Levels of high-sensitivity C-reactive protein were measured before and after 3 months of treatment with antispastic agents(calcium antagonists and/or isosorbide dinitrate)in 27 patients who had coronary vasospastic an...Levels of high-sensitivity C-reactive protein were measured before and after 3 months of treatment with antispastic agents(calcium antagonists and/or isosorbide dinitrate)in 27 patients who had coronary vasospastic angina pectoris and no hemodynamically significant coronary artery disease. Levels of high-sensitivity C-reactive protein decreased after treatment with antispastic agents.展开更多
Background: The use of serum high-sensitivity C-reactive protein(hs-CRP) for cardiovascular risk profiling requires knowledge of the distribution in different populations. We studied serum hs-CRP in a healthy Brazilia...Background: The use of serum high-sensitivity C-reactive protein(hs-CRP) for cardiovascular risk profiling requires knowledge of the distribution in different populations. We studied serum hs-CRP in a healthy Brazilian population, with no evidence of heart disease, relative to gender and smoking status as well as other clinical and laboratory variables. Methods: 684 healthy Brazilian individuals, aged 14-74 years(mean 40-.6 years), 295 men(43.1%) and 389 women(56.9%), were enrolled between July 1998 and July 2001. The relationship between the log-transformed hs-CRP, stratified by gender and smoking status(non-smokers, smokers), and clinical and laboratory variables were analyzed using the Spearman correlation coefficient and multiple linear regression. Results: In a multiple linear regression model age(β=1.0069, p=0.03), body mass index(BMI) (β=1.0093, p< 0.01), total cholesterol/HDL cholesterol ratio(TC/HDL-C)(β=1.1015, p< 0.01) and heart rate(β=1.0139, p< 0.01) were independently correlated with hs-CRP. Stratification according to gender and smoking was able to disclose different interactions between these variables and hs-CRP. Variables significantly correlated in each stratum were as follows: in smoker men, age(β=1.0236, p=0.04) and TC/HDL-C (β=1.2065, p< 0.01); in non-smoker men, BMI(β=1.0786, p< 0.01) and TC/HDL-C(β=1.1397, p=0.01); in smoker women, BMI(β=1.1006, p=0.03); and in non-smoker women, BMI (β=1.0873, p< 0.01), TC/HDL-C(β=1.1405, p=0.01) and heart rate(β=1.0165, p=0.02). Conclusions: The clinical and laboratory variables studied influenced the concentration of hs-CRP according to gender and smoking. In assessing the risk of cardiovascular events in relation to serum hs-CRP level, stratification by gender and smoking status is indicated.展开更多
文摘Levels of high-sensitivity C-reactive protein were measured before and after 3 months of treatment with antispastic agents(calcium antagonists and/or isosorbide dinitrate)in 27 patients who had coronary vasospastic angina pectoris and no hemodynamically significant coronary artery disease. Levels of high-sensitivity C-reactive protein decreased after treatment with antispastic agents.
文摘Background: The use of serum high-sensitivity C-reactive protein(hs-CRP) for cardiovascular risk profiling requires knowledge of the distribution in different populations. We studied serum hs-CRP in a healthy Brazilian population, with no evidence of heart disease, relative to gender and smoking status as well as other clinical and laboratory variables. Methods: 684 healthy Brazilian individuals, aged 14-74 years(mean 40-.6 years), 295 men(43.1%) and 389 women(56.9%), were enrolled between July 1998 and July 2001. The relationship between the log-transformed hs-CRP, stratified by gender and smoking status(non-smokers, smokers), and clinical and laboratory variables were analyzed using the Spearman correlation coefficient and multiple linear regression. Results: In a multiple linear regression model age(β=1.0069, p=0.03), body mass index(BMI) (β=1.0093, p< 0.01), total cholesterol/HDL cholesterol ratio(TC/HDL-C)(β=1.1015, p< 0.01) and heart rate(β=1.0139, p< 0.01) were independently correlated with hs-CRP. Stratification according to gender and smoking was able to disclose different interactions between these variables and hs-CRP. Variables significantly correlated in each stratum were as follows: in smoker men, age(β=1.0236, p=0.04) and TC/HDL-C (β=1.2065, p< 0.01); in non-smoker men, BMI(β=1.0786, p< 0.01) and TC/HDL-C(β=1.1397, p=0.01); in smoker women, BMI(β=1.1006, p=0.03); and in non-smoker women, BMI (β=1.0873, p< 0.01), TC/HDL-C(β=1.1405, p=0.01) and heart rate(β=1.0165, p=0.02). Conclusions: The clinical and laboratory variables studied influenced the concentration of hs-CRP according to gender and smoking. In assessing the risk of cardiovascular events in relation to serum hs-CRP level, stratification by gender and smoking status is indicated.
文摘目的：探讨原发性高血压（EH）左室肥厚（LVH）患者血浆妊娠相关蛋白-A（pregnancy-associated plasma protein-A，PAPP-A）和C-反应蛋白（Creactive protein，CRP）的变化。方法：EH患者49例，行心脏彩色超声检查，测量室间隔厚度（IVST）、左室后壁厚度（LVPWT）及左室舒张末内径（LVDD），计算左室质量指数（LVMI）。根据LVH的诊断标准将EH患者分为LVH＋组和LVH一组。运用双抗体夹心酶联免疫吸附实验（EALAS法）测定血浆PAPP-A浓度和运用双抗体放射免疫法检测血浆高敏CRP（hs-CRP）浓度。结果：LVH＋组PAPP—A及hs-CRP均高于LVH-组[分别为8．28（5．90～30．91）mIU／L vs 4．39（3．02～6．98）n1IU／L和8．58（0．90～35．80）mg／L vs 1．90（0．50～2．23）mg／L，P均〈0．05J。PAPP-A与LVMI及hs-CRP与LVMI的相关分析显示：PAPP-A与LVMI呈显著正相关（r=0．649，P〈0．05），hs-CRP与LVMI呈显著正相关（r=0．441，P〈0．05）。结论：EH伴LVH患者PAPP-A及CRP较LVH-组显著升高，并且PAPP-A、hs-CRP与LVMI呈显著正相关。PAPP—A与CRP可能参与EH患者LVH的形成。PAPP—A与CRP可能是EH患者合并LVH的预测指标。
