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Microwave-assisted Green and Efficient Synthesis of N^6-(2-Hydroxyethyl)adenosine and its Analogues 被引量:3
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作者 Gui Rong QU Ming Wei GENG Su Hui HAN Zhi Guang ZHANG Feng XUE 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第9期1149-1151,共3页
An efficient protocol for the synthesis of N^6-(2-Hydroxyethyl)adenosine and its analogues through nucleophilic substitution was developed. All the reactions were completed in 10 rain under microwave irradiation. Us... An efficient protocol for the synthesis of N^6-(2-Hydroxyethyl)adenosine and its analogues through nucleophilic substitution was developed. All the reactions were completed in 10 rain under microwave irradiation. Using water as solvent makes our method eco-friendly and easy to handle with. 展开更多
关键词 N^6 -(2-hydroxyethyl)adenosine nucleoside analogues microwave irradiation.
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Synthesis of Racemic Bis[2-(6-fluoro-2-chromanyl)-2-hydroxyethyl]-amine Methanesulfonic Acid Salt Using Lithium Aluminum Amide as a Promoter in Regioselective Ring Opening of Epoxide
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作者 Yun Xu YANG Nai Xing WANG +4 位作者 Ya Lan XING Wu Wei WANG Jia ZHAO Gui Xia WANG Shi TANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第12期1577-1580,共4页
Lithium aluminium amide [LiAI(NHR)4] 5 obtained by treating the primary amine 4 with LiAlH4 could promote the ring opening of epoxide 2 and led to high regioselective product of racemic bis[2-(6-fluoro-2-chromanyl... Lithium aluminium amide [LiAI(NHR)4] 5 obtained by treating the primary amine 4 with LiAlH4 could promote the ring opening of epoxide 2 and led to high regioselective product of racemic bis[2-(6-fluoro-2-chromanyl)-2-hydroxyethyl]amine methanesulfonic acid salt 7. 展开更多
关键词 EPOXIDE lithium aluminium amide bis[2-(6-fluoro-2-chromanyl)-2-hydroxyethyl]-amine
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Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis 被引量:3
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作者 An-Qi Zhang Lu Wang +11 位作者 Yi-Xiu Wang Shan-Shan Hong Yu-Shan Zhong Ru-Yi Yu Xin-Lu Wu Bing-Bing Zhou Qi-Min Yu Hai-Feng Fu Shuang-Dong Chen Yun-Chang Mo Qin-Xue Dai Jun-Lu Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第11期2504-2511,共8页
Previous studies have suggested that miR-324-3p is related to the pathophysiology of cerebral ischemia,but the mechanism underlying this relationship is unclea r.In this study,we found that miR-324-3p expression was d... Previous studies have suggested that miR-324-3p is related to the pathophysiology of cerebral ischemia,but the mechanism underlying this relationship is unclea r.In this study,we found that miR-324-3p expression was decreased in patients with acute ischemic stroke and in in vitro and in vivo models of ischemic stro ke.miR-324-3p agomir potentiated ischemic brain damage in rats subjected to middle cerebral artery occlusion,as indicated by increased infarct volumes and cell apoptosis rates and greater neurological deficits.In a PC12 cell oxygen-glucose deprivation/reoxygenation model,a miR-324-3 p mimic decreased cell viability and expression of the anti-apoptotic protein BCL2 and increased expression of the pro-apoptotic protein BAX and rates of cell apoptosis,whereas treatment with a miR-324-3p inhibitor had the opposite effects.Silencing miR-324-3p increased adenosine A1 receptor(A1R)expression thro ugh regulation of GATA binding protein 2(GATA2).These findings suggest that silencing miR-324-3p reduces ischemic brain damage via the GATA2/A1R axis. 展开更多
关键词 acute ischemic stroke adenosine A1 receptor apoptosis cerebral ischemia-reperfusion injury cortical neurons GATA2 middle cerebral artery occlusion miR-324-3p oxygen-glucose deprivation/reoxygenation PC12 cells
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SYNTHESIS AND CHARACTERIZATION OF POLY{4-[2-(tert-BUTYLDIMETHYLSILOXY)ETHYL]STYRENE}AND ITS HYDROLYSIS DERIVATIVE 被引量:1
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作者 郭文莉 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2009年第3期399-405,共7页
The living cationic polymerization of 4-[2-(tert-butyldimethylsiloxy)ethyl]styrene (TBDMES) was studied in methylcyclohexane (MeChx)/methylchloride (MeCl) (50/50 V/V) solvent mixture at -80 degrees C. The initiator 1,... The living cationic polymerization of 4-[2-(tert-butyldimethylsiloxy)ethyl]styrene (TBDMES) was studied in methylcyclohexane (MeChx)/methylchloride (MeCl) (50/50 V/V) solvent mixture at -80 degrees C. The initiator 1,1-diphenylethylene (DPE) capped 2-chloro-2,4,4-trimethylpentane (TMPCl) was formed in situ in conjunction with titanium tetrachloride (TiCl(4)). The Lewis acidity of TiCl(4) was decreased by the addition of titanium(IV) isopropoxide (Ti(OiPr)(4)) to accomplish living polymerization of TBDMES. Hydrolysis of poly(TBDMES) in the presence of tetra-butylammonium fluoride yielded poly[4-(2-hydroxyethyl)styrene] (poly(HOES)). FT-IR, NMR and DSC demonstrated the hydrolysis was complete. 展开更多
关键词 Living carbocationic polymerization Poly[4-(2-hydroxyethyl)styrene] HYDROLYSIS Pendant hydroxyl groups
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Synthesis and characterization of yellow water-borne polyurethane using a diol colorant as extender 被引量:5
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作者 Zhang, He Zhang, Xing Yuan +1 位作者 Dai, Jia Bing Li, Wei Hu 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第2期143-145,共3页
A novel and facile method toward a series of yellow water-borne polyurethane was developed by using an intrinsically colored diol in this paper.The yellow aqueous dispersion PCLD-HENA-PU was synthesized based on isoph... A novel and facile method toward a series of yellow water-borne polyurethane was developed by using an intrinsically colored diol in this paper.The yellow aqueous dispersion PCLD-HENA-PU was synthesized based on isophorone diisocyanate(IPDI), polycaprolactonediol(PCLD) and 2,2-dimethylol propionic acid(DMPA) using a yellow diol N,N-bis(2-hydroxyethyl)-4-nitroaniline (HENA) as a chain extender.Due to the complete reaction of OH group in colorant HENA with NCO group in diisocyanate,a series of stable yellow p... 展开更多
关键词 Colored diol EXTENDER Polycaprolactonediol N N-bis(2-hydroxyethyl)-4-nitroaniline Yellow polyurethane
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