Copper(Ⅱ) complexes Cu(C6H6N2)2(ClO4)2 (1) and Cu2(OAc)4(C5H5ClN2)2 (2) with amino pyridine derivatives ligands have been synthesized and characterized by elemental analysis and IR spectrum. Their crystal structures ...Copper(Ⅱ) complexes Cu(C6H6N2)2(ClO4)2 (1) and Cu2(OAc)4(C5H5ClN2)2 (2) with amino pyridine derivatives ligands have been synthesized and characterized by elemental analysis and IR spectrum. Their crystal structures are determined by X ray diffraction method. Compound 1, C12H16Cl2CuN4O8, Mr=478.73, triclinic, space <IMG SRC="IMAGE/04170000.JPG" HEIGHT=14 WIDTH=16>group , a=0.7641(1)nm, b=0.7987(1)nm, c=0.7990(1)nm, α =106.78(1)° ,β =95.71(1)° , γ =108.85(1)° , V=0.4317(1)nm3, Z=1, Dc=1.841g· cm- 3, μ =1.627mm- 1, F(000) =243,R1=0.0264, ω R2=0.0641 (I >2σ (I)). In 1, the center metal ion Cu? possesses distorted octahedral geometry. Compound 2, C18H22C12Cu2N4O8, Mr=620.38,monoclinic, space group C2/c, a=1.9888(3), b=0.9158(1), c=1.4241(2)nm, β =115.89(1)° , V=2.3336(5)nm3, Z=4, Dc=1.766mg· cm- 3, μ =2.104mm- 1, F(000)=1256, R1=0.0263, wR2=0.0676 (I >2σ (I)). Compound 2 is dinuclear structure, in which each Cu? adopts five coordinated distorted square pyramid geometry. CCDC: 193109; 193110.展开更多
A novel compound Cu（phen）（m-CBA）2 was synthesized with m-chlorobenzoic acid（m-CBA）, 1,10-phenanthroline（phen） and Cu（OAc）2·H2O. It was characterized by IR, UV, elemental analyses and X-ray crystallograp...A novel compound Cu（phen）（m-CBA）2 was synthesized with m-chlorobenzoic acid（m-CBA）, 1,10-phenanthroline（phen） and Cu（OAc）2·H2O. It was characterized by IR, UV, elemental analyses and X-ray crystallography. It crystallizes in the monoclinic crystal system with C2/c space group, a=2.9699（4） nm, b=1.15452（2） nm, c=1.5335（2） nm, β=111.118（2）°, V=4.905 1（1） nm3, Z=8, F（000）=2 328, R1=0.072 8, wR2=0.223 4 [I2σ（I）]. Structure analysis shows that the copper center coordinates with two nitrogen atoms from one 1,10-phenanthroline molecule, two oxygen atoms from two m-chlorobenzoic acid molecules, giving a distorted squared planar coordination geometry. This novel compound shows paramagnetic interactions between copper centers.展开更多
A pyridine-copper inclusion complex with [Cu(py)4Cl]+ core was prepared in the presence of tripodal ligand tbst {tbst = 1,3,5-tris(2-benzimidazol)sulfanylmethyl-2,4,6-trimethyl- benzene}, and its structure has been de...A pyridine-copper inclusion complex with [Cu(py)4Cl]+ core was prepared in the presence of tripodal ligand tbst {tbst = 1,3,5-tris(2-benzimidazol)sulfanylmethyl-2,4,6-trimethyl- benzene}, and its structure has been determined. It crystallizes in triclinic, space group P with a = 9.0822(2), b = 17.6026(4), c = 18.7156(4) ? a = 93.40, b = 91.2980(1), g = 91.5560(1), V = 2984.81(1) 3, C58H63Cl2CuN11O4S3, Mr = 1208.81, Z = 2, F(000) = 1262, Dc = 1.345 g/cm3, m = 0.615 mm-1, R = 0.0713 and wR = 0.1307 for 7798 observed reflections (I > 2s(I)). X-ray analysis reveals that the uncoordinated tbst and pyridine as guest molecules are included in the complex with formula {[Cu(py)4Cl]Cl}(tbst)(py)4H2O. The tbst, pyridine, aqua and Cl- anion in the com- plex form extensive hydrogen-bonding interactions, building up a quasi-dinuclear structure.展开更多
