To develop near-infrared （NIR） reflectance spectroscopic methods for the quantitative analysis of cefoperazone sodium/ sulbactam sodium from different manufacturers for injection powder medicaments. Various powders ...To develop near-infrared （NIR） reflectance spectroscopic methods for the quantitative analysis of cefoperazone sodium/ sulbactam sodium from different manufacturers for injection powder medicaments. Various powders of cefoperazone sodium/ sulbactam sodium were directly analyzed by non-destructive NIR reflectance spectroscopy using the spectrometer EQUINOX55. Two quantitative methods via integrating sphere （IS） and fiberoptic probe （FOP） models were explored from 6 batches of commercial samples and 42 batches of laboratory samples at a content ranging from 30% to 70% for cefoperazone and 60% to 20% for sulbactam. The root mean square errors of cross validation （RMSECV） and the root mean square errors of prediction （RMSEP） of IS were 1.79% and 2.85%, respectively, for cefoperazone sodium, and were 1.86% and 3.08%, respectively, for sulbactam sodium; and those of FOP were 2.93% and 2.92%, respectively, for cefoperazone sodium, and were 2.23% and 3.01%, respectively, for sulbactam sodium. Based on the ICH guidelines and Ref. 12, the quantitative models were then evaluated in terms of specificity, linearity, accuracy, precision, robustness and model transferability. The non-destructive quantitative NIR methods used in this study are applicable for rapid analysis of injectable powdered drugs from different manufacturers.展开更多
In cloud computing,fairness is one of the most significant indicators to evaluate resource allocation algorithms,which reveals whether each user is allocated as much as that of all other users having the same bottlene...In cloud computing,fairness is one of the most significant indicators to evaluate resource allocation algorithms,which reveals whether each user is allocated as much as that of all other users having the same bottleneck.However,how fair an allocation algorithm is remains an urgent issue.In this paper,we propose Dynamic Evaluation Framework for Fairness(DEFF),a framework to evaluate the fairness of an resource allocation algorithm.In our framework,two sub-models,Dynamic Demand Model(DDM) and Dynamic Node Model(DNM),are proposed to describe the dynamic characteristics of resource demand and the computing node number under cloud computing environment.Combining Fairness on Dominant Shares and the two sub-models above,we finally obtain DEFF.In our experiment,we adopt several typical resource allocation algorithms to prove the effectiveness on fairness evaluation by using the DEFF framework.展开更多
As a hot topic in Landscape Ecology study,ecological connectivity is an important indicator for regional land sustainable use and biological protection. This paper conducted a systematic assessment of ecological conne...As a hot topic in Landscape Ecology study,ecological connectivity is an important indicator for regional land sustainable use and biological protection. This paper conducted a systematic assessment of ecological connectivity using remote sensing images of Dongshan Island in 1994, 2003 and2011. Based on least-cost modelling, the method takes into consideration the type of barrier, the distance impact, and the adjacent land use types to obtain the Barrier Effect Index(BEI) and Ecological Connectivity Index(ECI). The application of this method to Dongshan Island showed the ecological connectivity index(ECI) was low in 1994, improved in 2003, and decreased significantly in 2011. The results of the dynamic analysis of landscape structure showed farmland and roads were the main landscape classes that caused the low observed ECI in 1994 and 2003;these tended to divide the landscape and cause fragmentation. Construction land and roads were the main landscape classes resulting in low ECI in 2011,while forest and grassland had a high ECI. Trajectory analysis showed ECI tended to decrease in the low mountain forest zone of the northwestern and southeastern parts of Dongshan Island as well as in the coastal protection forest area. The areas where ECI became high were located in the northeastern part of Dongshan Island where cities and towns are concentrated with high human populations.Therefore, rapid urbanization has been the most important factor driving changes in landscape structure and patterns during the last 17 years on Dongshan Island. The approach not only assists us in revealing the driving mechanism of landscape dynamics from another aspect, but also can assess the impacts of regional and urban plans on landscape structure and function.展开更多
Micropipette aspiration(MA) is widely applied in cell mechanics, however, at small deformations a common model corresponding to the MA is the half-space model wherein the finite cell size and cell compressibility are ...Micropipette aspiration(MA) is widely applied in cell mechanics, however, at small deformations a common model corresponding to the MA is the half-space model wherein the finite cell size and cell compressibility are neglected. This study extends the half-space model by accounting for the influence of cell geometry and compressibility(sphere model). Using a finite element analysis of cell aspiration into a micropipette, an elastic approximation formula of the aspirated length was derived for the sphere model. The approximation formula includes the geometry parameter of the sphere model(ζ = R/a, R is the radius of the cell, and a is the inner radius of the micropipette) and the Poisson's ratio v of the cell. The results indicate that the parameter and Poisson's ratio v markedly affect the aspirated length, particularly for small and v. When ζ→∞ and v→0.5,the approximation formula tends to the analytical solution for the half-space model. In the incompressible case(v = 0.5), within the general experimental range(ζ varying from 2 to 4), the difference between the analytical solution and the approximate one is significant, and is up to 29% of the approximation solution when ζ= 2. Additionally, parametere was introduced to evaluate the error of elastic moduli between the half-space model and sphere model. Based on the approximation formula, the ζ thresholds, beyond which e becomes larger than 10% and 20%, were derived.展开更多
基金National Key Technologies R&D Program Foundation of China (Grant No. 2006BAK04A11)
文摘To develop near-infrared （NIR） reflectance spectroscopic methods for the quantitative analysis of cefoperazone sodium/ sulbactam sodium from different manufacturers for injection powder medicaments. Various powders of cefoperazone sodium/ sulbactam sodium were directly analyzed by non-destructive NIR reflectance spectroscopy using the spectrometer EQUINOX55. Two quantitative methods via integrating sphere （IS） and fiberoptic probe （FOP） models were explored from 6 batches of commercial samples and 42 batches of laboratory samples at a content ranging from 30% to 70% for cefoperazone and 60% to 20% for sulbactam. The root mean square errors of cross validation （RMSECV） and the root mean square errors of prediction （RMSEP） of IS were 1.79% and 2.85%, respectively, for cefoperazone sodium, and were 1.86% and 3.08%, respectively, for sulbactam sodium; and those of FOP were 2.93% and 2.92%, respectively, for cefoperazone sodium, and were 2.23% and 3.01%, respectively, for sulbactam sodium. Based on the ICH guidelines and Ref. 12, the quantitative models were then evaluated in terms of specificity, linearity, accuracy, precision, robustness and model transferability. The non-destructive quantitative NIR methods used in this study are applicable for rapid analysis of injectable powdered drugs from different manufacturers.
