metamorphism at ca. 450 Ma, and amphibolite-facies metamorphism at ca. 420 Ma, re- spectively. A comprehensive study of these granitic rocks, along with the regional geological background, mafic-ultramafic rocks, and HP-UHP metamorphism, indicates that the four episodes of granitic magmatism are sequentially derived from the partial melting of the earlier subducted oceanic crust at 517 Ma, the thickened continental crust due to continental subduction at ca. 500 Ma, the mid-upper crust in response to slab breakoff at ca. 450 Ma, and the tectonic transition from contraction to extension at ca. 420 Ma. The formation age of 517 Ma for oceanic adakite provides a direct constraint on the time of the oce- anic subduction in South Altyn. In addition, there is a ca. i0 Myr interval between the oceanic subduction to the continental deep subduction, suggesting that the Early Paleozoic tectonic evolution might have been a successive process in South Altyn. The four episodes of formation of granitic rocks, mafic-ultramafic rocks, and HP-UHP metamorphic rocks have fully recorded the tectonic evolution, beginning with the oceanic subduction, followed by continental subduction, and later exhumation dur- ing the Early Paleozoic in South Altyn.展开更多
High-temperature(HT, >850℃) metamorphism in continental collision orogens, particularly for those ultrahigh-pressure(UHP) metamorphic rocks, has become one of the remarkable topics in Earth science. It has bearing...High-temperature(HT, >850℃) metamorphism in continental collision orogens, particularly for those ultrahigh-pressure(UHP) metamorphic rocks, has become one of the remarkable topics in Earth science. It has bearing on the element and isotope behaviors of UHP rocks, their partial melting and related geodynamic effects during exhumation. In this paper, five representative continental collision orogens with typical HT/UHP rocks, including the Dabie orogen in China, the Kokchetav in Kazakhstan, the Caledonides in Greenland, the Rhodope in Greece, and the Erzgebirge in Germany are introduced, and their HT/UHP metamorphism and evolution processes are summarized. In addition, metamorphic P-T-t paths, multistage exhumation processes, and partial melting and preservation and retrogression of UHP index minerals during exhumation and their possible mechanisms are discussed. On this basis, the forthcoming key fields and scientific subjects of HT/UHP rocks within continental subduction channel are proposed.展开更多
To test the hypothesis that transient nonischemic stimulation of hypertrophy would render the heart resistant to subsequent ischemic stress,short-term transverse aortic constriction(TAC)was performed in mice and then ...To test the hypothesis that transient nonischemic stimulation of hypertrophy would render the heart resistant to subsequent ischemic stress,short-term transverse aortic constriction(TAC)was performed in mice and then withdrawn for several days by aortic debanding,followed by subsequent myocardial exposure to ischemia/reperfusion(I/R).Following I/R injury,the myocardial infarct size and apoptosis were markedly reduced,and contractile function was significantly improved in the TAC preconditioning group compared with the control group.Mechanistically,hypertrophic preconditioning remarkably alleviated I/R-induced oxidative stress,as evidenced by the increased reduced nicotinamide adenine dinucleotide phosphate(NADPH)/nicotinamide adenine dinucleotide phosphate(NADP)ratio,increase in the reduced glutathione(GSH)/oxidized glutathione(GSSH)ratio,and reduced mitochondrial reactive oxygen species(ROS)production.Moreover,TAC preconditioning inhibited caspase-3 activation and mitigated the mitochondrial impairment by deacetylating isocitrate dehydrogenase 2(IDH2)via a sirtuin 3(SIRT3)-dependent mechanism.In addition,the expression of a genetic deacetylation mimetic IDH2 mutant(IDH2 K413R)in cardiomyocytes,which increased IDH2 enzymatic activity and decreased mitochondrial ROS production,and ameliorated I/R injury,whereas the expression of a genetic acetylation mimetic(IDH2 K413Q)in cardiomyocytes abolished these protective effects of hypertrophic preconditioning.Furthermore,both the activity and expression of the SIRT3 protein were markedly increased in preconditioned mice exposed to I/R.Treatment with an adenovirus encoding SIRT3 partially emulated the actions of hypertrophic preconditioning,whereas genetic ablation of SIRT3 in mice blocked the cardioprotective effects of hypertrophic preconditioning.The present study identifies hypertrophic preconditioning as a novel endogenous self-defensive and cardioprotective strategy for cardiac I/R injury that induces IDH2 deacetylation through a SIRT3-dependent mechanism.A therapeutic strategy targeting IDH2 may be a promising treatment for cardiac ischemic injury.展开更多
文摘正1、引言安全是相对的,所以有人把安全定义为能将人员伤亡或财产损失控制在可接受的水平状态,对安全程度的高要求往往意味着昂贵的成本,但另一方面安全又是降低成本的最好方式。ALARP准则认为,任何工业活动都具有风险,不可能通过预防措施来彻底消除风险,必须在风险水平与利益之间做出平衡,因此它也被称为最低合理可行(As Low As ReasonablyPracticale)准则,剑桥大学Fischhoff在1981年出版的《可接受风险》(Acceptable Risk)一书中就专门探讨了可接受风险,主张接受风险不是无条件的,仅仅在获得利益可以补偿所带来的损失时才是可以接受的。
文摘The transmitting models of ultrasonic vibration in ultrasonic transducer and capillary were presented according to the propagating mechanism of ultrasonic wave in elastic body. The coupling characteristics of ultrasonic longitudinal-complex transverse vibration system were simulated by Matlab software. The ultrasonic vibration displacement and the velocity of high frequency were measured by using the PSV-400-M2(1.5MHz) laser Doppler vibrometer. The vibration locus shapes driven by the same frequency and different frequencies were tested by using GDS-820S dual channel digital oscilloscope. The microstructures at bonding interface were observed by means of KYKY2800 scanning electron microscope. The results show that ultrasonic vibration displacement or velocity and energy density increase with the decrease of section area in the transmitting process. The vibration locus shapes driven simultaneously by the same frequency and different frequencies are elliptical (or circular) loci and rectangular (or square) loci, respectively. And the characteristics at bonding interface are improved by coupling loci.