A mononuclear chiral copper（ll） complex, [Cu（RRchxn）2（C（CN）3）2]＇H20 （RRchxn = （1R, 2R）-diaminocyclohexane） （RRchxnH）, and its deuterated compound, [Cu（RRchxn）2（C（CN）3）z].D20 （RRchxnD）, and their...A mononuclear chiral copper（ll） complex, [Cu（RRchxn）2（C（CN）3）2]＇H20 （RRchxn = （1R, 2R）-diaminocyclohexane） （RRchxnH）, and its deuterated compound, [Cu（RRchxn）2（C（CN）3）z].D20 （RRchxnD）, and their isomers, [Cu（trchxn）2（C（CN）3）2]＇H20 （trchxn = trans-l,2-diaminocyclohexane） （trchxnH） and [Cu（trchxn）2（C（CN）3）2]＇D20 （trchxnD） have been prepared and characterized by means of 1R （infrared）, electronic, and CD （circular dichroism） spectra, magnetic susceptibility, and variable-temperature X-ray crystallography as single crystals or powder. Interestingly, depending on grain size of samples, RRchxnH exhibits the monoclinic form and the orthorhombic form, which are distinguished by systematic absence and powder XRD （X-ray diffraction） patterns clearly. Although single crystals did not exhibit phase transition, powder XRD patterns of RRchxnH and weakly hydrogen bonded RRchxnD emerged low-temperature phase of monoclinic in the orthorhombic patterns only around 200-220 K. However, as a control, powder XRD patterns of both trchxnH and trchxnD did not exhibit such phase transition clearly.展开更多
A curcumin derivative ligand,1,7-bis(3-methoxyl-4-acetoxyl)phenyl-1,6-heptadiene-3,5-diketone (diacetylcurcumin,abbreviated as HL),and its Cu and Ni complexes have been synthesized and fully characterized by elemental...A curcumin derivative ligand,1,7-bis(3-methoxyl-4-acetoxyl)phenyl-1,6-heptadiene-3,5-diketone (diacetylcurcumin,abbreviated as HL),and its Cu and Ni complexes have been synthesized and fully characterized by elemental analyses,IR,1 HNMR and molar conductivity.The resulting complexes exhibit two-photon excited fluorescence (TPEF) in DMF,and have been proven to be potentially useful for two-photon microscopy imaging in living cells.In addition,cytotoxicity tests showed that the low-micromolar concentrations of ML 2 did not cause significant reduction in cell viability over a period of at least 24 h and should be safe for further biological studies.展开更多
By applying an indirect strategy, a new copper （II） complex of a thiosemicarbazone L has been successfully developed as a colorimetric cbemosensor for the sensitive detection of mercury （II） ions. In the presence ...By applying an indirect strategy, a new copper （II） complex of a thiosemicarbazone L has been successfully developed as a colorimetric cbemosensor for the sensitive detection of mercury （II） ions. In the presence of copper （II） ions, the colorless so- lution of L became yellow; however, upon the addition of traces of mercury （II） ions, the yellow color faded to colorless im- mediately. Other ions, including Fe3＋, Ag＋, Ca2＋, Zn2＋, Pb2＋, Cd2＋, Ni2＋, Co2＋, Cr3＋ and Mg2＋ had a negligible influence on the probe behavior. The detection limits were 5.0×10^-6 M and 3.0×10^-7 M of Hg2＋ using the visual color changes and UV-vis changes respectively. Test strips based on Cu-L were fabricated, which could act as a convenient and efficient Hg2＋ test kits.展开更多
A new polymeric demethylcantharidato （DCA） bridged copper（II） phenanthroline （phen） complex （[Cu（DCA）（phen）]n-nH20） has been synthesized and characterized by elemental analysis, IR and electronic spectra s...A new polymeric demethylcantharidato （DCA） bridged copper（II） phenanthroline （phen） complex （[Cu（DCA）（phen）]n-nH20） has been synthesized and characterized by elemental analysis, IR and electronic spectra studies, molar conductivity measure- ment, and single crystal X-ray diffraction. The complex crystallizes in the orthorhombic space group Pbca with crystallo- graphic data： a -- 12.4537（4）/~, b = 9.3897（5） A, c = 30.1264（10） A, and Z = 8. In the crystal structure, the octahedral coordi- nated copper（II） ions are bridged by demethylcantharidate ligands