基金supported in part by Program for Changjiang Scholars and Innovative Research Team in University No.IRT1078The Key Program of NSFC-Guangdong Union Foundation No.U1135002The Fundamental Research Funds for the Central Universities No.JY0900120301
文摘In cloud computing,fairness is one of the most significant indicators to evaluate resource allocation algorithms,which reveals whether each user is allocated as much as that of all other users having the same bottleneck.However,how fair an allocation algorithm is remains an urgent issue.In this paper,we propose Dynamic Evaluation Framework for Fairness(DEFF),a framework to evaluate the fairness of an resource allocation algorithm.In our framework,two sub-models,Dynamic Demand Model(DDM) and Dynamic Node Model(DNM),are proposed to describe the dynamic characteristics of resource demand and the computing node number under cloud computing environment.Combining Fairness on Dominant Shares and the two sub-models above,we finally obtain DEFF.In our experiment,we adopt several typical resource allocation algorithms to prove the effectiveness on fairness evaluation by using the DEFF framework.
基金supported by the National Natural Science Foundation of China(Grant Nos.31200365,31370624,and 41301203)the Youth Science Fund of the Forestry College of Fujian Agriculture and Forestry University(Grant No.6112C039V)
文摘As a hot topic in Landscape Ecology study,ecological connectivity is an important indicator for regional land sustainable use and biological protection. This paper conducted a systematic assessment of ecological connectivity using remote sensing images of Dongshan Island in 1994, 2003 and2011. Based on least-cost modelling, the method takes into consideration the type of barrier, the distance impact, and the adjacent land use types to obtain the Barrier Effect Index(BEI) and Ecological Connectivity Index(ECI). The application of this method to Dongshan Island showed the ecological connectivity index(ECI) was low in 1994, improved in 2003, and decreased significantly in 2011. The results of the dynamic analysis of landscape structure showed farmland and roads were the main landscape classes that caused the low observed ECI in 1994 and 2003;these tended to divide the landscape and cause fragmentation. Construction land and roads were the main landscape classes resulting in low ECI in 2011,while forest and grassland had a high ECI. Trajectory analysis showed ECI tended to decrease in the low mountain forest zone of the northwestern and southeastern parts of Dongshan Island as well as in the coastal protection forest area. The areas where ECI became high were located in the northeastern part of Dongshan Island where cities and towns are concentrated with high human populations.Therefore, rapid urbanization has been the most important factor driving changes in landscape structure and patterns during the last 17 years on Dongshan Island. The approach not only assists us in revealing the driving mechanism of landscape dynamics from another aspect, but also can assess the impacts of regional and urban plans on landscape structure and function.
基金supported by the National Natural Science Foundation of China(Grant No.11032008)the Youth Fund of Taiyuan University of Technology
文摘Micropipette aspiration(MA) is widely applied in cell mechanics, however, at small deformations a common model corresponding to the MA is the half-space model wherein the finite cell size and cell compressibility are neglected. This study extends the half-space model by accounting for the influence of cell geometry and compressibility(sphere model). Using a finite element analysis of cell aspiration into a micropipette, an elastic approximation formula of the aspirated length was derived for the sphere model. The approximation formula includes the geometry parameter of the sphere model(ζ = R/a, R is the radius of the cell, and a is the inner radius of the micropipette) and the Poisson's ratio v of the cell. The results indicate that the parameter and Poisson's ratio v markedly affect the aspirated length, particularly for small and v. When ζ→∞ and v→0.5,the approximation formula tends to the analytical solution for the half-space model. In the incompressible case(v = 0.5), within the general experimental range(ζ varying from 2 to 4), the difference between the analytical solution and the approximate one is significant, and is up to 29% of the approximation solution when ζ= 2. Additionally, parametere was introduced to evaluate the error of elastic moduli between the half-space model and sphere model. Based on the approximation formula, the ζ thresholds, beyond which e becomes larger than 10% and 20%, were derived.