基金supported by the National Basic Research Program of China(Grant No.2015CB856103)the National Natural Science Foundation of China(Grant Nos.41430209,4140020262&41421002)Regional Geological Survey Project of Key Area in Western Kunlun-South Altyn from China Geological Survey and Special Fund from the State Key Laboratory of Continental Dynamics,Northwest University
文摘Four episodes of granitic rocks at 517, 501-496, 462-451, and 426-385 Ma occurred in the South Altyn subduction-collision complex. The first episode of granite emplacement predates the formation of the ophiolite type mafic rock （〉500 Ma）, and the three subsequent episodes can be temporally correlated to high-pressure （HP） to ultrahigh-pressure （UHP） metamorphism at ca 500 Ma, retrograde granulite-facies metamorphism at ca. 450 Ma, and amphibolite-facies metamorphism at ca. 420 Ma, re- spectively. A comprehensive study of these granitic rocks, along with the regional geological background, mafic-ultramafic rocks, and HP-UHP metamorphism, indicates that the four episodes of granitic magmatism are sequentially derived from the partial melting of the earlier subducted oceanic crust at 517 Ma, the thickened continental crust due to continental subduction at ca. 500 Ma, the mid-upper crust in response to slab breakoff at ca. 450 Ma, and the tectonic transition from contraction to extension at ca. 420 Ma. The formation age of 517 Ma for oceanic adakite provides a direct constraint on the time of the oce- anic subduction in South Altyn. In addition, there is a ca. i0 Myr interval between the oceanic subduction to the continental deep subduction, suggesting that the Early Paleozoic tectonic evolution might have been a successive process in South Altyn. The four episodes of formation of granitic rocks, mafic-ultramafic rocks, and HP-UHP metamorphic rocks have fully recorded the tectonic evolution, beginning with the oceanic subduction, followed by continental subduction, and later exhumation dur- ing the Early Paleozoic in South Altyn.
基金supported by the National Basic Research Program of China(Grant No.2015CB856104)the National Natural Science Foundation of China(Grant No.41273036)
文摘High-temperature(HT, >850℃) metamorphism in continental collision orogens, particularly for those ultrahigh-pressure(UHP) metamorphic rocks, has become one of the remarkable topics in Earth science. It has bearing on the element and isotope behaviors of UHP rocks, their partial melting and related geodynamic effects during exhumation. In this paper, five representative continental collision orogens with typical HT/UHP rocks, including the Dabie orogen in China, the Kokchetav in Kazakhstan, the Caledonides in Greenland, the Rhodope in Greece, and the Erzgebirge in Germany are introduced, and their HT/UHP metamorphism and evolution processes are summarized. In addition, metamorphic P-T-t paths, multistage exhumation processes, and partial melting and preservation and retrogression of UHP index minerals during exhumation and their possible mechanisms are discussed. On this basis, the forthcoming key fields and scientific subjects of HT/UHP rocks within continental subduction channel are proposed.
基金supported by the National Natural Science Foundation of China(81870290,81521001,81800235,and 81800238)。
文摘To test the hypothesis that transient nonischemic stimulation of hypertrophy would render the heart resistant to subsequent ischemic stress,short-term transverse aortic constriction(TAC)was performed in mice and then withdrawn for several days by aortic debanding,followed by subsequent myocardial exposure to ischemia/reperfusion(I/R).Following I/R injury,the myocardial infarct size and apoptosis were markedly reduced,and contractile function was significantly improved in the TAC preconditioning group compared with the control group.Mechanistically,hypertrophic preconditioning remarkably alleviated I/R-induced oxidative stress,as evidenced by the increased reduced nicotinamide adenine dinucleotide phosphate(NADPH)/nicotinamide adenine dinucleotide phosphate(NADP)ratio,increase in the reduced glutathione(GSH)/oxidized glutathione(GSSH)ratio,and reduced mitochondrial reactive oxygen species(ROS)production.Moreover,TAC preconditioning inhibited caspase-3 activation and mitigated the mitochondrial impairment by deacetylating isocitrate dehydrogenase 2(IDH2)via a sirtuin 3(SIRT3)-dependent mechanism.In addition,the expression of a genetic deacetylation mimetic IDH2 mutant(IDH2 K413R)in cardiomyocytes,which increased IDH2 enzymatic activity and decreased mitochondrial ROS production,and ameliorated I/R injury,whereas the expression of a genetic acetylation mimetic(IDH2 K413Q)in cardiomyocytes abolished these protective effects of hypertrophic preconditioning.Furthermore,both the activity and expression of the SIRT3 protein were markedly increased in preconditioned mice exposed to I/R.Treatment with an adenovirus encoding SIRT3 partially emulated the actions of hypertrophic preconditioning,whereas genetic ablation of SIRT3 in mice blocked the cardioprotective effects of hypertrophic preconditioning.The present study identifies hypertrophic preconditioning as a novel endogenous self-defensive and cardioprotective strategy for cardiac I/R injury that induces IDH2 deacetylation through a SIRT3-dependent mechanism.A therapeutic strategy targeting IDH2 may be a promising treatment for cardiac ischemic injury.