into a one-dimensional zigzag-like structure with the Cu＇＂Cu separation of 6.1719/~, along with phen ligands attached to both sides of the chain altematively. Interdigitation of the chelating phen ligands of two neighboring chains via hydrophobic interaction and van der Waals forces along ac plane forms two-dimensional polymeric bilayers with discrete water sandwich layer between the adjacent polymeric bilayers. The evalua- tion of the cytotoxic activity of the copper（II） complex against HCT-8 （colorectal carcinoma）, A549 （pulmonary carcinoma）, HeLa （cervical cancer）, HepG2 （hepatocarcinoma）, BGC-823 （gastric carcinoma）, and MCF-7 （breast adenocarcinoma） cell lines revealed that it is a potent cytotoxic agent, superior to Na2DCA and phen against HeLa, HepG2 and BGC-823 cells.展开更多
文摘Copper(Ⅱ) complexes Cu(C6H6N2)2(ClO4)2 (1) and Cu2(OAc)4(C5H5ClN2)2 (2) with amino pyridine derivatives ligands have been synthesized and characterized by elemental analysis and IR spectrum. Their crystal structures are determined by X ray diffraction method. Compound 1, C12H16Cl2CuN4O8, Mr=478.73, triclinic, space <IMG SRC="IMAGE/04170000.JPG" HEIGHT=14 WIDTH=16>group , a=0.7641(1)nm, b=0.7987(1)nm, c=0.7990(1)nm, α =106.78(1)° ,β =95.71(1)° , γ =108.85(1)° , V=0.4317(1)nm3, Z=1, Dc=1.841g· cm- 3, μ =1.627mm- 1, F(000) =243,R1=0.0264, ω R2=0.0641 (I >2σ (I)). In 1, the center metal ion Cu? possesses distorted octahedral geometry. Compound 2, C18H22C12Cu2N4O8, Mr=620.38,monoclinic, space group C2/c, a=1.9888(3), b=0.9158(1), c=1.4241(2)nm, β =115.89(1)° , V=2.3336(5)nm3, Z=4, Dc=1.766mg· cm- 3, μ =2.104mm- 1, F(000)=1256, R1=0.0263, wR2=0.0676 (I >2σ (I)). Compound 2 is dinuclear structure, in which each Cu? adopts five coordinated distorted square pyramid geometry. CCDC: 193109; 193110.
基金Project (21001118) supported by the National Natural Science Foundation of China
文摘A novel compound Cu（phen）（m-CBA）2 was synthesized with m-chlorobenzoic acid（m-CBA）, 1,10-phenanthroline（phen） and Cu（OAc）2·H2O. It was characterized by IR, UV, elemental analyses and X-ray crystallography. It crystallizes in the monoclinic crystal system with C2/c space group, a=2.9699（4） nm, b=1.15452（2） nm, c=1.5335（2） nm, β=111.118（2）°, V=4.905 1（1） nm3, Z=8, F（000）=2 328, R1=0.072 8, wR2=0.223 4 [I2σ（I）]. Structure analysis shows that the copper center coordinates with two nitrogen atoms from one 1,10-phenanthroline molecule, two oxygen atoms from two m-chlorobenzoic acid molecules, giving a distorted squared planar coordination geometry. This novel compound shows paramagnetic interactions between copper centers.
基金This work was supported by the National Natural Science Foundation of China (No. 39970177 29733090 and 29973047)
文摘A pyridine-copper inclusion complex with [Cu(py)4Cl]+ core was prepared in the presence of tripodal ligand tbst {tbst = 1,3,5-tris(2-benzimidazol)sulfanylmethyl-2,4,6-trimethyl- benzene}, and its structure has been determined. It crystallizes in triclinic, space group P with a = 9.0822(2), b = 17.6026(4), c = 18.7156(4) ? a = 93.40, b = 91.2980(1), g = 91.5560(1), V = 2984.81(1) 3, C58H63Cl2CuN11O4S3, Mr = 1208.81, Z = 2, F(000) = 1262, Dc = 1.345 g/cm3, m = 0.615 mm-1, R = 0.0713 and wR = 0.1307 for 7798 observed reflections (I > 2s(I)). X-ray analysis reveals that the uncoordinated tbst and pyridine as guest molecules are included in the complex with formula {[Cu(py)4Cl]Cl}(tbst)(py)4H2O. The tbst, pyridine, aqua and Cl- anion in the com- plex form extensive hydrogen-bonding interactions, building up a quasi-dinuclear structure.
文摘A mononuclear chiral copper（ll） complex, [Cu（RRchxn）2（C（CN）3）2]＇H20 （RRchxn = （1R, 2R）-diaminocyclohexane） （RRchxnH）, and its deuterated compound, [Cu（RRchxn）2（C（CN）3）z].D20 （RRchxnD）, and their isomers, [Cu（trchxn）2（C（CN）3）2]＇H20 （trchxn = trans-l,2-diaminocyclohexane） （trchxnH） and [Cu（trchxn）2（C（CN）3）2]＇D20 （trchxnD） have been prepared and characterized by means of 1R （infrared）, electronic, and CD （circular dichroism） spectra, magnetic susceptibility, and variable-temperature X-ray crystallography as single crystals or powder. Interestingly, depending on grain size of samples, RRchxnH exhibits the monoclinic form and the orthorhombic form, which are distinguished by systematic absence and powder XRD （X-ray diffraction） patterns clearly. Although single crystals did not exhibit phase transition, powder XRD patterns of RRchxnH and weakly hydrogen bonded RRchxnD emerged low-temperature phase of monoclinic in the orthorhombic patterns only around 200-220 K. However, as a control, powder XRD patterns of both trchxnH and trchxnD did not exhibit such phase transition clearly.
基金supported by the National Natural Science Foundation of China (21071001)Department of Education Committee of Anhui Province (KJ2010A222)the Natural Science Foundation of Anhui Unversity of Traditional Chinese Medicine (2011zr005A)
文摘A curcumin derivative ligand,1,7-bis(3-methoxyl-4-acetoxyl)phenyl-1,6-heptadiene-3,5-diketone (diacetylcurcumin,abbreviated as HL),and its Cu and Ni complexes have been synthesized and fully characterized by elemental analyses,IR,1 HNMR and molar conductivity.The resulting complexes exhibit two-photon excited fluorescence (TPEF) in DMF,and have been proven to be potentially useful for two-photon microscopy imaging in living cells.In addition,cytotoxicity tests showed that the low-micromolar concentrations of ML 2 did not cause significant reduction in cell viability over a period of at least 24 h and should be safe for further biological studies.
基金supported by the National Natural Science Foundation of China (21262032, 21064006 and 21161018)the Natural Science Foundation of Gansu Province (1010RJZA018)the Program for Changjian Scholars and Innovative Research Team in University of Minisry of Education of China (IRT1177)
文摘By applying an indirect strategy, a new copper （II） complex of a thiosemicarbazone L has been successfully developed as a colorimetric cbemosensor for the sensitive detection of mercury （II） ions. In the presence of copper （II） ions, the colorless so- lution of L became yellow; however, upon the addition of traces of mercury （II） ions, the yellow color faded to colorless im- mediately. Other ions, including Fe3＋, Ag＋, Ca2＋, Zn2＋, Pb2＋, Cd2＋, Ni2＋, Co2＋, Cr3＋ and Mg2＋ had a negligible influence on the probe behavior. The detection limits were 5.0×10^-6 M and 3.0×10^-7 M of Hg2＋ using the visual color changes and UV-vis changes respectively. Test strips based on Cu-L were fabricated, which could act as a convenient and efficient Hg2＋ test kits.
基金supported by the Doctoral Fund of Ministry of Education of China (20110001110054)
文摘A new polymeric demethylcantharidato （DCA） bridged copper（II） phenanthroline （phen） complex （[Cu（DCA）（phen）]n-nH20） has been synthesized and characterized by elemental analysis, IR and electronic spectra studies, molar conductivity measure- ment, and single crystal X-ray diffraction. The complex crystallizes in the orthorhombic space group Pbca with crystallo- graphic data： a -- 12.4537（4）/~, b = 9.3897（5） A, c = 30.1264（10） A, and Z = 8. In the crystal structure, the octahedral coordi- nated copper（II） ions are bridged by demethylcantharidate ligands into a one-dimensional zigzag-like structure with the Cu＇＂Cu separation of 6.1719/~, along with phen ligands attached to both sides of the chain altematively. Interdigitation of the chelating phen ligands of two neighboring chains via hydrophobic interaction and van der Waals forces along ac plane forms two-dimensional polymeric bilayers with discrete water sandwich layer between the adjacent polymeric bilayers. The evalua- tion of the cytotoxic activity of the copper（II） complex against HCT-8 （colorectal carcinoma）, A549 （pulmonary carcinoma）, HeLa （cervical cancer）, HepG2 （hepatocarcinoma）, BGC-823 （gastric carcinoma）, and MCF-7 （breast adenocarcinoma） cell lines revealed that it is a potent cytotoxic agent, superior to Na2DCA and phen against HeLa, HepG2 and BGC-823 cells.
